Irradiation-induced localization of IL-12-expressing mesenchymal stem cells to enhance the curative effect in murine metastatic hepatoma

International Journal of Cancer

Volumn 137, Issue 3, 2015, Pages 721-730

  Jeong, Keun Yeong ^a   Lee, Eun Jung ^a   Kim, Su Jin ^b   Yang, Seung Hyun ^a   Sung, Young Chul ^b   Seong, Jinsil ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

gene therapy; HCC; IL 12; irradiation; mesenchymal stem cell; metastasis

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GENE THERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; DRUG EFFICACY; DRUG RESPONSE; LIVER CELL CARCINOMA; LUNG METASTASIS; MESENCHYMAL STEM CELL; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RADIATION DOSE; RADIATION RESPONSE; TUMOR GROWTH; TUMOR MICROENVIRONMENT; ANIMAL; DISEASE MODEL; GENE EXPRESSION REGULATION; GENE THERAPY; GENETICS; IMMUNOLOGY; IONIZING RADIATION; LIVER NEOPLASMS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; METASTASIS; MONOCYTE; PATHOLOGY; RADIOTHERAPY; T LYMPHOCYTE SUBPOPULATION; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC THERAPY; INTERLEUKIN-12; KILLER CELLS, NATURAL; LIVER NEOPLASMS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MONOCYTES; NEOPLASM METASTASIS; RADIATION, IONIZING; RADIOTHERAPY; T-LYMPHOCYTE SUBSETS;

EID: 84929508307     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29428     Document Type: Article

References (34)

1. Barazani Y, Hiatt JR, Tong MJ, et al., Chronic viral hepatitis and hepatocellular carcinoma. World J Surg 2007; 31: 1243-8.
2. Befeler AS, Di Bisceglie AM., Hepatocellular carcinoma: diagnosis and treatment. Gastroenterology 2002; 122: 1609-19.
3. Matsuura M, Nakajima N, Arai K, et al., The usefulness of radiation therapy for hepatocellular carcinoma. Hepatogastroenterology 1998; 45: 791- 6.
4. Bujold A, Dawson LA., Stereotactic radiation therapy and selective internal radiation therapy for hepatocellular carcinoma. Cancer Radiother 2011; 15: 54- 63.
5. Willemart S, Nicaise N, Struyven J, et al., Acute radiation-induced hepatic injury: evaluation by triphasic contrast enhanced helical CT. Br J Radiol 2000; 73: 544- 6.
6. Kickingereder P, Dorn F, Blau T, et al., Differentiation of local tumor recurrence from radiation-induced changes after stereotactic radiosurgery for treatment of brain metastasis: case report and review of the literature. Radiat Oncol 2013; 8: 52.
7. Kawashita Y, Ohtsuru A, Kaneda Y, et al., Regression of hepatocellular carcinoma in vitro and in vivo by radiosensitizing suicide gene therapy under the inducible and spatial control of radiation. Hum Gene Ther 1999; 10: 1509- 19.
8. Klopp AH, Spaeth EL, Dembinski JL, et al., Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment. Cancer Res 2007; 67: 11687-95.
9. Pittenger MF, Mackay AM, Beck SC, et al., Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143-7.
10. Barry FP, Murphy JM., Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol 2004; 36: 568-84.
11. Kim SW, Kim SJ, Park SH, et al., Complete regression of metastatic renal cell carcinoma by multiple injections of engineered mesenchymal stem cells expressing dodecameric TRAIL and HSV-TK. Clin Cancer Res 2013; 19: 415-27.
12. Seo SH, Kim KS, Park SH, et al., The effects of mesenchymal stem cells injected via different routes on modified IL-12-mediated antitumor activity. Gene Ther 2011; 18: 488-95.
13. Niess H, Bao Q, Conrad C, et al., Selective targeting of genetically engineered mesenchymal stem cells to tumor stroma microenvironments using tissue-specific suicide gene expression suppresses growth of hepatocellular carcinoma. Ann Surg 2011; 254: 767-74; discussion 74-5.
14. Uchino K, Tateishi R, Shiina S, et al., Hepatocellular carcinoma with extrahepatic metastasis: clinical features and prognostic factors. Cancer 2011; 117: 4475-83.
15. Uekusa Y, Gao P, Yamaguchi N, et al., A role for endogenous IL-12 in tumor immunity: IL-12 is required for the acquisition of tumor-migratory capacity by T cells and the development of T cell-accepting capacity in tumor masses. J Leukoc Biol 2002; 72: 864-73.
16. Milas L, Wike J, Hunter N, et al., Macrophage content of murine sarcomas and carcinomas: associations with tumor growth parameters and tumor radiocurability. Cancer Res 1987; 47: 1069-75.
17. Darlington GJ., Liver cell lines. Methods Enzymol 1987; 151: 19-38.
18. Kim W, Seong J, An JH, et al., Enhancement of tumor radioresponse by wortmannin in C3H/HeJ hepatocarcinoma. J Radiat Res 2007; 48: 187-95.
19. Boxall SA, Jones E., Markers for characterization of bone marrow multipotential stromal cells. Stem cells Int 2012;2012: 975871.
20. Elzaouk L, Moelling K, Pavlovic J., Anti-tumor activity of mesenchymal stem cells producing IL-12 in a mouse melanoma model. Exp Dermatol 2006; 15: 865-74.
21. Zhou YF, Bosch-Marce M, Okuyama H, et al., Spontaneous transformation of cultured mouse bone marrow-derived stromal cells. Cancer Res 2006; 66: 10849-54.
22. Karnoub AE, Dash AB, Vo AP, et al., Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007; 449: 557-63.
23. Letvin NL., Progress toward an HIV vaccine. Annu Rev Med 2005; 56: 213-23.
24. Lee HJ, Yang HM, Choi YS, et al., A therapeutic strategy for metastatic malignant fibrous histiocytoma through mesenchymal stromal cell-mediated TRAIL production. Ann Surg 2013; 257: 952-60.
25. Dwyer RM, Potter-Beirne SM, Harrington KA, et al., Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells. Clin Cancer Res 2007; 13: 5020-7.
26. Liu X, Duan B, Cheng Z, et al., SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion. Protein Cell 2011; 2: 845-54.
27. Darlington GJ, Bernhard HP, Miller RA, et al., Expression of liver phenotypes in cultured mouse hepatoma cells. J Natl Cancer Inst 1980; 64: 809-19.
28. Zhang Y, Deng ZS, Liao MM, et al., Tumor associated glycoprotein-72 is a novel marker for poor survival in hepatocellular carcinoma. Pathol Oncol Res 2012; 18: 911 -1 6.
29. Pegram HJ, Lee JC, Hayman EG, et al., Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood 2012; 119: 4133-41.
30. Multhoff G, Radons J., Radiation, inflammation, and immune responses in cancer. Front Oncol 2012; 2: 58.
31. Gao Y, Yao A, Zhang W, et al., Human mesenchymal stem cells overexpressing pigment epithelium-derived factor inhibit hepatocellular carcinoma in nude mice. Oncogene 2010; 29: 2784-94.
32. van Poll D, Parekkadan B, Cho CH, et al., Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo. Hepatology 2008; 47: 1634-43.
33. Park HJ, Griffin RJ, Hui S, et al., Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS). Radiat Res 2012; 177: 311-27.
34. Goebel WS, Yoder MC, Pech NK, et al., Donor chimerism and stem cell function in a murine congenic transplantation model after low-dose radiation conditioning: effects of a retroviral-mediated gene transfer protocol and implications for gene therapy. Exp Hematol 2002; 30: 1324-32.