CD8+IL-17+ T cells mediate neutrophilic airway obliteration in T-bet-deficient mouse lung allograft recipients

American Journal of Respiratory Cell and Molecular Biology

Volumn 52, Issue 5, 2015, Pages 622-633

  Lendermon, Elizabeth A ^a   Dodd O, Jeffrey M ^a,b   Coon, Tiffany A ^a   Miller, Hannah L ^a   Ganguly, Sudipto ^b   Popescu, Iulia ^a   O'Donnell, Christopher P ^a   Cardenes, Nayra ^a   Levine, Melanie ^a   Rojas, Mauricio ^a   Weathington, Nathaniel M ^a   Zhao, Jing ^a   Zhao, Yutong ^a   McDyer, John F ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute rejection; IL 17; Mouse orthotopic lung transplant; Neutrophils; T bet

Indexed keywords

CD40 LIGAND; CD8 ANTIGEN; CXCL1 CHEMOKINE; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 4; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR ALPHA; ANTIBODY; AUTACOID; IL17A PROTEIN, MOUSE; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21;

ACUTE GRAFT REJECTION; ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHIOLITIS OBLITERANS; CD4 CD8 RATIO; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; IN VITRO STUDY; LUNG ALVEOLUS CELL; LUNG GRAFT REJECTION; LUNG TRANSPLANTATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MONONUCLEAR CELL; MOUSE; NEUTROPHIL COUNT; NONHUMAN; POLYMORPHONUCLEAR CELL; 129 MOUSE; ACUTE DISEASE; ADVERSE EFFECTS; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; GENETICS; GRAFT REJECTION; HISTOCOMPATIBILITY; IMMUNOLOGY; LUNG; METABOLISM; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PNEUMONIA; TRANSGENIC MOUSE;

ANIMALIA; MUS;

ACUTE DISEASE; ALLOGRAFTS; ANIMALS; ANTIBODIES; CD40 LIGAND; CD8-POSITIVE T-LYMPHOCYTES; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; GRAFT REJECTION; HISTOCOMPATIBILITY; INFLAMMATION MEDIATORS; INTERFERON-GAMMA; INTERLEUKIN-17; LUNG; LUNG TRANSPLANTATION; MICE, 129 STRAIN; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUTROPHILS; PNEUMONIA; T-BOX DOMAIN PROTEINS;

EID: 84929494025     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2014-0059OC     Document Type: Article

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