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Volumn 21, Issue 17, 2015, Pages 2216-2224

Towards a stratified targeted approach with biologic treatments in rheumatoid arthritis: Role of synovial pathobiology

Author keywords

Biologics; Pathobiology; Rheumatoid arthritis; Stratification; Synovial biopsy; Synovial tissue

Indexed keywords

ABATACEPT; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; RHEUMATOID FACTOR; RITUXIMAB; TOCILIZUMAB; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER;

EID: 84929493316     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612821666150310145758     Document Type: Article
Times cited : (38)

References (112)
  • 1
    • 1042302772 scopus 로고    scopus 로고
    • Successful therapy of rheumatoid arthritis with rituximab: Renewed interest in the role of B cells in the pathogenesis of rheumatoid arthritis
    • Kramm H, Hansen KE, Gowing E, Bridges A. Successful therapy of rheumatoid arthritis with rituximab: renewed interest in the role of B cells in the pathogenesis of rheumatoid arthritis. J Clin Rheumatol : Practical Reports On Rheumatic & Musculoskeletal Diseases 2004; 10(1): 28-32.
    • (2004) J Clin Rheumatol : Practical Reports on Rheumatic & Musculoskeletal Diseases , vol.10 , Issue.1 , pp. 28-32
    • Kramm, H.1    Hansen, K.E.2    Gowing, E.3    Bridges, A.4
  • 2
    • 33846239331 scopus 로고    scopus 로고
    • British Society for Rheumatology Biologics R. Outcomes after switching from one anti-tumor necrosis factor alpha agent to a second antitumor necrosis factor alpha agent in patients with rheumatoid arthritis: Results from a large UK national cohort study
    • Hyrich KL, Lunt M, Watson KD, Symmons DP, Silman AJ, British Society for Rheumatology Biologics R. Outcomes after switching from one anti-tumor necrosis factor alpha agent to a second antitumor necrosis factor alpha agent in patients with rheumatoid arthritis: results from a large UK national cohort study. Arthritis Rheum 2007; 56(1): 13-20.
    • (2007) Arthritis Rheum , vol.56 , Issue.1 , pp. 13-20
    • Hyrich, K.L.1    Lunt, M.2    Watson, K.D.3    Symmons, D.P.4    Silman, A.J.5
  • 3
    • 84893721202 scopus 로고    scopus 로고
    • Efficacy of biological disease-modifying antirheumatic drugs: A systematic literature review informing the 2013 update of the EULAR recommendations for the management of rheumatoid arthritis
    • Nam JL, Ramiro S, Gaujoux-Viala C, et al. Efficacy of biological disease-modifying antirheumatic drugs: a systematic literature review informing the 2013 update of the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis 2014; 73(3): 516-28.
    • (2014) Ann Rheum Dis , vol.73 , Issue.3 , pp. 516-528
    • Nam, J.L.1    Ramiro, S.2    Gaujoux-Viala, C.3
  • 4
    • 43049158205 scopus 로고    scopus 로고
    • Clinical identification and treatment of a rapidly progressing disease state in patients with rheumatoid arthritis
    • Emery P, McInnes IB, van Vollenhoven R, Kraan MC. Clinical identification and treatment of a rapidly progressing disease state in patients with rheumatoid arthritis. Rheumatology (Oxford) 2008; 47(4): 392-8.
    • (2008) Rheumatology (Oxford) , vol.47 , Issue.4 , pp. 392-398
    • Emery, P.1    McInnes, I.B.2    Van Vollenhoven, R.3    Kraan, M.C.4
  • 5
    • 78049500292 scopus 로고    scopus 로고
    • Clinical trials: Tight control in early RA pays off in the long run
    • Scott DL, Kowalczyk A. Clinical trials: Tight control in early RA pays off in the long run. Nat Rev Rheumatol 2010; 6(11): 623-4.
    • (2010) Nat Rev Rheumatol , vol.6 , Issue.11 , pp. 623-624
    • Scott, D.L.1    Kowalczyk, A.2
  • 6
    • 77956036473 scopus 로고    scopus 로고
    • Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative
    • Aletaha D, Neogi T, Silman AJ, et al 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 2010; 69(9): 1580-8.
    • (2010) Ann Rheum Dis , vol.69 , Issue.9 , pp. 1580-1588
    • Aletaha, D.1    Neogi, T.2    Silman, A.J.3
  • 7
    • 84893772728 scopus 로고    scopus 로고
    • EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update
    • Smolen JS, Landewe R, Breedveld FC, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis 2014; 73(3): 492-509.
    • (2014) Ann Rheum Dis , vol.73 , Issue.3 , pp. 492-509
    • Smolen, J.S.1    Landewe, R.2    Breedveld, F.C.3
  • 8
    • 33646188202 scopus 로고    scopus 로고
    • Should aggressive therapy for rheumatoid arthritis require early use of weekly low-dose methotrexate, as the first disease-modifying anti-rheumatic drug in most patients?
    • Pincus T, Sokka T. Should aggressive therapy for rheumatoid arthritis require early use of weekly low-dose methotrexate, as the first disease-modifying anti-rheumatic drug in most patients? Rheumatology (Oxford) 2006; 45(5): 497-9.
    • (2006) Rheumatology (Oxford) , vol.45 , Issue.5 , pp. 497-499
    • Pincus, T.1    Sokka, T.2
  • 9
    • 84865780053 scopus 로고    scopus 로고
    • Efficacy of leflunomide 100mg weekly compared to low dose methotrexate in patients with active rheumatoid arthritis. Double blind, randomized clinical trial
    • Jaimes-Hernandez J, Melendez-Mercado CI, Mendoza-Fuentes A, Aranda-Pereira P, Castaneda-Hernandez G. Efficacy of leflunomide 100mg weekly compared to low dose methotrexate in patients with active rheumatoid arthritis. Double blind, randomized clinical trial. Reumatologia clinica 2012; 8(5): 243-9.
    • (2012) Reumatologia Clinica , vol.8 , Issue.5 , pp. 243-249
    • Jaimes-Hernandez, J.1    Melendez-Mercado, C.I.2    Mendoza-Fuentes, A.3    Aranda-Pereira, P.4    Castaneda-Hernandez, G.5
  • 10
    • 0033596065 scopus 로고    scopus 로고
    • Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group
    • PubMed PMID: 10573044
    • Strand V, Cohen S, Schiff M, et al. Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group. Arch Intern Med 1999; 159(21): 2542-50. PubMed PMID: 10573044.
    • (1999) Arch Intern Med , vol.159 , Issue.21 , pp. 2542-2550
    • Strand, V.1    Cohen, S.2    Schiff, M.3
  • 11
    • 84857697133 scopus 로고    scopus 로고
    • Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: A randomized trial
    • Bakker MF, Jacobs JW, Welsing PM, et al. Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: a randomized trial. Ann Internal Med 2012; 156(5): 329-39.
    • (2012) Ann Internal Med , vol.156 , Issue.5 , pp. 329-339
    • Bakker, M.F.1    Jacobs, J.W.2    Welsing, P.M.3
  • 12
    • 84871089146 scopus 로고    scopus 로고
    • Induction therapy with a combination of DMARDs is better than methotrexate monotherapy: First results of the tREACH trial
    • de Jong PH, Hazes JM, Barendregt PJ, et al. Induction therapy with a combination of DMARDs is better than methotrexate monotherapy: first results of the tREACH trial. Ann Rheum Dis 2013; 72(1): 72-8.
    • (2013) Ann Rheum Dis , vol.72 , Issue.1 , pp. 72-78
    • De Jong, P.H.1    Hazes, J.M.2    Barendregt, P.J.3
  • 13
    • 78049509056 scopus 로고    scopus 로고
    • Early combination disease-modifying antirheumatic drug therapy and tight disease control improve long-term radiologic outcome in patients with early rheumatoid arthritis: The 11-year results of the Finnish Rheumatoid Arthritis Combination Therapy trial
    • Rantalaiho V, Korpela M, Laasonen L, et al. Early combination disease-modifying antirheumatic drug therapy and tight disease control improve long-term radiologic outcome in patients with early rheumatoid arthritis: the 11-year results of the Finnish Rheumatoid Arthritis Combination Therapy trial. Arthritis Res Ther 2010; 12(3): R122.
    • (2010) Arthritis Res Ther , vol.12 , Issue.3
    • Rantalaiho, V.1    Korpela, M.2    Laasonen, L.3
  • 14
    • 79953752083 scopus 로고    scopus 로고
    • American College of Rheumatology/European League Against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials
    • Felson DT, Smolen JS, Wells G, et al. American College of Rheumatology/European League Against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials. Arthritis Rheum 2011; 63(3): 573-86.
    • (2011) Arthritis Rheum , vol.63 , Issue.3 , pp. 573-586
    • Felson, D.T.1    Smolen, J.S.2    Wells, G.3
  • 15
    • 77954962834 scopus 로고    scopus 로고
    • A matrix risk model for the prediction of rapid radiographic progression in patients with rheumatoid arthritis receiving different dynamic treatment strategies: Post hoc analyses from the BeSt study
    • Visser K, Goekoop-Ruiterman YP, de Vries-Bouwstra JK, et al. A matrix risk model for the prediction of rapid radiographic progression in patients with rheumatoid arthritis receiving different dynamic treatment strategies: post hoc analyses from the BeSt study. Ann Rheum Dis 2010; 69(7): 1333-7.
    • (2010) Ann Rheum Dis , vol.69 , Issue.7 , pp. 1333-1337
    • Visser, K.1    Goekoop-Ruiterman, Y.P.2    De Vries-Bouwstra, J.K.3
  • 16
    • 78650896708 scopus 로고    scopus 로고
    • Prognostic factors of radiological damage in rheumatoid arthritis: A 10-year retrospective study
    • Markatseli TE, Voulgari PV, Alamanos Y, Drosos AA. Prognostic factors of radiological damage in rheumatoid arthritis: a 10-year retrospective study. J Rheumatol 2011; 38(1): 44-52.
    • (2011) J Rheumatol , vol.38 , Issue.1 , pp. 44-52
    • Markatseli, T.E.1    Voulgari, P.V.2    Alamanos, Y.3    Drosos, A.A.4
  • 17
    • 85027919018 scopus 로고    scopus 로고
    • Clinical, functional and radiographic consequences of achieving stable low disease activity and remission with adalimumab plus methotrexate or methotrexate alone in early rheumatoid arthritis: 26-week results from the randomised, controlled OPTIMA study
    • Kavanaugh A, Fleischmann RM, Emery P, et al. Clinical, functional and radiographic consequences of achieving stable low disease activity and remission with adalimumab plus methotrexate or methotrexate alone in early rheumatoid arthritis: 26-week results from the randomised, controlled OPTIMA study. Ann Rheum Dis 2013; 72(1): 64-71.
    • (2013) Ann Rheum Dis , vol.72 , Issue.1 , pp. 64-71
    • Kavanaugh, A.1    Fleischmann, R.M.2    Emery, P.3
  • 18
    • 65349176911 scopus 로고    scopus 로고
    • Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors
    • Westhovens R, Robles M, Ximenes AC, et al. Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors. Ann Rheum Dis 2009; 68(12): 1870-7.
    • (2009) Ann Rheum Dis , vol.68 , Issue.12 , pp. 1870-1877
    • Westhovens, R.1    Robles, M.2    Ximenes, A.C.3
  • 19
    • 84889667445 scopus 로고    scopus 로고
    • A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with moderate to severe rheumatoid arthritis (SUMMACTA study)
    • Burmester GR, Rubbert-Roth A, Cantagrel A, et al. A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional disease-modifying antirheumatic drugs in patients with moderate to severe rheumatoid arthritis (SUMMACTA study). Ann Rheum Dis 2014; 73(1): 69-74.
    • (2014) Ann Rheum Dis , vol.73 , Issue.1 , pp. 69-74
    • Burmester, G.R.1    Rubbert-Roth, A.2    Cantagrel, A.3
  • 20
    • 78650645377 scopus 로고    scopus 로고
    • Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: The IMAGE trial
    • Tak PP, Rigby WF, Rubbert-Roth A, et al. Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial. Ann Rheum Dis 2011; 70(1): 39-46.
    • (2011) Ann Rheum Dis , vol.70 , Issue.1 , pp. 39-46
    • Tak, P.P.1    Rigby, W.F.2    Rubbert-Roth, A.3
  • 21
    • 33746961890 scopus 로고    scopus 로고
    • Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebocontrolled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
    • Cohen SB, Emery P, Greenwald MW, et al. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebocontrolled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum 2006; 54(9): 2793-806.
    • (2006) Arthritis Rheum , vol.54 , Issue.9 , pp. 2793-2806
    • Cohen, S.B.1    Emery, P.2    Greenwald, M.W.3
  • 22
    • 77955896561 scopus 로고    scopus 로고
    • Efficacy and safety of different doses and retreatment of rituximab: A randomised, placebo-controlled trial in patients who are biological naive with active rheumatoid arthritis and an inadequate response to methotrexate (Study Evaluating Rituximab's Efficacy in MTX iNadequate rEsponders (SERENE))
    • Emery P, Deodhar A, Rigby WF, et al. Efficacy and safety of different doses and retreatment of rituximab: a randomised, placebo-controlled trial in patients who are biological naive with active rheumatoid arthritis and an inadequate response to methotrexate (Study Evaluating Rituximab's Efficacy in MTX iNadequate rEsponders (SERENE)). Ann Rheum Dis 2010; 69(9): 1629-35.
    • (2010) Ann Rheum Dis , vol.69 , Issue.9 , pp. 1629-1635
    • Emery, P.1    Deodhar, A.2    Rigby, W.F.3
  • 23
    • 84888157037 scopus 로고    scopus 로고
    • Efficacy, safety and tolerability of tofacitinib in patients with an inadequate response to disease modifying anti-rheumatic drugs: A meta-analysis of randomized double-blind controlled studies
    • Berhan A. Efficacy, safety and tolerability of tofacitinib in patients with an inadequate response to disease modifying anti-rheumatic drugs: a meta-analysis of randomized double-blind controlled studies. BMC Musculoskelet Disord 2013; 14: 332.
    • (2013) BMC Musculoskelet Disord , vol.14 , pp. 332
    • Berhan, A.1
  • 24
    • 79953711736 scopus 로고    scopus 로고
    • B cell activation biomarkers as predictive factors for the response to rituximab in rheumatoid arthritis: A six-month, national, multicenter, open-label study
    • Sellam J, Hendel-Chavez H, Rouanet S, et al. B cell activation biomarkers as predictive factors for the response to rituximab in rheumatoid arthritis: a six-month, national, multicenter, open-label study. Arthritis Rheum 2011; 63(4): 933-8.
    • (2011) Arthritis Rheum , vol.63 , Issue.4 , pp. 933-938
    • Sellam, J.1    Hendel-Chavez, H.2    Rouanet, S.3
  • 25
    • 84860898796 scopus 로고    scopus 로고
    • Fcgamma receptor type IIIA polymorphism influences treatment outcomes in patients with rheumatoid arthritis treated with rituximab
    • Ruyssen-Witrand A, Rouanet S, Combe B, et al. Fcgamma receptor type IIIA polymorphism influences treatment outcomes in patients with rheumatoid arthritis treated with rituximab. Ann Rheum Dis 2012; 71(6): 875-7.
    • (2012) Ann Rheum Dis , vol.71 , Issue.6 , pp. 875-877
    • Ruyssen-Witrand, A.1    Rouanet, S.2    Combe, B.3
  • 26
    • 84875577862 scopus 로고    scopus 로고
    • Association between -871C>T promoter polymorphism in the B-cell activating factor gene and the response to rituximab in rheumatoid arthritis patients
    • Ruyssen-Witrand A, Rouanet S, Combe B, et al. Association between -871C>T promoter polymorphism in the B-cell activating factor gene and the response to rituximab in rheumatoid arthritis patients. Rheumatology (Oxford) 2013; 52(4): 636-41.
    • (2013) Rheumatology (Oxford) , vol.52 , Issue.4 , pp. 636-641
    • Ruyssen-Witrand, A.1    Rouanet, S.2    Combe, B.3
  • 27
    • 84897831924 scopus 로고    scopus 로고
    • The status of rheumatoid factor and anticyclic citrullinated peptide antibody are not associated with the effect of anti-TNFalpha agent treatment in patients with rheumatoid arthritis: A meta-analysis
    • Lv Q, Yin Y, Li X, et al. The status of rheumatoid factor and anticyclic citrullinated peptide antibody are not associated with the effect of anti-TNFalpha agent treatment in patients with rheumatoid arthritis: a meta-analysis. PLoS One 2014; 9(2): e89442.
    • (2014) Plos One , vol.9 , Issue.2
    • Lv, Q.1    Yin, Y.2    Li, X.3
  • 28
    • 0031750237 scopus 로고    scopus 로고
    • The long-term outcomes of rheumatoid arthritis: A 23-year prospective, longitudinal study of total joint replacement and its predictors in 1, 600 patients with rheumatoid arthritis
    • Wolfe F, Zwillich SH. The long-term outcomes of rheumatoid arthritis: a 23-year prospective, longitudinal study of total joint replacement and its predictors in 1, 600 patients with rheumatoid arthritis. Arthritis Rheum 1998; 41(6): 1072-82.
    • (1998) Arthritis Rheum , vol.41 , Issue.6 , pp. 1072-1082
    • Wolfe, F.1    Zwillich, S.H.2
  • 29
    • 78751704593 scopus 로고    scopus 로고
    • Indirect comparisons of the efficacy of biological antirheumatic agents in rheumatoid arthritis in patients with an inadequate response to conventional disease-modifying antirheumatic drugs or to an anti-tumour necrosis factor agent: A meta-analysis
    • Salliot C, Finckh A, Katchamart W, et al. Indirect comparisons of the efficacy of biological antirheumatic agents in rheumatoid arthritis in patients with an inadequate response to conventional disease-modifying antirheumatic drugs or to an anti-tumour necrosis factor agent: a meta-analysis. Ann Rheum Dis 2011; 70(2): 266-71.
    • (2011) Ann Rheum Dis , vol.70 , Issue.2 , pp. 266-271
    • Salliot, C.1    Finckh, A.2    Katchamart, W.3
  • 30
    • 79953017150 scopus 로고    scopus 로고
    • Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2010
    • Furst DE, Keystone EC, Braun J, et al. Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2010. Ann Rheum Dis 2011; 70 Suppl 1: i2-36.
    • (2011) Ann Rheum Dis , vol.70
    • Furst, D.E.1    Keystone, E.C.2    Braun, J.3
  • 31
    • 67650379733 scopus 로고    scopus 로고
    • Golimumab in patients with active rheumatoid arthritis after treatment with tumour necrosis factor alpha inhibitors (GO-AFTER study): A multicentre, randomised, double-blind, placebo-controlled, phase III trial
    • Smolen JS, Kay J, Doyle MK, et al. Golimumab in patients with active rheumatoid arthritis after treatment with tumour necrosis factor alpha inhibitors (GO-AFTER study): a multicentre, randomised, double-blind, placebo-controlled, phase III trial. Lancet 2009; 374(9685): 210-21.
    • (2009) Lancet , vol.374 , Issue.9685 , pp. 210-221
    • Smolen, J.S.1    Kay, J.2    Doyle, M.K.3
  • 32
    • 79951712039 scopus 로고    scopus 로고
    • Anti-TNF therapy is associated with an increased risk of serious infections in patients with rheumatoid arthritis especially in the first 6 months of treatment: Updated results from the British Society for Rheumatology Biologics Register with special emphasis on risks in the elderly
    • Galloway JB, Hyrich KL, Mercer LK, et al. Anti-TNF therapy is associated with an increased risk of serious infections in patients with rheumatoid arthritis especially in the first 6 months of treatment: updated results from the British Society for Rheumatology Biologics Register with special emphasis on risks in the elderly. Rheumatology (Oxford) 2011; 50(1): 124-31.
    • (2011) Rheumatology (Oxford) , vol.50 , Issue.1 , pp. 124-131
    • Galloway, J.B.1    Hyrich, K.L.2    Mercer, L.K.3
  • 33
    • 67650096563 scopus 로고    scopus 로고
    • Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective French Research Axed on Tolerance of Biotherapies registry
    • Tubach F, Salmon D, Ravaud P, et al. Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective French Research Axed on Tolerance of Biotherapies registry. Arthritis Rheum 2009; 60(7): 1884-94.
    • (2009) Arthritis Rheum , vol.60 , Issue.7 , pp. 1884-1894
    • Tubach, F.1    Salmon, D.2    Ravaud, P.3
  • 34
    • 84886952980 scopus 로고    scopus 로고
    • Demyelination and other neurological adverse events after anti- TNF therapy
    • Kaltsonoudis E, Voulgari PV, Konitsiotis S, Drosos AA. Demyelination and other neurological adverse events after anti- TNF therapy. Autoimmun Rev 2014; 13(1): 54-8.
    • (2014) Autoimmun Rev , vol.13 , Issue.1 , pp. 54-58
    • Kaltsonoudis, E.1    Voulgari, P.V.2    Konitsiotis, S.3    Drosos, A.A.4
  • 35
    • 84879414277 scopus 로고    scopus 로고
    • Pro-atherogenic lipid changes and decreased hepatic LDL receptor expression by tocilizumab in rheumatoid arthritis
    • Strang AC, Bisoendial RJ, Kootte RS, et al. Pro-atherogenic lipid changes and decreased hepatic LDL receptor expression by tocilizumab in rheumatoid arthritis. Atherosclerosis 2013; 229(1): 174-81.
    • (2013) Atherosclerosis , vol.229 , Issue.1 , pp. 174-181
    • Strang, A.C.1    Bisoendial, R.J.2    Kootte, R.S.3
  • 36
    • 80755182205 scopus 로고    scopus 로고
    • Lower gastrointestinal perforation in rheumatoid arthritis patients treated with conventional DMARDs or tocilizumab: A systematic literature review
    • Gout T, Ostor AJ, Nisar MK. Lower gastrointestinal perforation in rheumatoid arthritis patients treated with conventional DMARDs or tocilizumab: a systematic literature review. Clin Rheumatol 2011; 30(11): 1471-4.
    • (2011) Clin Rheumatol , vol.30 , Issue.11 , pp. 1471-1474
    • Gout, T.1    Ostor, A.J.2    Nisar, M.K.3
  • 37
    • 0036225386 scopus 로고    scopus 로고
    • Delay to institution of therapy and induction of remission using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis
    • Mottonen T, Hannonen P, Korpela M, et al. Delay to institution of therapy and induction of remission using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis. Arthritis Rheum 2002; 46(4): 894-8.
    • (2002) Arthritis Rheum , vol.46 , Issue.4 , pp. 894-898
    • Mottonen, T.1    Hannonen, P.2    Korpela, M.3
  • 38
    • 77950535433 scopus 로고    scopus 로고
    • The Michael Mason prize: Early rheumatoid arthritis--the window narrows
    • Raza K. The Michael Mason prize: early rheumatoid arthritis--the window narrows. Rheumatology (Oxford) 2010; 49(3): 406-10.
    • (2010) Rheumatology (Oxford) , vol.49 , Issue.3 , pp. 406-410
    • Raza, K.1
  • 39
    • 78650048259 scopus 로고    scopus 로고
    • Long-term impact of delay in assessment of patients with early arthritis
    • van der Linden MP, le Cessie S, et al. Long-term impact of delay in assessment of patients with early arthritis. Arthritis Rheum 2010; 62(12): 3537-46.
    • (2010) Arthritis Rheum , vol.62 , Issue.12 , pp. 3537-3546
    • Van Der Linden, M.P.1    Le Cessie, S.2
  • 41
    • 73249150529 scopus 로고    scopus 로고
    • Fibroblast-like synoviocytes in inflammatory arthritis pathology: The emerging role of cadherin-11
    • Chang SK, Gu Z, Brenner MB. Fibroblast-like synoviocytes in inflammatory arthritis pathology: the emerging role of cadherin-11. Immunol Rev 2010; 233(1): 256-66.
    • (2010) Immunol Rev , vol.233 , Issue.1 , pp. 256-266
    • Chang, S.K.1    Gu, Z.2    Brenner, M.B.3
  • 42
    • 33749023888 scopus 로고    scopus 로고
    • Mechanisms of disease: The molecular and cellular basis of joint destruction in rheumatoid arthritis
    • Muller-Ladner U, Pap T, Gay RE, Neidhart M, Gay S. Mechanisms of disease: the molecular and cellular basis of joint destruction in rheumatoid arthritis. Nat Clin Pract Rheumatol 2005; 1(2): 102-10.
    • (2005) Nat Clin Pract Rheumatol , vol.1 , Issue.2 , pp. 102-110
    • Muller-Ladner, U.1    Pap, T.2    Gay, R.E.3    Neidhart, M.4    Gay, S.5
  • 43
    • 84863861008 scopus 로고    scopus 로고
    • Understanding the dynamics: Pathways involved in the pathogenesis of rheumatoid arthritis
    • Choy E. Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford) 2012; 51 Suppl 5: v3-11.
    • (2012) Rheumatology (Oxford) , vol.51 , Issue.5
    • Choy, E.1
  • 44
    • 33746510950 scopus 로고    scopus 로고
    • Synovial inflammation does not change in the absence of effective treatment: Implications for the use of synovial histopathology as biomarker in early phase clinical trials in rheumatoid arthritis
    • Baeten D, Houbiers J, Kruithof E, et al. Synovial inflammation does not change in the absence of effective treatment: implications for the use of synovial histopathology as biomarker in early phase clinical trials in rheumatoid arthritis. Ann Rheum Dis 2006; 65(8): 990-7.
    • (2006) Ann Rheum Dis , vol.65 , Issue.8 , pp. 990-997
    • Baeten, D.1    Houbiers, J.2    Kruithof, E.3
  • 45
    • 0038011833 scopus 로고    scopus 로고
    • Evolving concepts of rheumatoid arthritis
    • Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003; 423(6937): 356-61.
    • (2003) Nature , vol.423 , Issue.6937 , pp. 356-361
    • Firestein, G.S.1
  • 46
    • 59249104722 scopus 로고    scopus 로고
    • Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium
    • Humby F, Bombardieri M, Manzo A, et al. Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium. PLoS Med 2009; 6(1): e1.
    • (2009) Plos Med , vol.6 , Issue.1
    • Humby, F.1    Bombardieri, M.2    Manzo, A.3
  • 47
    • 73249126744 scopus 로고    scopus 로고
    • Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: From inflammation to autoimmunity and tissue damage/remodeling
    • Manzo A, Bombardieri M, Humby F, Pitzalis C. Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling. Immunol Rev 2010; 233(1): 267-85.
    • (2010) Immunol Rev , vol.233 , Issue.1 , pp. 267-285
    • Manzo, A.1    Bombardieri, M.2    Humby, F.3    Pitzalis, C.4
  • 49
    • 84875874716 scopus 로고    scopus 로고
    • New learnings on the pathophysiology of RA from synovial biopsies
    • Pitzalis C, Kelly S, Humby F. New learnings on the pathophysiology of RA from synovial biopsies. Curr Opin Rheumatol 2013; 25(3): 334-44.
    • (2013) Curr Opin Rheumatol , vol.25 , Issue.3 , pp. 334-344
    • Pitzalis, C.1    Kelly, S.2    Humby, F.3
  • 50
    • 33344475672 scopus 로고    scopus 로고
    • Lymphoid neogenesis in chronic inflammatory diseases
    • Aloisi F, Pujol-Borrell R. Lymphoid neogenesis in chronic inflammatory diseases. Nat Rev Immunol 2006; 6(3): 205-17.
    • (2006) Nat Rev Immunol , vol.6 , Issue.3 , pp. 205-217
    • Aloisi, F.1    Pujol-Borrell, R.2
  • 51
    • 21044435315 scopus 로고    scopus 로고
    • Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis
    • Manzo A, Paoletti S, Carulli M, et al. Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis. Eur J Immunol 2005; 35(5): 1347-59.
    • (2005) Eur J Immunol , vol.35 , Issue.5 , pp. 1347-1359
    • Manzo, A.1    Paoletti, S.2    Carulli, M.3
  • 52
    • 34547726636 scopus 로고    scopus 로고
    • Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: Identification of the interleukin- 7 signaling pathway in tissues with lymphoid neogenesis
    • Timmer TC, Baltus B, Vondenhoff M, et al. Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin- 7 signaling pathway in tissues with lymphoid neogenesis. Arthritis Rheum 2007; 56(8): 2492-502.
    • (2007) Arthritis Rheum , vol.56 , Issue.8 , pp. 2492-2502
    • Timmer, T.C.1    Baltus, B.2    Vondenhoff, M.3
  • 53
    • 0035879123 scopus 로고    scopus 로고
    • Lymphoid neogenesis in rheumatoid synovitis
    • Takemura S, Braun A, Crowson C, et al. Lymphoid neogenesis in rheumatoid synovitis. J Immunol 2001; 167(2): 1072-80.
    • (2001) J Immunol , vol.167 , Issue.2 , pp. 1072-1080
    • Takemura, S.1    Braun, A.2    Crowson, C.3
  • 54
    • 0037405570 scopus 로고    scopus 로고
    • Circulating tumour necrosis factor alpha and soluble tumour necrosis factor receptors in patients with different patterns of rheumatoid synovitis
    • Klimiuk PA, Sierakowski S, Latosiewicz R, et al. Circulating tumour necrosis factor alpha and soluble tumour necrosis factor receptors in patients with different patterns of rheumatoid synovitis. Ann Rheum Dis 2003; 62(5): 472-5.
    • (2003) Ann Rheum Dis , vol.62 , Issue.5 , pp. 472-475
    • Klimiuk, P.A.1    Sierakowski, S.2    Latosiewicz, R.3
  • 55
    • 13444250902 scopus 로고    scopus 로고
    • Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: Evidence of a link between an increased myofibroblast-like phenotype and highinflammation synovitis
    • Kasperkovitz PV, Timmer TC, Smeets TJ, et al. Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased myofibroblast-like phenotype and highinflammation synovitis. Arthritis Rheum 2005; 52(2): 430-41.
    • (2005) Arthritis Rheum , vol.52 , Issue.2 , pp. 430-441
    • Kasperkovitz, P.V.1    Timmer, T.C.2    Smeets, T.J.3
  • 56
    • 70350542778 scopus 로고    scopus 로고
    • Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes
    • Bauer S, Jendro MC, Wadle A, et al. Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes. Arthritis Res Ther 2006; 8(6): R171.
    • (2006) Arthritis Res Ther , vol.8 , Issue.6
    • Bauer, S.1    Jendro, M.C.2    Wadle, A.3
  • 57
    • 22244468716 scopus 로고    scopus 로고
    • Invasiveness of fibroblast-like synoviocytes is an individual patient characteristic associated with the rate of joint destruction in patients with rheumatoid arthritis
    • Tolboom TC, van der Helm-Van Mil AH, Nelissen RG, Breedveld FC, Toes RE, Huizinga TW. Invasiveness of fibroblast-like synoviocytes is an individual patient characteristic associated with the rate of joint destruction in patients with rheumatoid arthritis. Arthritis Rheum 2005; 52(7): 1999-2002.
    • (2005) Arthritis Rheum , vol.52 , Issue.7 , pp. 1999-2002
    • Tolboom, T.C.1    Van Der Helm-Van Mil, A.H.2    Nelissen, R.G.3    Breedveld, F.C.4    Toes, R.E.5    Huizinga, T.W.6
  • 58
    • 0141788392 scopus 로고    scopus 로고
    • Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue
    • Bradfield PF, Amft N, Vernon-Wilson E, et al. Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue. Arthritis Rheum 2003; 48(9): 2472-82.
    • (2003) Arthritis Rheum , vol.48 , Issue.9 , pp. 2472-2482
    • Bradfield, P.F.1    Amft, N.2    Vernon-Wilson, E.3
  • 59
    • 80052502019 scopus 로고    scopus 로고
    • A BAFF/APRILdependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells
    • Bombardieri M, Kam NW, Brentano F, et al. A BAFF/APRILdependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells. Ann Rheum Dis 2011; 70(10): 1857-65.
    • (2011) Ann Rheum Dis , vol.70 , Issue.10 , pp. 1857-1865
    • Bombardieri, M.1    Kam, N.W.2    Brentano, F.3
  • 60
    • 36348958437 scopus 로고    scopus 로고
    • CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis
    • Manzo A, Bugatti S, Caporali R, et al. CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis. Am J Pathol 2007; 171(5): 1549-62.
    • (2007) Am J Pathol , vol.171 , Issue.5 , pp. 1549-1562
    • Manzo, A.1    Bugatti, S.2    Caporali, R.3
  • 61
    • 79957774659 scopus 로고    scopus 로고
    • Why does chronic inflammation persist: An unexpected role for fibroblasts
    • Buckley CD. Why does chronic inflammation persist: An unexpected role for fibroblasts. Immunol Lett 2011; 138(1): 12-4.
    • (2011) Immunol Lett , vol.138 , Issue.1 , pp. 12-14
    • Buckley, C.D.1
  • 62
    • 84881476266 scopus 로고    scopus 로고
    • Epstein-Barr virus persistence and infection of autoreactive plasma cells in synovial lymphoid structures in rheumatoid arthritis
    • Croia C, Serafini B, Bombardieri M, et al. Epstein-Barr virus persistence and infection of autoreactive plasma cells in synovial lymphoid structures in rheumatoid arthritis. Ann Rheum Dis 2012.
    • (2012) Ann Rheum Dis
    • Croia, C.1    Serafini, B.2    Bombardieri, M.3
  • 63
    • 34247872819 scopus 로고    scopus 로고
    • Cellular responses to viral infection in humans: Lessons from Epstein-Barr virus
    • Hislop AD, Taylor GS, Sauce D, Rickinson AB. Cellular responses to viral infection in humans: lessons from Epstein-Barr virus. Annu Rev Immunol 2007; 25: 587-617.
    • (2007) Annu Rev Immunol , vol.25 , pp. 587-617
    • Hislop, A.D.1    Taylor, G.S.2    Sauce, D.3    Rickinson, A.B.4
  • 64
    • 84888768379 scopus 로고    scopus 로고
    • The role of viruses in autoreactive B cell activation within tertiary lymphoid structures in autoimmune diseases
    • Lucchesi D, Bombardieri M. The role of viruses in autoreactive B cell activation within tertiary lymphoid structures in autoimmune diseases. J Leukoc Biol 2013; 94(6): 1191-9.
    • (2013) J Leukoc Biol , vol.94 , Issue.6 , pp. 1191-1199
    • Lucchesi, D.1    Bombardieri, M.2
  • 65
    • 80052512017 scopus 로고    scopus 로고
    • Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling
    • Coppola D, Nebozhyn M, Khalil F, et al. Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling. Am J Pathol 2011; 179(1): 37-45.
    • (2011) Am J Pathol , vol.179 , Issue.1 , pp. 37-45
    • Coppola, D.1    Nebozhyn, M.2    Khalil, F.3
  • 66
    • 84865129252 scopus 로고    scopus 로고
    • Neogenesis of lymphoid structures and antibody responses occur in human melanoma metastases
    • Cipponi A, Mercier M, Seremet T, et al. Neogenesis of lymphoid structures and antibody responses occur in human melanoma metastases. Cancer Res 2012; 72(16): 3997-4007.
    • (2012) Cancer Res , vol.72 , Issue.16 , pp. 3997-4007
    • Cipponi, A.1    Mercier, M.2    Seremet, T.3
  • 67
    • 34247342697 scopus 로고    scopus 로고
    • Tertiary lymphoid tissues generate effector and memory T cells that lead to allograft rejection
    • Nasr IW, Reel M, Oberbarnscheidt MH, et al. Tertiary lymphoid tissues generate effector and memory T cells that lead to allograft rejection. Am J Transplant 2007; 7(5): 1071-9.
    • (2007) Am J Transplant , vol.7 , Issue.5 , pp. 1071-1079
    • Nasr, I.W.1    Reel, M.2    Oberbarnscheidt, M.H.3
  • 68
    • 84903376485 scopus 로고    scopus 로고
    • Ectopic lymphoid-like structures in infection, cancer and autoimmunity
    • Pitzalis C, Jones GW, Bombardieri M, Jones SA. Ectopic lymphoid-like structures in infection, cancer and autoimmunity. Nat Rev Immunol 2014; 14(7): 447-62.
    • (2014) Nat Rev Immunol , vol.14 , Issue.7 , pp. 447-462
    • Pitzalis, C.1    Jones, G.W.2    Bombardieri, M.3    Jones, S.A.4
  • 69
    • 0036467429 scopus 로고    scopus 로고
    • Ectopic expression of the murine chemokines CCL21a and CCL21b induces the formation of lymph node-like structures in pancreas, but not skin, of transgenic mice
    • Chen SC, Vassileva G, Kinsley D, et al. Ectopic expression of the murine chemokines CCL21a and CCL21b induces the formation of lymph node-like structures in pancreas, but not skin, of transgenic mice. J Immunol 2002; 168(3): 1001-8.
    • (2002) J Immunol , vol.168 , Issue.3 , pp. 1001-1008
    • Chen, S.C.1    Vassileva, G.2    Kinsley, D.3
  • 70
    • 84862186837 scopus 로고    scopus 로고
    • Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases
    • Corsiero E, Bombardieri M, Manzo A, Bugatti S, Uguccioni M, Pitzalis C. Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases. Immunol Lett 2012; 145(1-2): 62-7.
    • (2012) Immunol Lett , vol.145 , Issue.1-2 , pp. 62-67
    • Corsiero, E.1    Bombardieri, M.2    Manzo, A.3    Bugatti, S.4    Uguccioni, M.5    Pitzalis, C.6
  • 71
    • 8644249868 scopus 로고    scopus 로고
    • Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis
    • Carlsen HS, Baekkevold ES, Morton HC, Haraldsen G, Brandtzaeg P. Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis. Blood 2004; 104(10): 3021-7.
    • (2004) Blood , vol.104 , Issue.10 , pp. 3021-3027
    • Carlsen, H.S.1    Baekkevold, E.S.2    Morton, H.C.3    Haraldsen, G.4    Brandtzaeg, P.5
  • 72
    • 33746256850 scopus 로고    scopus 로고
    • Follicular B helper T cell activity is confined to CXCR5(Hi)ICOS(hi) CD4 T cells and is independent of CD57 expression
    • Rasheed AU, Rahn HP, Sallusto F, Lipp M, Muller G. Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression. Eur J Immunol 2006; 36(7): 1892-903.
    • (2006) Eur J Immunol , vol.36 , Issue.7 , pp. 1892-1903
    • Rasheed, A.U.1    Rahn, H.P.2    Sallusto, F.3    Lipp, M.4    Muller, G.5
  • 73
    • 55849110806 scopus 로고    scopus 로고
    • Mature antigen-experienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid joint
    • Manzo A, Vitolo B, Humby F, et al. Mature antigen-experienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid joint. Arthritis Rheum 2008; 58(11): 3377-87.
    • (2008) Arthritis Rheum , vol.58 , Issue.11 , pp. 3377-3387
    • Manzo, A.1    Vitolo, B.2    Humby, F.3
  • 74
    • 0030070295 scopus 로고    scopus 로고
    • Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis
    • Schroder AE, Greiner A, Seyfert C, Berek C. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc Natl Acad Sci USA 1996; 93(1): 221-5.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.1 , pp. 221-225
    • Schroder, A.E.1    Greiner, A.2    Seyfert, C.3    Berek, C.4
  • 75
    • 47949114181 scopus 로고    scopus 로고
    • B lymphocyte autoimmunity in rheumatoid synovitis is independent of ectopic lymphoid neogenesis
    • Cantaert T, Kolln J, Timmer T, et al. B lymphocyte autoimmunity in rheumatoid synovitis is independent of ectopic lymphoid neogenesis. J Immunol 2008; 181(1): 785-94.
    • (2008) J Immunol , vol.181 , Issue.1 , pp. 785-794
    • Cantaert, T.1    Kolln, J.2    Timmer, T.3
  • 76
    • 45349084358 scopus 로고    scopus 로고
    • Synovial lymphoid neogenesis does not define a specific clinical rheumatoid arthritis phenotype
    • Thurlings RM, Wijbrandts CA, Mebius RE, et al. Synovial lymphoid neogenesis does not define a specific clinical rheumatoid arthritis phenotype. Arthritis Rheum 2008; 58(6): 1582-9.
    • (2008) Arthritis Rheum , vol.58 , Issue.6 , pp. 1582-1589
    • Thurlings, R.M.1    Wijbrandts, C.A.2    Mebius, R.E.3
  • 77
    • 0038240921 scopus 로고    scopus 로고
    • Ectopic germinal center formation in rheumatoid synovitis
    • Weyand CM, Goronzy JJ. Ectopic germinal center formation in rheumatoid synovitis. Ann N Y Acad Sci 2003; 987: 140-9.
    • (2003) Ann N Y Acad Sci , vol.987 , pp. 140-149
    • Weyand, C.M.1    Goronzy, J.J.2
  • 78
    • 78650784468 scopus 로고    scopus 로고
    • V-region gene analysis of locally defined synovial B and plasma cells reveals selected B cell expansion and accumulation of plasma cell clones in rheumatoid arthritis
    • Scheel T, Gursche A, Zacher J, Haupl T, Berek C. V-region gene analysis of locally defined synovial B and plasma cells reveals selected B cell expansion and accumulation of plasma cell clones in rheumatoid arthritis. Arthritis Rheum 2011; 63(1): 63-72.
    • (2011) Arthritis Rheum , vol.63 , Issue.1 , pp. 63-72
    • Scheel, T.1    Gursche, A.2    Zacher, J.3    Haupl, T.4    Berek, C.5
  • 80
    • 52449085305 scopus 로고    scopus 로고
    • Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab
    • Rosengren S, Wei N, Kalunian KC, Zvaifler NJ, Kavanaugh A, Boyle DL. Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab. Arthritis Res Ther 2008; 10(5): R105.
    • (2008) Arthritis Res Ther , vol.10 , Issue.5
    • Rosengren, S.1    Wei, N.2    Kalunian, K.C.3    Zvaifler, N.J.4    Kavanaugh, A.5    Boyle, D.L.6
  • 81
    • 0036720677 scopus 로고    scopus 로고
    • Soluble adhesion molecules (ICAM-1, VCAM-1, and E-selectin) and vascular endothelial growth factor (VEGF) in patients with distinct variants of rheumatoid synovitis
    • Klimiuk PA, Sierakowski S, Latosiewicz R, et al. Soluble adhesion molecules (ICAM-1, VCAM-1, and E-selectin) and vascular endothelial growth factor (VEGF) in patients with distinct variants of rheumatoid synovitis. Ann Rheum Dis 2002; 61(9): 804-9.
    • (2002) Ann Rheum Dis , vol.61 , Issue.9 , pp. 804-809
    • Klimiuk, P.A.1    Sierakowski, S.2    Latosiewicz, R.3
  • 82
    • 84870660290 scopus 로고    scopus 로고
    • Synovium CD20 expression is a potential new predictor of bone erosion progression in very-early arthritis treated by sequential DMARDs monotherapy -- a pilot study from the VErA cohort
    • Lanfant-Weybel K, Michot C, Daveau R, et al. Synovium CD20 expression is a potential new predictor of bone erosion progression in very-early arthritis treated by sequential DMARDs monotherapy -- a pilot study from the VErA cohort. Joint Bone Spine 2012; 79(6): 574-80.
    • (2012) Joint Bone Spine , vol.79 , Issue.6 , pp. 574-580
    • Lanfant-Weybel, K.1    Michot, C.2    Daveau, R.3
  • 83
    • 79952364363 scopus 로고    scopus 로고
    • Presence of lymphocyte aggregates in the synovium of patients with early arthritis in relationship to diagnosis and outcome: Is it a constant feature over time?
    • van de Sande MG, Thurlings RM, Boumans MJ, et al. Presence of lymphocyte aggregates in the synovium of patients with early arthritis in relationship to diagnosis and outcome: is it a constant feature over time? Ann Rheum Dis 2011; 70(4): 700-3.
    • (2011) Ann Rheum Dis , vol.70 , Issue.4 , pp. 700-703
    • Van De Sande, M.G.1    Thurlings, R.M.2    Boumans, M.J.3
  • 84
    • 0031043106 scopus 로고    scopus 로고
    • Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity
    • Tak PP, Smeets TJ, Daha MR, et al. Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity. Arthritis Rheum 1997; 40(2): 217-25.
    • (1997) Arthritis Rheum , vol.40 , Issue.2 , pp. 217-225
    • Tak, P.P.1    Smeets, T.J.2    Daha, M.R.3
  • 85
    • 0030066502 scopus 로고    scopus 로고
    • Synovial tissue macrophage populations and articular damage in rheumatoid arthritis
    • Mulherin D, Fitzgerald O, Bresnihan B. Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum 1996; 39(1): 115-24.
    • (1996) Arthritis Rheum , vol.39 , Issue.1 , pp. 115-124
    • Mulherin, D.1    Fitzgerald, O.2    Bresnihan, B.3
  • 86
    • 19544374324 scopus 로고    scopus 로고
    • Synovial tissue macrophages: A sensitive biomarker for response to treatment in patients with rheumatoid arthritis
    • Haringman JJ, Gerlag DM, Zwinderman AH, et al. Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis. Ann Rheum Dis 2005; 64(6): 834-8.
    • (2005) Ann Rheum Dis , vol.64 , Issue.6 , pp. 834-838
    • Haringman, J.J.1    Gerlag, D.M.2    Zwinderman, A.H.3
  • 87
    • 33847632067 scopus 로고    scopus 로고
    • Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: Standardization and consistency across centers
    • Bresnihan B, Gerlag DM, Rooney T, et al. Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers. J Rheumatol 2007; 34(3): 620-2.
    • (2007) J Rheumatol , vol.34 , Issue.3 , pp. 620-622
    • Bresnihan, B.1    Gerlag, D.M.2    Rooney, T.3
  • 88
    • 36048940661 scopus 로고    scopus 로고
    • Absence of changes in the number of synovial sublining macrophages after ineffective treatment for rheumatoid arthritis: Implications for use of synovial sublining macrophages as a biomarker
    • Wijbrandts CA, Vergunst CE, Haringman JJ, Gerlag DM, Smeets TJ, Tak PP. Absence of changes in the number of synovial sublining macrophages after ineffective treatment for rheumatoid arthritis: Implications for use of synovial sublining macrophages as a biomarker. Arthritis Rheum 2007; 56(11): 3869-71.
    • (2007) Arthritis Rheum , vol.56 , Issue.11 , pp. 3869-3871
    • Wijbrandts, C.A.1    Vergunst, C.E.2    Haringman, J.J.3    Gerlag, D.M.4    Smeets, T.J.5    Tak, P.P.6
  • 89
    • 47949100980 scopus 로고    scopus 로고
    • The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor alpha expression in the synovium
    • Wijbrandts CA, Dijkgraaf MG, Kraan MC, et al. The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor alpha expression in the synovium. Ann Rheum Dis 2008; 67(8): 1139-44.
    • (2008) Ann Rheum Dis , vol.67 , Issue.8 , pp. 1139-1144
    • Wijbrandts, C.A.1    Dijkgraaf, M.G.2    Kraan, M.C.3
  • 90
    • 52949119597 scopus 로고    scopus 로고
    • The value of synovial cytokine expression in predicting the clinical response to TNF antagonist therapy (Infliximab)
    • Buch MH, Reece RJ, Quinn MA, et al. The value of synovial cytokine expression in predicting the clinical response to TNF antagonist therapy (infliximab). Rheumatology (Oxford) 2008; 47(10): 1469-75.
    • (2008) Rheumatology (Oxford) , vol.47 , Issue.10 , pp. 1469-1475
    • Buch, M.H.1    Reece, R.J.2    Quinn, M.A.3
  • 91
    • 70350546030 scopus 로고    scopus 로고
    • The relationship between synovial lymphocyte aggregates and the clinical response to infliximab in rheumatoid arthritis: A prospective study
    • Klaasen R, Thurlings RM, Wijbrandts CA, et al. The relationship between synovial lymphocyte aggregates and the clinical response to infliximab in rheumatoid arthritis: a prospective study. Arthritis Rheum 2009; 60(11): 3217-24.
    • (2009) Arthritis Rheum , vol.60 , Issue.11 , pp. 3217-3224
    • Klaasen, R.1    Thurlings, R.M.2    Wijbrandts, C.A.3
  • 92
    • 66149147550 scopus 로고    scopus 로고
    • Clinical significance of synovial lymphoid neogenesis and its reversal after anti-tumour necrosis factor alpha therapy in rheumatoid arthritis
    • Canete JD, Celis R, Moll C, et al. Clinical significance of synovial lymphoid neogenesis and its reversal after anti-tumour necrosis factor alpha therapy in rheumatoid arthritis. Ann Rheum Dis 2009; 68(5): 751-6.
    • (2009) Ann Rheum Dis , vol.68 , Issue.5 , pp. 751-756
    • Canete, J.D.1    Celis, R.2    Moll, C.3
  • 93
    • 39549100140 scopus 로고    scopus 로고
    • Assessment of rituximab's immunomodulatory synovial effects (ARISE trial). 1: Clinical and synovial biomarker results
    • Kavanaugh A, Rosengren S, Lee SJ, et al. Assessment of rituximab's immunomodulatory synovial effects (ARISE trial). 1: clinical and synovial biomarker results. Ann Rheum Dis 2008; 67(3): 402-8.
    • (2008) Ann Rheum Dis , vol.67 , Issue.3 , pp. 402-408
    • Kavanaugh, A.1    Rosengren, S.2    Lee, S.J.3
  • 95
    • 38149044612 scopus 로고    scopus 로고
    • Synovial tissue response to rituximab: Mechanism of action and identification of biomarkers of response
    • Thurlings RM, Vos K, Wijbrandts CA, Zwinderman AH, Gerlag DM, Tak PP. Synovial tissue response to rituximab: mechanism of action and identification of biomarkers of response. Ann Rheum Dis 2008; 67(7): 917-25.
    • (2008) Ann Rheum Dis , vol.67 , Issue.7 , pp. 917-925
    • Thurlings, R.M.1    Vos, K.2    Wijbrandts, C.A.3    Zwinderman, A.H.4    Gerlag, D.M.5    Tak, P.P.6
  • 96
    • 84886790652 scopus 로고    scopus 로고
    • Rituximab-induced T cell depletion in patients with rheumatoid arthritis: Association with clinical response
    • Melet J, Mulleman D, Goupille P, Ribourtout B, Watier H, Thibault G. Rituximab-induced T cell depletion in patients with rheumatoid arthritis: association with clinical response. Arthritis Rheum 2013; 65(11): 2783-90.
    • (2013) Arthritis Rheum , vol.65 , Issue.11 , pp. 2783-2790
    • Melet, J.1    Mulleman, D.2    Goupille, P.3    Ribourtout, B.4    Watier, H.5    Thibault, G.6
  • 97
    • 79952011168 scopus 로고    scopus 로고
    • CXCL13: A novel biomarker of B-cell return following rituximab treatment and synovitis in patients with rheumatoid arthritis
    • Rosengren S, Wei N, Kalunian KC, Kavanaugh A, Boyle DL. CXCL13: a novel biomarker of B-cell return following rituximab treatment and synovitis in patients with rheumatoid arthritis. Rheumatology (Oxford) 2011; 50(3): 603-10.
    • (2011) Rheumatology (Oxford) , vol.50 , Issue.3 , pp. 603-610
    • Rosengren, S.1    Wei, N.2    Kalunian, K.C.3    Kavanaugh, A.4    Boyle, D.L.5
  • 98
    • 84898016179 scopus 로고    scopus 로고
    • Abatacept or tocilizumab after rituximab in rheumatoid arthritis? An exploratory study suggests non-response to rituximab is associated with persistently high IL-6 and better clinical response to IL-6 blocking therapy
    • Das S, Vital EM, Horton S, et al. Abatacept or tocilizumab after rituximab in rheumatoid arthritis? An exploratory study suggests non-response to rituximab is associated with persistently high IL-6 and better clinical response to IL-6 blocking therapy. Ann Rheum Dis 2014; 73(5): 909-12.
    • (2014) Ann Rheum Dis , vol.73 , Issue.5 , pp. 909-912
    • Das, S.1    Vital, E.M.2    Horton, S.3
  • 99
    • 84879693915 scopus 로고    scopus 로고
    • Immunohistological analysis of synovium treated with abatacept in rheumatoid arthritis
    • Kanbe K, Chiba J, Nakamura A. Immunohistological analysis of synovium treated with abatacept in rheumatoid arthritis. Rheumatol Int 2013; 33(7): 1883-7.
    • (2013) Rheumatol Int , vol.33 , Issue.7 , pp. 1883-1887
    • Kanbe, K.1    Chiba, J.2    Nakamura, A.3
  • 100
    • 84897019337 scopus 로고    scopus 로고
    • Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium
    • Ducreux J, Durez P, Galant C, et al. Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol 2014; 66(1): 15-23.
    • (2014) Arthritis Rheumatol , vol.66 , Issue.1 , pp. 15-23
    • Ducreux, J.1    Durez, P.2    Galant, C.3
  • 101
    • 80755188949 scopus 로고    scopus 로고
    • Inhibition of MAP kinase in synovium by treatment with tocilizumab in rheumatoid arthritis
    • Kanbe K, Chen Q, Nakamura A, Hobo K. Inhibition of MAP kinase in synovium by treatment with tocilizumab in rheumatoid arthritis. Clin Rheumatol 2011; 30(11): 1407-13.
    • (2011) Clin Rheumatol , vol.30 , Issue.11 , pp. 1407-1413
    • Kanbe, K.1    Chen, Q.2    Nakamura, A.3    Hobo, K.4
  • 102
    • 64749116002 scopus 로고    scopus 로고
    • How to perform and analyse synovial biopsies
    • Gerlag DM, Tak PP. How to perform and analyse synovial biopsies. Best Pract Res Clin Rheumatol 2009; 23(2): 221-32.
    • (2009) Best Pract Res Clin Rheumatol , vol.23 , Issue.2 , pp. 221-232
    • Gerlag, D.M.1    Tak, P.P.2
  • 104
    • 67649401923 scopus 로고    scopus 로고
    • Evaluation of arthroscopy and macroscopic scoring
    • af Klint E, Catrina AI, Matt P, et al. Evaluation of arthroscopy and macroscopic scoring. Arthritis Res Ther 2009; 11(3): R81.
    • (2009) Arthritis Res Ther , vol.11 , Issue.3
    • Af Klint, E.1    Catrina, A.I.2    Matt, P.3
  • 105
    • 85027911751 scopus 로고    scopus 로고
    • Ultrasound-guided synovial biopsy: A safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients
    • Kelly S, Humby F, Filer A, et al. Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients. Ann Rheum Dis 2013 Dec 13.
    • (2013) Ann Rheum Dis
    • Kelly, S.1    Humby, F.2    Filer, A.3
  • 106
    • 19544367986 scopus 로고    scopus 로고
    • Ultrasound guided synovial biopsy using portal and forceps
    • Koski JM, Helle M. Ultrasound guided synovial biopsy using portal and forceps. Ann Rheum Dis 2005; 64(6): 926-9.
    • (2005) Ann Rheum Dis , vol.64 , Issue.6 , pp. 926-929
    • Koski, J.M.1    Helle, M.2
  • 107
    • 33751301620 scopus 로고    scopus 로고
    • Power Doppler ultrasonography and synovitis: Correlating ultrasound imaging with histopathological findings and evaluating the performance of ultrasound equipments
    • Koski JM, Saarakkala S, Helle M, Hakulinen U, Heikkinen JO, Hermunen H. Power Doppler ultrasonography and synovitis: correlating ultrasound imaging with histopathological findings and evaluating the performance of ultrasound equipments. Ann Rheum Dis 2006; 65(12): 1590-5.
    • (2006) Ann Rheum Dis , vol.65 , Issue.12 , pp. 1590-1595
    • Koski, J.M.1    Saarakkala, S.2    Helle, M.3    Hakulinen, U.4    Heikkinen, J.O.5    Hermunen, H.6
  • 108
    • 79951510331 scopus 로고    scopus 로고
    • Ultrasound imaging for the rheumatologist. XXVIII. Impact of sonographic knee joint involvement in recent-onset inflammatory polyarthritis
    • Scire CA, Iagnocco A, Meenagh G, et al. Ultrasound imaging for the rheumatologist. XXVIII. Impact of sonographic knee joint involvement in recent-onset inflammatory polyarthritis. Clin Exp Rheumatol 2010; 28(4): 449-53.
    • (2010) Clin Exp Rheumatol , vol.28 , Issue.4 , pp. 449-453
    • Scire, C.A.1    Iagnocco, A.2    Meenagh, G.3
  • 109
    • 36448962702 scopus 로고    scopus 로고
    • Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: Validation of a minimally invasive ultrasound-guided synovial biopsy procedure
    • Scire CA, Epis O, Codullo V, et al. Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure. Arthritis Res Ther 2007; 9(5): R101.
    • (2007) Arthritis Res Ther , vol.9 , Issue.5
    • Scire, C.A.1    Epis, O.2    Codullo, V.3
  • 111
    • 79951508967 scopus 로고    scopus 로고
    • Evaluating antirheumatic treatments using synovial biopsy: A recommendation for standardisation to be used in clinical trials
    • van de Sande MG, Gerlag DM, Lodde BM, et al. Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials. Ann Rheum Dis 2011; 70(3): 423-7.
    • (2011) Ann Rheum Dis , vol.70 , Issue.3 , pp. 423-427
    • Van De Sande, M.G.1    Gerlag, D.M.2    Lodde, B.M.3
  • 112
    • 0036676818 scopus 로고    scopus 로고
    • Comparison of synovial tissues from the knee joints and the small joints of rheumatoid arthritis patients: Implications for pathogenesis and evaluation of treatment
    • Kraan MC, Reece RJ, Smeets TJ, Veale DJ, Emery P, Tak PP. Comparison of synovial tissues from the knee joints and the small joints of rheumatoid arthritis patients: Implications for pathogenesis and evaluation of treatment. Arthritis Rheum 2002; 46(8): 2034-8. 
    • (2002) Arthritis Rheum , vol.46 , Issue.8 , pp. 2034-2038
    • Kraan, M.C.1    Reece, R.J.2    Smeets, T.J.3    Veale, D.J.4    Emery, P.5    Tak, P.P.6


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