Multi-triazole-resistant Aspergillus fumigatus infections in Australia

Mycoses

Volumn 58, Issue 6, 2015, Pages 350-355

  Kidd, Sarah E ^a   Goeman, Emma ^b   Meis, Jacques F ^c,d   Slavin, Monica A ^e   Verweij, Paul E ^c  

^a SA Pathology   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d CANISIUS WILHELMINA HOSPITAL   (Netherlands)

^e PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

Antifungal resistance; Aspergillus fumigatus; Itraconazole; Posaconazole; Voriconazole

Indexed keywords

AMPHOTERICIN B; ITRACONAZOLE; POSACONAZOLE; TRIAZOLE DERIVATIVE; VORICONAZOLE; ANTIFUNGAL AGENT; CYTOCHROME P-450 CYP51A, ASPERGILLUS; CYTOCHROME P450; FUNGAL PROTEIN;

ADULT; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; ASPERGILLOSIS; AUSTRALIA; BRONCHIECTASIS; BRONCHOSCOPY; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; FUNGUS MUTATION; GENE; HUMAN; LUNG FIBROSIS; LUNG INFILTRATE; LUNG LAVAGE; MALE; MIDDLE AGED; MINIMUM INHIBITORY CONCENTRATION; MULTI TRIAZOLE RESISTANT ASPERGILLUS FUMIGATUS INFECTION; PNEUMONIA; PRIORITY JOURNAL; RESPIRATORY FAILURE; RETROSPECTIVE STUDY; SECONDARY INFECTION; SPUTUM; SPUTUM CULTURE; THORAX RADIOGRAPHY; ANTIFUNGAL RESISTANCE; ASPERGILLUS FUMIGATUS; DRUG EFFECTS; GENETICS; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MISSENSE MUTATION;

ASPERGILLUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS LENTULUS;

ADULT; ANTIFUNGAL AGENTS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; AUSTRALIA; CYTOCHROME P-450 ENZYME SYSTEM; DRUG RESISTANCE, FUNGAL; FEMALE; FUNGAL PROTEINS; HUMANS; ITRACONAZOLE; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MUTATION, MISSENSE; RETROSPECTIVE STUDIES; TRIAZOLES; VORICONAZOLE;

EID: 84929509782     PISSN: 09337407     EISSN: 14390507     Source Type: Journal    
DOI: 10.1111/myc.12324     Document Type: Article

References (41)

1. Blyth CC, Gilroy NM, Guy SD et al. Consensus guidelines for the treatment of invasive mould infections in haematological malignancy and haemopoietic stem cell transplantation. Intern Med J 2014; 44: 1333-49.
2. Liss B, Vehreschild JJ, Bangard C et al. Our 2015 approach to invasive pulmonary aspergillosis. Mycoses 2015. doi: 10.1111/myc.12319
3. Walsh TJ, Anaissie EJ, Denning DW et al. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis 2008; 46: 327-60.
4. Vermeulen E, Lagrou K, Verweij PE. Azole resistance in Aspergillus fumigatus: a growing public health concern. Curr Opin Infect Dis 2013; 26: 493-500.
5. Chowdhary A, Sharma C, Hagen F, Meis JF. Exploring azole antifungal drug resistance in Aspergillus fumigatus with special reference to resistance mechanisms. Future Microbiol 2014; 9: 697-711.
6. Verweij PE, Mellado E, Melchers WJ. Multiple-triazole-resistant aspergillosis. N Engl J Med 2007; 356: 1481-3.
7. Snelders E, van der Lee HA, Kuijpers J et al. Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism. PLoS Med 2008; 5: e219.
8. Van der Linden JW, Snelders E, Kampinga GA et al. Clinical implications of azole resistance in Aspergillus fumigatus, The Netherlands, 2007-2009. Emerg Infect Dis 2011; 17: 1846-54.
9. Steinmann J, Hamprecht A, Vehreschild MJ et al. Emergence of azole-resistant invasive aspergillosis in HSCT recipients in Germany. J Antimicrob Chemother 2015; 70: doi:10.1093/jac/dku566.
10. Ahmad S, Joseph L, Hagen F, Meis JF, Khan Z. Concomitant occurrence of itraconazole-resistant and -susceptible strains of Aspergillus fumigatus in routine cultures. J Antimicrob Chemother 2015; 70: 412-5.
11. Chowdhary A, Kathuria S, Randhawa HS, Gaur SN, Klaassen CH, Meis JF. Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India. J Antimicrob Chemother 2012; 67: 362-6.
12. Sharma C, Hagen F, Moroti R, Meis JF, Chowdhary A. Triazole resistant Aspergillus fumigatus harbouring G54 mutation: is it de novo or environmentally acquired? J Glob Antimicrob Resist 2015; 3: doi. doi.org/10.1016/j.jgar.2015.01.005.
13. Prigitano A, Venier V, Cogliati M, de Lorenzis G, Esposto MC, Tortorano AM. Azole-resistant Aspergillus fumigatus in the environment of northern Italy, May 2011 to June 2012. Euro Surveill 2014; 19: 20747.
14. Chowdhary A, Sharma C, Kathuria S, Hagen F, Meis JF. Azole-resistant Aspergillus fumigatus with the environmental TR46/Y121F/T289A mutation in India. J Antimicrob Chemother 2014; 69: 555-7.
15. 34/L98H mutations in the cyp51A gene in Iran. Mycoses 2013; 56: 659-63.
16. Chowdhary A, Sharma C, van den Boom M et al. Multi-azole-resistant Aspergillus fumigatus in the environment in Tanzania. J Antimicrob Chemother 2014; 69: 2979-83.
17. Lockhart SR, Frade JP, Etienne KA, Pfaller MA, Diekema DJ, Balajee SA. Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene. Antimicrob Agents Chemother 2011; 55: 4465-8.
18. Chowdhary A, Kathuria S, Xu J, Meis JF. Emergence of azole-resistant Aspergillus fumigatus strains due to agricultural azole use creates an increasing threat to human health. PLoS Pathog 2013; 9: e1003633; doi:10.1371/journal.ppat.1003633.
19. Pham CD, Reiss E, Hagen F, Meis JF, Lockhart SR. Passive surveillance for azole-resistant Aspergillus fumigatus, United States, 2011-2013. Emerg Infect Dis 2014; 20: 1498-503.
20. Van der Linden LJ, Arendrup MC, Warris A et al. Prospective multicentre international surveillance of azole resistance in Aspergillus fumigatus (SCARE). Emerg Infect Dis 2015 in press.
21. CLSI. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi; approved standard CLSI document M38-A2. Wayne, PA: Clinical and Laboratory Standards Institute, 2008.
22. Espinel-Ingroff A, Diekema DJ, Fothergill A et al. Wild-type MIC distributions and epidemiological cutoff values for the triazoles and six Aspergillus spp. for the CLSI broth microdilution method (M38-A2 document). J Clin Microbiol 2010; 48: 3251-7.
23. Alcazar-Fuoli L, Mellado E, Alastruey-Izquierdo A, Cuenca-Estrella M, Rodriguez-Tudela JL. Aspergillus section Fumigati: antifungal susceptibility patterns and sequence-based identification. Antimicrob Agents Chemother 2008; 52: 1244-51.
24. Snelders E, Karawajczyk A, Schaftenaar G, Verweij PE, Melchers WJ. Azole resistance profile of amino acid changes in Aspergillus fumigatus CYP51A based on protein homology modeling. Antimicrob Agents Chemother 2010; 54: 2425-30.
25. Klaassen CH, de Valk HA, Curfs-Breuker IM, Meis JF. Novel mixed-format real-time PCR assay to detect mutations conferring resistance to triazoles in Aspergillus fumigatus and prevalence of multi-triazole resistance among clinical isolates in the Netherlands. J Antimicrob Chemother 2010; 65: 901-5.
26. de Valk HA, Klaassen CH, Meis JF. Molecular typing of Aspergillus species. Mycoses 2008; 51: 463-76.
27. Kidd SE, Ling LM, Meyer W, Morrissey CO, Chen SCA, Slavin MA. Molecular epidemiology of invasive aspergillosis. Lessons learned from an outbreak investigation in an Australian hematology unit. Infect Control Hosp Epidemiol 2009; 30: 1223-6.
28. de Valk HA, Meis JF, Curfs IM, Muehlethaler K, Mouton JW, Klaassen CH. Use of a novel panel of nine short tandem repeats for exact and high-resolution fingerprinting of Aspergillus fumigatus isolates. J Clin Microbiol 2005; 43: 4112-20.
29. Balajee SA, Gribskov JL, Hanley E, Nickle D, Marr KA. Aspergillus lentulus sp. nov., a new sibling species of A. fumigatus. Eukaryot Cell 2005; 4: 625-32.
30. Snelders E, Camps SM, Karawajczyk A et al. Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus. PLoS ONE 2012; 7: e31801.
31. Verweij PE, Snelders E, Kema GH, Mellado E, Melchers WJ. Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use? Lancet Infect Dis 2009; 9: 789-95.
32. 34/L98H mutations in the cyp51A gene in India. PLoS ONE 2012; 7: e52871.
33. Ellis DH, Pfeiffer TJ. Natural habitat of Cryptococcus neoformans var. gattii. J Clin Microbiol 1990; 28: 1642-4.
34. Harun A, Gilgado F, Chen SC, Meyer W. Abundance of Pseudallescheria/Scedosporium species in the Australian urban environment suggests a possible source for scedosporiosis including the colonization of airways in cystic fibrosis. Med Mycol 2010; 48(Suppl 1): S70-S76.
35. Escribano P, Recio S, Peláez T, Bouza E, Guinea J. Aspergillus fumigatus strains with mutations in the cyp51A gene do not always show phenotypic resistance to itraconazole, voriconazole, or posaconazole. Antimicrob Agents Chemother 2011; 55: 2460-2.
36. Albarrag AM, Anderson MJ, Howard SJ et al. Interrogation of related clinical pan-azole-resistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter. Antimicrob Agents Chemother 2011; 55: 5113-21.
37. Howard SJ, Cerar D, Anderson MJ et al. Frequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failure. Emerg Infect Dis 2009; 15: 1068-76.
38. van der Linden JW, Snelders E, Arends JP, Daenen SM, Melchers WJ, Verweij PE. Rapid diagnosis of azole-resistant aspergillosis by direct PCR using tissue specimens. J Clin Microbiol 2010; 48: 1478-80.
39. Spiess B, Postina P, Reinwald M et al. Incidence of cyp51A key mutations in Aspergillus fumigatus - a study on primary clinical samples of immunocompromised patients in the period of 1995-2013. PLoS ONE 2014; 9: e103113.
40. Halliday CL, Kidd SE, Sorrell TC, Chen SCA. Molecular diagnostic methods for invasive fungal disease: the horizon draws nearer? Pathology 2015; 47(3): 257-63.
41. Rodriguez-Tudela JL, Donnelly JP, Arendrup MC et al. EUCAST Technical Note on the method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for conidia-forming moulds. Clin Microbiol Infect 2008; 14: 982-4.