MicroRNA-494 promotes cyclosporine-induced nephrotoxicity and epithelial to mesenchymal transition by inhibiting PTEN

American Journal of Transplantation

Volumn 15, Issue 6, 2015, Pages 1682-1691

  Yuan, J ^a   Benway, C J ^a,b   Bagley, J ^a   Iacomini, J ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Graduate Program in Genetics   (United States)

Author keywords

basic (laboratory) research science; calcineurin inhibitor: cyclosporine A (CsA); complication; drug toxicity; immunosuppressant; immunosuppression immune modulation; kidney failure injury; kidney transplantation nephrology; molecular biology: micro RNA; translational research science

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALVASCULIN; CYCLOSPORIN A; MICRORNA; MICRORNA 494; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; UNCLASSIFIED DRUG; UVOMORULIN; CYCLOSPORIN; MIRN494 MICRORNA, MOUSE; PTEN PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC MANIPULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY INJURY; KIDNEY TUBULE CELL; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PTEN GENE; UPREGULATION; ACUTE KIDNEY FAILURE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICALLY INDUCED; DOWN REGULATION; DRUG EFFECTS; EPITHELIUM CELL; GENETICS; KIDNEY TUBULE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ACUTE KIDNEY INJURY; ANIMALS; CYCLOSPORINE; DOWN-REGULATION; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; KIDNEY TUBULES; MALE; MICE; MICE, INBRED C57BL; MICRORNAS; MODELS, ANIMAL; PTEN PHOSPHOHYDROLASE; UP-REGULATION;

EID: 84929505124     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.13161     Document Type: Article

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