Differences in angiotensin (1–7) between men and women

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 308, Issue 9, 2015, Pages H1171-H1176

  Sullivan, Jennifer C ^a   Rodriguez Miguelez, Paula ^a   Zimmerman, Margaret A ^a   Harris, Ryan A ^a,b  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

ANG (1 7); Blood pressure; Renin angiotensin system; Sex

Indexed keywords

ANGIOTENSIN II; ANGIOTENSIN[1-7]; EDETIC ACID; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN; ANGIOTENSIN I; ANGIOTENSIN I (1-7); PEPTIDE FRAGMENT;

ADULT; ARTERY DIAMETER; ARTICLE; BLOOD PRESSURE; BLOOD SAMPLING; BLOOD VESSEL FUNCTION; BRACHIAL ARTERY; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; HORMONE BLOOD LEVEL; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SHEAR RATE; VASCULAR ENDOTHELIUM; VASODILATATION; BLOOD; BLOOD FLOW; BLOOD FLOW VELOCITY; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; HEALTH DISPARITY; MIDDLE AGED; PHYSIOLOGY; SEX DIFFERENCE; YOUNG ADULT;

ADULT; ANGIOTENSIN I; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BRACHIAL ARTERY; CROSS-SECTIONAL STUDIES; ENDOTHELIUM, VASCULAR; FEMALE; HEALTH STATUS DISPARITIES; HEALTHY VOLUNTEERS; HUMANS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; REGIONAL BLOOD FLOW; SEX FACTORS; VASODILATION; YOUNG ADULT;

EID: 84929687582     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00897.2014     Document Type: Article

References (42)

1. Benter IF, Ferrario CM, Morris M, Diz DI. Antihypertensive actions of angiotensin-(1–7) in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 269: H313–H319, 1995.
2. Benter IF, Yousif MH, Al-Saleh FM, Raghupathy R, Chappell MC, Diz DI. Angiotensin-(1–7) blockade attenuates captopril- or hydralazineinduced cardiovascular protection in spontaneously hypertensive rats treated with NG-nitro-L-arginine methyl ester. J Cardiovasc Pharmacol 57: 559–567, 2011.
3. Benter IF, Yousif MH, Anim JT, Cojocel C, Diz DI. Angiotensin-(1–7) prevents development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME. Am J Physiol Heart Circ Physiol 290: H684–H691, 2006.
4. Bhatia K, Zimmerman MA, Sullivan JC. Sex differences in angiotensin- converting enzyme modulation of Ang (1–7) levels in normotensive WKY rats. Am J Hypertens 26: 591–598, 2013.
5. Calhoun DA, Jones D, Textor S, Goff DC, Murphy TP, Toto RD, White A, Cushman WC, White W, Sica D, Ferdinand K, Giles TD, Falkner B, Carey RM. Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension 51: 1403–1419, 2008.
6. Canzanello VJ, Baranco-Pryor E, Rahbari-Oskoui F, Schwartz GL, Boerwinkle E, Turner ST, Chapman AB. Predictors of blood pressure response to the angiotensin receptor blocker candesartan in essential hypertension. Am J Hypertens 21: 61–66, 2008.
7. Carter TL, Pedrini S, Ghiso J, Ehrlich ME, Gandy S. Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosis. Neurosci Lett 392: 235–239, 2006.
8. Chappell MC, Marshall AC, Alzayadneh EM, Shaltout HA, Diz DI. Update on the Angiotensin converting enzyme 2-Angiotensin (1–7)-MAS receptor axis: fetal programing, sex differences, and intracellular pathways. Front Endocrinol (Lausanne) 4: 201, 2014.
9. Chappell MC, Westwood BM, Yamaleyeva LM. Differential effects of sex steroids in young and aged female mRen2.Lewis rats: a model of estrogen and salt-sensitive hypertension. Gend Med 5, Suppl A: S65–S75, 2008.
10. Dharmashankar K, Widlansky ME. Vascular endothelial function and hypertension: insights and directions. Curr Hypertens Rep 12: 448–455, 2010.
11. Falconnet C, Bochud M, Bovet P, Maillard M, Burnier M. Gender difference in the response to an angiotensin-converting enzyme inhibitor and a diuretic in hypertensive patients of African descent. J Hypertens 22: 1213–1220, 2004.
12. Faria-Silva R, Duarte FV, Santos RA. Short-term angiotensin(1–7) receptor MAS stimulation improves endothelial function in normotensive rats. Hypertension 46: 948–952, 2005.
13. Fernandes L, Fortes ZB, Casarini DE, Nigro D, Tostes RC, Santos RA, de Carvalho MH. Role of PGI2 and effects of ACE inhibition on the bradykinin potentiation by angiotensin-(1–7) in resistance vessels of SHR. Regul Pept 127: 183–189, 2005.
14. Flores-Munoz M, Work LM, Douglas K, Denby L, Dominiczak AF, Graham D, Nicklin SA. Angiotensin-(1–9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor. Hypertension 59: 300–307, 2012.
15. Gallagher PE, Li P, Lenhart JR, Chappell MC, Brosnihan KB. Estrogen regulation of angiotensin-converting enzyme mRNA. Hypertension 33: 323–328, 1999.
16. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Judd SE, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Mackey RH, Magid DJ, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER 3rd, Moy CS, Mussolino ME, Neumar RW, Nichol G, Pandey DK, Paynter NP, Reeves MJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Wong ND, Woo D, Turner MB; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics—2014 update: a report from the American Heart Association. Circulation 129: e28–e292, 2014.
17. Gupte M, Thatcher SE, Boustany-Kari CM, Shoemaker R, Yiannikouris F, Zhang X, Karounos M, Cassis LA. Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice. Arterioscler Thromb Vasc Biol 32: 1392–1399, 2012.
18. Harris RA, Nishiyama SK, Wray DW, Richardson RS. Ultrasound assessment of flow-mediated dilation. Hypertension 55: 1075–1085, 2010.
19. Heitsch H, Brovkovych S, Malinski T, Wiemer G. Angiotensin-(1–7)- Stimulated Nitric Oxide and Superoxide Release From Endothelial Cells. Hypertension 37: 72–76, 2001.
20. James GD, Sealey JE, Muller F, Alderman M, Madhavan S, Laragh JH. Renin relationship to sex, race and age in a normotensive population. J Hypertens Suppl 4: S387–S389, 1986.
21. Kitta Y, Obata JE, Nakamura T, Hirano M, Kodama Y, Fujioka D, Saito Y, Kawabata K, Sano K, Kobayashi T, Yano T, Nakamura K, Kugiyama K. Persistent impairment of endothelial vasomotor function has a negative impact on outcome in patients with coronary artery disease. J Am Coll Cardiol 53: 323–330, 2009.
22. Lee VC, Lloyd EN, Dearden HC, Wong K. A systematic review to investigate whether Angiotensin-(1–7) is a promising therapeutic target in human heart failure. Int J Pept 2013: 260346, 2013.
23. Meng Y, Yu CH, Li W, Li T, Luo W, Huang S, Wu PS, Cai SX, Li X. Angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis protects against lung fibrosis by inhibiting the MAPK/NF-kappaB pathway. Am J Respir Cell Mol Biol 50: 723–736, 2014.
24. Miller JA, Cherney DZ, Duncan JA, Lai V, Burns KD, Kennedy CR, Zimpelmann J, Gao W, Cattran DC, Scholey JW. Gender differences in the renal response to renin-angiotensin system blockade. J Am Soc Nephrol 17: 2554–2560, 2006.
25. Pacurari M, Kafoury R, Tchounwou PB, Ndebele K. The Renin-Angiotensin-aldosterone system in vascular inflammation and remodeling. Int J Inflam 2014: 689360, 2014.
26. Patel SK, Velkoska E, Freeman M, Wai B, Lancefield TF, Burrell LM. From gene to protein-experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Front Physiol 5: 227, 2014.
27. Pickering TG, Hall JE, Appel LJ, Falkner BE, Graves J, Hill MN, Jones DW, Kurtz T, Sheps SG, Roccella EJ; Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Recommendations for blood pressure measurement in humans and experimental animals: Part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Hypertension 45: 142–161, 2005.
28. Reckelhoff JF, Zhang H, Srivastava K. Gender differences in development of hypertension in spontaneously hypertensive rats: role of the renin-angiotensin system. Hypertension 35: 480–483, 2000.
29. Reyes-Engel A, Morcillo L, Aranda FJ, Ruiz M, Gaitan MJ, Mayor-Olea A, Aranda P, Ferrario CM. Influence of gender and genetic variability on plasma angiotensin peptides. J Renin Angiotensin Aldosterone Syst 7: 92–97, 2006.
30. Sandberg K, Ji H. Sex differences in primary hypertension. Biol Sex Differ 3: 7, 2012.
31. Santos RA. Angiotensin-(1–7). Hypertension 63: 1138–1147, 2014.
32. Silva-Antonialli MM, Tostes RC, Fernandes L, Fior-Chadi DR, Akamine EH, Carvalho MH, Fortes ZB, Nigro D. A lower ratio of AT1/AT2 receptors of angiotensin II is found in female than in male spontaneously hypertensive rats. Cardiovasc Res 62: 587–593, 2004.
33. Sullivan JC. Sex and the renin-angiotensin system: inequality between the sexes in response to RAS stimulation and inhibition. Am J Physiol Regul Integr Comp Physiol 294: R1220–R1226, 2008.
34. Sullivan JC, Bhatia K, Yamamoto T, Elmarakby AA. Angiotensin (1–7) receptor antagonism equalizes angiotensin II-induced hypertension in male and female spontaneously hypertensive rats. Hypertension 56: 658–666, 2010.
35. Sullivan JC, Semprun-Prieto L, Boesen EI, Pollock DM, Pollock JS. Sex and sex hormones influence the development of albuminuria and renal macrophage infiltration in spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol 293: R1573–R1579, 2007.
36. Trenkwalder P, Elmfeldt D, Hofman A, Lithell H, Olofsson B, Papademetriou V, Skoog I, Zanchetti A; Study on COgnition and Prognosis in the Elderly (SCOPE). The Study on COgnition and Prognosis in the Elderly (SCOPE)—major CV events and stroke in subgroups of patients. Blood Press 14: 31–37, 2005.
37. Wray DW, Witman MA, Ives SJ, McDaniel J, Trinity JD, Conklin JD, Supiano MA, Richardson RS. Does brachial artery flow-mediated vasodilation provide a bioassay for NO? Hypertension 62: 345–351, 2013.
38. Ye M, Wysocki J, Gonzalez-Pacheco FR, Salem M, Evora K, Garcia-Halpin L, Poglitsch M, Schuster M, Batlle D. Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2. Hypertension 60: 730–740, 2012.
39. Zimmerman MA, Baban B, Tipton AJ, O’Connor PM, Sullivan JC. Chronic Ang II infusion induces sex-specific increases in renal T cells in Sprague-Dawley rats. Am J Physiol Renal Physiol 308: F706–F712, 2015
40. Zimmerman MA, Harris RA, Sullivan JC. Female spontaneously hypertensive rats are more dependent on ANG (1–7) to mediate effects of low-dose AT1 receptor blockade than males. Am J Physiol Renal Physiol 306: F1136–F1142, 2014.
41. Zimmerman MA, Sullivan JC. Hypertension: what’s sex got to do with it? Physiology (Bethesda) 28: 234–244, 2013.
42. Zisman LS, Meixell GE, Bristow MR, Canver CC. Angiotensin-(1–7) formation in the intact human heart: in vivo dependence on angiotensin II as substrate. Circulation 108: 1679–1681, 2003.