Wogonin suppresses melanoma cell B16-F10 invasion and migration by inhibiting ras-medicated pathways

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Zhao, Kai ^a   Wei, Libin ^a   Hui, Hui ^a   Dai, Qinsheng ^a   You, Qi Dong ^a   Guo, Qing Long ^a   Lu, Na ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DACARBAZINE; GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; RAC1 PROTEIN; RAS PROTEIN; WOGONIN; ANTINEOPLASTIC AGENT; FLAVANONE DERIVATIVE; GELATINASE B; PHOSPHATIDYLINOSITOL 3 KINASE; TUMOR NECROSIS FACTOR ALPHA;

ACTIN FILAMENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL ADHESION; CELL INVASION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; MELANOMA; METASTASIS INHIBITION; MIGRATION INHIBITION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; CELL MOTION; CYTOSKELETON; DRUG EFFECTS; EXPERIMENTAL MELANOMA; GENE EXPRESSION REGULATION; MALE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR INVASION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL ADHESION; CELL MOVEMENT; CYTOSKELETON; FLAVANONES; GENE EXPRESSION REGULATION, NEOPLASTIC; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MELANOMA, EXPERIMENTAL; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM INVASIVENESS; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RAS PROTEINS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84929505746     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0106458     Document Type: Article

References (28)

1. Aladowicz E, Ferro L, Vitali GC, Venditti E, Fornasari L, et al. (2013) Molecular networks in melanoma invasion and metastasis. Future Oncol 9: 713-726.
2. Price JT, Thompson EW (2002) Mechanisms of tumour invasion and metastasis: Emerging targets for therapy. Expert Opin Ther Targets 6: 217-233.
3. Pai SY, Kim C, Williams DA (2010) Rac GTPases in human diseases. Dis Markers 29: 177-187.
4. McCawley LJ, Matrisian LM (2000) Matrix metalloproteinases: Multifunctional contributors to tumor progression. Mol Med Today 6: 149-156.
5. Yan C, Boyd DD (2007) Regulation of matrix metalloproteinase gene expression. J Cell Physiol 211: 19-26.
6. Dye DE, Medic S, Ziman M, Coombe DR (2013) Melanoma Biomolecules: Independently Identified but Functionally Intertwined. Front Oncol 3: 252.
7. Fernandez-Medarde A, Santos E (2011) Ras in cancer and developmental diseases. Genes Cancer 2: 344-358.
8. Rajalingam K, Schreck R, Rapp UR, Albert S (2007) Ras oncogenes and their downstream targets. Biochim Biophys Acta 1773: 1177-1195.
9. Yang BC, Wang YS, Liu HS, Lin SJ (2000) Ras signaling is involved in the expression of Fas-L in glioma. Lab Invest 80: 529-537.
10. Chakraborti S, Mandal M, Das S, Mandal A, Chakraborti T (2003) Regulation of matrix metalloproteinases: An overview. Mol Cell Biochem 253: 269-285.
11. Kim D, Kim S, Koh H, Yoon SO, Chung AS, et al. (2001) Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J 15: 1953-1962.
12. Ikemoto S, Sugimura K, Yoshida N, Yasumoto R, Wada S, et al. (2000) Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. Urology 55: 951-955.
13. Chen XM, Bai Y, Zhong YJ, Xie XL, Long HW, et al. (2013) Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7alpha and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. PLoS One 8: E79201.
14. Chen P, Lu N, Ling Y, Chen Y, Hui H, et al. (2011) Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9. Toxicology 282: 122-128.
15. Hui KM, Huen MS, Wang HY, Zheng H, Sigel E, et al. (2002) Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. Biochem Pharmacol 64: 1415-1424.
16. Xu L, Deng X (2006) Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro-and m-calpains. J Biol Chem 281: 4457-4466.
17. Virtanen SS, Vaananen HK, Harkonen PL, Lakkakorpi PT (2002) Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. Cancer Res 62: 2708-2714.
18. Yoon SO, Kim MM, Chung AS (2001) Inhibitory effect of selenite on invasion of HT1080 tumor cells. J Biol Chem 276: 20085-20092.
19. Peng PL, Hsieh YS, Wang CJ, Hsu JL, Chou FP (2006) Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Toxicol Appl Pharmacol 214: 8-15.
20. Adya R, Tan BK, Punn A, Chen J, Randeva HS (2008) Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: Novel insights into visfatin-induced angiogenesis. Cardiovasc Res 78: 356-365.
21. Wang S, Liu Q, Zhang Y, Liu K, Yu P, et al. (2009) Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action. Mol Cancer 8: 81.
22. Shtivelman E, Davies MQ, Hwu P, Yang J, Lotem M, et al. (2014) Pathways and therapeutic targets in melanoma. Oncotarget 5: 1701-1752.
23. Lu N, Ling Y, Gao Y, Chen Y, Mu R, et al. (2008) Endostar suppresses invasion through downregulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells. Exp Biol Med (Maywood) 233: 1013-1020.
24. Nagase H (1998) Cell surface activation of progelatinase A (proMMP-2) and cell migration. Cell Res 8: 179-186.
25. Frohlich E (2010) Proteases in cutaneous malignant melanoma: Relevance as biomarker and therapeutic target. Cell Mol Life Sci 67: 3947-3960.
26. Giltnane JM, Balko JM (2014) Rationale for targeting the Ras/MAPK pathway in triple-negative breast cancer. Discov Med 17: 275-283.
27. Anisimov VN, Bartke A (2013) The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer. Crit Rev Oncol Hematol 87: 201-223.
28. Zidi I, Mestiri S, Bartegi A, Amor NB (2010) TNF-alpha and its inhibitors in cancer. Med Oncol 27: 185-198.