Electrophysiological properties under heart failure conditions in a human ventricular cell: A modeling study

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

Volumn , Issue , 2014, Pages 4324-4329

  Elshrif, Mohamed M ^a   Shi, Pengcheng ^a   Cherry, Elizabeth M ^b  

^a Rochester Institute of Technology   (United States)

^b ROCHESTER INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLOGY; DYNAMICS; ELECTROPHYSIOLOGY;

ACTION POTENTIAL DURATIONS; EARLY AFTER DEPOLARIZATION; ELECTRICAL AND MECHANICAL PROPERTIES; ELECTROPHYSIOLOGICAL PROPERTIES; MEMBRANE POTENTIALS; REALISTIC GEOMETRY; VENTRICULAR ARRHYTHMIAS; VENTRICULAR MYOCYTES;

HEART;

ACTION POTENTIAL; BIOLOGICAL MODEL; COMPUTER SIMULATION; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE; HEART VENTRICLE FIBRILLATION; HUMAN; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ACTION POTENTIALS; COMPUTER SIMULATION; HEART FAILURE; HEART VENTRICLES; HUMANS; MODELS, BIOLOGICAL; MYOCYTES, CARDIAC; VENTRICULAR FIBRILLATION;

EID: 84929497797     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/EMBC.2014.6944581     Document Type: Conference Paper

References (35)

1. Go AS, et al. Heart disease and stroke statistics-2014 update: a report from the American Heart Association. Circ. 2014.
2. Soltysinska E, et al. Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts. Pflugers Arch. 459:11-23, 2009.
3. Glukhov AV, et al. Transmural dispersion of repolarization in failing and nonfailing human ventricle. Circ. Res. 106: 981-991, 2010.
4. Thomas O'Hara, László Virág, András Varró, and Yoram Rudy. Simulation of the undiseased human cardiac ventricular action potential: Model formulation and experimental validation. PLoS Comput Biol, 7 (5):e1002061, 05 2011.
5. Elshrif, Mohamed M., and Cherry, Elizabeth M., A Quantitative Comparison of the Behavior of Human Ventricular Cardiac Electro-physiology Models in Tissue. PLoS ONE, 9: e84401, 2014.
6. M.J. Janse, Electrophysiological changes in heart failure and their relationship to arrhythmogenesis. Cardiovasc Res 61: 208-217, 2004.
7. Leo Priebe and Dirk J. Beuckelmann. Simulation study of cellular electric properties in heart failure. Circ. Res., 82 (11):1206-1223, 98.
8. Yunliang Zang and Ling Xia. Electrical remolding and mechanical changes in heart failure: A model study. Volume 6330 of Lecture Notes in Computer Science, pages 421-429, 2010.
9. Carmen R. Valdivia, William W. Chu, Jielin Pu, Jason D. Foell, Robert A. Haworth, Mathew R. Wolff, Timothy J. Kamp, and Jonathan C. Makielski. Increased late sodium current in myocytes from a canine heart failure model and from failing human heart. Journal of Molecular and Cellular Cardiology, 38 (3): 475-483, 2005.
10. Stephen Zicha, Ling Xiao, Sara Stafford, Tae Joon Cha, Wei Han, Andras Varro, and Stanley Nattel. Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts. The Journal of Physiology, 561 (3):735-748, 2004.
11. + current down-regulation in canine tachycardia-induced heart failure. American Journal of Physiology - Heart and Circulatory Physiology, 288 (6):H2887-H2896, 2005.
12. Kr in transmural repolarization abnormalities in human heart failure. Circulation, 124 (A16014), 2011.
13. 2+ exchange activity in canine pacing-induced heart failure. Circulation Research, 87 (8):690-698, 2000.
14. 2+ exchanger protein levels in human heart failure. Circulation, 99 (16):2105-2112, 1999.
15. Victor A. Maltsev, Norman Silverman, Hani N. Sabbah, and Albertas I. Undrovinas. Chronic heart failure slows late sodium current in human and canine ventricular myocytes: Implications for repolarization variability. European Journal of Heart Failure, 9 (3):219-227, 2007.
16. Gui-Rong Li, Chu-Pak Lau, Tack-Ki Leung, and Stanley Nattel. Ionic current abnormalities associated with prolonged action potentials in cardiomyocytes from diseased human right ventricles. Heart Rhythm, 1 (4):460-468, 2004.
17. +/Ca2+ exchange function in human heart failure. Circulation 108:222429, 2003.
18. Ming Tao Jiang, Andrew J. Lokuta, Emily F. Farrell, Matthew R. Wolff, Robert A. Haworth, and Hctor H. Valdivia. Abnormal ca2+ release, but normal ryanodine receptors, in canine and human heart failure. Circulation Research, 91 (11):1015-1022, 2002.
19. Cherry EM, Fenton FH (2007) A tale of two dogs: analyzing two models of canine ventricular electrophysiology. Am J Physiol Heart Circ Physiol 292: H43-55. doi:00955.2006.
20. E. Pueyo, P. Smetana, P. Caminal, A. Bayes de Luna, M. Malik, and P. Laguna. Characterization of qt interval adaptation to rr interval changes and its use as a risk-stratifier of arrhythmic mortality in amiodarone-treated survivors of acute myocardial infarction. Biomedical Engineering, IEEE Transactions on, 51 (9):1511-1520, Sept 2004.
21. Chu Pak Lau, Andrew R. Freedman, Simon Fleming, Markek Malik, A. John Canm, and David E. Ward. Hysteresis of the ventricular paced qt interval in response to abrupt changes in pacing rate. Cardiovascular Research, 22 (1):67-72, 1988
22. M. R. Franz, C. D. Swerdlow, L. B. Liem, and J. Schaefer. Cycle length dependence of human action potential duration in vivo. effects of single extrastimuli, sudden sustained rate acceleration and deceleration, and different steady-state frequencies. The Journal of Clinical Investigation, 82 (3):972979, 9 1988.
23. Rush S., and Larsen H., A practical algorithm for solving dynamic membrane equations. IEEE Trans Biomed Eng 25: 389392, 1978.
24. Hodgkin AL., Huxley AF, A quantitative description of membrane currents and its application to conduction and excitation in nerve. J Physiol 117:500544, 1952.
25. Gui-Rong Li, Chu-Pak Lau, Anique Ducharme, Jean-Claude Tardif, and Stanley Nattel. Transmural action potential and ionic current remodeling in ventricles of failing canine hearts. American Journal of Physiology - Heart and Circ. Physio., 283 (3):H1031-H1041, 2002.
26. Gorgels AP Vos MA Smeets JL and Wellens HJ. Ventricular arrhythmias in heart failure. Am J Cardiol., 70 (10):37C43C, 1992
27. Gong-Xin Liu, Bum-Rak Choi, Ohad Ziv, Weiyan Li, Enno de Lange, Zhilin Qu, and Gideon Koren. Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbits. The Journal of Physiology, 590 (5):11711180, 2012.
28. A. I. Undrovinas, V. A. Maltsev, and H. N. Sabbah. Repolarization abnormalities in cardiomyocytes of dogs with chronic heart failure: role of sustained inward current. Cellular and Molecular Life Sciences CMLS, 55:494505, 1999.
29. Li G, Lau C, Leung T., Nattel S, Ionic current abnormalities associated with prolonged action potentials in cardiomyocytes from diseased human right ventricles. Heart Rhythm 4: 460-468, 2004.
30. D. J. Beuckelmann, M. Nbauer, and E. Erdmann. Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure. Circulation, 85 (3):104655, 1992.
31. Yuri A. Kuryshev, Gary M. Brittenham, Hisashi Fujioka, Perry Kan-nan, Char-Chang Shieh, Sidney A. Cohen, and Arthur M. Brown. Decreased sodium and increased transient outward potassium currents in iron-loaded cardiac myocytes: Implications for the arrhythmogenesis of human siderotic heart disease. Circulation, 100 (6):675683, 1999.
32. Gwathmey G, Copelas L, MacKinnon R., Schoen F, Feldman M, et al. Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ Res 61: 70-76, 1987.
33. DM Bers. Excitation-Contraction Coupling and Cardiac Contractile Force. Kluwer Academic, Netherlands, Dordrecht, 2001.
34. Walmsley J, et al. mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: A population-based simulation study. PLoS ONE 8 (2):e56359, 2013.
35. Wilson LD, Jeyaraj D, Wan X., Hoeker GS, Said TH, Gittinger M, Laurita K.R., Rosenbaum DS. Heart failure enhances susceptibility to arrhythmogenic cardiac alternans. Heart Rhythm. 6:251259, 2009.