TH2 cells and their cytokines regulate formation and function of lymphatic vessels

Nature Communications

Volumn 6, Issue , 2015, Pages

  Shin, Kihyuk ^a   Kataru, Raghu P ^a   Park, Hyeung Ju ^a   Kwon, Bo In ^a   Kim, Tae Woo ^a   Hong, Young Kwon ^b   Lee, Seung Hyo ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CD4 ANTIGEN; GLYCOPROTEIN; INTERLEUKIN 13; INTERLEUKIN 4; JANUS KINASE; NEUTRALIZING ANTIBODY; TRANSCRIPTION FACTOR; CELL SURFACE RECEPTOR; FUNGUS ANTIGEN; HOMEODOMAIN PROTEIN; IL4RA PROTEIN, MOUSE; OVALBUMIN; PROSPERO-RELATED HOMEOBOX 1 PROTEIN; TUMOR SUPPRESSOR PROTEIN; XLKD1 PROTEIN, MOUSE;

ALLERGY; CELLS AND CELL COMPONENTS; IMMUNE RESPONSE; INHIBITION; NEUTRALIZATION; PATHOGENICITY;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CD4+ T LYMPHOCYTE; CELL DENSITY; CELL DIFFERENTIATION; COCULTURE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; EXPERIMENTAL ASTHMA; FEMALE; FLOW CYTOMETRY; HISTOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; LIMIT OF QUANTITATION; LUNG FUNCTION; LYMPH VESSEL; LYMPHANGIOGENESIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; TH2 CELL; TRANSGENIC MOUSE; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; ASPERGILLUS ORYZAE; ASTHMA; CHEMICALLY INDUCED; CHEMISTRY; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LUNG; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIGENS, FUNGAL; ASPERGILLUS ORYZAE; ASTHMA; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HOMEODOMAIN PROTEINS; HUMANS; INTERLEUKIN-13; INTERLEUKIN-4; LUNG; LYMPHANGIOGENESIS; LYMPHATIC VESSELS; MICE; MICE, TRANSGENIC; OVALBUMIN; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TH2 CELLS; TUMOR SUPPRESSOR PROTEINS;

EID: 84929679692     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7196     Document Type: Article

References (43)

1. Adams, R. H. & Alitalo, K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat. Rev. Mol. Cell Biol. 8, 464-478 (2007).
2. Carmeliet, P. Angiogenesis in health and disease. Nat. Med. 9, 653-660 (2003).
3. Alitalo, K., Tammela, T. & Petrova, T. V. Lymphangiogenesis in development and human disease. Nature 438, 946-953 (2005).
4. Schulte-Merker, S., Sabine, A. & Petrova, T. V. Lymphatic vascular morphogenesis in development, physiology, and disease. J. Cell. Biol. 193, 607-618 (2011).
5. Pflicke, H. & Sixt, M. Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels. J. Exp. Med. 206, 2925-2935 (2009).
6. Oliver, G. Lymphatic vasculature development. Nat. Rev. Immunol. 4, 35-45 (2004).
7. Oliver, G. & Alitalo, K. The lymphatic vasculature: recent progress and paradigms. Annu. Rev. Cell Dev. Biol. 21, 457-483 (2005).
8. Cueni, L. N. & Detmar, M. New insights into the molecular control of the lymphatic vascular system and its role in disease. J. Invest. Dermatol. 126, 2167-2177 (2006).
9. Cueni, L. N. & Detmar, M. The lymphatic system in health and disease. Lymphat. Res. Biol. 6, 109-122 (2008).
10. He, Y. et al. Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer. Res. 65, 4739-4746 (2005).
11. Achen, M. G. & Stacker, S. A. Tumor lymphangiogenesis and metastatic spread-new players begin to emerge. Int. J. Cancer. 119, 1755-1760 (2006).
12. Kataru, R. P. et al. Critical role of CD11b macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution. Blood 113, 5650-5659 (2009).
13. Johnson, N. C. et al. Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. Genes Dev. 22, 3282-3291 (2008).
14. Petrova, T. V. et al. Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO. J. 21, 4593-4599 (2002).
15. Wigle, J. T. & Oliver, G. Prox1 function is required for the development of the murine lymphatic system. Cell 98, 769-778 (1999).
16. Choi, I. et al. Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse. Blood 117, 362-365 (2011).
17. Pepper, M. S. & Skobe, M. Lymphatic endothelium: morphological, molecular and functional properties. J. Cell. Biol. 163, 209-213 (2003).
18. Halin, C., Tobler, N. E., Vigl, B., Brown, L. F. & Detmar, M. VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood 110, 3158-3167 (2007).
19. Angeli, V. et al. B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity 24, 203-215 (2006).
20. Chyou, S. et al. Fibroblast-type reticular stromal cells regulate the lymph node vasculature. J. Immunol. 181, 3887-3896 (2008).
21. Kataru, R. P. et al. T lymphocytes negatively regulate lymph node lymphatic vessel formation. Immunity 34, 96-107 (2011).
22. Zhu, J., Yamane, H. & Paul, W. E. Differentiation of effector CD4 T cell populations (). Annu. Rev. Immunol. 28, 445-489 (2010).
23. Cohn, L., Elias, J. A. & Chupp, G. L. Asthma: mechanisms of disease persistence and progression. Annu. Rev. Immunol. 22, 789-815 (2004).
24. Wills-Karp, M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol. 17, 255-281 (1999).
25. Zurawski, S. M. et al. The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptor. J. Biol. Chem. 270, 13869-13878 (1995).
26. Gadani, S. P., Cronk, J. C., Norris, G. T. & Kipnis, J. IL-4 in the brain: a cytokine to remember. J. Immunol. 189, 4213-4219 (2012).
27. Volpert, O. V. et al. Inhibition of angiogenesis by interleukin 4. J. Exp. Med. 188, 1039-1046 (1998).
28. Geahlen, R. L. & McLaughlin, J. L. Piceatannol (3, 4, 30, 50-tetrahydroxy-transstilbene) is a naturally occurring protein-tyrosine kinase inhibitor. Biochem. Biophys. Res. Commun. 165, 241-245 (1989).
29. Kheradmand, F. et al. A protease-activated pathway underlying Th cell type 2 activation and allergic lung disease. J. Immunol. 169, 5904-5911 (2002).
30. Jain, R. K., Munn, L. L. & Fukumura, D. Lymphangiography of the mouse ear. Cold Spring Harb. Protoc. 2012, 1179-1180 (2012).
31. Jain, R. K., Munn, L. L. & Fukumura, D. Lymphangiography of the mouse ear. Cold Spring Harb. Protoc. 2012, 1179-1180 (2012).
32. Alitalo, K. The lymphatic vasculature in disease. Nat. Med. 17, 1371-1380 (2011).
33. Avraham, T. et al. Th2 differentiation is necessary for soft tissue fibrosis and lymphatic dysfunction resulting from lymphedema. FASEB J. 27, 1114-1126 (2013).
34. Lasinski, B. B. Complete decongestive therapy for treatment of lymphedema. Semin. Oncol. Nurs. 29, 20-27 (2013).
35. Prevo, R., Banerji, S., Ferguson, D. J., Clasper, S. & Jackson, D. G. Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium. J. Biol. Chem. 276, 19420-19430 (2001).
36. Baluk, P. et al. Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J. Clin. Invest. 115, 247-257 (2005).
37. Zampell, J. C. et al. CD4() cells regulate fibrosis and lymphangiogenesis in response to lymphatic fluid stasis. PLoS ONE 7, e49940 (2012).
38. Chauhan, S. K. et al. A novel pro-lymphangiogenic function for Th17/IL-17. Blood 118, 4630-4634 (2011).
39. Ebina, M. Remodeling of airway walls in fatal asthmatics decreases lymphatic distribution; beyond thickening of airway smooth muscle layers. Allergol. Int. 57, 165-174 (2008).
40. Kim, T. H. et al. Remodelling of nasal mucosa in mild and severe persistent allergic rhinitis with special reference to the distribution of collagen, proteoglycans, and lymphatic vessels. Clin. Exp. Allergy 40, 1742-1754 (2010).
41. Yoo, J. et al. Opposing regulation of PROX1 by interleukin-3 receptor and NOTCH directs differential host cell fate reprogramming by Kaposi sarcoma herpes virus. PLoS Pathog. 8, e1002770 (2012).
42. Corry, D. B. et al. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183, 109-117 (1996).
43. Lee, S. H. et al. Differential requirement for CD18 in T-helper effector homing. Nat. Med. 9, 1281-1286 (2003).