Ectopic expression of the gastric inhibitory polypeptide receptor gene is a sufficient genetic event to induce benign adrenocortical tumor in a xenotransplantation model

Endocrinology

Volumn 147, Issue 2, 2006, Pages 782-790

  Mazzuco, Tania L ^a,b,c   Chabre, Olivier ^a,b,c   Sturm, Nathalie ^d   Feige, Jean Jacques ^a,b   Thomas, Michaël ^a,b  

^a INSERM   (France)

^b CEA GRENOBLE   (France)

^c GRENOBLE UNIVERSITY HOSPITAL   (France)

^d Laboratoire de Pathologie Cellulaire   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR; HORMONE RECEPTOR; UNCLASSIFIED DRUG;

ADRENAL CORTEX; ADRENAL CORTEX CELL; ADRENAL CORTEX TUMOR; ADRENALECTOMY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL TRANSPLANTATION; CONTROLLED STUDY; CUSHING SYNDROME; GENE EXPRESSION; GENETIC ENGINEERING; HISTOLOGY; HYDROCORTISONE RELEASE; HYPERGLYCEMIA; IMMUNE DEFICIENCY; KIDNEY CAPSULE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; XENOTRANSPLANTATION;

EID: 30944431530     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2005-0921     Document Type: Article

References (40)

1. Spiegel AM 1998 G proteins, receptors, and disease. Totawa, NJ: Humana Press
2. Lacroix A, Baldacchino V, Bourdeau I, Hamet P, Tremblay J 2004 Cushing's syndrome variants secondary to aberrant hormone receptors. Trends Endocrinol Metab 15:375-382
3. Groussin L, Perlemoine K, Contesse V, Lefebvre H, Tabarin A, Thieblot P, Schlienger JL, Luton JP, Bertagna X, Bertherat J 2002 The ectopic expression of the gastric inhibitory polypeptide receptor is frequent in adrenocorticotropin- independent bilateral macronodular adrenal hyperplasia, but rare in unilateral tumors. J Clin Endocrinol Metab 87:1980-1985
4. Lu M, Wheeler MB, Leng XH, Boyd 3rd AE 1993 The role of the free cytosolic calcium level in β-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37). Endocrinology 132:94-100
5. Volz A, Goke R, Lankat-Buttgereit B, Fehmann HC, Bode HP, Goke B 1995 Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma. FEBS Lett 373:23-29
6. Kubota A, Yamada Y, Yasuda K, Someya Y, Ihara Y, Kagimoto S, Watanabe R, Kuroe A, Ishida H, Seino Y 1997 Gastric inhibitory polypeptide activates MAP kinase through the wortmannin-sensitive and -insensitive pathways. Biochem Biophys Res Commun 235:171-175
7. Trumper A, Trumper K, Trusheim H, Arnold R, Goke B, Horsch D 2001 Glucose-dependent insulinotropic polypeptide is a growth factor for β(INS-1) cells by pleiotropic signaling. Mol Endocrinol 15:1559-1570
8. Chabre O, Liakos P, Vivier J, Chaffanjon P, Labat-Moleur F, Martinie M, Bottari SP, Bachelot I, Chambaz EM, Defaye G, Feige JJ 1998 Cushing's syndrome due to a gastric inhibitory polypeptide-dependent adrenal adenoma: insights into hormonal control of adrenocortical tumorigenesis. J Clin Endocrinol Metab 83:3134-3143
9. Lebrethon MC, Avallet O, Reznik Y, Archambeaud F, Combes J, Usdin TB, Narboni G, Mahoudeau J, Saez JM 1998 Food-dependent Cushing's syndrome: characterization and functional role of gastric inhibitory polypeptide receptor in the adrenals of three patients. J Clin Endocrinol Metab 83:4514-4519
10. Luton JP, Bertherat J, Kuhn JM, Bertagna X 1998 [Aberrant expression of the GIP (gastric inhibitory polypeptide) receptor in an adrenal cortical adenoma responsible for a case of food-dependent Cushing's syndrome]. Bull Acad Natl Med 182:1839 -1849; discussion 1849-1850 (French)
11. N'Diaye N, Hamet P, Tremblay J, Boutin JM, Gaboury L, Lacroix A 1999 Asynchronous development of bilateral nodular adrenal hyperplasia in gastric inhibitory polypeptide-dependent Cushing's syndrome. J Clin Endocrinol Metab 84:2616-2622
12. N'Diaye N, Tremblay J, Hamet P, De Herder WW, Lacroix A 1998 Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome. J Clin Endocrinol Metab 83:2781-2785
13. Usdin TB, Mezey E, Button DC, Brownstein MJ, Bonner TI 1993 Gastric inhibitory polypeptide receptor, a member of the secretin- vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. Endocrinology 133:2861-2870
14. Wheeler MB, Gelling RW, McIntosh CH, Georgiou J, Brown JC, Pederson RA 1995 Functional expression of the rat pancreatic islet glucose-dependent insulinotropic polypeptide receptor: ligand binding and intracellular signaling properties. Endocrinology 136:4629-4639
15. Hamet P, Larochelle P, Franks DJ, Cartier P, Bolte E 1987 Cushing syndrome with food-dependent periodic hormonogenesis. Clin Invest Med 10:530-533
16. Lacroix A, Bolte E, Tremblay J, Dupre J, Poitras P, Fournier H, Garon J, Garrel D, Bayard F, Taillefer R 1992 Gastric inhibitory polypeptide-dependent cortisol hypersecretion: a new cause of Cushing's syndrome. N Engl J Med 327:974-980
17. Reznik Y, Allali-Zerah V, Chayvialle JA, Leroyer R, Leymarie P, Travert G, Lebrethon MC, Budi I, Balliere AM, Mahoudeau J 1992 Food-dependent Cushing's syndrome mediated by aberrant adrenal sensitivity to gastric inhibitory polypeptide. N Engl J Med 327:981-986
18. Croughs RJ, Zelissen PM, van Vroonhoven TJ, Hofland LJ, N'Diaye N, Lacroix A, de Herder WW 2000 GIP-dependent adrenal Cushing's syndrome with incomplete suppression of ACTH. Clin Endocrinol (Oxf) 52:235-240
19. de Herder WW, Hofland LJ, Usdin TB, de Jong FH, Uitterlinden P, van Koetsveld P, Mezey E, Bonner TI, Bonjer HJ, Lamberts SW 1996 Food-dependent Cushing's syndrome resulting from abundant expression of gastric inhibitory polypeptide receptors in adrenal adenoma cells. J Clin Endocrinol Metab 81:3168-3172
20. Pralong FP, Gomez F, Guillou L, Mosimann F, Franscella S, Gaillard RC 1999 Food-dependent Cushing's syndrome: possible involvement of leptin in cortisol hypersecretion. J Clin Endocrinol Metab 84:3817-3822
21. Tsagarakis S, Tsigos C, Vassiliou V, Tsiotra P, Pratsinis H, Kletsas D, Trivizas P, Nikou A, Mavromatis T, Sotsiou F, Raptis S, Thalassinos N 2001 Food-dependent androgen and cortisol secretion by a gastric inhibitory polypeptide-receptor expressive adrenocortical adenoma leading to hirsutism and subclinical Cushing's syndrome: in vivo and in vitro studies. J Clin Endocrinol Metab 86:583-589
22. Antonini SR, N'Diaye N, Baldacchino V, Hamet P, Tremblay J, Lacroix A 2004 Analysis of the putative regulatory region of the gastric inhibitory polypeptide receptor gene in food-dependent Cushing's syndrome. J Steroid Biochem Mol Biol 91:171-177
23. Thomas M, Northrup SR, Hornsby PJ 1997 Adrenocortical tissue formed by transplantation of normal clones of bovine adrenocortical cells in scid mice replaces the essential functions of the animals' adrenal glands. Nat Med 3:978-983
24. Thomas M, Hornsby PJ 1999 Transplantation of primary bovine adrenocortical cells into scid mice. Mol Cell Endocrinol 153:125-136
25. Thomas M, Suwa T, Yang L, Zhao L, Hawks CL, Hornsby PJ 2002 Cooperation of hTERT, SV40 T antigen and oncogenic Ras in tumorigenesis: a cell transplantation model using bovine adrenocortical cells. Neoplasia 4:493-500
26. Duperray A, Chambaz EM 1980 Effect of prostaglandin E1 and ACTH on proliferation and steroidogenic activity of bovine adreno-cortical cells in primary culture. J Steroid Biochem 13:1359-1364
27. Vander Heiden MG, Thompson CB 1999 Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat Cell Biol 1:E209-E216
28. Forough R, Xi Z, MacPhee M, Friedman S, Engleka KA, Sayers T, Wiltrout RH, Maciag T 1993 Differential transforming abilities of non-secreted and secreted forms of human fibroblast growth factor-1. J Biol Chem 268:2960-2968
29. Lewis JT, Dayanandan B, Habener JF, Kieffer TJ 2000 Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist. Endocrinology 141:3710-3716
30. Negoescu A, Labat-Moleur F, Defaye G, Mezin P, Drouet C, Brambilla E, Chambaz EM, Feige JJ 1995 Contribution of apoptosis to the phenotypic changes of adrenocortical cells in primary culture. Mol Cell Endocrinol 110:175-184
31. Arnaldi G, Angeli A, Atkinson AB, Bertagna X, Cavagnini F, Chrousos GP, Fava GA, Findling JW, Gaillard RC, Grossman AB, Kola B, Lacroix A, Mancini T, Mantero F, Newell-Price J, Nieman LK, Sonino N, Vance ML, Giustina A, Boscaro M 2003 Diagnosis and complications of Cushing's syndrome: a consensus statement. J Clin Endocrinol Metab 88:5593-5602
32. Stenzel-Poore MP, Cameron VA, Vaughan J, Sawchenko PE, Vale W 1992 Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice. Endocrinology 130:3378-3386
33. Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, Orban PC, Bock R, Klein R, Schutz G 1999 Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23:99-103
34. Yano H, Readhead C, Nakashima M, Ren SG, Melmed S 1998 Pituitary-directed leukemia inhibitory factor transgene causes Cushing's syndrome: neuro-immune-endocrine modulation of pituitary development. Mol Endocrinol 12:1708-1720
35. Thomas M, Keramidas M, Monchaux E, Feige JJ 2004 Dual hormonal regulation of endocrine tissue mass and vasculature by adrenocorticotropin in the adrenal cortex. Endocrinology 145:4320-4329
36. Swords FM, Aylwin S, Perry L, Arola J, Grossman AB, Monson JP, Clark AJ 2005 The aberrant expression of the gastric inhibitory polypeptide (GIP) receptor in adrenal hyperplasia: does chronic adrenocorticotropin exposure stimulate up-regulation of GIP receptors in Cushing's disease? J Clin Endocrinol Metab 90:3009-3016
37. Dallman MF 1984 Control of adrenocortical growth in vivo. Endocr Res 10:213-242
38. Hornsby PJ 1984 Regulation of adrenocortical cell proliferation in culture. Endocr Res 10:259-281
39. Noon LA, Franklin JM, King PJ, Goulding NJ, Hunyady L, Clark AJ 2002 Failed export of the adrenocorticotrophin receptor from the endoplasmic reticulum in non-adrenal cells: evidence in support of a requirement for a specific adrenal accessory factor. J Endocrinol 174:17-25
40. Rohrer DK, Kobilka BK 1998 G protein-coupled receptors: functional and mechanistic insights through altered gene expression. Physiol Rev 78:35-52