Oxidative stress by layered double hydroxide nanoparticles via an SFK-JNK and p38-NF-κB signaling pathway mediates induction of interleukin-6 and interleukin-8 in human lung epithelial cells

International Journal of Nanomedicine

Volumn 10, Issue , 2015, Pages 3217-3229

  Choi, Soo Jin ^a   Paek, Hee Jeong ^a   Yu, Jin ^a  

^a Seoul Women University   (South Korea)

Author keywords

Infammatory cytokine; Layered double hydroxide; Mitogen activated protein kinases; Nuclear factor kappa B; Oxidative stress; Src family kinases

Indexed keywords

CATALASE; GLUCOSE REDUCTASE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; LAYERED DOUBLE HYDROXIDE NANOPARTICLE; MITOGEN ACTIVATED PROTEIN KINASE; NANOPARTICLE; NUCLEAR FACTOR KAPPA B P38 SUBUNIT; OXIDOREDUCTASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; HYDROXIDE; INTERLEUKIN DERIVATIVE; PROTEIN TYROSINE KINASE;

A549 CELL LINE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPOSURE; HUMAN; HUMAN CELL; INFLAMMATION; INTRACELLULAR SIGNALING; LUNG ALVEOLUS EPITHELIUM CELL; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; CELL LINE; CHEMISTRY; DRUG EFFECTS; METABOLISM; SIGNAL TRANSDUCTION;

CELL LINE; HUMANS; HYDROXIDES; INTERLEUKINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NANOPARTICLES; NF-KAPPA B; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 84929395875     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S82061     Document Type: Article

References (36)

1. Barry RC, Lin Y, Wang J, Liu G, Timchalk CA. Nanotechnology-based electrochemical sensors for biomonitoring chemical exposures. J Expo Sci Environ Epidemiol. 2009;19:1–18.
2. Cormode DP, Skajaa T, Fayad ZA, Mulder WJ. Nanotechnology in medical imaging: probe design and applications. Arterioscler Thromb Vasc Biol. 2009;29:992–1000.
3. Choi SJ, Lee JK, Jeong J, et al. Toxicity evaluation of inorganic nanoparticles: considerations and challenges. Mol Cell Toxicol. 2013; 9:205–210.
4. Krpetic Z, Anguissola S, Garry D, Kelly PM, Dawson KA. Nanoma-terials: impact on cells and cell organelles. Adv Exp Med Biol. 2014; 811:135–156.
5. Shang L, Nienhaus K, Nienhaus GU. Engineered nanoparticles interacting with cells: size matters. J Nanobiotechnology. 2014;12:5.
6. Choi SJ, Choy JH. Effect of physico-chemical parameters on the toxicity of inorganic nanoparticles. J Mater Chem. 2011;21:5547–5554.
7. Choi SJ, Choy JH. Layered double hydroxide nanoparticles as target-specific delivery carriers: uptake mechanism and toxicity. Nanomedicine (Lond). 2011;6:803–814.
8. Evans DG, Duan X. Preparation of layered double hydroxides and their applications as additives in polymers, as precursors to magnetic materials and in biology and medicine. Chem Commun (Camb). 2006;5:485–496.
9. Choy JH, Choi SJ, Oh JM, et al. Clay minerals and layered double hydroxides for novel biological applications. Appl Clay Sci. 2007;36: 122–132.
10. Kura AU, Hussein MZ, Fakurazi S, Arulselvan P. Layered double hydroxide nanocomposite for drug delivery systems; bio-distribution, toxicity, and drug activity enhancement. Chem Cent J. 2014;8:47.
11. Choi SJ, Oh JM, Choy JH. Toxicological effects of inorganic nano-particles on human lung cancer A549 cells. J Inorg Biochem. 2009; 103:463–471.
12. Manke A, Wang L, Rojanasakul Y. Mechanism of nanoparticle-induced oxidative stress and toxicity. Biomed Res Int. 2013;2013:92916.
13. Donaldson K, Poland CA. Inhaled nanoparticles and lung cancer – what we can learn from conventional particle toxicology. Swiss Med Wkly. 2012;142:w13547.
14. Pacurari M, Yin XJ, Zhao J, et al. Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-kappaB, and Akt in normal and malignant human mesothelial cells. Environ Health Perspect. 2008;116:1211–1217.
15. Takeda K, Matsuzawa A, Nishitoh H, et al. Roles of MAPKKK ASK1 in stress-induced cell death. Cell Struct Funct. 2003;28:23–29.
16. Jayakumar AR, Panickar KS, Murthy ChR, Norenberg MD. Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. J Neurosci. 2006;26:4774–4484.
17. Puddicombe SM, Davies DE. The role of MAP kinases in intracellular signal transduction in bronchial epithelium. Clin Exp Allergy. 2000; 30:7–11.
18. Li DQ, Luo L, Chen Z, et al. JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells. Exp Eye Res. 2006;82:588–596.
19. Hsu HY, Chiu SL, Wen MH, Chen KY, Hua KF. Ligands of mac-rophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways. J Biol Chem. 2001; 276:28719–28730.
20. Kitagawa D, Tanemura S, Ohata S, et al. Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation. Its implication in an anti-apoptotic function. J Biol Chem. 2002;277:366–371.
21. Pinkus R, Weiner LM, Daniel V. Role of oxidants and antioxidants in the induction of AP-1, NF-kappaB, and glutathione S-transferase gene expression. J Biol Chem. 1996;271:13422–13429.
22. Jin W, Wang H, Ya n W, et al. Disruption of Nrf2 enhances upregula-tion of nuclear factor-kappaB activity, proinfammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury. Mediat Infamm. 2008;2008:725174.
23. Owuor ED, Kong AN. Antioxidants and oxidants regulated signal transduction pathways. Biochem Pharm. 2002;64:765–770.
24. Itoh K, Chiba T, Takahashi S, et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophy Res Commun. 1997;236: 313–322.
25. Zhang X, Chen X, Song H, Chen HZ, Rovin BH. Activation of the Nrf2/antioxidant response pathway increases IL-8 expression. Eur J Immunol. 2005;35:3258–3267.
26. Eom HJ, Choi J. Oxidative stress of CeO2 nanoparticles via p38-Nrf-2 signaling pathway in human bronchial epithelial cell, Beas-2B. Toxicol Lett. 2009;187:77–83.
27. Wang J, Li N, Zheng L, et al. P38-Nrf-2 signaling pathway of oxidative stress in mice caused by nanoparticulate TiO2. Biol Trace Elem Res. 2011;140:186–197.
28. Ovrevik J, Lag M, Schwarze P, Refsnes M. p38 and Src-ERK1/2 pathways regulate crystalline silica-induced chemokine release in pulmonary epithelial cells. Toxicol Sci. 2004;81:480–490.
29. Park EJ, Park K. Oxidative stress and pro-infammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicol Lett. 2009; 184:18–25.
30. Foucaud L, Goulaouic S, Bennasroune A, et al. Oxidative stress induction by nanoparticles in THP-1 cells with 4-HNE production: stress biomarker or oxidative stress signalling molecule? Toxicol In Vitro. 2010;24:1512–1520.
31. Choi SJ, Oh JM, Choy JH. Safety aspect of inorganic layered nanoparti-cles: size-dependency in vitro and in vivo. J Nanosci Nanotechnol. 2008; 8:5297–5301.
32. Li A, Qin L, Zhu D, Zhu R, Sun J, Wang S. Signalling pathways involved in the activation of dendritic cells by layered double hydroxide nanoparticles. Biomaterials. 2010;31:748–756.
33. Eom HJ, Choi J. Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B. Toxicol In Vitro. 2009;23:1326–1332.
34. Manna SK, Sarkar S, Barr J, et al. Single-walled carbon nanotube induces oxidative stress and activates nuclear transcription factor-kappaB in human keratinocytes. Nano Lett. 2005;5:1676–1684.
35. He X, Young SH, Schwegler-Berry D, Chisholm WP, Fernback JE, Ma Q. Multiwalled carbon nanotubes induce a fibrogenic response by stimulating reactive oxygen species production, activating NF-kappaB signaling, and promoting fibroblast-to-myofibroblast transformation. Chem Res Toxicol. 2011;24:2237–2248.
36. Park EJ, Yi J, Chung KH, Ryu DY, Choi J, Park K. Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells. Toxicol Lett. 2008;180:222–229.