메뉴 건너뛰기




Volumn 20, Issue 2, 2015, Pages 201-210

Engineering antibodies for dual specificity and enhanced potency

Author keywords

antibody engineering; bispecific antibody; dual specificity; therapeutic antibody

Indexed keywords

CELL ENGINEERING; MONOCLONAL ANTIBODIES;

EID: 84929454314     PISSN: 12268372     EISSN: 19763816     Source Type: Journal    
DOI: 10.1007/s12257-014-0575-6     Document Type: Review
Times cited : (4)

References (54)
  • 1
    • 84858785688 scopus 로고    scopus 로고
    • Antibody therapy of cancer
    • COI: 1:CAS:528:DC%2BC38XksVegsbs%3D
    • Scott, A. M., J. D. Wolchok, and L. J. Old (2012) Antibody therapy of cancer. Nat. Rev. Cancer. 12: 278–287.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 278-287
    • Scott, A.M.1    Wolchok, J.D.2    Old, L.J.3
  • 3
    • 81255188940 scopus 로고    scopus 로고
    • Tumor angiogenesis: molecular pathways and therapeutic targets
    • COI: 1:CAS:528:DC%2BC3MXhsVOisLfE
    • Weis, S. M. and D. A. Cheresh (2011) Tumor angiogenesis: molecular pathways and therapeutic targets. Nat. Med. 17: 1359–1370.
    • (2011) Nat. Med , vol.17 , pp. 1359-1370
    • Weis, S.M.1    Cheresh, D.A.2
  • 4
    • 84866596013 scopus 로고    scopus 로고
    • Advances in bispecific biotherapeutics for the treatment of cancer
    • COI: 1:CAS:528:DC%2BC38XhtF2rtbvM
    • May, C., P. Sapra, and H.-P. Gerber (2012) Advances in bispecific biotherapeutics for the treatment of cancer. Biochem. Pharmacol. 84: 1105–1112.
    • (2012) Biochem. Pharmacol , vol.84 , pp. 1105-1112
    • May, C.1    Sapra, P.2    Gerber, H.-P.3
  • 5
    • 73649149433 scopus 로고    scopus 로고
    • Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models
    • COI: 1:CAS:528:DC%2BD1MXhsFGrtbnM
    • Scheuer, W., T. Friess, H. Burtscher, B. Bossenmaier, J. Endl, and M. Hasmann (2009) Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res. 69: 9330–9336.
    • (2009) Cancer Res , vol.69 , pp. 9330-9336
    • Scheuer, W.1    Friess, T.2    Burtscher, H.3    Bossenmaier, B.4    Endl, J.5    Hasmann, M.6
  • 7
    • 79251472492 scopus 로고    scopus 로고
    • Review of catumaxomab in the treatment of malignant ascites
    • COI: 1:CAS:528:DC%2BC3cXhsVGjt7bL
    • Sebastian, M. (2010) Review of catumaxomab in the treatment of malignant ascites. Cancer Manag. Res. 2: 283–286.
    • (2010) Cancer Manag. Res , vol.2 , pp. 283-286
    • Sebastian, M.1
  • 8
    • 77956344338 scopus 로고    scopus 로고
    • Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC3cXhtFWqsrrP
    • Seimetz, D., H. Lindhofer, and C. Bokemeyer (2010) Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy. Cancer Treat. Rev. 36: 458–467.
    • (2010) Cancer Treat. Rev , vol.36 , pp. 458-467
    • Seimetz, D.1    Lindhofer, H.2    Bokemeyer, C.3
  • 9
    • 0020518331 scopus 로고
    • Hybrid hybridomas and their use in immunohistochemistry
    • COI: 1:CAS:528:DyaL3sXlslCju7Y%3D
    • Milstein, C. and A. C. Cuello (1983) Hybrid hybridomas and their use in immunohistochemistry. Nature 305: 537–540.
    • (1983) Nature , vol.305 , pp. 537-540
    • Milstein, C.1    Cuello, A.C.2
  • 11
    • 0029063312 scopus 로고
    • Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies
    • COI: 1:CAS:528:DyaK2MXmsFKht7w%3D
    • Lindhofer, H., R. Mocikat, B. Steipe, and S. Thierfelder (1995) Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies. J. Immunol. 155: 219–225.
    • (1995) J. Immunol , vol.155 , pp. 219-225
    • Lindhofer, H.1    Mocikat, R.2    Steipe, B.3    Thierfelder, S.4
  • 12
    • 0034051390 scopus 로고    scopus 로고
    • The Fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells
    • COI: 1:CAS:528:DC%2BD3cXltl2lsr4%3D
    • Zeidler, R., J. Mysliwietz, M. Csanady, A. Walz, I. Ziegler, B. Schmitt, B. Wollenberg, and H. Lindhofer (2000) The Fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells. Br. J. Cancer. 83: 261–266.
    • (2000) Br. J. Cancer , vol.83 , pp. 261-266
    • Zeidler, R.1    Mysliwietz, J.2    Csanady, M.3    Walz, A.4    Ziegler, I.5    Schmitt, B.6    Wollenberg, B.7    Lindhofer, H.8
  • 13
    • 66249126868 scopus 로고    scopus 로고
    • The trifunctional antibody ertumaxomab destroys tumor cells that express low levels of human epidermal growth factor receptor 2
    • Jäger, M., A. Schoberth, P. Ruf, J. Hess, and H. Lindhofer (2009) The trifunctional antibody ertumaxomab destroys tumor cells that express low levels of human epidermal growth factor receptor 2. Cancer Res. 69: 4270–4276.
    • (2009) Cancer Res , vol.69 , pp. 4270-4276
    • Jäger, M.1    Schoberth, A.2    Ruf, P.3    Hess, J.4    Lindhofer, H.5
  • 14
    • 0001303221 scopus 로고
    • Recombination of a mixture of univalent antibody fragments of different specificity
    • COI: 1:CAS:528:DyaF3MXhtFeht7g%3D
    • Nisonoff, A. and M. M. Rivers (1961) Recombination of a mixture of univalent antibody fragments of different specificity. Arch. Biochem. Biophys. 93: 460–462.
    • (1961) Arch. Biochem. Biophys , vol.93 , pp. 460-462
    • Nisonoff, A.1    Rivers, M.M.2
  • 15
    • 0032919486 scopus 로고    scopus 로고
    • A phase I study of a HER2/neu bispecific antibody with granulocyte-colony-stimulating factor in patients with metastatic breast cancer that overexpresses HER2/neu
    • COI: 1:CAS:528:DyaK1MXjtlaks7c%3D
    • Pullarkat, V., Y. Deo, J. Link, L. Spears, V. Marty, R. Curnow, S. Groshen, C. Gee, and J. S. Weber (1999) A phase I study of a HER2/neu bispecific antibody with granulocyte-colony-stimulating factor in patients with metastatic breast cancer that overexpresses HER2/neu. Cancer Immunol. Immun. 48: 9–21.
    • (1999) Cancer Immunol. Immun , vol.48 , pp. 9-21
    • Pullarkat, V.1    Deo, Y.2    Link, J.3    Spears, L.4    Marty, V.5    Curnow, R.6    Groshen, S.7    Gee, C.8    Weber, J.S.9
  • 16
    • 36348965935 scopus 로고    scopus 로고
    • A phase-I trial of the epidermal growth factor receptor directed bispecific antibody MDX-447 without and with recombinant human granulocyte-colony stimulating factor in patients with advanced solid tumors
    • COI: 1:CAS:528:DC%2BD2sXhtlaqt7vN
    • Fury, M., A. Lipton, K. Smith, C. Winston, and D. Pfister (2008) A phase-I trial of the epidermal growth factor receptor directed bispecific antibody MDX-447 without and with recombinant human granulocyte-colony stimulating factor in patients with advanced solid tumors. Cancer Immunol. Immun. 57: 155–163.
    • (2008) Cancer Immunol. Immun , vol.57 , pp. 155-163
    • Fury, M.1    Lipton, A.2    Smith, K.3    Winston, C.4    Pfister, D.5
  • 17
    • 0030974954 scopus 로고    scopus 로고
    • Treatment of refractory Hodgkin’s disease with an anti-CD16/CD30 bispecific antibody
    • COI: 1:CAS:528:DyaK2sXhvVarsrc%3D
    • Hartmann, F., C. Renner, W. Jung, C. Deisting, M. Juwana, B. Eichentopf, M. Kloft, and M. Pfreundschuh (1997) Treatment of refractory Hodgkin’s disease with an anti-CD16/CD30 bispecific antibody. Blood. 89: 2042–2047.
    • (1997) Blood , vol.89 , pp. 2042-2047
    • Hartmann, F.1    Renner, C.2    Jung, W.3    Deisting, C.4    Juwana, M.5    Eichentopf, B.6    Kloft, M.7    Pfreundschuh, M.8
  • 20
    • 0000096835 scopus 로고    scopus 로고
    • Click chemistry: diverse chemical function from a few good reactions
    • COI: 1:CAS:528:DC%2BD3MXksVOis78%3D
    • Kolb, H. C., M. G. Finn, and K. B. Sharpless (2001) Click chemistry: diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. 40: 2004–2021.
    • (2001) Angew. Chem. Int. Ed , vol.40 , pp. 2004-2021
    • Kolb, H.C.1    Finn, M.G.2    Sharpless, K.B.3
  • 21
    • 0032882746 scopus 로고    scopus 로고
    • Bispecific antibodies in cancer therapy
    • COI: 1:CAS:528:DyaK1MXmslahsLc%3D
    • Segal, D. M., G. J. Weiner, and L. M. Weiner (1999) Bispecific antibodies in cancer therapy. Curr. Opin. Immunol. 11: 558–562.
    • (1999) Curr. Opin. Immunol , vol.11 , pp. 558-562
    • Segal, D.M.1    Weiner, G.J.2    Weiner, L.M.3
  • 22
    • 0345195967 scopus 로고    scopus 로고
    • Factors influencing the dimer to monomer transition of an antibody single-chain Fv fragment
    • COI: 1:CAS:528:DyaK1cXltlKltro%3D
    • Arndt, K. M., K. M. Müller, and A. Plückthun (1998) Factors influencing the dimer to monomer transition of an antibody single-chain Fv fragment. Biochem. 37: 12918–12926.
    • (1998) Biochem , vol.37 , pp. 12918-12926
    • Arndt, K.M.1    Müller, K.M.2    Plückthun, A.3
  • 23
    • 0027197493 scopus 로고
    • Diabodies”: small bivalent and bispecific antibody fragments
    • COI: 1:CAS:528:DyaK3sXltlOjur8%3D
    • Holliger, P., T. Prospero, and G. Winter (1993) “Diabodies”: small bivalent and bispecific antibody fragments. Proc. Natl. Acad. Sci. USA. 90: 6444–6448.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6444-6448
    • Holliger, P.1    Prospero, T.2    Winter, G.3
  • 24
    • 0032855541 scopus 로고    scopus 로고
    • A bispecific diabody that mediates natural killer cell cytotoxicity against xenotransplantated human Hodgkin’s tumors
    • COI: 1:CAS:528:DyaK1MXmslagtbw%3D
    • Arndt, M. A., J. Krauss, S. M. Kipriyanov, M. Pfreundschuh, and M. Little (1999) A bispecific diabody that mediates natural killer cell cytotoxicity against xenotransplantated human Hodgkin’s tumors. Blood. 94: 2562–2568.
    • (1999) Blood , vol.94 , pp. 2562-2568
    • Arndt, M.A.1    Krauss, J.2    Kipriyanov, S.M.3    Pfreundschuh, M.4    Little, M.5
  • 25
    • 84856300610 scopus 로고    scopus 로고
    • Half-life extension of a single-chain diabody by fusion to domain B of staphylococcal protein A
    • COI: 1:CAS:528:DC%2BC38Xht1Wgtr4%3D
    • Unverdorben, F., A. Färber-Schwarz, F. Richter, M. Hutt, and R. E. Kontermann (2012) Half-life extension of a single-chain diabody by fusion to domain B of staphylococcal protein A. Protein Eng. Des. Sel. 25: 81–88.
    • (2012) Protein Eng. Des. Sel , vol.25 , pp. 81-88
    • Unverdorben, F.1    Färber-Schwarz, A.2    Richter, F.3    Hutt, M.4    Kontermann, R.E.5
  • 26
    • 0030909820 scopus 로고    scopus 로고
    • Remodeling domain interfaces to enhance heterodimer formation
    • COI: 1:CAS:528:DyaK2sXisFWgsbw%3D
    • Zhu, Z., L. G. Presta, G. Zapata, and P. Carter (1997) Remodeling domain interfaces to enhance heterodimer formation. Protein Sci. 6: 781–788.
    • (1997) Protein Sci , vol.6 , pp. 781-788
    • Zhu, Z.1    Presta, L.G.2    Zapata, G.3    Carter, P.4
  • 28
    • 58849085569 scopus 로고    scopus 로고
    • BiTE: Teaching antibodies to engage T-cells for cancer therapy
    • COI: 1:CAS:528:DC%2BC3cXnt1Kgtbw%3D
    • Baeuerle, P. A., P. Kufer, and R. Bargou (2009) BiTE: Teaching antibodies to engage T-cells for cancer therapy. Curr. Opin. Mol. Ther. 11: 22–30.
    • (2009) Curr. Opin. Mol. Ther , vol.11 , pp. 22-30
    • Baeuerle, P.A.1    Kufer, P.2    Bargou, R.3
  • 30
    • 0029148633 scopus 로고
    • A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity
    • COI: 1:CAS:528:DyaK2MXntVSktLg%3D
    • Mack, M., G. Riethmüller, and P. Kufer (1995) A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity. Proc. Natl. Acad. Sci. USA. 92: 7021–7025.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7021-7025
    • Mack, M.1    Riethmüller, G.2    Kufer, P.3
  • 32
    • 34548229364 scopus 로고    scopus 로고
    • FcRn: The neonatal Fc receptor comes of age
    • COI: 1:CAS:528:DC%2BD2sXpsV2qtbw%3D
    • Roopenian, D. C. and S. Akilesh (2007) FcRn: The neonatal Fc receptor comes of age. Nat. Rev. Immunol. 7: 715–725.
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 715-725
    • Roopenian, D.C.1    Akilesh, S.2
  • 33
    • 84882579911 scopus 로고    scopus 로고
    • Tailoring immunoglobulin Fc for highly potent and serum-stable therapeutic antibodies
    • COI: 1:CAS:528:DC%2BC3sXht1Onsb7F
    • Jung, S. (2013) Tailoring immunoglobulin Fc for highly potent and serum-stable therapeutic antibodies. Biotechnol. Bioproc. Eng. 18: 625–636.
    • (2013) Biotechnol. Bioproc. Eng , vol.18 , pp. 625-636
    • Jung, S.1
  • 34
    • 77951520735 scopus 로고    scopus 로고
    • Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-IgTM) molecules
    • Wu, C., H. Ying, S. Bose, R. Miller, L. Medina, L. Santora, and T. Ghayur (2009) Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-IgTM) molecules. MAbs. 1: 339–347.
    • (2009) MAbs , vol.1 , pp. 339-347
    • Wu, C.1    Ying, H.2    Bose, S.3    Miller, R.4    Medina, L.5    Santora, L.6    Ghayur, T.7
  • 36
    • 84877877265 scopus 로고    scopus 로고
    • The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen
    • Correia, I., J. Sung, R. Burton, C. G. Jakob, B. Carragher, T. Ghayur, and C. Radziejewski (2013) The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen. MAbs. 5: 364–372.
    • (2013) MAbs , vol.5 , pp. 364-372
    • Correia, I.1    Sung, J.2    Burton, R.3    Jakob, C.G.4    Carragher, B.5    Ghayur, T.6    Radziejewski, C.7
  • 37
    • 77951523463 scopus 로고    scopus 로고
    • Bispecific antibodies for cancer therapy: the light at the end of the tunnel
    • Chames, P. and D. Baty (2009) Bispecific antibodies for cancer therapy: the light at the end of the tunnel? MAbs. 1: 539–547.
    • (2009) MAbs , vol.1 , pp. 539-547
    • Chames, P.1    Baty, D.2
  • 38
    • 0029946383 scopus 로고    scopus 로고
    • ‘Knobs-intoholes’ engineering of antibody CH3 domains for heavy chain heterodimerization
    • COI: 1:CAS:528:DyaK28XkvVaksrk%3D
    • Ridgway, J. B. B., L. G. Presta, and P. Carter (1996) ‘Knobs-intoholes’ engineering of antibody CH3 domains for heavy chain heterodimerization. Protein Eng. 9: 617–621.
    • (1996) Protein Eng , vol.9 , pp. 617-621
    • Ridgway, J.B.B.1    Presta, L.G.2    Carter, P.3
  • 39
    • 0031552589 scopus 로고    scopus 로고
    • Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library
    • COI: 1:CAS:528:DyaK2sXkvFCisL4%3D
    • Atwell, S., J. B. B. Ridgway, J. A. Wells, and P. Carter (1997) Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library. J. Mol. Biol. 270: 26–35.
    • (1997) J. Mol. Biol , vol.270 , pp. 26-35
    • Atwell, S.1    Ridgway, J.B.B.2    Wells, J.A.3    Carter, P.4
  • 41
    • 0023691177 scopus 로고
    • Analysis of immunoglobulin domain interactions: Evidence for a dominant role of salt bridges
    • COI: 1:CAS:528:DyaL1cXmt1yiurg%3D
    • Schiffer, M., C. H. Chang, V. M. Naik, and F. J. Stevens (1988) Analysis of immunoglobulin domain interactions: Evidence for a dominant role of salt bridges. J. Mol. Biol. 203: 799–802.
    • (1988) J. Mol. Biol , vol.203 , pp. 799-802
    • Schiffer, M.1    Chang, C.H.2    Naik, V.M.3    Stevens, F.J.4
  • 43
    • 0022555989 scopus 로고
    • Bispecific monoclonal antibodies from hybrid hybridomas
    • John H. V. V., Langone J., (eds), Academic Press, USA
    • Suresh, M. R., A. C. Cuello, and C. Milstein (1986) Bispecific monoclonal antibodies from hybrid hybridomas. pp. 210–228. In: H. V. V. John and J. Langone (ed.). Methods in Enzymology. Academic Press, USA.
    • (1986) Methods in Enzymology , pp. 210-228
    • Suresh, M.R.1    Cuello, A.C.2    Milstein, C.3
  • 44
    • 84871565611 scopus 로고    scopus 로고
    • LUZ-Y, a novel platform for the mammalian cell production of full-length IgG-bispecific antibodies
    • COI: 1:CAS:528:DC%2BC38XhvVOrt7%2FO
    • Wranik, B. J., E. L. Christensen, G. Schaefer, J. K. Jackman, A. C. Vendel, and D. Eaton (2012) LUZ-Y, a novel platform for the mammalian cell production of full-length IgG-bispecific antibodies. J. Biol. Chem. 287: 43331–43339.
    • (2012) J. Biol. Chem , vol.287 , pp. 43331-43339
    • Wranik, B.J.1    Christensen, E.L.2    Schaefer, G.3    Jackman, J.K.4    Vendel, A.C.5    Eaton, D.6
  • 48
    • 76249100176 scopus 로고    scopus 로고
    • Aglycosylated IgG variants expressed in bacteria that selectively bind FcãRI potentiate tumor cell killing by monocyte-dendritic cells
    • COI: 1:CAS:528:DC%2BC3cXhtFCmsr4%3D
    • Jung, S. T., S. T. Reddy, T. H. Kang, M. J. Borrok, I. Sandlie, P. W. Tucker, and G. Georgiou (2010) Aglycosylated IgG variants expressed in bacteria that selectively bind FcãRI potentiate tumor cell killing by monocyte-dendritic cells. Proc. Natl. Acad. Sci. USA. 107: 604–609.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 604-609
    • Jung, S.T.1    Reddy, S.T.2    Kang, T.H.3    Borrok, M.J.4    Sandlie, I.5    Tucker, P.W.6    Georgiou, G.7
  • 49
    • 84874101229 scopus 로고    scopus 로고
    • Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcãRIIa affinity and selectivity
    • COI: 1:CAS:528:DC%2BC38XhsVCgtrnP
    • Jung, S. T., W. Kelton, T. H. Kang, S. T. W. Ng, J. T. Andersen, I. Sandlie, C. A. Sarkar, and G. Georgiou (2013) Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcãRIIa affinity and selectivity. ACS Chem. Biol. 8: 368–375.
    • (2013) ACS Chem. Biol , vol.8 , pp. 368-375
    • Jung, S.T.1    Kelton, W.2    Kang, T.H.3    Ng, S.T.W.4    Andersen, J.T.5    Sandlie, I.6    Sarkar, C.A.7    Georgiou, G.8
  • 50
    • 80052622662 scopus 로고    scopus 로고
    • Bypassing glycosylation: engineering aglycosylated full length IgG antibodies for human therapy
    • COI: 1:CAS:528:DC%2BC3MXhsFOhtLfJ
    • Jung, S. T., T. H. Kang, W. Kelton, and G. Georgiou (2011) Bypassing glycosylation: engineering aglycosylated full length IgG antibodies for human therapy. Curr. Opin. Biotechnol. 22: 858–867.
    • (2011) Curr. Opin. Biotechnol , vol.22 , pp. 858-867
    • Jung, S.T.1    Kang, T.H.2    Kelton, W.3    Georgiou, G.4
  • 51
    • 84904344421 scopus 로고    scopus 로고
    • Aglycosylated full-length IgG antibodies: Steps toward next-generation immunotherapeutics
    • COI: 1:CAS:528:DC%2BC2cXhtlCisbbN
    • Ju, M. S. and S. T. Jung (2014) Aglycosylated full-length IgG antibodies: Steps toward next-generation immunotherapeutics. Curr. Opin. Biotechnol. 30: 128–139.
    • (2014) Curr. Opin. Biotechnol , vol.30 , pp. 128-139
    • Ju, M.S.1    Jung, S.T.2
  • 52
    • 58149510052 scopus 로고    scopus 로고
    • Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors
    • COI: 1:CAS:528:DC%2BD1MXhsFWgtw%3D%3D
    • Sazinsky, S. L., R. G. Ott, N. W Silver, S. Tidor, J. V. Ravetch, and K. D. Wittrup (2008) Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors. Proc. Natl. Acad. Sci. USA. 105: 20167–20172.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 20167-20172
    • Sazinsky, S.L.1    Ott, R.G.2    Silver, N.W.3    Tidor, S.4    Ravetch, J.V.5    Wittrup, K.D.6
  • 53
    • 84904364868 scopus 로고    scopus 로고
    • Engineering an aglycosylated Fc variant for enhanced FcãI engagement and pHdependent human FcRn binding
    • Jung, S. T., T. H. Kang, and D. I. Kim (2014) Engineering an aglycosylated Fc variant for enhanced FcãI engagement and pHdependent human FcRn binding. Biotechnol. Bioproc. Eng. in press
    • (2014) Biotechnol. Bioproc. Eng
    • Jung, S.T.1    Kang, T.H.2    Kim, D.I.3
  • 54
    • 62849095162 scopus 로고    scopus 로고
    • Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
    • COI: 1:CAS:528:DC%2BD1MXjt1Cqurw%3D
    • Bostrom, J., S.-F. Yu, D. Kan, B. A. Appleton, C. V. Lee, K. Billeci, W. Man, F. Peale, S. Ross, C. Wiesmann, and G. Fuh (2009) Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site. Sci. 323: 1610–1614.
    • (2009) Sci , vol.323 , pp. 1610-1614
    • Bostrom, J.1    S.-F, Y.2    Kan, D.3    Appleton, B.A.4    Lee, C.V.5    Billeci, K.6    Man, W.7    Peale, F.8    Ross, S.9    Wiesmann, C.10    Fuh, G.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.