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Volumn 5, Issue , 2015, Pages

Integrated Genomics Identifies Convergence of Ankylosing Spondylitis with Global Immune Mediated Disease Pathways

Author keywords

[No Author keywords available]

Indexed keywords

STAT2 PROTEIN; STAT3 PROTEIN;

EID: 84929429316     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep10314     Document Type: Article
Times cited : (21)

References (43)
  • 1
    • 84897929623 scopus 로고    scopus 로고
    • Might axial myofascial properties and biomechanical mechanisms be relevant to ankylosing spondylitis and axial spondyloarthritis?
    • Masi, A. T. Might axial myofascial properties and biomechanical mechanisms be relevant to ankylosing spondylitis and axial spondyloarthritis? Arthritis Res. Ther. 16, 107, doi:10.1186/ar4532 (2014).
    • (2014) Arthritis Res. Ther. , vol.16 , pp. 107
    • Masi, A.T.1
  • 2
    • 77949458118 scopus 로고    scopus 로고
    • ARTS1 polymorphisms are associated with ankylosing spondylitis in Koreans
    • Choi, C. B. et al. ARTS1 polymorphisms are associated with ankylosing spondylitis in Koreans. Ann. Rheum. Dis. 69, 582-584, doi:10.1136/ard.2008.105296 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 582-584
    • Choi, C.B.1
  • 3
    • 78650711124 scopus 로고    scopus 로고
    • Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease
    • Danoy, P. et al. Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease. PLoS genetics 6, e1001195, doi:10.1371/journal.pgen.1001195 (2010).
    • (2010) PLoS Genetics , vol.6 , pp. e1001195
    • Danoy, P.1
  • 4
    • 79960899377 scopus 로고    scopus 로고
    • Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
    • Evans, D. M. et al. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nature genetics 43, 761-767, doi:10.1038/ng.873 (2011).
    • (2011) Nature Genetics , vol.43 , pp. 761-767
    • Evans, D.M.1
  • 5
    • 84879691837 scopus 로고    scopus 로고
    • Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
    • International Genetics of Ankylosing Spondylitis, C. et al. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nature genetics 45, 730-738, doi:10.1038/ng.2667 (2013).
    • (2013) Nature Genetics , vol.45 , pp. 730-738
    • International Genetics of Ankylosing Spondylitis, C.,1
  • 6
    • 84881129322 scopus 로고    scopus 로고
    • UGT2B17 copy number gain in a large ankylosing spondylitis multiplex family
    • Uddin, M. et al. UGT2B17 copy number gain in a large ankylosing spondylitis multiplex family. BMC genetics 14, 67, doi:10.1186/1471-2156-14-67 (2013).
    • (2013) BMC Genetics , vol.14 , pp. 67
    • Uddin, M.1
  • 7
    • 80054966401 scopus 로고    scopus 로고
    • Progress in the genetics of ankylosing spondylitis
    • Brown, M. A. Progress in the genetics of ankylosing spondylitis. Briefings in functional genomics 10, 249-257, doi:10.1093/bfgp/elr023 (2011).
    • (2011) Briefings in Functional Genomics , vol.10 , pp. 249-257
    • Brown, M.A.1
  • 9
    • 84882449068 scopus 로고    scopus 로고
    • Genetic insights into common pathways and complex relationships among immune-mediated diseases
    • Parkes, M., Cortes, A., van Heel, D. A. & Brown, M. A. Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nature reviews. Genetics 14, 661-673, doi:10.1038/nrg3502 (2013).
    • (2013) Nature Reviews. Genetics , vol.14 , pp. 661-673
    • Parkes, M.1    Cortes, A.2    Van Heel, D.A.3    Brown, M.A.4
  • 10
    • 84903590570 scopus 로고    scopus 로고
    • Brain-expressed exons under purifying selection are enriched for de novo mutations in autism spectrum disorder
    • Uddin, M. et al. Brain-expressed exons under purifying selection are enriched for de novo mutations in autism spectrum disorder. Nature genetics 46, 742-747, doi:10.1038/ng.2980 (2014).
    • (2014) Nature Genetics , vol.46 , pp. 742-747
    • Uddin, M.1
  • 11
    • 84860741138 scopus 로고    scopus 로고
    • Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
    • O'Roak, B. J. et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature 485, 246-250, doi:10.1038/nature10989 (2012).
    • (2012) Nature , vol.485 , pp. 246-250
    • O'Roak, B.J.1
  • 12
    • 84889561601 scopus 로고    scopus 로고
    • Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism
    • Parikshak, N. N. et al. Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism. Cell 155, 1008-1021, doi:10.1016/j.cell.2013.10.031 (2013).
    • (2013) Cell , vol.155 , pp. 1008-1021
    • Parikshak, N.N.1
  • 13
    • 84889583293 scopus 로고    scopus 로고
    • Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism
    • Willsey, A. J. et al. Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. Cell 155, 997-1007, doi:10.1016/j.cell.2013.10.020 (2013).
    • (2013) Cell , vol.155 , pp. 997-1007
    • Willsey, A.J.1
  • 14
    • 84901682858 scopus 로고    scopus 로고
    • Network analysis identifies protein clusters of functional importance in juvenile idiopathic arthritis
    • Stevens, A., Meyer, S., Hanson, D., Clayton, P. & Donn, R. P. Network analysis identifies protein clusters of functional importance in juvenile idiopathic arthritis. Arthritis Res. Ther. 16, R109, doi:10.1186/ar4559 (2014).
    • (2014) Arthritis Res. Ther. , vol.16 , pp. R109
    • Stevens, A.1    Meyer, S.2    Hanson, D.3    Clayton, P.4    Donn, R.P.5
  • 15
    • 74249100674 scopus 로고    scopus 로고
    • Genome-wide association data reveal a global map of genetic interactions among protein complexes
    • Hannum, G. et al. Genome-wide association data reveal a global map of genetic interactions among protein complexes. PLoS genetics 5, e1000782, doi:10.1371/journal.pgen.1000782 (2009).
    • (2009) PLoS Genetics , vol.5 , pp. e1000782
    • Hannum, G.1
  • 16
    • 84896385770 scopus 로고    scopus 로고
    • Integrative biology approach identifies cytokine targeting strategies for psoriasis
    • Perera, G. K. et al. Integrative biology approach identifies cytokine targeting strategies for psoriasis. Science translational medicine 6, 223ra222, doi:10.1126/scitranslmed.3007217 (2014).
    • (2014) Science Translational Medicine , vol.6 , pp. 223ra222
    • Perera, G.K.1
  • 17
    • 79851502150 scopus 로고    scopus 로고
    • Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology
    • Rossin, E. J. et al. Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS genetics 7, e1001273, doi:10.1371/journal.pgen.1001273 (2011).
    • (2011) PLoS Genetics , vol.7 , pp. e1001273
    • Rossin, E.J.1
  • 18
    • 84863116742 scopus 로고    scopus 로고
    • A systematic survey of loss-of-function variants in human protein-coding genes
    • MacArthur, D. G. et al. A systematic survey of loss-of-function variants in human protein-coding genes. Science 335, 823-828, doi:10.1126/science.1215040 (2012).
    • (2012) Science , vol.335 , pp. 823-828
    • MacArthur, D.G.1
  • 19
    • 84874443928 scopus 로고    scopus 로고
    • Psoriasis and phenotype of patients with early inflammatory back pain
    • Richette, P. et al. Psoriasis and phenotype of patients with early inflammatory back pain. Ann. Rheum. Dis. 72, 566-571, doi:10.1136/annrheumdis-2012-201610 (2013).
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. 566-571
    • Richette, P.1
  • 20
    • 84879907073 scopus 로고    scopus 로고
    • Incidence of Spondyloarthropathy in patients with ulcerative colitis: A population-based study
    • Shivashankar, R. et al. Incidence of Spondyloarthropathy in patients with ulcerative colitis: a population-based study. J. Rheumatol. 40, 1153-1157, doi:10.3899/jrheum.121029 (2013).
    • (2013) J. Rheumatol. , vol.40 , pp. 1153-1157
    • Shivashankar, R.1
  • 21
    • 34547742519 scopus 로고    scopus 로고
    • A common genetic background for inflammatory bowel disease and ankylosing spondylitis: A genealogic study in Iceland
    • Thjodleifsson, B., Geirsson, A. J., Bjornsson, S. & Bjarnason, I. A common genetic background for inflammatory bowel disease and ankylosing spondylitis: a genealogic study in Iceland. Arthritis and rheumatism 56, 2633-2639, doi:10.1002/art.22812 (2007).
    • (2007) Arthritis and Rheumatism , vol.56 , pp. 2633-2639
    • Thjodleifsson, B.1    Geirsson, A.J.2    Bjornsson, S.3    Bjarnason, I.4
  • 22
    • 69049103047 scopus 로고    scopus 로고
    • Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondylitis
    • Wang, X., Lin, Z., Wei, Q., Jiang, Y. & Gu, J. Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondylitis. Rheumatology international 29, 1343-1347, doi:10.1007/s00296-009-0883-x (2009).
    • (2009) Rheumatology International , vol.29 , pp. 1343-1347
    • Wang, X.1    Lin, Z.2    Wei, Q.3    Jiang, Y.4    Gu, J.5
  • 23
    • 33646236097 scopus 로고    scopus 로고
    • Preferential type 1 chemokine receptors and cytokine production of CD28- T cells in ankylosing spondylitis
    • Duftner, C. et al. Preferential type 1 chemokine receptors and cytokine production of CD28- T cells in ankylosing spondylitis. Ann. Rheum. Dis. 65, 647-653, doi:10.1136/ard.2005.042085 (2006).
    • (2006) Ann. Rheum. Dis. , vol.65 , pp. 647-653
    • Duftner, C.1
  • 24
    • 80155146569 scopus 로고    scopus 로고
    • Relation of HLA-B27, tumor necrosis factor-alpha promoter gene polymorphisms, and T cell cytokine production in ankylosing spondylitis - A comprehensive genotype-phenotype analysis from an observational cohort
    • Poddubnyy, D. A. et al. Relation of HLA-B27, tumor necrosis factor-alpha promoter gene polymorphisms, and T cell cytokine production in ankylosing spondylitis - a comprehensive genotype-phenotype analysis from an observational cohort. J. Rheumatol. 38, 2436-2441, doi:10.3899/jrheum.110130 (2011).
    • (2011) J. Rheumatol. , vol.38 , pp. 2436-2441
    • Poddubnyy, D.A.1
  • 25
    • 33845875436 scopus 로고    scopus 로고
    • Comparison of serum IL-1 beta, sIL-2R, IL-6, and TNF-alpha levels with disease activity parameters in ankylosing spondylitis
    • Bal, A. et al. Comparison of serum IL-1 beta, sIL-2R, IL-6, and TNF-alpha levels with disease activity parameters in ankylosing spondylitis. Clinical rheumatology 26, 211-215, doi:10.1007/s10067-006-0283-5 (2007).
    • (2007) Clinical Rheumatology , vol.26 , pp. 211-215
    • Bal, A.1
  • 26
    • 59149106117 scopus 로고    scopus 로고
    • Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
    • Nair, R. P. et al. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nature genetics 41, 199-204, doi:10.1038/ng.311 (2009).
    • (2009) Nature Genetics , vol.41 , pp. 199-204
    • Nair, R.P.1
  • 27
    • 61549115034 scopus 로고    scopus 로고
    • Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease
    • Wang, K. et al. Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am. J. Hum. Genet. 84, 399-405, doi:10.1016/j.ajhg.2009.01.026 (2009).
    • (2009) Am. J. Hum. Genet. , vol.84 , pp. 399-405
    • Wang, K.1
  • 28
    • 77950534540 scopus 로고    scopus 로고
    • T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis
    • Axtell, R. C. et al. T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nature medicine 16, 406-412, doi:10.1038/nm.2110 (2010).
    • (2010) Nature Medicine , vol.16 , pp. 406-412
    • Axtell, R.C.1
  • 29
    • 36849036211 scopus 로고    scopus 로고
    • IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner
    • Wei, L., Laurence, A., Elias, K. M. & O'Shea, J. J. IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J. Biol. Chem. 282, 34605-34610, doi:10.1074/jbc.M705100200 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 34605-34610
    • Wei, L.1    Laurence, A.2    Elias, K.M.3    O'Shea, J.J.4
  • 30
    • 84865718141 scopus 로고    scopus 로고
    • IL-17-producing gammadelta T cells and innate lymphoid cells
    • Sutton, C. E., Mielke, L. A. & Mills, K. H. IL-17-producing gammadelta T cells and innate lymphoid cells. European journal of immunology 42, 2221-2231, doi:10.1002/eji.201242569 (2012).
    • (2012) European Journal of Immunology , vol.42 , pp. 2221-2231
    • Sutton, C.E.1    Mielke, L.A.2    Mills, K.H.3
  • 31
    • 77954143695 scopus 로고    scopus 로고
    • Innate IL-17-producing cells: The sentinels of the immune system
    • Cua, D. J. & Tato, C. M. Innate IL-17-producing cells: the sentinels of the immune system. Nature reviews. Immunology 10, 479-489, doi:10.1038/nri2800 (2010).
    • (2010) Nature Reviews. Immunology , vol.10 , pp. 479-489
    • Cua, D.J.1    Tato, C.M.2
  • 32
    • 84905576130 scopus 로고    scopus 로고
    • Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease
    • Flanagan, S. E. et al. Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. Nature genetics 46, 812-814, doi:10.1038/ng.3040 (2014).
    • (2014) Nature Genetics , vol.46 , pp. 812-814
    • Flanagan, S.E.1
  • 33
    • 84872143942 scopus 로고    scopus 로고
    • Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants
    • Fu, W. et al. Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature 493, 216-220, doi:10.1038/nature11690 (2013).
    • (2013) Nature , vol.493 , pp. 216-220
    • Fu, W.1
  • 34
    • 84860712363 scopus 로고    scopus 로고
    • Patterns and rates of exonic de novo mutations in autism spectrum disorders
    • Neale, B. M. et al. Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature 485, 242-245, doi:10.1038/nature11011 (2012).
    • (2012) Nature , vol.485 , pp. 242-245
    • Neale, B.M.1
  • 35
    • 84860780495 scopus 로고    scopus 로고
    • De novo mutations revealed by whole-exome sequencing are strongly associated with autism
    • Sanders, S. J. et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature 485, 237-241, doi:10.1038/nature10945 (2012).
    • (2012) Nature , vol.485 , pp. 237-241
    • Sanders, S.J.1
  • 36
    • 84860297457 scopus 로고    scopus 로고
    • De novo gene disruptions in children on the autistic spectrum
    • Iossifov, I. et al. De novo gene disruptions in children on the autistic spectrum. Neuron 74, 285-299, doi:10.1016/j.neuron.2012.04.009 (2012).
    • (2012) Neuron , vol.74 , pp. 285-299
    • Iossifov, I.1
  • 37
    • 84881664021 scopus 로고    scopus 로고
    • Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing
    • Jiang, Y. H. et al. Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing. Am. J. Hum. Genet. 93, 249-263, doi:10.1016/j.ajhg.2013.06.012 (2013).
    • (2013) Am. J. Hum. Genet. , vol.93 , pp. 249-263
    • Jiang, Y.H.1
  • 38
    • 79957589237 scopus 로고    scopus 로고
    • Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations
    • O'Roak, B. J. et al. Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations. Nature genetics 43, 585-589, doi:10.1038/ng.835 (2011).
    • (2011) Nature Genetics , vol.43 , pp. 585-589
    • O'Roak, B.J.1
  • 39
    • 84922296279 scopus 로고    scopus 로고
    • Transcriptome sequencing from diverse human populations reveals differentiated regulatory architecture
    • Martin, A. R. et al. Transcriptome sequencing from diverse human populations reveals differentiated regulatory architecture. PLoS genetics 10, e1004549, doi:10.1371/journal.pgen.1004549 (2014).
    • (2014) PLoS Genetics , vol.10 , pp. e1004549
    • Martin, A.R.1
  • 40
    • 84901599553 scopus 로고    scopus 로고
    • A draft map of the human proteome
    • Kim, M. S. et al. A draft map of the human proteome. Nature 509, 575-581, doi:10.1038/nature13302 (2014).
    • (2014) Nature , vol.509 , pp. 575-581
    • Kim, M.S.1
  • 41
    • 84883575046 scopus 로고    scopus 로고
    • GeneMANIA prediction server 2013 update
    • Zuberi, K. et al. GeneMANIA prediction server 2013 update. Nucleic acids research 41, W115-122, doi:10.1093/nar/gkt533 (2013).
    • (2013) Nucleic Acids Research , vol.41 , pp. W115-W122
    • Zuberi, K.1
  • 42
    • 84885173893 scopus 로고    scopus 로고
    • Network-based interpretation of genomic variation data
    • Halldorsson, B. V. & Sharan, R. Network-based interpretation of genomic variation data. J. Mol. Biol. 425, 3964-3969, doi:10.1016/j.jmb.2013.07.026 (2013).
    • (2013) J. Mol. Biol. , vol.425 , pp. 3964-3969
    • Halldorsson, B.V.1    Sharan, R.2


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