Prognostic Value of Bronchoalveolar Lavage Neutrophilia in Stable Lung Transplant Recipients

Journal of Heart and Lung Transplantation

Volumn 28, Issue 5, 2009, Pages 468-474

  Neurohr, Claus ^a   Huppmann, Patrick ^a   Samweber, Benedikt ^a   Leuschner, Stefan ^a   Zimmermann, Gregor ^a   Leuchte, Hanno ^a   Baumgartner, Rainer ^a   Hatz, Rudolf ^a   Frey, Ludwig ^a   Ueberfuhr, Peter ^a   Bittmann, Iris ^b   Behr, Juergen ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 8; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR;

ADULT; ARTICLE; BRONCHIOLITIS OBLITERANS; BRONCHITIS; BRONCHOALVEOLAR LAVAGE NEUTROPHILIA; BRONCHOSCOPY; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; LUNG GRAFT REJECTION; LUNG LAVAGE; LUNG TRANSPLANTATION; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; NEUTROPHILIA; PRIORITY JOURNAL; PROGNOSIS; RISK FACTOR;

ADULT; BIOPSY; BRONCHI; BRONCHIOLITIS OBLITERANS; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOSCOPY; COHORT STUDIES; FEMALE; GRAFT REJECTION; HUMANS; INTERLEUKIN-8; LEUKOCYTE COUNT; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; NEUTROPHILS; POSTOPERATIVE COMPLICATIONS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SECRETORY LEUKOCYTE PEPTIDASE INHIBITOR;

EID: 67349111761     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2009.01.014     Document Type: Article

References (39)

1. Orens J.B., Estenne M., Arcasoy S., et al. Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation. International guidelines for the selection of lung transplant candidates: 2006 update--a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant 25 (2006) 745-755
2. Trulock E.P., Christie J.D., Edwards L.B., et al. Registry of the International Society for Heart and Lung Transplantation: twenty-fourth official adult lung and heart-lung transplantation report--2007. J Heart Lung Transplant 26 (2007) 782-795
3. Sharples L.D., McNeil K., Stewart S., and Wallwork J. Risk factors for bronchiolitis obliterans: a systematic review of recent publications. J Heart Lung Transplant 21 (2002) 271-281
4. Estenne M., Maurer J.R., Boehler A., et al. Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria. J Heart Lung Transplant 21 (2002) 297-310
5. Glanville A.R. The role of bronchoscopic surveillance monitoring in the care of lung transplant recipients. Semin Respir Crit Care Med 27 (2006) 480-491
6. Tiroke A.H., Bewig B., and Haverich A. Bronchoalveolar lavage in lung transplantation. State of the art. Clin Transplant 13 (1999) 131-157
7. Vanaudenaerde B.M., Wuyts W.A., Geudens N., et al. Broncho-alveolar lavage fluid recovery correlates with airway neutrophilia in lung transplant patients. Respir Med 102 (2007) 339-347
8. Reynaud-Gaubert M., Thomas P., Gregoire R., et al. Clinical utility of bronchoalveolar lavage cell phenotype analyses in the postoperative monitoring of lung transplant recipients. Eur J Cardiothorac Surg 21 (2002) 60-66
9. Behr J., Maier K., Braun B., Schwaiblmair M., and Vogelmeier C. Evidence for oxidative stress in bronchiolitis obliterans syndrome after lung and heart-lung transplantation. The Munich Lung Transplant Group. Transplantation 69 (2000) 1856-1860
10. Nicod L.P. Mechanisms of airway obliteration after lung transplantation. Proc Am Thorac Soc 3 (2006) 444-449
11. Riise G.C., Andersson B.A., Kjellström C., et al. Persistent high BAL fluid granulocyte activation marker levels as early indicators of bronchiolitis obliterans after lung transplant. Eur Respir J 14 (1999) 1123-1130
12. Henke J.A., Golden J.A., Yelin E.H., Keith F.A., and Blanc P.D. Persistent increases of BAL neutrophils as a predictor of mortality following lung transplant. Chest 115 (1999) 403-409
13. Weldon S., McGarry N., Taggart C.C., and McElvaney N.G. The role of secretory leucoprotease inhibitor in the resolution of inflammatory responses. Biochem Soc Trans 35 (2007) 273-276
14. Hirsch J., Elssner A., Mazur G., et al. Bronchiolitis obliterans syndrome after (heart-)lung transplantation. Impaired antiprotease defense and increased oxidant activity. Am J Respir Crit Care Med 160 (1999) 1640-1646
15. Gerhardt S.G., McDyer J.F., Girgis R.E., Conte J.V., Yang S.C., and Orens J.B. Maintenance azithromycin therapy for bronchiolitis obliterans syndrome: results of a pilot study. Am J Respir Crit Care Med 168 (2003) 121-125
16. Verleden G.M., Vanaudenaerde B.M., Dupont L.J., and Van Raemdonck D.E. Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 174 (2006) 566-570
17. Gottlieb J., Szangolies J., Koehnlein T., Golpon H., Simon A., and Welte T. Long-term azithromycin for bronchiolitis obliterans syndrome after lung transplantation. Transplantation 85 (2008) 36-41
18. Marsh S.G., Albert E.D., Bodmer W.F., Bontrop R.E., et al. Nomenclature for factors of the HLA system, 2004. Hum Immunol 66 (2005) 571-636
19. Hunninghake G.W., Gadek J.E., Kawanami O., Ferrans J.V., and Chrystal R.G. Inflammatory and immune processes in the human lung in health and disease: evaluation of bronchoalveolar lavage. Am J Pathol 97 (1979) 149
20. Elssner A., Jaumann F., Dobmann S., et al. Elevated levels of interleukin-8 and transforming growth factor-beta in bronchoalveolar lavage fluid from patients with bronchiolitis obliterans syndrome: proinflammatory role of bronchial epithelial cells. Munich Lung Transplant Group. Transplantation 70 (2000) 362-367
21. Yousem S.A., Berry G.J., Cagle P.T., et al. Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung Rejection Study Group. J Heart Lung Transplant 15 (1996) 1-15
22. Chakinala M.M., Ritter J., Gage B.F., et al. Yield of surveillance bronchoscopy for acute rejection and lymphocytic bronchitis/bronchiolitis after lung transplantation. J Heart Lung Transplant 23 (2004) 1396-1404
23. Slebos D.J., Postma D.S., Koëter G.H., Van Der Bij W., Boezen M., and Kauffman H.F. Bronchoalveolar lavage fluid characteristics in acute and chronic lung transplant rejection. J Heart Lung Transplant 23 (2004) 532-540
24. Vanaudenaerde B.M., Dupont L.J., Wuyts W.A., et al. The role of interleukin-17 during acute rejection after lung transplantation. Eur Respir J 27 (2006) 779-787
25. Husain A.N., Siddiqui M.T., Holmes E.W., et al. Analysis of risk factors for the development of bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 159 (1999) 829-833
26. Tikkanen J., Lemström K., Halme M., Pakkala S., Taskinen E., and Koskinen P. Cytological monitoring of peripheral blood, bronchoalveolar lavage fluid, and transbronchial biopsy specimens during acute rejection and cytomegalovirus infection in lung and heart--lung allograft recipients. Clin Transplant 15 (2001) 77-88
27. DiGiovine B., Lynch III J.P., Martinez F.J., et al. Bronchoalveolar lavage neutrophilia is associated with obliterative bronchiolitis after lung transplantation: role of IL-8. J Immunol 157 (1996) 4194-4202 Nov 1
28. Scholma J., Slebos D.J., Boezen H.M., et al. Eosinophilic granulocytes and interleukin-6 level in bronchoalveolar lavage fluid are associated with the development of obliterative bronchiolitis after lung transplantation. Am J Respir Crit Care Med 162 (2000) 2221-2225
29. Reynaud-Gaubert M., Marin V., Thirion X., et al. Upregulation of chemokines in bronchoalveolar lavage fluid as a predictive marker of post-transplant airway obliteration. J Heart Lung Transplant 21 (2002) 721-730
30. Zheng L., Whitford H.M., Orsida B., et al. The dynamics and associations of airway neutrophilia post lung transplantation. Am J Transplant 6 (2006) 599-608
31. Slebos D.J., Scholma J., Boezen H.M., et al. Longitudinal profile of bronchoalveolar lavage cell characteristics in patients with a good outcome after lung transplantation. Am J Respir Crit Care Med 165 (2002) 501-507
32. Hodge G., Hodge S., Chambers D., Reynolds P.N., and Holmes M. Acute lung transplant rejection is associated with localized increase in T-cell IFNgamma and TNFalpha proinflammatory cytokines in the airways. Transplantation 84 (2007) 1452-1458
33. Keane M.P., Gomperts B.N., Weigt S., et al. IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome. J Immunol 178 (2007) 511-519
34. Vogelmeier C., Gillissen A., and Buhl R. Use of secretory leukoprotease inhibitor to augment lung antineutrophil elastase activity. Chest 110 6 suppl (1996) 261S-266S
35. Anderson R.L., Hiemstra P.S., Ward C., et al. Antimicrobial peptides in lung transplant recipients with bronchiolitis obliterans syndrome. Eur Respir J 32 (2008) 670-677
36. Gabbay E., Haydn Walters E., et al. In stable lung transplant recipients, exhaled nitric oxide levels positively correlate with airway neutrophilia and bronchial epithelial iNOS. Am J Respir Crit Care Med 160 (1999) 2093-2099
37. Mamessier E., Milhe F., Badier M., et al. Comparison of induced sputum and bronchoalveolar lavage in lung transplant recipients. J Heart Lung Transplant 25 (2006) 523-532
38. Gabbay E., Walters E.H., Orsida B., et al. Post-lung transplant bronchiolitis obliterans syndrome (BOS) is characterized by increased exhaled nitric oxide levels and epithelial inducible nitric oxide synthase. Am J Respir Crit Care Med 162 (2000) 2182-2187
39. Vanaudenaerde B.M., Meyts I., Vos R., et al. A dichotomy in bronchiolitis obliterans syndrome after lung transplantation revealed by azithromycin therapy. Eur Respir J 32 (2008) 832-843