Delirium from the gliocentric perspective

Frontiers in Cellular Neuroscience

Volumn 9, Issue MAY, 2015, Pages

  Sfera, Adonis ^a   Osorio, Carolina ^b   Price, Amy I ^c   Gradini, Roberto ^d   Cummings, Michael ^a  

^a PATTON STATE HOSPITAL   (United States)

^b LOMA LINDA UNIVERSITY   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Acethylcholine; AQP 4; Extracellular space; Immunity; Volume transmission

Indexed keywords

3 (2, 4 DIMETHOXYBENZYLIDENE) ANABASEINE; ACETYLCHOLINE; AMYLOID BETA PROTEIN; APOLIPOPROTEIN A1; AQUAPORIN; BUNGAROTOXIN RECEPTOR; CHOLINE ACETYLTRANSFERASE; GELATINASE B; GLIAL FIBRILLARY ACIDIC PROTEIN; HAPTOGLOBIN; PROCALCITONIN; PROTEIN S100B; SERINE PROTEINASE INHIBITOR; TRANSFERRIN; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTE; CONNECTOME; DELIRIUM; EXTRACELLULAR SPACE; GLIA; GLIA CELL; HUMAN; NERVOUS SYSTEM INFLAMMATION;

EID: 84929574901     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2015.00171     Document Type: Article

References (67)

1. Agnati, L. F., Zoli, M., Strömberg, I., and Fuxe, K. (1995). Intercellular communication in the brain: wiring versus volume transmission. Neuroscience 69, 711-726. doi: 10.1016/0306-4522(95)00308-6
2. Bauer, J., Gebicke-Haerter, P. J., Ganter, U., Richter, I., and Gerok, W. (1988). Astrocytes synthesize and secrete alpha 2-macroglobulin: differences between the regulation of alpha 2-macroglobulin synthesis in rat liver and brain. Adv. Exp. Med. Biol. 240, 199-205. doi: 10.1007/978-1-4613-1057-0_24
3. Brinker, T., Stopa, E., Morrison, J., and Klinge, P. (2014). A new look at cerebrospinal fluid circulation. Fluids Barriers CNS 11:10. doi: 10.1186/2045-8118-11-10
4. Brownell, E., Lee, A. S., Pekar, S. K, Pravtcheva, D., Ruddle, F. H., and Bayney, R. M. (1991). Glial fibrillary acid protein, an astrocytic-specific marker, maps to human chromosome 17. Genomics 10, 1087-1089. doi: 10.1016/0888-7543(91)90205-s
5. Budde, M. D., Janes, L., Gold, E., Turtzo, L. C., and Frank, J. A. (2011). The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using fourier analysis of stained tissue sections. Brain 134, 2248-2260. doi: 10.1093/brain/awr161
6. Buisson, A., Nicole, O., Docagne, F., Sartelet, H., Mackenzie, E. T., and Vivien, D. (1998). Up-regulation of a serine protease inhibitor in astrocytes mediates the neuroprotective activity of transforming growth factor beta1. FASEB J. 12, 1683-1691.
7. de Jonge, W. J., and Ulloa, L. (2007). The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation. Br. J. Pharmacol. 151, 915-929. doi: 10.1038/sj.bjp.0707264
8. DeMattos, R. B., Brendza, R. P., Heuser, J. E., Kierson, M., Cirrito, J. R., Fryer, J., et al. (2001). Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice. Neurochem. Int. 39, 415-425. doi: 10.1016/s0197-0186(01)00049-3
9. Dudek, F. E., and Rogawski, M. A. (2005). Regulation of brain water: is there a role for aquaporins in epilepsy? Epilepsy Curr. 5, 104-106. doi: 10.1111/j.1535-7511.2005.05310.x
10. Duttaroy, A., Zimliki, C. L., Gautam, D., Cui, Y., Mears, D., and Wess, J. (2004). Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice. Diabetes 53, 1714-1720. doi: 10.2337/diabetes.53.7.1714
11. Engel, G. L., and Romano, J. (1959). Delirium, a syndrome of cerebral insufficiency. J. Chronic Dis. 9, 260-277. doi: 10.1016/0021-9681(59)90165-1
12. Ferretti, M., Fabbiano, C., Di Bari, M., Conte, C., Castigli, E., Sciaccaluga, M., et al. (2013). M2 receptor activation inhibits cell cycle progression and survival in human glioblastoma cells. J. Cell. Mol. Med. 17, 552-566. doi: 10.1111/jcmm.12038
13. Fukuda, A. M., and Badaut, J. (2012). Aquaporin 4: a player in cerebral edema and neuroinflammation. J. Neuroinflammation 9:279. doi: 10.1186/1742-2094-9-279
14. Gollin, P. A., Kalaria, R. N., Eikelenboom, P., Rozemuller, A., and Perry, G. (1992). Alpha 1-antitrypsin and alpha 1-antichymotrypsin are in the lesions of Alzheimer’s disease. Neuroreport 3, 201-203. doi: 10.1097/00001756-199202000-00020
15. Gualtieri, T. C. (2002). Brain Injury and Mental Retardation: Psychopharmacology and Neuropsychiatry. (Philadelphia: Lippincott Williams and Wilkins), 464-465.
16. Gundersen, G. A. (2013). Roles of Aquaporin-4 in Brain Fluid Dynamics. Thesis for the degree of Philosophiae Doctor. University of Oslo, Norway: Centre for Molecular Medicine Norway University of Oslo. (ISBN 978-82-8264-090-9)
17. Han, Z., Li, L., Wang, L. L., Degos, V., Maze, M., and Su, H. (2014). Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress and brain injury in mice with ischemic stroke and bone fracture. J. Neurochem. 131, 498-508. doi: 10.1111/jnc.12817
18. Harsan, L. A., Poulet, P., Guignard, B., Parizel, N., Skoff, R. P., and Ghandour, M. S. (2007). Astrocytic hypertrophy in dysmyelination influences the diffusion anisotropy of white matter. J. Neurosci. Res. 85, 935-944. doi: 10.1002/ jnr.21201
19. Hshieh, T. T., Fong, T. G., Marcantonio, E. R., and Inouye, S. K. (2008). Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence. J. Gerontol. A Biol. Sci. Med. Sci. 63,764-772. doi: 10.1093/gerona/63.7.764
20. Hsiao, T. W., Swarup, V. P., Kuberan, B., Tresco, P. A., and Hlady, V. (2013). Astrocytes specifically remove surface-adsorbed fibrinogen and locally express chondroitin sulfate proteoglycans. Acta Biomater. 9, 7200-7208. doi: 10.1016/j.actbio.2013.02.047
21. Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., et al. (2012). A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci. Transl. Med. 4:147-481. doi: 10.1126/scitranslmed.3003748
22. Ito, J., Nagayasu, Y., Kato, K., Sato, R., and Yokoyama, S. (2002). Apolipoprotein A-I induces translocation of cholesterol, phospholipid and caveolin-1 to cytosol in rat astrocytes. J. Biol. Chem. 277, 7929-7935. doi: 10.1074/jbc. m103878200
23. Jang, E., Kim, J. H., Lee, S., Kim, J. H., Seo, J. W., Jin, M., et al. (2013). Phenotypic polarization of activated astrocytes: the critical role of lipocalin-2 in the classicalinflammatory activation of astrocytes. J. Immunol. 15, 5204-5219. doi: 10.4049/jimmunol.1301637
24. Kox, M., Pompe, J. C., Peters, E., Vaneker, M., van der Laak, J. V., van der Hoeven, J. G., et al. (2011). α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates ventilator-induced tumour necrosis factor-α production and lung injury. Br. J. Anaesth. 107, 559-566. doi: 10.1093/bja/aer202
25. Lakhan, S. E., and Kirchgessne, A. (2011). Anti-inflammatory effects of nicotine in obesity and ulcerative colitis. J. Transl. Med. 9:129. doi: 10.1186/1479-5876-9-129
26. Lampron, A., Elali, A., and Rivest, S. (2013). Innate immunity in the CNS: redefining the relationship between the cns and its environment. Neuron 78, 214-232. doi: 10.1016/j.neuron.2013.04.005
27. Lasagna-Reeves, C. A., and Kayed, R. (2011). Astrocytes contain amyloid-β annular protofibrils in Alzheimer’s disease brains. FEBS Lett. 585, 3052-3057. doi: 10.1016/j.febslet.2011.08.027
28. Lazar, M. (2010). Mapping brain anatomical connectivity using white matter tractography. NMR Biomed. 23, 821-835. doi: 10.1002/nbm.1579
29. Lazar, M., Weinstein, D. M., Tsuruda, J. S., Hasan, K. M., Arfanakis, K., Meyerand, M. E., et al. (2003). White matter tractography using diffusion tensor deflection. Hum. Brain Mapp. 18, 306-321. doi: 10.1002/hbm.10102
30. Lee, M. Y., Kim, S. Y., Choi, J. S., Lee, I. H., Choi, Y. S., Jin, J. Y., et al. (2002). Upregulation of haptoglobin in reactive astrocytes after transient forebrain ischemia in rats. J. Cereb. Blood Flow Metab. 22, 1176-1180. doi: 10.1097/00004647-200210000-00004
31. Malmsten, L., Vijayaraghavan, S., Hovatta, O., Marutle, A., and Darreh-Shori, T. (2014). Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation. J. Cell. Mol. Med. 18, 1874-1888. doi: 10.1111/jcmm.12343
32. Maranto, J., Rappaport, J., and Datta, P. K. (2008). Regulation of complement component C3 in astrocytes by IL-1beta and morphine. J. Neuroimmune Pharmacol. 3, 43-51. doi: 10.1007/s11481-007-9096-9
33. McGrane, S., Girard, T. D., Thompson, J. L., Shintani, A. K., Woodworth, A., Ely, E. W., et al. (2011). Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients. Crit. Care 15:R78. doi: 10.1186/cc10070
34. Meng, S., Qiao, M., Lin, L., Del Bigio, M. R., Tomanek, B., and Tuor, U. I. (2004). Correspondence of AQP4 expression and hypoxic-ischaemic brain oedema monitored by magnetic resonance imaging in the immature and juvenile rat. Eur. J. Neurosci. 19, 2261-2269. doi: 10.1111/j.0953-816x.2004.03315.x
35. Nagele, R. G., D’Andrea, M. R., Lee, H., Venkataraman, V., and Wang, H. Y. (2003). Astrocytes accumulate A beta 42 and give rise to astrocytic amyloidplaques in Alzheimer disease brains. Brain Res. 971, 197-209. doi: 10.1016/s0006-8993(03)02361-8
36. Nagelhus, E. A., and Ottersen, O. P. (2013). Physiological roles of Aquaporin-4 in brain. Physiol. Rev. 93, 1543-1562. doi: 10.1152/physrev.00011.2013
37. Norman, G. J., Morris, J. S., Karelina, K., Weil, Z. M., Zhang, N., Al-Abed, Y., et al. (2011). Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors. J. Neurosci. 31, 3446-3452. doi: 10.1523/JNEUROSCI.4558-10.2011
38. Ojeda, M. L., Ambrosiani, J., Tavares, E., Maldonado, R., and Miñano, F. J. (2006). Identification and localization of procalcitonin-like immunoreactivity in the rat hypothalamus. Neurosci. Lett. 408, 40-45. doi: 10.1016/j.neulet.2006.07.076
39. Paco, S., Pozas, E., and Aguado, F. (2010). Secretogranin III is an astrocyte granin that is overexpressed in reactive glia. Cereb. Cortex 20, 1386-1397. doi: 10.1093/cercor/bhp202
40. Pandharipande, P. P., Girard, T. D., Jackson, J. C., Morandi, J. A., Thompson, J. L., Pun, B. T., et al. (2013). Long-term cognitive im-pairment after critical illness. N. Engl. J. Med. 369, 1306-1316. doi: 10.1056/NEJMoa13 01372
41. Pereira, A. Jr., and Furlan, A. (2010). Astrocytes and human cognition: modeling information integration and modulation of neuronal activity. Prog. Neurobiol. 92, 405-420. doi: 10.1016/j.pneurobio.2010.07.001
42. Perry, V. H., and Teeling, J. (2013). Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration. Semin. Immunopathol. 35, 601-612. doi: 10.1007/s00281-013-0382-8
43. Pichler, L., Muchitsch, E. M., and Schwarz, H. P. (1999). Preclinical investigation of alpha 1-acid glycoprotein (orosomucoid). Wien. Klin. Wochenschr. 111,192-198.
44. Poljak, A., Hill, M., Hall, R. J., MacLullich, A. M., Raftery, M. J., Tai, J., et al. (2014). Quantitative proteomics of delirium cerebrospinal fluid. Transl. Psychiatry 4:e477. doi: 10.1038/tp.2014.114
45. Qian, Z. M., To, Y., Tang, P. L., and Feng, Y. M. (1999). Transferrin receptors on the plasma membrane of cultured rat astrocytes. Exp. Brain Res. 129, 473-476.doi: 10.1007/s002210050916
46. Rodriguez, R., Kallenbach, U., Singer, W., and Munk, M. H. J. (2004). Short-and long-term effects of cholinergic modulation on gamma oscillations and response synchronization in the visual cortex. J. Neurosci. 24, 10369-10378. doi: 10.1523/jneurosci.1839-04.2004
47. Shaked, I., Meerson, A., Wolf, Y., Avni, R., Greenberg, D., Gilboa-Geffen, A., et al. (2009). MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase. Immunity 31, 965-973. doi: 10.1016/j.immuni.2009.09.019
48. Sokolowski, J. D., and Mandell, J. W. (2011). Phagocytic clearance in neurodegeneration. Am. J. Pathol. 178, 1416-1428. doi: 10.1016/j.ajpath.2010.12.051
49. Spindel, E. R. (2012). Muscarinic receptor agonists and antagonists: effects on cancer. Handb. Exp. Pharmacol. 208, 451-468. doi: 10.1007/978-3-642-23274-9_19
50. Stieler, J. T., Lederer, C., BruÈckner, M. K., Wolf, H., Holzer, M., Gertz, H. J., et al. (2001). Impairment of mitogenic activation of peripheral blood lymphocytes in Alzheimer’s disease. Neuroreport 12, 3969-3972. doi: 10.1097/00001756-200112210-00023
51. Taber, K. H., and Hurley, R. A. (2014). Volume transmission in the brain: beyond the synapse. J. Neuropsychiatry Clin. Neurosci. 26, 1-4. doi: 10.1176/appi.neuropsych.13110351
52. Takata, N., Mishima, T., Hisatsune, C., Nagai, T., Ebisui, E., Mikoshiba, K., et al. (2011). Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo. J. Neurosci. 31, 18155-18165. doi: 10.1523/JNEUROSCI.5289-11.2011
53. Tateishi, N., Shimoda, T., Yada, N., Shinagawa, R., and Kagamiishi, Y. (2006). S100B: astrocyte specific protein. Nihon Shinkei Seishin Yakurigaku Zasshi 26,11-16.
54. Thrane, A. S., Rangroo Thrane, V., and Nedergaard, M. (2014). Drowning stars: reassessing the role of astrocytes in brain edema. Trends Neurosci. 37, 620-628. doi: 10.1016/j.tins.2014.08.010
55. Tourdias, T., Dragonu, I., Fushimi, Y., Deloire, M. S., Boiziau, C., Brochet, B., et al. (2009). Aquaporin 4 correlates with apparent diffusion coefficient and hydrocephalus severity in the rat brain: a combined MRI-histological study. Neuroimage 47, 659-666. doi: 10.1016/j.neuroimage.2009.04.070
56. Tracey, K. J. (2009). Reflex control of immunity. Nat. Rev. Immunol. 9, 418-428. doi: 10.1038/nri2566
57. Tyagi, E., Agrawal, R., Nath, C., and Shukla, R. (2010). Inhibitory role of cholinergic system mediated via alpha7 nicotinic acetylcholine receptor in LPS-induced neuro-inflammation. Innate Immun. 16, 3-13. doi: 10.1177/1753425909104680
58. van Eijk, M. M., Roes, K. C., Honing, M. L., Kuiper, M. A., Karakus, A., van der Jagt, M., et al. (2010). Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial. Lancet 376, 1829-1837. doi: 10.1016/S0140-6736(10)61855-7
59. Vijayaraghavan, S., Karami, A., Aeinehband, S., Behbahani, H., Grandien, A., Nilsson, B., et al. (2013). Regulated extracellular choline acetyltransferase activity—the Plausible missing link of the distant action of Acetylcholine in the cholinergic anti-inflammatory pathway. PLOS One 8:e65936. doi: 10.1371/journal.pone.0065936
60. Vizi, E. S., Fekete, A., Karoly, R., and Mike, A. (2010). Non-synaptic receptors and transporters involved in brain functions and targets of drug treatment. Br. J. Pharmacol. 160, 785-809. doi: 10.1111/j.1476-5381.2009.00624.x
61. Witlox, J., Eurelings, L. S., de Jonghe, J. F., Kalisvaart, K. J., Eikelenboom, P., and van Gool, W. A. (2010). Delirium in elderly patients and the risk of postdischarge mortality, institutionalization and dementia: a meta-analysis. JAMA 304, 443-451. doi: 10.1001/jama.2010.1013
62. Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., et al. (2013). Sleep drives metabolite clearance from the adult brain. Science 342, 373-377. doi: 10.1126/science.1241224
63. Yang, L., Kress, B. T., Weber, H. J., Thiyagarajan, M., Wang, B., Deane, R., et al. (2013). Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer. J. Transl. Med. 11:107. doi: 10.1186/1479-5876-11-107
64. Yin, K. J., Cirrito, J. R., Yan, P., Hu, X., Xiao, Q., Pan, X., et al. (2006). Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism. J. Neurosci. 26, 10939-10948. doi: 10.1523/jneurosci.2085-06.2006
65. Yu, W., Mechawar, N., Krantic, S., Chabot, J. G., and Quirion, R. (2012). Upregulation of astrocytic α7 nicotinic receptors in Alzheimer’s disease brain-possible relevant to amyloid pathology. Mol. Neurodegener. 7(Suppl. 1):O7. doi: 10.1186/1750-1326-7-s1-o7
66. Zhan, X., Ander, B. P., Jickling, G., Turner, R., Stamova, B., Xu, H., et al. (2010). Brief focal cerebral ischemia that simulates transient ischemic attacks in humans regulates gene expression in rat peripheral blood. J. Cereb. Blood Flow Metab. 30, 110-118. doi: 10.1038/jcbfm.2009.189
67. Zhao, M., He, X., Bi, X. Y., Yu, X. J., Gil Wier, W., and Zang, W. J. (2013). Vagal stimulation triggers peripheral vascular protection through the cholinergic anti-inflammatory pathway in a rat model of myocardial ischemia/reperfusion. Basic Res. Cardiol. 108:345. doi: 10.1007/s00395-013-0345-1