The small GTPase Rab7 as a central regulator of hepatocellular lipophagy

Hepatology

Volumn 61, Issue 6, 2015, Pages 1896-1907

  Schroeder, Barbara ^a   Schulze, Ryan J ^a   Weller, Shaun G ^a   Sletten, Arthur C ^a   Casey, Carol A ^b   McNiven, Mark A ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAT DROPLET; RAB7 PROTEIN; RAB PROTEIN; RILP PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CATABOLISM; CELL FRACTIONATION; CELL STRUCTURE; CONTROLLED STUDY; ESCHERICHIA COLI; HUMAN; HUMAN CELL; LIPOPHAGOCYTOSIS; LIVER CELL; LYSOSOME; MOUSE; MULTIVESICULAR BODY; NONHUMAN; PRIORITY JOURNAL; LIPOLYSIS; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AUTOPHAGY; CELL LINE, TUMOR; HEPATOCYTES; HUMANS; LIPID DROPLETS; LIPOLYSIS; LYSOSOMES; MULTIVESICULAR BODIES; RAB GTP-BINDING PROTEINS;

EID: 84929606449     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27667     Document Type: Article

References (48)

1. Liu K, Czaja MJ. Regulation of lipid stores and metabolism by lipophagy. Cell Death Differ 2013;20:3-11.
2. Sahini N, Borlak J. Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes. Prog Lipid Res 2014;54:86-112.
3. Walther TC, Farese RV Jr. Lipid droplets and cellular lipid metabolism. Annu Rev Biochem 2012;81:687-714.
4. Christian P, Sacco J, Adeli K. Autophagy: emerging roles in lipid homeostasis and metabolic control. Biochim Biophys Acta 2013;1831:819-824.
5. Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, et al. Autophagy regulates lipid metabolism. Nature 2009;458:1131-1135.
6. Devereaux K, Dall'Armi C, Alcazar-Roman A, Ogasawara Y, Zhou X, Wang F, et al. Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis. PloS One 2013;8:e76405.
7. Stenmark H. Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol 2009;10:513-525.
8. Gutierrez MG. Functional role(s) of phagosomal Rab GTPases. Small GTPases 2013;4:148-158.
9. Ao X, Zou L, Wu Y. Regulation of autophagy by the Rab GTPase network. Cell Death Differ 2014;21:348-358.
10. Hyttinen JM, Niittykoski M, Salminen A, Kaarniranta K. Maturation of autophagosomes and endosomes: a key role for Rab7. Biochim Biophys Acta 2013;1833:503-510.
11. Bucci C, Thomsen P, Nicoziani P, McCarthy J, van Deurs B. Rab7: a key to lysosome biogenesis. Mol Biol Cell 2000;11:467-480.
12. Feng Y, Press B, Chen W, Zimmerman J, Wandinger-Ness A. Expression and properties of Rab7 in endosome function. Methods Enzymol 2001;329:175-187.
13. Vonderheit A, Helenius A. Rab7 associates with early endosomes to mediate sorting and transport of Semliki forest virus to late endosomes. PLoS Biol 2005;3:e233.
14. Peralta ER, Martin BC, Edinger AL. Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence. J Biol Chem 2010;285:16814-16821.
15. Benard V, Bokoch GM. Assay of Cdc42, Rac, and Rho GTPase activation by affinity methods. Methods Enzymol 2002;345:349-359.
16. Schulze RJ, Weller SG, Schroeder B, Krueger EW, Chi S, Casey CA, et al. Lipid droplet breakdown requires Dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes. J Cell Biol 2013;203:315-326.
17. Agola JO, Hong L, Surviladze Z, Ursu O, Waller A, Strouse JJ, et al. A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition. ACS Chem Biol 2012;7:1095-1108.
18. Hong L, Simons P, Waller A, Strouse J, Surviladze Z, Ursu O, et al. A small molecule pan-inhibitor of Ras-superfamily GTPases with high efficacy towards Rab7. In: Probe Reports from the NIH Molecular Libraries Program. Bethesda, MD: National Center for Biotechnology Information; 2010.
19. Metcalf D, Isaacs AM. The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes. Biochem Soc Trans 2010;38:1469-1473.
20. Rusten TE, Stenmark H. How do ESCRT proteins control autophagy? J Cell Sci 2009;122:2179-2183.
21. Jager S, Bucci C, Tanida I, Ueno T, Kominami E, Saftig P, et al. Role for Rab7 in maturation of late autophagic vacuoles. J Cell Sci 2004;117:4837-4848.
22. Gutierrez MG, Munafo DB, Beron W, Colombo MI. Rab7 is required for the normal progression of the autophagic pathway in mammalian cells. J Cell Sci 2004;117:2687-2697.
23. Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007;3:452-460.
24. Zhang M, Chen L, Wang S, Wang T. Rab7: roles in membrane trafficking and disease. Biosci Rep 2009;29:193-209.
25. Vanlandingham PA, Ceresa BP. Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestration. J Biol Chem 2009;284:12110-12124.
26. Taelman VF, Dobrowolski R, Plouhinec JL, Fuentealba LC, Vorwald PP, Gumper I, et al. Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell 2010;143:1136-1148.
27. Nara A, Mizushima N, Yamamoto A, Kabeya Y, Ohsumi Y, Yoshimori T. SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation. Cell Struct Funct 2002;27:29-37.
28. Hamano T, Gendron TF, Causevic E, Yen SH, Lin WL, Isidoro C, et al. Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression. Eur J Neurosci 2008;27:1119-1130.
29. Barr FA. Rab GTPases and membrane identity: causal or inconsequential? J Cell Biol 2013;202:191-199.
30. ten Klooster JP, Hordijk PL. Targeting and localized signalling by small GTPases. Biol Cell 2007;99:1-12.
31. Wright LP, Philips MR. Lipid posttranslational modifications: CAAX modification and membrane targeting of Ras. J Lipid Res 2006;47:883-891.
32. Wu M, Wang T, Loh E, Hong W, Song H. Structural basis for recruitment of RILP by small GTPase Rab7. EMBO J 2005;24:1491-1501.
33. Progida C, Malerod L, Stuffers S, Brech A, Bucci C, Stenmark H. RILP is required for the proper morphology and function of late endosomes. J Cell Sci 2007;120:3729-3737.
34. Wang T, Ming Z, Xiaochun W, Hong W. Rab7: role of its protein interaction cascades in endo-lysosomal traffic. Cell Signal 2011;23:516-521.
35. Marino SF. High-level production and characterization of a G-protein coupled receptor signaling complex. FEBS J 2009;276:4515-4528.
36. Fader CM, Colombo MI. Autophagy and multivesicular bodies: two closely related partners. Cell Death Differ 2009;16:70-78.
37. Fader CM, Sanchez DG, Mestre MB, Colombo MI. TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways. Biochim Biophys Acta 2009;1793:1901-1916.
38. Morvan J, Kochl R, Watson R, Collinson LM, Jefferies HB, Tooze SA. In vitro reconstitution of fusion between immature autophagosomes and endosomes. Autophagy 2009;5:676-689.
39. Hansen TE, Johansen T. Following autophagy step by step. BMC Biol 2011;9:39.
40. Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007;8:931-937.
41. Bright NA, Gratian MJ, Luzio JP. Endocytic delivery to lysosomes mediated by concurrent fusion and kissing events in living cells. Curr Biol 2005;15:360-365.
42. Desjardins M. Biogenesis of phagolysosomes: the "kiss and run" hypothesis. Trends Cell Biol 1995;5:183-186.
43. Vieira OV, Bucci C, Harrison RE, Trimble WS, Lanzetti L, Gruenberg J, et al. Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase. Mol Cell Biol 2003;23:2501-2514.
44. Harrison RE, Bucci C, Vieira OV, Schroer TA, Grinstein S. Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP. Mol Cell Biol 2003;23:6494-6506.
45. Pankiv S, Alemu EA, Brech A, Bruun JA, Lamark T, Overvatn A, et al. FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. J Cell Biol 2010;188:253-269.
46. Pawelec A, Arsic J, Kolling R. Mapping of Vps21 and HOPS binding sites in Vps8 and effect of binding site mutants on endocytic trafficking. Eukaryot Cell 2010;9:602-610.
47. Jiang P, Nishimura T, Sakamaki Y, Itakura E, Hatta T, Natsume T, et al. The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17. Mol Biol Cell 2014;25:1327-1337.
48. Lizaso A, Tan KT, Lee YH. Beta-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation. Autophagy 2013;9:1228-1243.