Insulin attenuates arsenic-induced neurite outgrowth impairments by activating the PI3K/Akt/SIRT1 signaling pathway

Toxicology Letters

Volumn 236, Issue 3, 2015, Pages 138-144

  Niyomchan, Apichaya ^a,b   Watcharasit, Piyajit ^a,b,c   Visitnonthachai, Daranee ^a   Homkajorn, Benjaporn ^a   Thiantanawat, Apinya ^a,b,c   Satayavivad, Jutamaad ^a,b,c  

^a Chulabhorn Research Institute   (Thailand)

^b Research and Innovation   (Thailand)

^c Center of Excellence on Environmental Health and Toxicology (EHT) Office of the Higher Education Commission   (Thailand)

Author keywords

Akt; Arsenic; Insulin; Neurite outgrowth; PI3K; SIRT1

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; ARSENIC; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR BETA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SIRTUIN 1; TRICIRIBINE; UNCLASSIFIED DRUG; ARSENITE SODIUM; ARSENOUS ACID DERIVATIVE; SIRT1 PROTEIN, HUMAN; SODIUM DERIVATIVE;

ARTICLE; CELL DIFFERENTIATION; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOLYSIS; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; INSULIN TREATMENT; INTRACELLULAR SIGNALING; NERVE FIBER GROWTH; NEUROPROTECTION; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEURITE; NEUROBLASTOMA; PHYSIOLOGY; TUMOR CELL LINE;

ARSENITES; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; HUMANS; INSULIN; NEURITES; NEUROBLASTOMA; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIRTUIN 1; SODIUM COMPOUNDS;

EID: 84929619970     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2015.05.008     Document Type: Article

References (32)

1. Aung K.H., Kurihara R., Nakashima S., Maekawa F., Nohara K., Kobayashi T., et al. Inhibition of neurite outgrowth and alteration of cytoskeletal gene expression by sodium arsenite. Neurotoxicology 2013, 34:226-235.
2. Banks W.A., Owen J.B., Erickson M.A. Insulin in the brain: there and back again. Pharmacol. Ther. 2012, 136:82-93.
3. Chattopadhyay S., Bhaumik S., Nag Chaudhury A., Das Gupta S. Arsenic induced changes in growth development and apoptosis in neonatal and adult brain cells in vivo and in tissue culture. Toxicol. Lett. 2002, 128:73-84.
4. Chiu S.L., Chen C.M., Cline H.T. Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo. Neuron 2008, 58:708-719.
5. Chiu S.L., Cline H.T. Insulin receptor signaling in the development of neuronal structure and function. Neural Dev. 2010, 5:7.
6. Frankel S., Concannon J., Brusky K., Pietrowicz E., Giorgianni S., Thompson W.D., et al. Arsenic exposure disrupts neurite growth and complexity in vitro. Neurotoxicology 2009, 30:529-537.
7. Gu T., Zhao T., Hewes R.S. Insulin signaling regulates neurite growth during metamorphic neuronal remodeling. Biol. Open 2014, 3:81-93.
8. Hur E.M., Zhou F.Q. GSK3 signalling in neural development. Nat. Rev. Neurosci. 2010, 11:539-551.
9. Jing J., Zheng G., Liu M., Shen X., Zhao F., Wang J., et al. Changes in the synaptic structure of hippocampal neurons and impairment of spatial memory in a rat model caused by chronic arsenite exposure. Neurotoxicology 2012, 33:1230-1238.
10. Jung H.S., Kim H.S., Lee M.J., Shin H.Y., Ahn H.S., Ryu K.H., et al. Arsenic trioxide concentration determines the fate of Ewing's sarcoma family tumors and neuroblastoma cells in vitro. FEBS Lett. 2006, 580:4969-4975.
11. Khodosevich K., Monyer H. Signaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro. BMC Neurosci. 2010, 11:18.
12. Kim B., van Golen C.M., Feldman E.L. Insulin-like growth factor-I signaling in human neuroblastoma cells. Oncogene 2004, 23:130-141.
13. Kobayashi M., Nagata S., Kita Y., Nakatsu N., Ihara S., Kaibuchi K., et al. Expression of a constitutively active phosphatidylinositol 3-kinase induces process formation in rat PC12 cells. Use of Cre/loxP recombination system. J. Biol. Chem. 1997, 272:16089-16092.
14. Liu Y., Yao Z., Zhang L., Zhu H., Deng W., Qin C. Insulin induces neurite outgrowth via SIRT1 in SH-SY5Y cells. Neuroscience 2013, 238:371-380.
15. Maekawa F., Tsuboi T., Oya M., Aung K.H., Tsukahara S., Pellerin L., et al. Effects of sodium arsenite on neurite outgrowth and glutamate AMPA receptor expression in mouse cortical neurons. Neurotoxicology 2013, 37:197-206.
16. Martinez-Finley E.J., Ali A.M., Allan A.M. Learning deficits in C57BL/6J mice following perinatal arsenic exposure: consequence of lower corticosterone receptor levels?. Pharmacol. Biochem. Behav. 2009, 94:271-277.
17. Martinez-Finley E.J., Goggin S.L., Labrecque M.T., Allan A.M. Reduced expression of MAPK/ERK genes in perinatal arsenic-exposed offspring induced by glucocorticoid receptor deficits. Neurotoxicol. Teratol. 2011, 33:530-537.
18. Parvez F., Wasserman G.A., Factor-Litvak P., Liu X., Slavkovich V., Siddique A.B., et al. Arsenic exposure and motor function among children in Bangladesh. Environ. Health Perspect. 2011, 119:1665-1670.
19. Paul D.S., Harmon A.W., Devesa V., Thomas D.J., Styblo M. Molecular mechanisms of the diabetogenic effects of arsenic: inhibition of insulin signaling by arsenite and methylarsonous acid. Environ. Health Perspect. 2007, 115:734-742.
20. Read D.E., Gorman A.M. Involvement of Akt in neurite outgrowth. Cell. Mol. Life Sci. 2009, 66:2975-2984.
21. Recio-Pinto E., Rechler M.M., Ishii D.N. Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons. J. Neurosci. 1986, 6:1211-1219.
22. Reese D., Drapeau P. Neurite growth patterns leading to functional synapses in an identified embryonic neuron. J. Neurosci. 1998, 18:5652-5662.
23. Rodriguez V.M., Carrizales L., Mendoza M.S., Fajardo O.R., Giordano M. Effects of sodium arsenite exposure on development and behavior in the rat. Neurotoxicol. Teratol. 2002, 24:743-750.
24. Schechter R., Whitmire J., Holtzclaw L., George M., Harlow R., Devaskar S.U. Developmental regulation of insulin in the mammalian central nervous system. Brain Res. 1992, 582:27-37.
25. Tsai S.Y., Chou H.Y., The H.W., Chen C.M., Chen C.J. The effects of chronic arsenic exposure from drinking water on the neurobehavioral development in adolescence. Neurotoxicology 2003, 24:747-753.
26. Tyler C.R., Allan A.M. The effects of arsenic exposure on neurological and cognitive dysfunction in human and rodent studies: a review. Curr. Environ. Health Rep. 2014, 1:132-147.
27. Van Ooyen A. Competition in neurite outgrowth and the development of nerve connections. Prog. Brain Res. 2005, 147:81-99.
28. von Ehrenstein O.S., Poddar S., Yuan Y., Mazumder D.G., Eskenazi B., Basu A., et al. Children's intellectual function in relation to arsenic exposure. Epidemiology 2007, 18:44-51.
29. Wang X., Meng D., Chang Q., Pan J., Zhang Z., Chen G., et al. Arsenic inhibits neurite outgrowth by inhibiting the LKB1-AMPK signaling pathway. Environ. Health Perspect. 2010, 118:627-634.
30. Wasserman G.A., Liu X., Loiacono N.J., Kline J., Factor-Litvak P., van Geen A., et al. A cross- sectional study of well water arsenic and child IQ in Maine schoolchildren. Environ. Health 2014, 13:23.
31. Wasserman G.A., Liu X., Parvez F., Ahsan H., Factor-Litvak P., van Geen A., et al. Water arsenic exposure and children's intellectual function in Araihazar, Bangladesh. Environ. Health Perspect. 2004, 112:1329-1333.
32. Watcharasit P., Visitnonthachai D., Suntararuks S., Thiantanawat A., Satayavivad J. Low arsenite concentrations induce cell proliferation via activation of VEGF signaling in human neuroblastoma SH-SY5Y cells. Environ. Toxicol. Pharmacol. 2012, 33:53-59.