Joint effect of ADARB1 gene, HTR2C gene and stressful life events on suicide attempt risk in patients with major psychiatric disorders

World Journal of Biological Psychiatry

Volumn 16, Issue 4, 2015, Pages 261-271

  Karanović, Jelena ^a   Šviković, Saša ^a   Pantović, Maja ^b   Durica, Svetlana ^a   Brajušković, Goran ^a   Damjanović, Aleksandar ^a,b   Jovanović, Vladimir ^a   Ivković, Maja ^a,b   Romac, Stanka ^a   Savić Pavićević, Dušanka ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b CLINICAL CENTER OF SERBIA   (Serbia)

Author keywords

Risk factors; RNA editing; Serotonin 2C receptor; Stressful events; Suicide attempted

Indexed keywords

SEROTONIN 2C RECEPTOR; ADARB1 PROTEIN, HUMAN; ADENOSINE DEAMINASE; RNA BINDING PROTEIN;

ADARB1 GENE; ADULT; ARTICLE; BIPOLAR DISORDER; CHILDHOOD INJURY; CONTROLLED STUDY; EARLY LIFE INVENTORY SELF REPORT; EARLY LIFE STRESS; EMOTIONAL ABUSE; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HTR2C GENE; HUMAN; LIST OF THREATENING EXPERIENCES QUESTIONNAIRE; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MENTAL DISEASE; MENTAL PATIENT; PHYSICAL ABUSE; PSYCHOLOGICAL RATING SCALE; QUESTIONNAIRE; RISK ASSESSMENT; RNA EDITING; SCHIZOPHRENIA; SELF REPORT; SEXUAL ABUSE; SINGLE NUCLEOTIDE POLYMORPHISM; SUICIDAL BEHAVIOR; SUICIDE ATTEMPT; COMPLICATION; COMPUTER ASSISTED TOMOGRAPHY; GENETICS; LIFE EVENT; MIDDLE AGED; PSYCHOLOGY; RISK FACTOR; STATISTICAL MODEL;

ADENOSINE DEAMINASE; ADULT; BIPOLAR DISORDER; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENOTYPE; HUMANS; LIFE CHANGE EVENTS; LOGISTIC MODELS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, SEROTONIN, 5-HT2C; RISK FACTORS; RNA EDITING; RNA-BINDING PROTEINS; SCHIZOPHRENIA; SUICIDE, ATTEMPTED; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84929623645     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622975.2014.1000374     Document Type: Article

References (53)

1. Antypa N, Serretti A, Rujescu D. 2013. Serotonergic genes and suicide: a systematic review. Eur Neuropsychopharmacol 23 : 1125-1142
2. Barnes NM, Sharp T. 1999. A review of central 5-HT receptors and their function. Neuropharmacology 38 : 1083-1152
3. Beautrais AL, Joyce PR, MulDer RT, Fergusson DM, Deavoll BJ, Nightingale SK. 1996. Prevalence and comorbidity of mental disorDers in persons making serious suicide attempts: a casecontrol study. Am J Psychiatry 153 : 1009-1014
4. Berg KA, Clarke WP, Cunningham KA, Spampinato U. 2008. Fine-tuning serotonin 2C receptor function in the brain: molecular and functional implications. Neuropharmacology 55 : 969-976
5. Bhansali P, Dunning J, Singer SE, David L, Schmauss C. 2007. Early life stress alters adult serotonin 2C receptor pre-mRNA editing and expression of the alpha subunit of the heterotrimeric G-protein G q. J Neurosci 27 : 1467-1473
6. Bremner JD, Bolus R, Mayer EA. 2007. Psychometric properties of the early trauma inventory-self report. J Nerv Ment Dis 195 : 211-218
7. Brent DA, Mann JJ. 2005. Family genetic studies, suicide, and suicidal behavior. Am J Med Genet C Semin Med Genet 133 : 13-24
8. Brezo J, Bureau A, Merette C, Jomphe V, Barker ED, Vitaro F, et al. 2010. Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorDers: a 22-year longitudinal gene-environment study. Mol Psychiatry 15 : 831-843
9. Brezo J, Paris J, Vitaro F, Hebert M, Tremblay RE, Turecki G. 2008. Predicting suicide attempts in young adults with histories of childhood abuse. Br J Psychiatry 193 : 134-139
10. Brodsky BS, Stanley B. 2008. Adverse childhood experiences and suicidal behavior. Psychiatr Clin North Am 31 : 223-235
11. Brugha T, Bebbington P, Tennant C, Hurry J. 1985. The list of threatening experiences: a subset of 12 life event categories with consiDerable long-term contextual threat. Psychol Med 15 : 189-194
12. Brugha TS, Cragg D. 1990. The List of Threatening Experiences: the reliability and validity of a brief life events questionnaire. Acta Psychiatr Scand 82 : 77-81
13. Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, SanDers-Bush E, et al. 1997. Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature 387 : 303-308
14. Dedic G. 2014. GenDer differences in suicide in Serbia within the period 2006-2010. Vojnosanit Pregl 71 : 265-270
15. Dracheva S, Patel N, Woo DA, Marcus SM, Siever LJ, Haroutunian V. 2008. Increased serotonin 2C receptor mRNA editing: a possible risk factor for suicide. Mol Psychiatry 13 : 1001-1010
16. Du Y, Davisson MT, Kafadar K, Gardiner K. 2006. A-to-I pre-mRNA editing of the serotonin 2C receptor: comparisons among inbred mouse strains. Gene 382 : 39-46
17. Dube SR, Anda RF, Felitti VJ, Chapman DP, Williamson DF, Giles WH. 2001. Childhood abuse, household dysfunction, and the risk of attempted suicide throughout the life span: fi ndings from the Adverse Childhood Experiences Study. JAMA 286 : 3089-3096
18. EnglanDer MT, Dulawa SC, Bhansali P, Schmauss C. 2005. How stress and fl uoxetine modulate serotonin 2C receptor premRNA editing. J Neurosci 25 : 648-651
19. Evans DM, Purcell S. 2012. Power calculations in genetic studies. Cold Spring Harb Protoc 2012 : 664-674
20. Fergusson DM, Woodward LJ, Horwood LJ. 2000. Risk factors and life processes associated with the onset of suicidal behaviour during adolescence and early adulthood. Psychol Med 30 : 23-39
21. First MB, Spitzer RL, Gibbon M, Williams JBW. 1996. Structured Clinical Interview for DSM-IV Axis I DisorDers, Clinician Version (SCID-CV). Washington, DC: American Psychiatric Press
22. Iwamoto K, Bundo M, Kato T. 2009. Serotonin receptor 2C and mental disorDers: genetic, expression and RNA editing studies. RNA Biol 6 : 248-253
23. Kawahara Y, Ito K, Ito M, Tsuji S, Kwak S. 2005. Novel splice variants of human ADAR2 mRNA: skipping of the exon encoding the dsRNA-binding domains, and multiple C-terminal splice sites. Gene 363 : 193-201
24. Klonsky ED, Moyer A. 2008. Childhood sexual abuse and non-suicidal self-injury: meta-Analysis. Br J Psychiatry 192 : 166-170
25. Lerer B, Macciardi F, Segman RH, Adolfsson R, Blackwood D, Blairy S, et al. 2001. Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorDer. Mol Psychiatry 6 : 579-585
26. Liu RT, Miller I. 2014. Life events and suicidal ideation and behavior: a systematic review. Clin Psychol Rev 34 : 181-192
27. Lyddon R, Dwork AJ, Keddache M, Siever LJ, Dracheva S. 2013. Serotonin 2c receptor RNA editing in major depression and suicide. World J Biol Psychiatry 14 : 590-601
28. Mann JJ. 2003. Neurobiology of suicidal behaviour. Nat Rev Neurosci 4 : 819-828
29. Martin CB, Hamon M, Lanfumey L, Mongeau R. 2014. Controversies on the role of 5-HT(2C) receptors in the mechanisms of action of antidepressant drugs. Neurosci Biobehav Rev 42 : 208-223
30. Mattick JS, Mehler MF. 2008. RNA editing, DNA recoding and the evolution of human cognition. Trends Neurosci 31 : 227-233
31. Meltzer HY, Massey BW. 2011. The role of serotonin receptors in the action of atypical antipsychotic drugs. Curr Opin Pharmacol 11 : 59-67
32. Mickey BJ, Sanford BJ, Love TM, Shen PH, Hodgkinson CA, Stohler CS, et al. 2012. Striatal dopamine release and genetic variation of the serotonin 2C receptor in humans. J Neurosci 32 : 9344-9350
33. Moscicki EK. 1994. GenDer differences in completed and attempted suicides. Ann Epidemiol 152 : 152-158
34. Nishikura K. 2010. Functions and regulation of RNA editing by ADAR deaminases. Annu Rev Biochem 79 : 321-349
35. Okada M, Northup JK, Ozaki N, Russell JT, Linnoila M, Goldman D. 2004. Modifi cation of human 5-HT(2C) receptor function by Cys23Ser, an abundant, naturally occurring amino-Acid substitution. Mol Psychiatry 9 : 55-64
36. Pettersson FH, AnDerson CA, Clarke GM, Cardon LR, Morris AP, ZonDervan KT. 2009. Marker selection for genetic case-control association studies. Nat Protoc 4 : 743-752
37. R Core Team. 2014. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing.
38. Rosenthal JJ, Seeburg PH. 2012. A-to-I RNA editing: effects on proteins key to neural excitability. Neuron 74 : 432-439
39. Ryding E, LindstrOm M, A skman-Bendz L. 2008. The role of dopamine and serotonin in suicidal behaviour and aggression. Prog Brain Res 172 : 307-315
40. Schadt EE, Molony C, Chudin E, Hao K, Yang X, Lum PY, et al. 2008. Mapping the genetic architecture of gene expression in human liver. PLoS Biol 6 : e107
41. Serretti A, Mandelli L, Giegling I, SchneiDer B, Hartmann AM, Schnabel A, et al. 2007. HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers. Am J Med Genet B Neuropsychiatr Genet 144B : 291-299
42. Silberberg G, Lundin D, Navon R,Ohman M. 2012. Deregulation of the A-to-I RNA editing mechanism in psychiatric disorDers. Hum Mol Genet 21 : 311-321
43. Simmons M, Meador-Woodruff JH, Sodhi MS. 2010. Increased cortical expression of an RNA editing enzyme occurs in major depressive suicide victims. Neuroreport 21 : 993-997
44. Singh M, Kesterson RA, Jacobs MM, Joers JM, Gore JC, Emeson RB. 2007. Hyperphagia-mediated obesity in transgenic mice misexpressing the RNA-editing enzyme ADAR2. J Biol Chem 282 : 22448-22459
45. Singh M, Singh MM, Na E, Agassandian K, Zimmerman MB, Johnson AK. 2011. Altered ADAR 2 equilibrium and 5HT(2C) R editing in the prefrontal cortex of ADAR 2 transgenic mice. Genes Brain Behav 10 : 637-647
46. Singh M, Zimmerman MB, Beltz TG, Johnson AK. 2009. Affectrelated behaviors in mice misexpressing the RNA editing enzyme ADAR2. Physiol Behav 97 : 446-454
47. Stefulj J, Bttner A, Kubat M, Zill P, Balija M, Eisenmenger W, et al. 2004. 5HT-2C receptor polymorphism in suicide victims. Association studies in German and Slavic populations. Eur Arch Psychiatry Clin Neurosci 254 : 224-227
48. Turecki G, Ernst C, Jollant F, LabonteB, Mechawar N. 2012. The neurodevelopmental origins of suicidal behavior. Trends Neurosci 35 : 14-23
49. van Nas A, Ingram-Drake L, Sinsheimer JS, Wang SS, Schadt EE, Drake T, et al. 2010. Expression quantitative trait loci: replication, tissue-And sex-specifi city in mice. Genetics 185 : 1059-1068
50. Videtic A, Peternelj TT, Zupanc T, Balazic J, Komel R. 2009. Promoter and functional polymorphisms of HTR2C and suicide victims. Genes Brain Behav 8 : 541-545
51. Werry TD, Loiacono R, Sexton PM, Christopoulos A. 2008. RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function. Pharmacol Ther 119 : 7-23
52. WHO (World Health Organization). 2012. http://www.euro.who. int/en/health-topics/noncommunicable-diseases/mental-health/data-And-statistics
53. Zhang J, Shen Y, He G, Li X, Meng J, Guo S, et al. 2008. Lack of association between three serotonin genes and suicidal behavior in Chinese psychiatric patients. Prog Neuropsychopharmacol Biol Psychiatry 32 : 467-471