-
1
-
-
84858785688
-
Antibody therapy of cancer
-
COI: 1:CAS:528:DC%2BC38XksVegsbs%3D
-
Scott, A. M., J. D. Wolchok, and L. J. Old (2012) Antibody therapy of cancer. Nat. Rev. Cancer. 12: 278–287.
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 278-287
-
-
Scott, A.M.1
Wolchok, J.D.2
Old, L.J.3
-
3
-
-
81255188940
-
Tumor angiogenesis: molecular pathways and therapeutic targets
-
COI: 1:CAS:528:DC%2BC3MXhsVOisLfE
-
Weis, S. M. and D. A. Cheresh (2011) Tumor angiogenesis: molecular pathways and therapeutic targets. Nat. Med. 17: 1359–1370.
-
(2011)
Nat. Med
, vol.17
, pp. 1359-1370
-
-
Weis, S.M.1
Cheresh, D.A.2
-
4
-
-
84866596013
-
Advances in bispecific biotherapeutics for the treatment of cancer
-
COI: 1:CAS:528:DC%2BC38XhtF2rtbvM
-
May, C., P. Sapra, and H.-P. Gerber (2012) Advances in bispecific biotherapeutics for the treatment of cancer. Biochem. Pharmacol. 84: 1105–1112.
-
(2012)
Biochem. Pharmacol
, vol.84
, pp. 1105-1112
-
-
May, C.1
Sapra, P.2
Gerber, H.-P.3
-
5
-
-
73649149433
-
Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models
-
COI: 1:CAS:528:DC%2BD1MXhsFGrtbnM
-
Scheuer, W., T. Friess, H. Burtscher, B. Bossenmaier, J. Endl, and M. Hasmann (2009) Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res. 69: 9330–9336.
-
(2009)
Cancer Res
, vol.69
, pp. 9330-9336
-
-
Scheuer, W.1
Friess, T.2
Burtscher, H.3
Bossenmaier, B.4
Endl, J.5
Hasmann, M.6
-
6
-
-
84887198387
-
Bispecific antibody to ErbB2 overcomes trastuzumab resistance through comprehensive blockade of ErbB2 heterodimerization
-
COI: 1:CAS:528:DC%2BC3sXhslWjt7rP
-
Li, B., Y. Meng, L. Zheng, X. Zhang, Q. Tong, W. Tan, S. Hu, H. Li, Y. Chen, J. Song, G. Zhang, L. Zhao, D. Zhang, S. Hou, W. Qian, and Y. Guo (2013) Bispecific antibody to ErbB2 overcomes trastuzumab resistance through comprehensive blockade of ErbB2 heterodimerization. Cancer Res. 73: 6471–6483.
-
(2013)
Cancer Res
, vol.73
, pp. 6471-6483
-
-
Li, B.1
Meng, Y.2
Zheng, L.3
Zhang, X.4
Tong, Q.5
Tan, W.6
Hu, S.7
Li, H.8
Chen, Y.9
Song, J.10
Zhang, G.11
Zhao, L.12
Zhang, D.13
Hou, S.14
Qian, W.15
Guo, Y.16
-
7
-
-
79251472492
-
Review of catumaxomab in the treatment of malignant ascites
-
COI: 1:CAS:528:DC%2BC3cXhsVGjt7bL
-
Sebastian, M. (2010) Review of catumaxomab in the treatment of malignant ascites. Cancer Manag. Res. 2: 283–286.
-
(2010)
Cancer Manag. Res
, vol.2
, pp. 283-286
-
-
Sebastian, M.1
-
8
-
-
77956344338
-
Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy
-
COI: 1:CAS:528:DC%2BC3cXhtFWqsrrP
-
Seimetz, D., H. Lindhofer, and C. Bokemeyer (2010) Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy. Cancer Treat. Rev. 36: 458–467.
-
(2010)
Cancer Treat. Rev
, vol.36
, pp. 458-467
-
-
Seimetz, D.1
Lindhofer, H.2
Bokemeyer, C.3
-
9
-
-
0020518331
-
Hybrid hybridomas and their use in immunohistochemistry
-
COI: 1:CAS:528:DyaL3sXlslCju7Y%3D
-
Milstein, C. and A. C. Cuello (1983) Hybrid hybridomas and their use in immunohistochemistry. Nature 305: 537–540.
-
(1983)
Nature
, vol.305
, pp. 537-540
-
-
Milstein, C.1
Cuello, A.C.2
-
10
-
-
0026572365
-
Selective highperformance liquid chromatographic purification of bispecific monoclonal antibodies
-
COI: 1:CAS:528:DyaK38Xkt1Cgur4%3D
-
Tarditi, L., M. Camagna, A. Parisi, C. Vassarotto, L. B. DeMonte, M. Letarte, F. Malavasi, and M. Mariani (1992) Selective highperformance liquid chromatographic purification of bispecific monoclonal antibodies. J. Chromatogr. A. 599: 13–20.
-
(1992)
J. Chromatogr. A
, vol.599
, pp. 13-20
-
-
Tarditi, L.1
Camagna, M.2
Parisi, A.3
Vassarotto, C.4
DeMonte, L.B.5
Letarte, M.6
Malavasi, F.7
Mariani, M.8
-
11
-
-
0029063312
-
Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies
-
COI: 1:CAS:528:DyaK2MXmsFKht7w%3D
-
Lindhofer, H., R. Mocikat, B. Steipe, and S. Thierfelder (1995) Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies. J. Immunol. 155: 219–225.
-
(1995)
J. Immunol
, vol.155
, pp. 219-225
-
-
Lindhofer, H.1
Mocikat, R.2
Steipe, B.3
Thierfelder, S.4
-
12
-
-
0034051390
-
The Fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells
-
COI: 1:CAS:528:DC%2BD3cXltl2lsr4%3D
-
Zeidler, R., J. Mysliwietz, M. Csanady, A. Walz, I. Ziegler, B. Schmitt, B. Wollenberg, and H. Lindhofer (2000) The Fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells. Br. J. Cancer. 83: 261–266.
-
(2000)
Br. J. Cancer
, vol.83
, pp. 261-266
-
-
Zeidler, R.1
Mysliwietz, J.2
Csanady, M.3
Walz, A.4
Ziegler, I.5
Schmitt, B.6
Wollenberg, B.7
Lindhofer, H.8
-
13
-
-
66249126868
-
The trifunctional antibody ertumaxomab destroys tumor cells that express low levels of human epidermal growth factor receptor 2
-
Jäger, M., A. Schoberth, P. Ruf, J. Hess, and H. Lindhofer (2009) The trifunctional antibody ertumaxomab destroys tumor cells that express low levels of human epidermal growth factor receptor 2. Cancer Res. 69: 4270–4276.
-
(2009)
Cancer Res
, vol.69
, pp. 4270-4276
-
-
Jäger, M.1
Schoberth, A.2
Ruf, P.3
Hess, J.4
Lindhofer, H.5
-
14
-
-
0001303221
-
Recombination of a mixture of univalent antibody fragments of different specificity
-
COI: 1:CAS:528:DyaF3MXhtFeht7g%3D
-
Nisonoff, A. and M. M. Rivers (1961) Recombination of a mixture of univalent antibody fragments of different specificity. Arch. Biochem. Biophys. 93: 460–462.
-
(1961)
Arch. Biochem. Biophys
, vol.93
, pp. 460-462
-
-
Nisonoff, A.1
Rivers, M.M.2
-
15
-
-
0032919486
-
A phase I study of a HER2/neu bispecific antibody with granulocyte-colony-stimulating factor in patients with metastatic breast cancer that overexpresses HER2/neu
-
COI: 1:CAS:528:DyaK1MXjtlaks7c%3D
-
Pullarkat, V., Y. Deo, J. Link, L. Spears, V. Marty, R. Curnow, S. Groshen, C. Gee, and J. S. Weber (1999) A phase I study of a HER2/neu bispecific antibody with granulocyte-colony-stimulating factor in patients with metastatic breast cancer that overexpresses HER2/neu. Cancer Immunol. Immun. 48: 9–21.
-
(1999)
Cancer Immunol. Immun
, vol.48
, pp. 9-21
-
-
Pullarkat, V.1
Deo, Y.2
Link, J.3
Spears, L.4
Marty, V.5
Curnow, R.6
Groshen, S.7
Gee, C.8
Weber, J.S.9
-
16
-
-
36348965935
-
A phase-I trial of the epidermal growth factor receptor directed bispecific antibody MDX-447 without and with recombinant human granulocyte-colony stimulating factor in patients with advanced solid tumors
-
COI: 1:CAS:528:DC%2BD2sXhtlaqt7vN
-
Fury, M., A. Lipton, K. Smith, C. Winston, and D. Pfister (2008) A phase-I trial of the epidermal growth factor receptor directed bispecific antibody MDX-447 without and with recombinant human granulocyte-colony stimulating factor in patients with advanced solid tumors. Cancer Immunol. Immun. 57: 155–163.
-
(2008)
Cancer Immunol. Immun
, vol.57
, pp. 155-163
-
-
Fury, M.1
Lipton, A.2
Smith, K.3
Winston, C.4
Pfister, D.5
-
17
-
-
0030974954
-
Treatment of refractory Hodgkin’s disease with an anti-CD16/CD30 bispecific antibody
-
COI: 1:CAS:528:DyaK2sXhvVarsrc%3D
-
Hartmann, F., C. Renner, W. Jung, C. Deisting, M. Juwana, B. Eichentopf, M. Kloft, and M. Pfreundschuh (1997) Treatment of refractory Hodgkin’s disease with an anti-CD16/CD30 bispecific antibody. Blood. 89: 2042–2047.
-
(1997)
Blood
, vol.89
, pp. 2042-2047
-
-
Hartmann, F.1
Renner, C.2
Jung, W.3
Deisting, C.4
Juwana, M.5
Eichentopf, B.6
Kloft, M.7
Pfreundschuh, M.8
-
18
-
-
78651091039
-
Chemical generation of bispecific antibodies
-
COI: 1:CAS:528:DC%2BC3MXkt1KktQ%3D%3D
-
Doppalapudi, V. R., J. Huang, D. Liu, P. Jin, B. Liu, L. Li, J. Desharnais, C. Hagen, N. J. Levin, M. J. Shields, M. Parish, R. E. Murphy, J. DelRosario, B. D. Oates, J. Y. Lai, M. J. Matin, Z. Ainekulu, A. Bhat, C. W. Bradshaw, G. Woodnutt, R. A. Lerner, and R. W. Lappe (2010) Chemical generation of bispecific antibodies. Proc. Natl. Acad. Sci. U S A. 107: 22611–22616.
-
(2010)
Proc. Natl. Acad. Sci. U S A
, vol.107
, pp. 22611-22616
-
-
Doppalapudi, V.R.1
Huang, J.2
Liu, D.3
Jin, P.4
Liu, B.5
Li, L.6
Desharnais, J.7
Hagen, C.8
Levin, N.J.9
Shields, M.J.10
Parish, M.11
Murphy, R.E.12
DelRosario, J.13
Oates, B.D.14
Lai, J.Y.15
Matin, M.J.16
Ainekulu, Z.17
Bhat, A.18
Bradshaw, C.W.19
Woodnutt, G.20
Lerner, R.A.21
Lappe, R.W.22
more..
-
19
-
-
84862538751
-
Synthesis of bispecific antibodies using genetically encoded unnatural amino acids
-
COI: 1:CAS:528:DC%2BC38XnsFCksro%3D
-
Kim, C. H., J. Y. Axup, A. Dubrovska, S. A. Kazane, B. A. Hutchins, E. D. Wold, V.V. Smider, and P.G. Schultz (2012) Synthesis of bispecific antibodies using genetically encoded unnatural amino acids. J. Am. Chem. Soc. 134: 9918–9921.
-
(2012)
J. Am. Chem. Soc
, vol.134
, pp. 9918-9921
-
-
Kim, C.H.1
Axup, J.Y.2
Dubrovska, A.3
Kazane, S.A.4
Hutchins, B.A.5
Wold, E.D.6
Smider, V.V.7
Schultz, P.G.8
-
20
-
-
0000096835
-
Click chemistry: diverse chemical function from a few good reactions
-
COI: 1:CAS:528:DC%2BD3MXksVOis78%3D
-
Kolb, H. C., M. G. Finn, and K. B. Sharpless (2001) Click chemistry: diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. 40: 2004–2021.
-
(2001)
Angew. Chem. Int. Ed
, vol.40
, pp. 2004-2021
-
-
Kolb, H.C.1
Finn, M.G.2
Sharpless, K.B.3
-
21
-
-
0032882746
-
Bispecific antibodies in cancer therapy
-
COI: 1:CAS:528:DyaK1MXmslahsLc%3D
-
Segal, D. M., G. J. Weiner, and L. M. Weiner (1999) Bispecific antibodies in cancer therapy. Curr. Opin. Immunol. 11: 558–562.
-
(1999)
Curr. Opin. Immunol
, vol.11
, pp. 558-562
-
-
Segal, D.M.1
Weiner, G.J.2
Weiner, L.M.3
-
22
-
-
0345195967
-
Factors influencing the dimer to monomer transition of an antibody single-chain Fv fragment
-
COI: 1:CAS:528:DyaK1cXltlKltro%3D
-
Arndt, K. M., K. M. Müller, and A. Plückthun (1998) Factors influencing the dimer to monomer transition of an antibody single-chain Fv fragment. Biochem. 37: 12918–12926.
-
(1998)
Biochem
, vol.37
, pp. 12918-12926
-
-
Arndt, K.M.1
Müller, K.M.2
Plückthun, A.3
-
23
-
-
0027197493
-
Diabodies”: small bivalent and bispecific antibody fragments
-
COI: 1:CAS:528:DyaK3sXltlOjur8%3D
-
Holliger, P., T. Prospero, and G. Winter (1993) “Diabodies”: small bivalent and bispecific antibody fragments. Proc. Natl. Acad. Sci. USA. 90: 6444–6448.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 6444-6448
-
-
Holliger, P.1
Prospero, T.2
Winter, G.3
-
24
-
-
0032855541
-
A bispecific diabody that mediates natural killer cell cytotoxicity against xenotransplantated human Hodgkin’s tumors
-
COI: 1:CAS:528:DyaK1MXmslagtbw%3D
-
Arndt, M. A., J. Krauss, S. M. Kipriyanov, M. Pfreundschuh, and M. Little (1999) A bispecific diabody that mediates natural killer cell cytotoxicity against xenotransplantated human Hodgkin’s tumors. Blood. 94: 2562–2568.
-
(1999)
Blood
, vol.94
, pp. 2562-2568
-
-
Arndt, M.A.1
Krauss, J.2
Kipriyanov, S.M.3
Pfreundschuh, M.4
Little, M.5
-
25
-
-
84856300610
-
Half-life extension of a single-chain diabody by fusion to domain B of staphylococcal protein A
-
COI: 1:CAS:528:DC%2BC38Xht1Wgtr4%3D
-
Unverdorben, F., A. Färber-Schwarz, F. Richter, M. Hutt, and R. E. Kontermann (2012) Half-life extension of a single-chain diabody by fusion to domain B of staphylococcal protein A. Protein Eng. Des. Sel. 25: 81–88.
-
(2012)
Protein Eng. Des. Sel
, vol.25
, pp. 81-88
-
-
Unverdorben, F.1
Färber-Schwarz, A.2
Richter, F.3
Hutt, M.4
Kontermann, R.E.5
-
26
-
-
0030909820
-
Remodeling domain interfaces to enhance heterodimer formation
-
COI: 1:CAS:528:DyaK2sXisFWgsbw%3D
-
Zhu, Z., L. G. Presta, G. Zapata, and P. Carter (1997) Remodeling domain interfaces to enhance heterodimer formation. Protein Sci. 6: 781–788.
-
(1997)
Protein Sci
, vol.6
, pp. 781-788
-
-
Zhu, Z.1
Presta, L.G.2
Zapata, G.3
Carter, P.4
-
27
-
-
77954757304
-
Effector cell recruitment with novel Fv-based dual-affinity re-targeting protein leads to potent tumor cytolysis and in vivo B-cell depletion
-
COI: 1:CAS:528:DC%2BC3cXntVals7k%3D
-
Johnson, S., S. Burke, L. Huang, S. Gorlatov, H. Li, W. Wang, W. Zhang, N. Tuaillon, J. Rainey, B. Barat, Y. Yang, L. Jin, V. Ciccarone, P. A. Moore, S. Koenig, and E. Bonvini (2010) Effector cell recruitment with novel Fv-based dual-affinity re-targeting protein leads to potent tumor cytolysis and in vivo B-cell depletion. J. Mol. Biol. 399: 436–449.
-
(2010)
J. Mol. Biol
, vol.399
, pp. 436-449
-
-
Johnson, S.1
Burke, S.2
Huang, L.3
Gorlatov, S.4
Li, H.5
Wang, W.6
Zhang, W.7
Tuaillon, N.8
Rainey, J.9
Barat, B.10
Yang, Y.11
Jin, L.12
Ciccarone, V.13
Moore, P.A.14
Koenig, S.15
Bonvini, E.16
-
28
-
-
58849085569
-
BiTE: Teaching antibodies to engage T-cells for cancer therapy
-
COI: 1:CAS:528:DC%2BC3cXnt1Kgtbw%3D
-
Baeuerle, P. A., P. Kufer, and R. Bargou (2009) BiTE: Teaching antibodies to engage T-cells for cancer therapy. Curr. Opin. Mol. Ther. 11: 22–30.
-
(2009)
Curr. Opin. Mol. Ther
, vol.11
, pp. 22-30
-
-
Baeuerle, P.A.1
Kufer, P.2
Bargou, R.3
-
29
-
-
84867858547
-
Blinatumomab: A historical perspective
-
COI: 1:CAS:528:DC%2BC38Xhtl2rs7vP
-
Nagorsen, D., P. Kufer, P. A. Baeuerle, and R. Bargou (2012) Blinatumomab: A historical perspective. Pharmacol. Therapeut. 136: 334–342.
-
(2012)
Pharmacol. Therapeut
, vol.136
, pp. 334-342
-
-
Nagorsen, D.1
Kufer, P.2
Baeuerle, P.A.3
Bargou, R.4
-
30
-
-
0029148633
-
A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity
-
COI: 1:CAS:528:DyaK2MXntVSktLg%3D
-
Mack, M., G. Riethmüller, and P. Kufer (1995) A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity. Proc. Natl. Acad. Sci. USA. 92: 7021–7025.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 7021-7025
-
-
Mack, M.1
Riethmüller, G.2
Kufer, P.3
-
31
-
-
49649120397
-
Tumor regression in cancer patients by very low doses of a T cell–engaging antibody
-
COI: 1:CAS:528:DC%2BD1cXpslWru70%3D
-
Bargou, R., E. Leo, G. Zugmaier, M. Klinger, M. Goebeler, S. Knop, R. Noppeney, A. Viardot, G. Hess, M. Schuler, H. Einsele, C. Brandl, A. Wolf, P. Kirchinger, P. Klappers, M. Schmidt, G. Riethmüller, C. Reinhardt, P. A. Baeuerle, and P. Kufer (2008) Tumor regression in cancer patients by very low doses of a T cell–engaging antibody. Sci. 321: 974–977.
-
(2008)
Sci
, vol.321
, pp. 974-977
-
-
Bargou, R.1
Leo, E.2
Zugmaier, G.3
Klinger, M.4
Goebeler, M.5
Knop, S.6
Noppeney, R.7
Viardot, A.8
Hess, G.9
Schuler, M.10
Einsele, H.11
Brandl, C.12
Wolf, A.13
Kirchinger, P.14
Klappers, P.15
Schmidt, M.16
Riethmüller, G.17
Reinhardt, C.18
Baeuerle, P.A.19
Kufer, P.20
more..
-
32
-
-
34548229364
-
FcRn: The neonatal Fc receptor comes of age
-
COI: 1:CAS:528:DC%2BD2sXpsV2qtbw%3D
-
Roopenian, D. C. and S. Akilesh (2007) FcRn: The neonatal Fc receptor comes of age. Nat. Rev. Immunol. 7: 715–725.
-
(2007)
Nat. Rev. Immunol
, vol.7
, pp. 715-725
-
-
Roopenian, D.C.1
Akilesh, S.2
-
33
-
-
84882579911
-
Tailoring immunoglobulin Fc for highly potent and serum-stable therapeutic antibodies
-
COI: 1:CAS:528:DC%2BC3sXht1Onsb7F
-
Jung, S. (2013) Tailoring immunoglobulin Fc for highly potent and serum-stable therapeutic antibodies. Biotechnol. Bioproc. Eng. 18: 625–636.
-
(2013)
Biotechnol. Bioproc. Eng
, vol.18
, pp. 625-636
-
-
Jung, S.1
-
34
-
-
77951520735
-
Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-IgTM) molecules
-
Wu, C., H. Ying, S. Bose, R. Miller, L. Medina, L. Santora, and T. Ghayur (2009) Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-IgTM) molecules. MAbs. 1: 339–347.
-
(2009)
MAbs
, vol.1
, pp. 339-347
-
-
Wu, C.1
Ying, H.2
Bose, S.3
Miller, R.4
Medina, L.5
Santora, L.6
Ghayur, T.7
-
35
-
-
35948977323
-
Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin
-
COI: 1:CAS:528:DC%2BD2sXht1Oru7zJ
-
Wu, C., H. Ying, C. Grinnell, S. Bryant, R. Miller, A. Clabbers, S. Bose, D. McCarthy, R.-R. Zhu, L. Santora, R. Davis-Taber, Y. Kunes, E. Fung, A. Schwartz, P. Sakorafas, J. Gu, E. Tarcsa, A. Murtaza, and T. Ghayur (2007) Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin. Nat. Biotechnol. 25: 1290–1297.
-
(2007)
Nat. Biotechnol
, vol.25
, pp. 1290-1297
-
-
Wu, C.1
Ying, H.2
Grinnell, C.3
Bryant, S.4
Miller, R.5
Clabbers, A.6
Bose, S.7
McCarthy, D.8
Zhu, R.-R.9
Santora, L.10
Davis-Taber, R.11
Kunes, Y.12
Fung, E.13
Schwartz, A.14
Sakorafas, P.15
Gu, J.16
Tarcsa, E.17
Murtaza, A.18
Ghayur, T.19
-
36
-
-
84877877265
-
The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen
-
Correia, I., J. Sung, R. Burton, C. G. Jakob, B. Carragher, T. Ghayur, and C. Radziejewski (2013) The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen. MAbs. 5: 364–372.
-
(2013)
MAbs
, vol.5
, pp. 364-372
-
-
Correia, I.1
Sung, J.2
Burton, R.3
Jakob, C.G.4
Carragher, B.5
Ghayur, T.6
Radziejewski, C.7
-
37
-
-
77951523463
-
Bispecific antibodies for cancer therapy: the light at the end of the tunnel
-
Chames, P. and D. Baty (2009) Bispecific antibodies for cancer therapy: the light at the end of the tunnel? MAbs. 1: 539–547.
-
(2009)
MAbs
, vol.1
, pp. 539-547
-
-
Chames, P.1
Baty, D.2
-
38
-
-
0029946383
-
‘Knobs-intoholes’ engineering of antibody CH3 domains for heavy chain heterodimerization
-
COI: 1:CAS:528:DyaK28XkvVaksrk%3D
-
Ridgway, J. B. B., L. G. Presta, and P. Carter (1996) ‘Knobs-intoholes’ engineering of antibody CH3 domains for heavy chain heterodimerization. Protein Eng. 9: 617–621.
-
(1996)
Protein Eng
, vol.9
, pp. 617-621
-
-
Ridgway, J.B.B.1
Presta, L.G.2
Carter, P.3
-
39
-
-
0031552589
-
Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library
-
COI: 1:CAS:528:DyaK2sXkvFCisL4%3D
-
Atwell, S., J. B. B. Ridgway, J. A. Wells, and P. Carter (1997) Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library. J. Mol. Biol. 270: 26–35.
-
(1997)
J. Mol. Biol
, vol.270
, pp. 26-35
-
-
Atwell, S.1
Ridgway, J.B.B.2
Wells, J.A.3
Carter, P.4
-
40
-
-
0031876578
-
An efficient route to human bispecific IgG
-
COI: 1:STN:280:DyaK1czisFKrsw%3D%3D
-
Merchant, A. M., Z. Zhu, J. Q. Yuan, A. Goddard, C. W. Adams, L. G. Presta, and P. Carter (1998) An efficient route to human bispecific IgG. Nat. Biotechnol. 16: 677–681.
-
(1998)
Nat. Biotechnol
, vol.16
, pp. 677-681
-
-
Merchant, A.M.1
Zhu, Z.2
Yuan, J.Q.3
Goddard, A.4
Adams, C.W.5
Presta, L.G.6
Carter, P.7
-
41
-
-
0023691177
-
Analysis of immunoglobulin domain interactions: Evidence for a dominant role of salt bridges
-
COI: 1:CAS:528:DyaL1cXmt1yiurg%3D
-
Schiffer, M., C. H. Chang, V. M. Naik, and F. J. Stevens (1988) Analysis of immunoglobulin domain interactions: Evidence for a dominant role of salt bridges. J. Mol. Biol. 203: 799–802.
-
(1988)
J. Mol. Biol
, vol.203
, pp. 799-802
-
-
Schiffer, M.1
Chang, C.H.2
Naik, V.M.3
Stevens, F.J.4
-
42
-
-
77953485268
-
Enhancing antibody Fc heterodimer formation through electrostatic steering effects: Application to bispecific molecules and monovalent IgG
-
COI: 1:CAS:528:DC%2BC3cXnt1Cmurw%3D
-
Gunasekaran, K., M. Pentony, M. Shen, L. Garrett, C. Forte, A. Woodward, S. B. Ng, T. Born, M. Retter, K. Manchulenko, H. Sweet, I. N. Foltz, M. Wittekind, and W. Yan (2010) Enhancing antibody Fc heterodimer formation through electrostatic steering effects: Application to bispecific molecules and monovalent IgG. J. Biol. Chem. 285: 19637–19646.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 19637-19646
-
-
Gunasekaran, K.1
Pentony, M.2
Shen, M.3
Garrett, L.4
Forte, C.5
Woodward, A.6
Ng, S.B.7
Born, T.8
Retter, M.9
Manchulenko, K.10
Sweet, H.11
Foltz, I.N.12
Wittekind, M.13
Yan, W.14
-
43
-
-
0022555989
-
Bispecific monoclonal antibodies from hybrid hybridomas
-
John H. V. V., Langone J., (eds), Academic Press, USA
-
Suresh, M. R., A. C. Cuello, and C. Milstein (1986) Bispecific monoclonal antibodies from hybrid hybridomas. pp. 210–228. In: H. V. V. John and J. Langone (ed.). Methods in Enzymology. Academic Press, USA.
-
(1986)
Methods in Enzymology
, pp. 210-228
-
-
Suresh, M.R.1
Cuello, A.C.2
Milstein, C.3
-
44
-
-
84871565611
-
LUZ-Y, a novel platform for the mammalian cell production of full-length IgG-bispecific antibodies
-
COI: 1:CAS:528:DC%2BC38XhvVOrt7%2FO
-
Wranik, B. J., E. L. Christensen, G. Schaefer, J. K. Jackman, A. C. Vendel, and D. Eaton (2012) LUZ-Y, a novel platform for the mammalian cell production of full-length IgG-bispecific antibodies. J. Biol. Chem. 287: 43331–43339.
-
(2012)
J. Biol. Chem
, vol.287
, pp. 43331-43339
-
-
Wranik, B.J.1
Christensen, E.L.2
Schaefer, G.3
Jackman, J.K.4
Vendel, A.C.5
Eaton, D.6
-
45
-
-
79960592856
-
Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies
-
COI: 1:CAS:528:DC%2BC3MXptV2huro%3D
-
Schaefer, W., J. T. Regula, M. Bähner, J. Schanzer, R. Croasdale, H. Dürr, C. Gassner, G. Georges, H. Kettenberger, S. Imhof-Jung, M. Schwaiger, K. G. Stubenrauch, C. Sustmann, M. Thomas, W. Scheuer, and C. Klein (2011) Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies. Proc. Natl. Acad. Sci. USA. 108: 11187–11192.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 11187-11192
-
-
Schaefer, W.1
Regula, J.T.2
Bähner, M.3
Schanzer, J.4
Croasdale, R.5
Dürr, H.6
Gassner, C.7
Georges, G.8
Kettenberger, H.9
Imhof-Jung, S.10
Schwaiger, M.11
Stubenrauch, K.G.12
Sustmann, C.13
Thomas, M.14
Scheuer, W.15
Klein, C.16
-
46
-
-
84881460836
-
Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies
-
COI: 1:CAS:528:DC%2BC3sXhtVKht7fF
-
Spiess, C., M. Merchant, A. Huang, Z. Zheng, N.-Y. Yang, J. Peng, D. Ellerman, W. Shatz, D. Reilly, D. G. Yansura, and J. M. Scheer (2013) Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies. Nat. Biotechnol. 31: 753–758.
-
(2013)
Nat. Biotechnol
, vol.31
, pp. 753-758
-
-
Spiess, C.1
Merchant, M.2
Huang, A.3
Zheng, Z.4
Yang, N.-Y.5
Peng, J.6
Ellerman, D.7
Shatz, W.8
Reilly, D.9
Yansura, D.G.10
Scheer, J.M.11
-
47
-
-
84884194586
-
Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 (IL-4) and interleukin-13 (IL-13) cytokines
-
COI: 1:CAS:528:DC%2BC3sXhsVClsrvO
-
Spiess, C., J. Bevers, J. Jackman, N. Chiang, G. Nakamura, M. Dillon, H. Liu, P. Molina, J. M. Elliott, W. Shatz, J. M. Scheer, G. Giese, J. Persson, Y. Zhang, M. S. Dennis, J. Giulianotti, P. Gupta, D. Reilly, E. Palma, J. Wang, E. Stefanich, H. Scheerens, G. Fuh, and L. C. Wu (2013) Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 (IL-4) and interleukin-13 (IL-13) cytokines. J. Biol. Chem. 288: 26583–26593.
-
(2013)
J. Biol. Chem
, vol.288
, pp. 26583-26593
-
-
Spiess, C.1
Bevers, J.2
Jackman, J.3
Chiang, N.4
Nakamura, G.5
Dillon, M.6
Liu, H.7
Molina, P.8
Elliott, J.M.9
Shatz, W.10
Scheer, J.M.11
Giese, G.12
Persson, J.13
Zhang, Y.14
Dennis, M.S.15
Giulianotti, J.16
Gupta, P.17
Reilly, D.18
Palma, E.19
Wang, J.20
Stefanich, E.21
Scheerens, H.22
Fuh, G.23
Wu, L.C.24
more..
-
48
-
-
76249100176
-
Aglycosylated IgG variants expressed in bacteria that selectively bind FcãRI potentiate tumor cell killing by monocyte-dendritic cells
-
COI: 1:CAS:528:DC%2BC3cXhtFCmsr4%3D
-
Jung, S. T., S. T. Reddy, T. H. Kang, M. J. Borrok, I. Sandlie, P. W. Tucker, and G. Georgiou (2010) Aglycosylated IgG variants expressed in bacteria that selectively bind FcãRI potentiate tumor cell killing by monocyte-dendritic cells. Proc. Natl. Acad. Sci. USA. 107: 604–609.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 604-609
-
-
Jung, S.T.1
Reddy, S.T.2
Kang, T.H.3
Borrok, M.J.4
Sandlie, I.5
Tucker, P.W.6
Georgiou, G.7
-
49
-
-
84874101229
-
Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcãRIIa affinity and selectivity
-
COI: 1:CAS:528:DC%2BC38XhsVCgtrnP
-
Jung, S. T., W. Kelton, T. H. Kang, S. T. W. Ng, J. T. Andersen, I. Sandlie, C. A. Sarkar, and G. Georgiou (2013) Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcãRIIa affinity and selectivity. ACS Chem. Biol. 8: 368–375.
-
(2013)
ACS Chem. Biol
, vol.8
, pp. 368-375
-
-
Jung, S.T.1
Kelton, W.2
Kang, T.H.3
Ng, S.T.W.4
Andersen, J.T.5
Sandlie, I.6
Sarkar, C.A.7
Georgiou, G.8
-
50
-
-
80052622662
-
Bypassing glycosylation: engineering aglycosylated full length IgG antibodies for human therapy
-
COI: 1:CAS:528:DC%2BC3MXhsFOhtLfJ
-
Jung, S. T., T. H. Kang, W. Kelton, and G. Georgiou (2011) Bypassing glycosylation: engineering aglycosylated full length IgG antibodies for human therapy. Curr. Opin. Biotechnol. 22: 858–867.
-
(2011)
Curr. Opin. Biotechnol
, vol.22
, pp. 858-867
-
-
Jung, S.T.1
Kang, T.H.2
Kelton, W.3
Georgiou, G.4
-
51
-
-
84904344421
-
Aglycosylated full-length IgG antibodies: Steps toward next-generation immunotherapeutics
-
COI: 1:CAS:528:DC%2BC2cXhtlCisbbN
-
Ju, M. S. and S. T. Jung (2014) Aglycosylated full-length IgG antibodies: Steps toward next-generation immunotherapeutics. Curr. Opin. Biotechnol. 30: 128–139.
-
(2014)
Curr. Opin. Biotechnol
, vol.30
, pp. 128-139
-
-
Ju, M.S.1
Jung, S.T.2
-
52
-
-
58149510052
-
Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors
-
COI: 1:CAS:528:DC%2BD1MXhsFWgtw%3D%3D
-
Sazinsky, S. L., R. G. Ott, N. W Silver, S. Tidor, J. V. Ravetch, and K. D. Wittrup (2008) Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors. Proc. Natl. Acad. Sci. USA. 105: 20167–20172.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 20167-20172
-
-
Sazinsky, S.L.1
Ott, R.G.2
Silver, N.W.3
Tidor, S.4
Ravetch, J.V.5
Wittrup, K.D.6
-
53
-
-
84904364868
-
Engineering an aglycosylated Fc variant for enhanced FcãI engagement and pHdependent human FcRn binding
-
Jung, S. T., T. H. Kang, and D. I. Kim (2014) Engineering an aglycosylated Fc variant for enhanced FcãI engagement and pHdependent human FcRn binding. Biotechnol. Bioproc. Eng. in press
-
(2014)
Biotechnol. Bioproc. Eng
-
-
Jung, S.T.1
Kang, T.H.2
Kim, D.I.3
-
54
-
-
62849095162
-
Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
-
COI: 1:CAS:528:DC%2BD1MXjt1Cqurw%3D
-
Bostrom, J., S.-F. Yu, D. Kan, B. A. Appleton, C. V. Lee, K. Billeci, W. Man, F. Peale, S. Ross, C. Wiesmann, and G. Fuh (2009) Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site. Sci. 323: 1610–1614.
-
(2009)
Sci
, vol.323
, pp. 1610-1614
-
-
Bostrom, J.1
S.-F, Y.2
Kan, D.3
Appleton, B.A.4
Lee, C.V.5
Billeci, K.6
Man, W.7
Peale, F.8
Ross, S.9
Wiesmann, C.10
Fuh, G.11
|