Helicobacter pylori promotes VEGF expression via the p38 MAPK-mediated COX-2-PGE2 pathway in MKN45 cells

Molecular Medicine Reports

Volumn 10, Issue 4, 2014, Pages 2123-2129

  Liu, Ningning ^b   Wu, Qiong ^b   Wang, Yan ^c   Sui, Hua ^b   Liu, Xuan ^b   Zhou, Ning ^b   Zhou, Lihong ^a   Wang, Yifei ^a   Ye, Naijing ^a   Fu, Xiaoling ^a   Yu, Nikitin Alexander ^d   Li, Qi ^a,c  

^a SHUGUANG HOSPITAL AFFILIATED TO SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Putuo Hospital   (China)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^d Department of Obstetrics Gynecology   (United States)

Author keywords

COX 2; Gastric cancer; Helicobacter pylori; p38 MAPK; VEGF

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; CYCLOOXYGENASE 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2; VASCULOTROPIN; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; IMIDAZOLE DERIVATIVE; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANESULFONAMIDE; NITROBENZENE DERIVATIVE; PYRIDINE DERIVATIVE; SMALL INTERFERING RNA; SULFONAMIDE; VASCULOTROPIN A;

ARTICLE; BACTERIUM CULTURE; CANCER CELL; CELL STRAIN; CELL STRAIN MKN45; CONTROLLED STUDY; HELICOBACTER INFECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STOMACH CANCER; STOMACH CARCINOGENESIS; TUMOR VASCULARIZATION; UPREGULATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HELICOBACTER PYLORI; HUMAN; METABOLISM; PATHOGENICITY; RNA INTERFERENCE; TUMOR CELL LINE;

CELL LINE, TUMOR; CYCLOOXYGENASE 2; DINOPROSTONE; HEK293 CELLS; HELICOBACTER PYLORI; HUMANS; IMIDAZOLES; NITROBENZENES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; RNA INTERFERENCE; RNA, SMALL INTERFERING; SULFONAMIDES; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84929506859     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2458     Document Type: Article

References (34)

1. Peek RM Jr and Crabtree JE: Helicobacter infection and gastric neoplasia. J Pathol 208: 233-248, 2006.
2. Ernst PB, Peura DA and Crowe SE: The translation of Helicobacter pylori basic research to patient care. Gastroenterology 130: 188-206; quiz 212-213, 2006.
3. No authors listed: IARC working group on the evaluation of carcinogenic risks to humans: some industrial chemicals. Lyon, 15-22 February 1994. IARC Monogr Eval Carcinog Risks Hum 60: 1-560, 1994.
4. Wroblewski LE, Peek RM, Jr and Wilson KT: Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev 23: 713-739, 2010.
5. Conteduca V, Sansonno D, Lauletta G, Russi S, Ingravallo G and Dammacco F: H. pylori infection and gastric cancer: state of the art (review). Int J Oncol 42: 5-18, 2013.
6. de Vries EF: Imaging of cyclooxygenase-2 (COX-2) expression: potential use in diagnosis and drug evaluation. Curr Pharm Des 12: 3847-3856, 2006.
7. Greenhough A, Smartt HJ, Moore AE, et al: The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis 30: 377-386, 2009.
8. Zidar N, Dolenc-Strazar Z, Jeruc J, et al: Expression of cyclooxygenase-1 and cyclooxygenase-2 in the normal human heart and in myocardial infarction. Cardiovasc Pathol 16: 300-304, 2007. (Pubitemid 47381500)
9. Zidar N, Odar K, Glavac D, Jerse M, Zupanc T and Stajer D: Cyclooxygenase in normal human tissues - is COX-1 really a constitutive isoform, and COX-2 an inducible isoform? J Cell Mol Med 13: 3753-3763, 2009.
10. Buskens CJ, Van Rees BP, Sivula A, et al: Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus. Gastroenterology 122: 1800-1807, 2002. (Pubitemid 34651424)
11. Erkinheimo TL, Lassus H, Sivula A, et al: Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma. Cancer Res 63: 7591-7594, 2003. (Pubitemid 37466678)
12. Juuti A, Louhimo J, Nordling S, Ristimäki A and Haglund C: Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer. J Clin Pathol 59: 382-386, 2006.
13. Menter DG, Schilsky RL and DuBois RN: Cyclooxygenase-2 and cancer treatment: understanding the risk should be worth the reward. Clin Cancer Res 16: 1384-1390, 2010.
14. Ristimäki A, Sivula A, Lundin J, et al: Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res 62: 632-635, 2002. (Pubitemid 34126931)
15. Thiel A, Mrena J and Ristimäki A: Cyclooxygenase-2 and gastric cancer. Cancer Metastasis Rev 30: 387-395, 2011.
16. Li Q, Liu N, Shen B, et al: Helicobacter pylori enhances cyclooxygenase 2 expression via p38MAPK/ATF-2 signaling pathway in MKN45 cells. Cancer Lett 278: 97-103, 2009.
17. Fujino H, Xu W and Regan JW: Prostaglandin E2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinases. J Biol Chem 278: 12151-12156, 2003. (Pubitemid 36800194)
18. Golijanin D, Tan JY, Kazior A, et al: Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis. Clin Cancer Res 10: 1024-1031, 2004. (Pubitemid 38198904)
19. Sheng H, Shao J, Washington MK and DuBois RN: Prostaglandin E2 increases growth and motility of colorectal carcinoma cells. J Biol Chem 276: 18075-18081, 2001.
20. Ding YB, Shi RH, Tong JD, et al: PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system. Exp Oncol 27: 108-113, 2005.
21. Pai R, Szabo IL, Soreghan BA, Atay S, Kawanaka H and Tarnawski AS: PGE(2) stimulates VEGF expression in endothelial cells via ERK2/JNK1 signaling pathways. Biochem Biophys Res Commun 286: 923-928, 2001. (Pubitemid 32924860)
22. Araki H, Ukawa H, Sugawa Y, Yagi K, Suzuki K and Takeuchi K: The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E2 in rat stomach. Aliment Pharmacol Ther 14 (Suppl 1): 116-124, 2000. (Pubitemid 30199115)
23. Breyer RM, Emeson RB, Tarng JL, et al: Alternative splicing generates multiple isoforms of a rabbit prostaglandin E2 receptor. J Biol Chem 269: 6163-6169, 1994. (Pubitemid 24243005)
24. Pang L and Knox AJ: Bradykinin stimulates IL-8 production in cultured human airway smooth muscle cells: role of cyclooxygenase products. J Immunol 161: 2509-2515, 1998. (Pubitemid 28397068)
25. Takeuchi K, Araki H, Umeda M, Komoike Y and Suzuki K: Adaptive gastric cytoprotection is mediated by prostaglandin EP1 receptors: a study using rats and knockout mice. J Pharmacol Exp Ther 297: 1160-1165, 2001. (Pubitemid 32472517)
26. Jain S, Chakraborty G, Raja R, Kale S and Kundu GC: Prostaglandin E2 regulates tumor angiogenesis in prostate cancer. Cancer Res 68: 7750-7759, 2008.
27. Cuenda A and Rousseau S: p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta 1773: 1358-1375, 2007. (Pubitemid 47125981)
28. Choi IJ, Kim JS, Kim JM, Jung HC and Song IS: Effect of inhibition of extracellular signal-regulated kinase 1 and 2 pathway on apoptosis and bcl-2 expression in Helicobacter pylori-infected AGS cells. Infection Immun 71: 830-837, 2003. (Pubitemid 36150777)
29. Kim H, Seo JH and Kim KH: The effect of p38 mitogen-activated protein kinase on mucin gene expression and apoptosis in Helicobacter pylori-infected gastric epithelial cells. Ann NY Acad Sci 1010: 90-94, 2003. (Pubitemid 38264956)
30. Seo JH, Lim JW, Kim H and Kim KH: Helicobacter pylori in a Korean isolate activates mitogen-activated protein kinases, AP-1, and NF-kappaB and induces chemokine expression in gastric epithelial AGS cells. Lab Invest 84: 49-62, 2004. (Pubitemid 41656434)
31. Kim JH, Studer RK, Vo NV, Sowa GA and Kang JD: p38 MAPK inhibition selectively mitigates inflammatory mediators and VEGF production in AF cells co-cultured with activated macrophage-like THP-1 cells. Osteoarthritis Cartilage 17: 1662-1669, 2009.
32. Goel HL and Mercurio AM: VEGF targets the tumour cell. Nat Rev Cancer 13: 871-882, 2013.
33. Wu CY, Wang CJ, Tseng CC, et al: Helicobacter pylori promote gastric cancer cells invasion through a NF-kappaB and COX-2-mediated pathway. World J Gastroenterol 11: 3197-3203, 2005.
34. Liu NN, Wang Y and Wu Q: Jianpi jiedu recipe inhibited Helicobacter pylori-induced the expression of cyclooxygenase-2 via p38MAPK/ATF-2 signal transduction pathway in human gastric cancer cells. Zhongguo Zhong Xi Yi Jie He Za Zhi 31: 926-931, 2011 (In Chinese).