An ADAM33 polymorphism associates with progression of preschool wheeze into childhood asthma: A prospective case-control study with replication in a birth cohort study

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Klaassen, Ester M M ^a   Penders, John ^a   Jöbsis, Quirijn ^a   Van De Kant, Kim D G ^a   Thijs, Carel ^a   Mommers, Monique ^a   Van Schayck, Constant P ^a   Van Eys, Guillaume ^b   Koppelman, Gerard H ^c   Dompeling, Edward ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; INTERLEUKIN 4; ADAM33 PROTEIN, HUMAN;

ADAM33 GENE; ALLELE; ARTICLE; ASTHMA; CASE CONTROL STUDY; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE COURSE; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GSDMB GENE; HUMAN; IL4 GENE; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; NETHERLANDS; ORMDL3 GENE; PROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; WHEEZING; ABNORMAL RESPIRATORY SOUND; BIRTH; COHORT ANALYSIS; GENETIC PREDISPOSITION; GENETICS; PATHOPHYSIOLOGY;

PHASCOLARCTIDAE;

ADAM PROTEINS; ASTHMA; CHILD; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; PARTURITION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RESPIRATORY SOUNDS;

EID: 84929452502     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0119349     Document Type: Article

References (48)

1. Pinto LA, Stein RT, Kabesch M. Impact of genetics in childhood asthma. J Pediatr (Rio J). 2008; 84: S68-75. doi: 10.2223/JPED.1781 PMID: 18690379
2. Thomsen SF, van der Sluis S, Kyvik KO, Skytthe A, Skadhauge LR, Backer V. Increase in the heritability of asthma from 1994 to 2003 among adolescent twins. Respir Med 2011; 105: 1147-1152. doi: 10.1016/j.rmed.2011.03.007 PMID: 21450446
3. Bisgaard H, Szefler S. Prevalence of asthma-like symptoms in young children. Pediatr Pulmonol 2007; 42: 723-728. PMID: 17598172
4. Pedersen SE, Hurd SS, Lemanske RF Jr, Becker A, Zar HJ, Sly PD, et al. Global strategy for the diagnosis and management of asthma in children 5 years and younger. Pediatr Pulmonol 2011; 46: 1-17. doi: 10.1002/ppul.21321 PMID: 20963782
5. Savenije OE, Granell R, Caudri D, Koppelman GH, Smit HA, Wijga A, et al. Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA. J Allergy Clin Immunol 2011; 127: 1505-1512 e1514. doi: 10.1016/j.jaci.2011.02.002 PMID: 21411131
6. Chang JC, Wang L, Chen RF, Liu CA Perinatal gene-gene and gene-environment interactions on IgE production and asthma development. Clin Dev Immunol 2012; 2012: 270869. doi: 10.1155/2012/270869 PMID: 22481967
7. Bottema RW, Kerkhof M, Reijmerink NE, Thijs C, Smit HA, van Schayck CP, et al. Gene-gene interaction in regulatory T-cell function in atopy and asthma development in childhood. J Allergy Clin Immunol 2010; 126: 338-346, 346 e331-310. doi: 10.1016/j.jaci.2010.04.024 PMID: 20599261
8. Rigoli L, Briuglia S, Caimmi S, Ferrau V, Gallizzi R, Leonardi S, et al. Gene-environment interaction in childhood asthma. Int J Immunopathol Pharmacol 2011; 24: 41-47. PMID: 22032786
9. van de Kant KD, Klaassen EM, Jobsis Q, Nijhuis AJ, van Schayck OC, Dompeling E. Early diagnosis of asthma in young children by using non-invasive biomarkers of airway inflammation and early lung function measurements: study protocol of a case-control study. BMC Public Health 2009; 9: 210. doi: 10.1186/1471-2458-9-210 PMID: 19563637
10. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 1998; 351: 1225-1232. PMID: 9643741
11. Klaassen EM, van Kant KD, Jobsis Q, Hovig ST, van Schayck CP, Rijkers GT, et al. Symptoms, but not a biomarker response to inhaled corticosteroids, predict asthma in preschool children with recurrent wheeze. Mediators Inflamm 2012; 2012: 162571. doi: 10.1155/2012/162571 PMID: 23304059
12. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J 2005; 26: 319-338. PMID: 16055882
13. Kummeling I, Thijs C, Penders J, Snijders BE, Stelma F, Reimerink J, et al. Etiology of atopy in infancy: the KOALA Birth Cohort Study. Pediatr Allergy Immunol 2005; 16: 679-684. PMID: 16343090
14. Bindels PJ, Grol MH, Ponsioen BP, Salome PL, Wiersma T, Goudswaard AN, et al. [Summary of the practice guideline 'Asthma in children' (second revision) from the Dutch College of General Practitioners]. Ned Tijdschr Geneeskd 2008; 152: 550-555. PMID: 18402320
15. rd ed New York: Cold Spring Harbor Laboratory Press.
16. Bottema RW, Reijmerink NE, Kerkhof M, Koppelman GH, Stelma FF, Gerritsen J, et al. Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study. Eur Respir J 2008; 32: 593-602. doi: 10.1183/09031936.00162407 PMID: 18417506
17. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265. PMID: 15297300
18. Frank E, Harrell J Regression Modeling Strategies. New York: NY: Springer. 2001
19. Steyerberg EW (2009) Clinical Prediction Models. New York: NY: Springer. 2009
20. Lettre G, Lange C, Hirschhorn JN. Genetic model testing and statistical power in population-based association studies of quantitative traits. Genet Epidemiol. 2007; 31: 358-362. PMID: 17352422
21. Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature. 2002; 418: 426-430. PMID: 12110844
22. Holloway JW, Davies DE, Powell R, Haitchi HM, Keith TP, Holgate ST. The discovery and role of ADAM33, a new candidate gene for asthma. Expert Rev Mol Med. 2004; 6: 1-12.
23. Ito I, Laporte JD, Fiset PO, Asai K, Yamauchi Y, Martin JG, et al. Downregulation of a disintegrin and metalloproteinase 33 by IFN-gamma in human airway smooth muscle cells. J Allergy Clin Immunol. 2007; 119: 89-97. PMID: 17208589
24. Noguchi E, Ohtsuki Y, Tokunaga K, Yamaoka-Sageshima M, Ichikawa K, Aoki T, et al. ADAM33 polymorphisms are associated with asthma susceptibility in a Japanese population. Clin Exp Allergy. 2006; 36: 602-608. PMID: 16650044
25. Lee JH, Park HS, Park SW, Jang AS, Uh ST, Rhim T, et al. ADAM33 polymorphism: association with bronchial hyper-responsiveness in Korean asthmatics. Clin Exp Allergy. 2004; 34: 860-865. PMID: 15196271
26. Haitchi HM, Powell RM, Shaw TJ, Howarth PH, Wilson SJ, Holgate ST, et al. ADAM33 expression in asthmatic airways and human embryonic lungs. Am J Respir Crit Care Med. 2005; 171: 958-965. PMID: 15709049
27. Foley SC, Mogas AK, Olivenstein R, Fiset PO, Chakir J, Bourbeau J, et al. Increased expression of ADAM33 and ADAM8 with disease progression in asthma. J Allergy Clin Immunol. 2007; 119: 863-871. PMID: 17339047
28. Kedda MA, Duffy DL, Bradley B, O'Hehir RE, Thompson PJ. ADAM33 haplotypes are associated with asthma in a large Australian population. Eur J Hum Genet. 2006; 14: 1027-1036. PMID: 16773130
29. Raby BA, Silverman EK, Kwiatkowski DJ, Lange C, Lazarus R, Weiss ST. ADAM33 polymorphisms and phenotype associations in childhood asthma. J Allergy Clin Immunol. 2004; 113: 1071-1078. PMID: 15208587
30. Howard TD, Postma DS, Jongepier H, Moore WC, Koppelman GH, Zheng SL, et al. Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. J Allergy Clin Immunol. 2003; 112: 717-722. PMID: 14564349
31. Reijmerink NE, Kerkhof M, Koppelman GH, Gerritsen J, de Jongste JC, Smit HA, et al. Smoke exposure interacts with ADAM33 polymorphisms in the development of lung function and hyperresponsiveness. Allergy. 2009; 64: 898-904. doi: 10.1111/j.1398-9995.2009.01939.x PMID: 19236319
32. Simpson A, Maniatis N, Jury F, Cakebread JA, Lowe LA, Holgate ST, et al. Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function. Am J Respir Crit Care Med. 2005; 172: 55-60. PMID: 15805180
33. Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature. 2007; 448: 470-473. PMID: 17611496
34. Sleiman PM, Annaiah K, Imielinski M, Bradfield JP, Kim CE, Frackelton EC, et al. ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry. J Allergy Clin Immunol. 2008; 122: 1225-1227. doi: 10.1016/j.jaci.2008.06.041 PMID: 18760456
35. Tavendale R, Macgregor DF, Mukhopadhyay S, Palmer CN. A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications. J Allergy Clin Immunol. 2008; 121: 860-863. doi: 10.1016/j.jaci.2008.01.015 PMID: 18395550
36. Kavalar MS, Balantic M, Silar M, Kosnik M, Korosec P, Rijavec M. Association of ORMDL3, STAT6 and TBXA2R gene polymorphisms with asthma. Int J Immunogenet. 2012; 39: 20-25. doi: 10.1111/j.1744-313X.2011.01051.x PMID: 22017802
37. Wu H, Romieu I, Sienra-Monge JJ, Li H, del Rio-Navarro BE, London SJ. Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma. Allergy. 2009; 64: 629-635. doi: 10.1111/j.1398-9995.2008.01912.x PMID: 19133921
38. Miller M, Tam AB, Cho JY, Doherty TA, Pham A, Khorram N, et al. ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A. 2012; 109: 16648-16653. doi: 10.1073/pnas.1204151109 PMID: 23011799
39. Holloway JW, Yang IA, Holgate ST. Genetics of allergic disease. J Allergy Clin Immunol. 2010; 125: S81-94. doi: 10.1016/j.jaci.2009.10.071 PMID: 20176270
40. Ha SG, Ge XN, Bahaie NS, Kang BN, Rao A, Sriramarao P. ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48. Nat Commun. 2013; 4: 2479. doi: 10.1038/ ncomms3479 PMID: 24056518
41. Bouzigon E, Corda E, Aschard H, Dizier MH, Boland A, Bousquet J, et al. Effect of 17q21 variants and smoking exposure in early-onset asthma. N Engl J Med. 2008; 359: 1985-1994. doi: 10.1056/NEJMoa0806604 PMID: 18923164
42. Blekic M, Kljaic Bukvic B, Aberle N, Marinho S, Hankinson J, Custovic A, et al. 17q12-21 and asthma: interactions with early-life environmental exposures. Ann Allergy Asthma Immunol. 2013; 110: 347-353 e342. doi: 10.1016/j.anai.2013.01.021 PMID: 23622005
43. Basehore MJ, Howard TD, Lange LA, Moore WC, Hawkins GA, Marshik PL, et al. A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects. J Allergy Clin Immunol. 2004; 114: 80-87. PMID: 15241348
44. Beghe B, Barton S, Rorke S, Peng Q, Sayers I, Gaunt T, et al. Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population. Clin Exp Allergy. 2003; 33: 1111-1117. PMID: 12911786
45. Kabesch M, Tzotcheva I, Carr D, Hofler C, Weiland SK, Fritzsch C, et al. A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood. J Allergy Clin Immunol. 2003; 112: 893-898. PMID: 14610476
46. de Faria IC, de Faria EJ, Toro AA, Ribeiro JD, Bertuzzo CS. Association of TGF-beta1, CD14, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents. J Pediatr (Rio J). 2008; 84: 203-210. doi: 10.2223/JPED.1783 PMID: 18425216
47. Schubert K, von Bonnsdorf H, Burke M, Ahlert I, Braun S, Berner R, et al. A comprehensive candidate gene study on bronchial asthma and juvenile idiopathic arthritis. Dis Markers. 2006; 22: 127-132. PMID: 16788246
48. Postma DS, Howard T. ADAM33 gene: confirming a gene without linkage. Clin Exp Allergy. 2004; 34: 1-3. PMID: 14720254