Differential effects of sex steroids in young and aged female mRen2.Lewis rats: A model of estrogen and salt-sensitive hypertension

Gender Medicine

Volumn 5, Issue SUPPL. 1, 2008, Pages

  Chappell, Mark C ^a   Westwood, Brian M ^a   Yamaleyeva, Liliya M ^a  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

Author keywords

estrogen; mRen2.Lewis; proteinuria; renin angiotensin aldosterone system; salt sensitivity

Indexed keywords

ESTROGEN; RENIN; SEX HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HEART DISEASE; HEART PROTECTION; HYPERTENSION; KIDNEY INJURY; LEWIS RAT; MEDLINE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PUBLICATION; RAT; RENAL PROTECTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SALT INTAKE; SALT TOLERANCE;

AGE FACTORS; ANIMALS; BLOOD PRESSURE; ESTROGENS; FEMALE; HYPERTENSION; KIDNEY; MODELS, ANIMAL; RATS; RATS, INBRED LEW; RENIN; RENIN-ANGIOTENSIN SYSTEM; SODIUM CHLORIDE;

EID: 41449087809     PISSN: 15508579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.genm.2008.03.007     Document Type: Article

References (56)

1. Reckelhoff J. Gender differences in the regulation of blood pressure. Hypertension 37 (2001) 1199-1208
2. Rosenthal T., and Oparil S. Hypertension in women. J Hum Hypertens 14 (2000) 691-704
3. White C., Shelton J., Chen S., et al. Estrogen restores endothelial cell function in an experimental model of vascular injury. Circulation 96 (1997) 1624-1630
4. Ferrario C., Trask A., and Jessup J. Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function. Am J Physiol Heart Circ Physiol 289 (2005) H2281-H2290
5. Chappell M. Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS receptor axis: More than regulation of blood pressure?. Hypertension 50 (2007) 596-599
6. Derry P. Hormones, menopause, and heart disease: Making sense of the Women's Health Initiative. Womens Health Issues 14 (2004) 212-219
7. Grady D., Herrington D., Bittner V., et al. Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/pprogestin Replacement Study follow-up (HERS II) [published correction appears in JAMA. 2002:288:1064]. JAMA 288 (2002) 49-57
8. Hsia J., Langer R., Manson J., et al., for the Women's Health Initiative Investigators. Conjugated equine estrogens and coronary heart disease: The Women's Health Initiative [published correction appears in Arch Intern Med. 2006:166:759]. Arch Intern Med 166 (2006) 357-365
9. Pendergrass K., Averill D., Ferrario C., et al. Differential expression of nuclear AT1 receptors and angiotensin II within the kidney of the male congenic mRen2.Lewis rat. Am J Physiol Renal Physiol 290 (2006) F1497-F1506
10. Crofton J., Ota M., and Share L. Role of vasopressin, the renin-angiotensin system and sex in Dahl salt-sensitive hypertension. J Hypertens 11 (1993) 1031-1038
11. Crofton J., and Share L. Gonadal hormones modulate deoxycorticosterone-salt hypertension in male and female rats. Hypertension 29 (1997) 494-499
12. Chappell M., Yamaleyeva L., and Westwood B. Estrogen and salt sensitivity in the female mRen(2).Lewis rat. Am J Physiol Regul Integr Comp Physiol 291 (2006) R1557-R1563
13. Reckelhoff J., Zhang H., Srivastava K., and Granger J. Gender differences in hypertension in spontaneously hypertensive rats: Role of androgens and androgen receptor. Hypertension 34 (1999) 920-923
14. Baltatu O., Cayla C., Iliescu R., et al. Abolition of hypertension-induced end-organ damage by androgen receptor blockade in transgenic rats harboring the mouse ren-2 gene. J Am Soc Nephrol 13 (2002) 2681-2687
15. Fang Z., Carlson S., Chen Y., et al. Estrogen depletion induces NaCl-sensitive hypertension in female spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol 281 (2001) R1934-R1939
16. Chappell M., Gallagher P., Averill D., et al. Estrogen or the AT1 antagonist olmesartan reverses the development of profound hypertension in the congenic mRen2.Lewis rat. Hypertension 42 (2003) 781-786
17. Takemori K., Ishida H., and Ito H. Continuous inhibition of the renin-angiotensin system and protection from hypertensive end-organ damage by brief treatment with angiotensin II type 1 receptor blocker in stroke-prone spontaneously hypertensive rats. Life Sci 77 (2005) 2233-2245
18. Ishiguro K., Sasamura H., Sakamaki Y., et al. Developmental activity of the renin-angiotensin system during the "critical period" modulates later L-NAME-induced hypertension and renal injury. Hypertens Res 30 (2007) 63-75
19. Harrison-Bernard L., Schulman I., and Raij L. Post-ovariectomy hypertension is linked to increased renal AT1 receptor and salt sensitivity. Hypertension 42 (2003) 1157-1163
20. Krishnamurthi K., Verbalis J., Zheng W., et al. Estrogen regulates angiotensin AT1 receptor expression via cytosolic proteins that bind to the 5' leader sequence of the receptor mRNA. Endocrinology 140 (1999) 5435-5438
21. Oestreicher E., Guo C., Seely E., et al. Estradiol increases proteinuria and angiotensin II type 1 receptor in kidneys of rats receiving L-NAME and angiotensin II. Kidney Int 70 (2006) 1759-1768
22. Yamaleyeva L., Gallagher P., Vinsant S., and Chappell M. Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2.Lewis rats. Am J Physiol Regul Integr Comp Physiol 292 (2007) R819-R826
23. Zhou M., Schulman I., and Raij L. Nitric oxide, angiotensin II, and hypertension. Semin Nephrol 24 (2004) 366-378
24. Wilcox C., Welch W., Murad F., et al. Nitric oxide synthase in macula densa regulates glomerular capillary pressure. Proc Natl Acad Sci U S A 89 (1992) 11993-11997
25. Castrop H., Schweda F., Mizel D., et al. Permissive role of nitric oxide in macula densa control of renin secretion. Am J Physiol Renal Physiol 286 (2004) F848-F857
26. Chappell M., Yamaleyeva L., Averill D., et al. Discoordinate regulation of aldosterone, renal COX 2 and NOS isoforms following estrogen depletion or high salt diet in the female mRen2.Lewis strain: 22. Hypertension 46 (2005) 818 Abstract
27. Pechere-Bertschi A., Maillard M., Stalder H., et al. Renal hemodynamic and tubular responses to salt in women using oral contraceptives. Kidney Int 64 (2003) 1374-1380
28. Pechere-BBertschi A., and Burnier M. Gonadal steroids, salt-sse ensitivity and renal function. Curr Opin Nephrol Hypertens 16 (2007) 16-21
29. Schulman I., Aranda P., Raij L., et al. Surgical menopause increases salt sensitivity of blood pressure. Hypertension 47 (2006) 1168-1174
30. Hinojosa-Laborde C., Craig T., Zheng W., et al. Ovariectomy augments hypertension in aging female Dahl salt-sensitive rats. Hypertension 44 (2004) 405-409
31. Groban I., Yamaleyeva L., Westwood B., et al. Progressive diastolic dysfunction in the female mRen2.Lewis rat: Influence of salt and ovarian hormones. J Gerontol 63 (2008) 3-11
32. Chappell M., Westwood B., Averill D., et al. Influence of gender on salt sensitivity and dysregulation of the renin-angiotensin system in the mRen2.Lewis rat. Hypertension 42 (2003) 430
33. Westwood B., and Chappell M. Application of correlate summation to data clustering in the estrogen-and salt-ssensitive female mRen2.Lewis rat. TMBIO (2006) 21-26
34. Nyguen G. The (pro)renin receptor: Pathophysiological roles in cardiovascular and renal pathology. Curr Opin Nephrol Hypertens 16 (2007) 129-133
35. Takahashi H., Ichihara A., Kaneshiro Y., et al. Regression of nephropathy developed in diabetes by (pro)renin receptor blockade. J Am Soc Nephrol 18 (2007) 2054-2061
36. Wilcox C. Oxidative stress and nitric oxide deficiency in the kidney: A critical link to hypertension?. Am J Physiol Regul Integr Comp Physiol 289 (2005) R913-R935
37. Mehta P., and Griendling K. Angiotensin II cell signaling: Physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol 292 (2007) C82-C97
38. Fortepiani L., and Reckelhoff J. Tempol from birth abrogates the sex difference in the depressor response to tempol in the SHR. J Hypertens 23 (2005) 801-805
39. Sartori-Valinotti J., Iliescu R., Fortepiani L., et al. Sex differences in oxidative stress and the impact on blood pressure control and cardiovascular disease. Clin Exp Pharmacol Physiol 34 (2006) 938-945
40. Ebrahimian T., He Y., Schiffrin E., and Touyz R. Differential regulation of thioredoxin and NAD(P) H oxidase by angiotensin II in male and female mice. J Hypertens 25 (2007) 1263-1271
41. Tatchum-Talom R., Eyster K., and Martin D. Sexual dimorphism in angiotensin II-induced hypertension and vascular alterations. Can J Physiol Pharmacol 83 (2005) 413-422
42. Rossouw J., Prentice R., Manson J., et al. Postmenopausal hormone therapy and risk of cardiovascular disease by age and year since menopause. JAMA 297 (2007) 1465-1477
43. Harrap S., Mitchell G., Casley D., et al. Angiotensin II, sodium, and cardiovascular hypertrophy in spontaneously hypertensive rats. Hypertension 21 (1993) 50-55
44. Zicha J., and Kunes J. Ontogenetic aspects of hypertension development: Analysis in the rat. Physiol Rev 79 (1999) 1227-1282
45. Dahl L., Knudsen K., Heine M., and Leitl G. Effects of chronic excess salt ingestion. Modification of experimental hypertension in the rat by variations in the diet. Circ Res 22 (1968) 11-18
46. Fortepiani L., Zhang H., Racusen L., et al. Characterization of an animal model of postmenopausal hypertension in spontaneously hypertensive rats. Hypertension 41 (2003) 640-645
47. Yamaleyeva L., Pendergrass K., Pirro N., et al. Ovariectomy is protective against renal injury in the high salt fed older mRen2.Lewis rat. Am J Physiol Heart Circ Physiol 293 (2007) H2064-H2071
48. Ichimura T., Bonventre J., Bailly V., et al. Kidney injury molecule-11 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem 273 (1998) 4135-4142
49. van Timmeren M., Bakker S., Vaidya V., et al. Tubular kidney injury molecule-1 in protein-overload nephropathy. Am J Physiol Renal Physiol 291 (2006) F456-F464
50. de Borst M., van Timmeren M., Vaidya V., et al. Induction of kidney injury molecule-1 in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system of p38 MAP kinase. Am J Physiol Renal Physiol 292 (2007) F313-F320
51. Ogle G., Rosenberg A., and Kainer G. Renal effects of growth hormone. I. Renal function and kidney growth. Pediatr Nephrol 6 (1992) 394-398
52. Wang S., Lapage J., and Hirschberg R. Glomerular ultrafiltration of IGF-I may contribute to increased renal sodium retention in diabetic nephropathy. J Lab Clin Med 134 (1999) 154-160
53. Bridgewater D., Ho J., Sauro V., and Matsell D. Insulin-like growth factors inhibit podocyte apoptosis through the P13 kinase pathway. Kidney Int 67 (2005) 1308-1314
54. Conti F., Striker L., Lesniak M., et al. Studies on binding and mitogenic effect of insulin and insulin-like growth factor I in glomerular mesangial cells. Endocrinology 122 (1988) 2788-2795
55. Zha Y., Le V., Higami Y., et al. Life-long suppression of growth hormone-insulin-like growth factor I activity in genetically altered rats could prevent age-related renal damage. Endocrinology 147 (2006) 5690-5698
56. Yamaleyeva L., Wilson B., Westwood B., et al. Estrogen-ddepletion reveals COX-2 dependent cardiovascular responses distinct from that of intact female and male congenic mRen2.Lewis rats. Hypertension LB01 (2007) E149 Abstract