Methylation of the oxytocin receptor gene in clinically depressed patients compared to controls: The role of OXTR rs53576 genotype

Journal of Psychiatric Research

Volumn 65, Issue , 2015, Pages 9-15

  Reiner, I ^a   Van IJzendoorn, M H ^b   Bakermans Kranenburg, M J ^b   Bleich, S ^c   Beutel, M ^a   Frieling, H ^c  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b LEIDEN UNIVERSITY   (Netherlands)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Biomarkers; Depression; Exon specific; Methylation; OXTR; Oxytocin

Indexed keywords

GENOMIC DNA; OXYTOCIN RECEPTOR; OXTR PROTEIN, HUMAN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DEPRESSION; DNA EXTRACTION; DNA ISOLATION; DNA METHYLATION; EXON; FEMALE; GENE FREQUENCY; GENE SEQUENCE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; LEUKOCYTE; MOLECULAR GENETICS; PREMENOPAUSE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN POLYMORPHISM; PSYCHOSOMATICS; GENETICS; MIDDLE AGED; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL;

ADULT; DEPRESSION; DNA METHYLATION; EXONS; FEMALE; GENOTYPE; HUMANS; LINEAR MODELS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OXYTOCIN;

EID: 84929504195     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2015.03.012     Document Type: Article

References (47)

1. Baker-Andresen D., Ratnu V.S., Bredy T.W. Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation. Trends Neurosci 2013, 36:3-13.
2. Bakermans-Kranenburg M., Van IJzendoorn M. Sniffing around oxytocin: review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy. Transl Psychiatry 2013, 3:e258.
3. Bakermans-Kranenburg M.J., van Ijzendoorn M.H. Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Soc Cognit Affect Neurosci 2008, 3:128-134.
4. Bakermans-Kranenburg M.J., van IJzendoorn M.H. Asociability gene? Meta-analysis of oxytocin receptor genotype effects in humans. Psychiatr Genet 2014, 24:45-51.
5. Bönsch D., Lenz B., Reulbach U., Kornhuber J., Bleich S. Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism. JNeural Transm 2004, 111:1611-1616.
6. Chen L., Pan H., Tuan T.A., Teh A.L., MacIsaac J.L., Mah S.M., et al. Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes. Dev Psychopathol 2015, 27:137-150.
7. Cornelis M.C., Glymour M.M., Chang S.C., Tchetgen E.J., Liang L., Koenen K.C., et al. Oxytocin receptor (OXTR) is not associated with optimism in the nurses' health study. Mol Psychiatry 2012, 17:1157-1159.
8. Costa B., Pini S., Gabelloni P., Abelli M., Lari L., Cardini A., et al. Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology 2009, 34:1506-1514.
9. Cyranowski J.M., Hofkens T.L., Frank E., Seltman H., Cai H.-M., Amico J.A. Evidence of dysregulated peripheral oxytocin release among depressed women. Psychosom Med 2008, 70:967-975.
10. Ehrlich M., Lacey M. DNA methylation and differentiation: silencing, upregulation and modulation of gene expression. Epigenomics 2013, 5:553-568.
11. Gregory S.G., Connelly J.J., Towers A.J., Johnson J., Biscocho D., Markunas C.A., et al. Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Med 2009, 7:62.
12. Harony-Nicolas H., Mamrut S., Brodsky L., Shahar-Gold H., Barki-Harrington L., Wagner S. Brain region-specific methylation in the promoter of the murine oxytocin receptor gene is involved in its expression regulation. Psychoneuroendocrinology 2014, 39:121-131.
13. Hillemacher T., Frieling H., Moskau S., Muschler M.A., Semmler A., Kornhuber J., et al. Global DNA methylation is influenced by smoking behaviour. Eur Neuropsychopharmacol 2008, 18:295-298.
14. Hoehe M.R., Wendel B., Grunewald I., Chiaroni P., Levy N., Morris-Rosendahl D., et al. Brief research communication: serotonin transporter (5-HTT) gene polymorphisms are not associated with susceptibility to mood disorders. Am J Med Genet 1998, 81:1-3.
15. Kawamura Y., Liu X., Akiyama T., Shimada T., Otowa T., Sakai Y., et al. The association between oxytocin receptor gene (OXTR) polymorphisms and affective temperaments, as measured by TEMPS-A. JAffect Disord 2010, 127:31-37.
16. Kumsta R., Heinrichs M. Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system. Curr Opin Neurobiol 2013, 23:11-16.
17. Kusui C., Kimura T., Ogita K., Nakamura H., Matsumura Y., Koyama M., et al. DNA methylation of the human oxytocin receptor gene promoter regulates tissue-specific gene suppression. Biochem Biophys Res Commun 2001, 289:681-686.
18. Lee H.J., Macbeth A.H., Pagani J.H., Young W.S. Oxytocin: the great facilitator of life. Prog Neurobiol 2009, 88:127-151.
19. Lépine J.-P., Briley M. The increasing burden of depression. Neuropsychiatr Dis Treat 2011, 7:3-7.
20. Levinson D.F. The genetics of depression: a review. Biol Psychiatry 2006, 60:84-92.
21. Lewin J., Schmitt A.O., Adorján P., Hildmann T., Piepenbrock C. Quantitative DNA methylation analysis based on four-dye trace data from direct sequencing of PCR amplificates. Bioinformatics 2004, 20:3005-3012.
22. Lotrich F.E., Pollock B.G. Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatr Genet 2004, 14:121-129.
23. Lucht M.J., Barnow S., Sonnenfeld C., Rosenberger A., Grabe H.J., Schroeder W., et al. Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Prog Neuro-Psychopharmacol Biological Psychiatry 2009, 33:860-866.
24. Mah B.L., Van IJzendoorn M.H., Smith R., Bakermans-Kranenburg M.J. Oxytocin in postnatally depressed mothers: its influence on mood and expressed emotion. Prog Neuro-Psychopharmacol Biological Psychiatry 2013, 40:267-272.
25. Mamrut S., Harony H., Sood R., Shahar-Gold H., Gainer H., Shi Y.-J., et al. DNA methylation of specific CpG sites in the promoter region regulates the transcription of the mouse oxytocin receptor. PloS One 2013, 8:e56869.
26. Meaney M.J. Epigenetics and the biological definition of gene× environment interactions. Child Dev 2010, 81:41-79.
27. Melas P.A., Rogdaki M., Lennartsson A., Björk K., Qi H., Witasp A., et al. Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression. Int J Neuropsychopharmacol 2012, 15:669-679.
28. Mendlewicz J., Crisafulli C., Calati R., Kocabas N.A., Massat I., Linotte S., et al. Influence of COX-2 and OXTR polymorphisms on treatment outcome in treatment resistant depression. Neurosci Lett 2012, 516:85-88.
29. Murgatroyd C., Patchev A.V., Wu Y., Micale V., Bockmühl Y., Fischer D., et al. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci 2009, 12:1559-1566.
30. Na Y.K., Hong H.S., Lee D.H., Lee W.K., Kim D.S. Effect of body mass index on global DNA methylation in healthy Korean women. Mol Cell 2014.
31. Ogilvie A., Battersby S., Fink G., Harmar A., Goodwin G., Bubb V., et al. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 1996, 347:731-733.
32. Ozsoy S., Esel E., Kula M. Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment. Psychiatry Res 2009, 169:249-252.
33. Parker K.J., Kenna H.A., Zeitzer J.M., Keller J., Blasey C.M., Amico J.A., et al. Preliminary evidence that plasma oxytocin levels are elevated in major depression. Psychiatry Res 2010, 178:359-362.
34. Pincus D., Kose S., Arana A., Johnson K., Morgan P.S., Borckardt J., et al. Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled FMRI study. Front Psychiatry 2010, 1.
35. Rodenhiser D., Mann M. Epigenetics and human disease: translating basic biology into clinical applications. Can Med Assoc J 2006, 174:341-348.
36. Rodrigues S.M., Saslow L.R., Garcia N., John O.P., Keltner D. Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc Natl Acad Sci U. S. A 2009, 106:21437-21441.
37. Saphire-Bernstein S., Way B.M., Kim H.S., Sherman D.K., Taylor S.E. Oxytocin receptor gene (OXTR) is related to psychological resources. Proc Natl Acad Sci U. S. A 2011, 108:15118-15122.
38. Schroeder M., Krebs M.O., Bleich S., Frieling H. Epigenetics and depression: current challenges and new therapeutic options. Curr Opin Psychiatry 2010, 23:588-592.
39. Steegenga W.T., Boekschoten M.V., Lute C., Hooiveld G.J., de Groot P.J., Morris T.J., et al. Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs. Age 2014, 1-18.
40. Strauss J.S., Freeman N.L., Shaikh S.A., Vetro A., Kiss E., Kapornai K., et al. No association between oxytocin or prolactin gene variants and childhood-onset mood disorders. Psychoneuroendocrinology 2010, 35:1422-1428.
41. Sullivan P.F., Neale M.C., Kendler K.S. Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 2000, 157:1552-1562.
42. Unternaehrer E., Luers P., Mill J., Dempster E., Meyer A., Staehli S., et al. Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress. Transl Psychiatry 2012, 2:e150.
43. Weaver I.C., Cervoni N., Champagne F.A., D'Alessio A.C., Sharma S., Seckl J.R., et al. Epigenetic programming by maternal behavior. Nat Neurosci 2004, 7:847-854.
44. Weaver I.C., Champagne F.A., Brown S.E., Dymov S., Sharma S., Meaney M.J., et al. Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. JNeurosci 2005, 25:11045-11054.
45. Wittchen H.U., Zaudig M., Fydrich T. SKID. Strukturiertes Klinisches Interview für DSM-IV. Achse I und II. Handanweisung 1997, Hogrefe, Göttingen.
46. Wu S., Jia M., Ruan Y., Liu J., Guo Y., Shuang M., et al. Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biol Psychiatry 2005, 58:74-77.
47. Zeilinger S., Kühnel B., Klopp N., Baurecht H., Kleinschmidt A., Gieger C., et al. Tobacco smoking leads to extensive genome-wide changes in DNA methylation. PloS One 2013, 8:e63812.