Simultaneous Detection of 3-Nitrotyrosine and 3-Nitro-4-hydroxyphenylacetic Acid in Human Urine by Online SPE LC-MS/MS and Their Association with Oxidative and Methylated DNA Lesions

Chemical Research in Toxicology

Volumn 28, Issue 5, 2015, Pages 997-1006

  Chao, Mu Rong ^a   Hsu, Yu Wen ^a,b   Liu, Hung Hsin ^a   Lin, Jia Hong ^a   Hu, Chiung Wen ^a,c  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b DA YEH UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; 3 NITRO 4 HYDROXYPHENYLACETIC ACID; 3 NITROTYROSINE; 7 METHYLGUANINE; 8 HYDROXYDEOXYGUANOSINE; 8 HYDROXYGUANINE; DIMETHYLNITROSAMINE; PHENYLACETIC ACID DERIVATIVE; STABLE ISOTOPE; UNCLASSIFIED DRUG; 3-NITROTYROSINE; 4-HYDROXY-5-NITROPHENYL ACETIC ACID; 7-METHYLGUANINE; 8-HYDROXYGUANINE; 8-OXO-7-HYDRODEOXYGUANOSINE; ADENINE; DEOXYGUANOSINE; GUANINE; N3-METHYLADENINE; NITROPHENOL; TYROSINE;

ADULT; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA METHYLATION; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOTOPE LABELING; KIDNEY CONCENTRATING CAPACITY; LIMIT OF QUANTITATION; METABOLITE; NITRATIVE STRESS; NORMAL HUMAN; ONLINE ANALYSIS; OXIDATIVE STRESS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; URINE; URINE CHEMISTRY; ANALOGS AND DERIVATIVES; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MIDDLE AGED; OXIDATION REDUCTION REACTION; VALIDATION STUDY; YOUNG ADULT;

ADENINE; ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DEOXYGUANOSINE; DIMETHYLNITROSAMINE; DNA METHYLATION; GUANINE; HUMANS; LIMIT OF DETECTION; MIDDLE AGED; NITROPHENOLS; OXIDATION-REDUCTION; PHENYLACETATES; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TYROSINE; YOUNG ADULT;

EID: 84929577342     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/acs.chemrestox.5b00031     Document Type: Article

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