-
1
-
-
79952773320
-
Pharmacokinetics (PK) of PF-02341066, a dual ALK/MET inhibitor after multiple oral doses to advanced cancer patients
-
abstr2596
-
Tan W, Wilner KD, Bang Y, et al. Pharmacokinetics (PK) of PF-02341066, a dual ALK/MET inhibitor after multiple oral doses to advanced cancer patients. J Clin Oncol. 2010;28(suppl):abstr2596.
-
(2010)
J Clin Oncol
, vol.28
-
-
Tan, W.1
Wilner, K.D.2
Bang, Y.3
-
2
-
-
84874985978
-
Updated results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC)
-
ix402
-
Kim D, Ahn M, Yang P, et al. Updated results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC). Ann Oncol. 2012;23(suppl 9):ix402.
-
(2012)
Ann Oncol
, vol.23
-
-
Kim, D.1
Ahn, M.2
Yang, P.3
-
3
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013;368(25):2385–2394.
-
(2013)
N Engl J Med
, vol.368
, Issue.25
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
-
4
-
-
84918804764
-
PROFILE 1014 Investigators. First-line crizotinib versus chemotherapy in ALK-positive lung cancer
-
Solomon BJ, Mok T, Kim DW, et al; PROFILE 1014 Investigators. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014;371(23):2167–2177.
-
(2014)
N Engl J Med
, vol.371
, Issue.23
, pp. 2167-2177
-
-
Solomon, B.J.1
Mok, T.2
Kim, D.W.3
-
6
-
-
80052806086
-
Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK)
-
Cui JJ, Tran-Dubé M, Shen H, et al. Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). J Med Chem. 2011;54(18):6342–6363.
-
(2011)
J Med Chem
, vol.54
, Issue.18
, pp. 6342-6363
-
-
Cui, J.J.1
Tran-Dubé, M.2
Shen, H.3
-
7
-
-
37549059613
-
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
-
Christensen JG, Zou HY, Arango ME, et al. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol Cancer Ther. 2007;6(12 pt 1):3314–3322.
-
(2007)
Mol Cancer Ther
, vol.6
, Issue.12
, pp. 3314-3322
-
-
Christensen, J.G.1
Zou, H.Y.2
Arango, M.E.3
-
8
-
-
44849126091
-
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
-
McDermott U, Iafrate AJ, Gray NS, et al. Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res. 2008;68(9):3389–3395.
-
(2008)
Cancer Res
, vol.68
, Issue.9
, pp. 3389-3395
-
-
McDermott, U.1
Iafrate, A.J.2
Gray, N.S.3
-
9
-
-
84863338079
-
ROS1 rearrangements define a unique molecular class of lung cancers
-
Bergethon K, Shaw AT, Ou SH, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol. 2012;30(8):863–870.
-
(2012)
J Clin Oncol
, vol.30
, Issue.8
, pp. 863-870
-
-
Bergethon, K.1
Shaw, A.T.2
Ou, S.H.3
-
10
-
-
84929402274
-
Pharmacokinetics (PK) of crizotinib (PF-02341066), a dual ALK/C-MET inhibitor, following administration of multiple oral doses to patients with advanced ALK-positive NSCLC in China
-
Tan W, O’Gorman M, Lanzalone S, et al. Pharmacokinetics (PK) of crizotinib (PF-02341066), a dual ALK/C-MET inhibitor, following administration of multiple oral doses to patients with advanced ALK-positive NSCLC in China. J Thorac Oncol. 2012;7(suppl 5):S491.
-
(2012)
J Thorac Oncol
, vol.7
, pp. S491
-
-
Tan, W.1
O’Gorman, M.2
Lanzalone, S.3
-
11
-
-
79951994379
-
Comparison of crizotinib (PF-02341066) pharmacokinetics between Asian and non-Asian patients with advanced malignancies
-
Ou S-HI, Salgia R, Clark J, et al. Comparison of crizotinib (PF-02341066) pharmacokinetics between Asian and non-Asian patients with advanced malignancies. J Thorac Oncol. 2010;5(suppl 5):S382.
-
(2010)
J Thorac Oncol
, vol.5
, pp. S382
-
-
Ou, S.-H.1
Salgia, R.2
Clark, J.3
-
12
-
-
80051779162
-
Pharmacokinetics (PK) of crizotinib (PF-02341066) in patients with advanced non-small cell lung cancer (NSCLC) and other solid tumors
-
abstre13065
-
Li C, Alvey C, Bello A, Wilner KD, Tan W. Pharmacokinetics (PK) of crizotinib (PF-02341066) in patients with advanced non-small cell lung cancer (NSCLC) and other solid tumors. J Clin Oncol. 2011;29(suppl):abstre13065.
-
(2011)
J Clin Oncol
, vol.29
-
-
Li, C.1
Alvey, C.2
Bello, A.3
Wilner, K.D.4
Tan, W.5
-
13
-
-
84929396746
-
Clinical implication of a population pharmacokinetic analysis of xalkori (Crizotinib) in 1,182 patients with non-small cell lung cancer (NSCLC) and 32 patients with other solid tumors
-
Wang E, Nickens D, Bello A, Khosravan R, Amantea M, Tan W. Clinical implication of a population pharmacokinetic analysis of xalkori (crizotinib) in 1,182 patients with non-small cell lung cancer (NSCLC) and 32 patients with other solid tumors. J Thorac Oncol. 2013;8(suppl 2):S296.
-
(2013)
J Thorac Oncol
, vol.8
, pp. S296
-
-
Wang, E.1
Nickens, D.2
Bello, A.3
Khosravan, R.4
Amantea, M.5
Tan, W.6
-
14
-
-
84872330303
-
Clinical significance of EML4-ALK fusion gene and association with EGFR and KRAS gene mutations in 208 Chinese patients with non-small cell lung cancer
-
Li Y, Li Y, Yang T, et al. Clinical significance of EML4-ALK fusion gene and association with EGFR and KRAS gene mutations in 208 Chinese patients with non-small cell lung cancer. PLoS One. 2013;8(1):e52093.
-
(2013)
Plos One
, vol.8
, Issue.1
-
-
Li, Y.1
Li, Y.2
Yang, T.3
-
15
-
-
77954399760
-
Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression
-
Zhang X, Zhang S, Yang X, et al. Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression. Mol Cancer. 2010;9:188.
-
(2010)
Mol Cancer
, vol.9
, pp. 188
-
-
Zhang, X.1
Zhang, S.2
Yang, X.3
-
16
-
-
84863104686
-
Identification of enriched driver gene alterations in subgroups of non-small cell lung cancer patients based on histology and smoking status
-
An SJ, Chen ZH, Su J, et al. Identification of enriched driver gene alterations in subgroups of non-small cell lung cancer patients based on histology and smoking status. PLoS One. 2012;7(6):e40109.
-
(2012)
Plos One
, vol.7
, Issue.6
, pp. e40109
-
-
An, S.J.1
Chen, Z.H.2
Su, J.3
-
17
-
-
57349113565
-
Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts
-
Takeuchi K, Choi YL, Soda M, et al. Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts. Clin Cancer Res. 2008;14(20):6618–6624.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.20
, pp. 6618-6624
-
-
Takeuchi, K.1
Choi, Y.L.2
Soda, M.3
-
18
-
-
48249114422
-
EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
-
Koivunen JP, Mermel C, Zejnullahu K, et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res. 2008;14(13):4275–4283.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.13
, pp. 4275-4283
-
-
Koivunen, J.P.1
Mermel, C.2
Zejnullahu, K.3
-
19
-
-
84881230220
-
Biomarkers (BM) France: Results of routine EGFR, HER2, KRAS, BRAF, PI3KCA mutations detection and EML4-ALK gene fusion assessment on the first 10,000 non-small cell lung cancer (NSCLC) patients (pts)
-
abstr8000
-
Barlesi F, Blons H, Beau-Faller M, et al. Biomarkers (BM) France: results of routine EGFR, HER2, KRAS, BRAF, PI3KCA mutations detection and EML4-ALK gene fusion assessment on the first 10,000 non-small cell lung cancer (NSCLC) patients (pts). J Clin Oncol. 2013;31(suppl):abstr8000.
-
(2013)
J Clin Oncol
, vol.31
-
-
Barlesi, F.1
Blons, H.2
Beau-Faller, M.3
-
20
-
-
84880421221
-
The Chinese expert consensus opinion of the diagnosis of ALK-positive NSCLC (2013 version)
-
Chinese
-
Zhang X, Lu S, Zhang L, et al. The Chinese expert consensus opinion of the diagnosis of ALK-positive NSCLC (2013 version). Chin J Pathol. 2013;42(6):402–406. [Chinese].
-
(2013)
Chin J Pathol
, vol.42
, Issue.6
, pp. 402-406
-
-
Zhang, X.1
Lu, S.2
Zhang, L.3
-
21
-
-
84884730006
-
Diagnostic value of a novel fully automated immunochemistry assay for detection of ALK rearrangement in primary lung adenocarcinoma
-
Ying J, Guo L, Qiu T, et al. Diagnostic value of a novel fully automated immunochemistry assay for detection of ALK rearrangement in primary lung adenocarcinoma. Ann Oncol. 2013;24(10):2589–2593.
-
(2013)
Ann Oncol
, vol.24
, Issue.10
, pp. 2589-2593
-
-
Ying, J.1
Guo, L.2
Qiu, T.3
-
22
-
-
84902440321
-
Immunohistochemistry, fluorescence in situ hybridization, and reverse transcription-polymerase chain reaction for the detection of anaplastic lymphoma kinase gene rearrangements in patients with non-small cell lung cancer: Potential advantages and methodologic pitfalls
-
Demidova I, Barinov A, Savelov N, et al. Immunohistochemistry, fluorescence in situ hybridization, and reverse transcription-polymerase chain reaction for the detection of anaplastic lymphoma kinase gene rearrangements in patients with non-small cell lung cancer: potential advantages and methodologic pitfalls. Arch Pathol Lab Med. 2014;138(6):794–802.
-
(2014)
Arch Pathol Lab Med
, vol.138
, Issue.6
, pp. 794-802
-
-
Demidova, I.1
Barinov, A.2
Savelov, N.3
-
23
-
-
84903777245
-
Clinical characteristics and outcomes of patients with primary lung adenocarcinoma harboring ALK rearrangements detected by FISH, IHC, and RT-PCR
-
Wang J, Cai Y, Dong Y, et al. Clinical characteristics and outcomes of patients with primary lung adenocarcinoma harboring ALK rearrangements detected by FISH, IHC, and RT-PCR. PLoS One. 2014;9(7):e101551.
-
(2014)
Plos One
, vol.9
, Issue.7
-
-
Wang, J.1
Cai, Y.2
Dong, Y.3
-
24
-
-
77649091118
-
A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry
-
Mino-Kenudson M, Chirieac LR, Law K, et al. A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry. Clin Cancer Res. 2010;16(5):1561–1571.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.5
, pp. 1561-1571
-
-
Mino-Kenudson, M.1
Chirieac, L.R.2
Law, K.3
-
25
-
-
84876482049
-
ALK status testing in non-small cell lung carcinoma: Correlation between ultrasensitive IHC and FISH
-
Minca EC, Portier BP, Wang Z, et al. ALK status testing in non-small cell lung carcinoma: correlation between ultrasensitive IHC and FISH. J Mol Diagn. 2013;15(3):341–346.
-
(2013)
J Mol Diagn
, vol.15
, Issue.3
, pp. 341-346
-
-
Minca, E.C.1
Portier, B.P.2
Wang, Z.3
-
26
-
-
84899477450
-
An international interpretation study using the ALK IHC antibody D5F3 and a sensitive detection kit demonstrates high concordance between ALK IHC and ALK FISH and between evaluators
-
Wynes MW, Sholl LM, Dietel M, et al. An international interpretation study using the ALK IHC antibody D5F3 and a sensitive detection kit demonstrates high concordance between ALK IHC and ALK FISH and between evaluators. J Thorac Oncol. 2014;9(5):631–638.
-
(2014)
J Thorac Oncol
, vol.9
, Issue.5
, pp. 631-638
-
-
Wynes, M.W.1
Sholl, L.M.2
Dietel, M.3
-
27
-
-
84929420095
-
-
Available from, Accessed November 24, 2014. [NLM identifier: NCT02042105
-
Guangdong Association of Clinical Trials. A Prospective Epidemiologic Study of ALK-Positive NSCLC in China (C-TALK); 2014. Available from: http://clinicaltrial.gov/ct2/show/NCT02042105. Accessed November 24, 2014. [NLM identifier: NCT02042105].
-
(2014)
A Prospective Epidemiologic Study of Alk-Positive NSCLC in China (C-TALK)
-
-
-
28
-
-
84864231379
-
Comparison of reverse transcription-polymerase chain reaction, immunohistochemistry, and fluorescence in situ hybridization methodologies for detection of echinoderm microtubule-associated proteinlike 4-anaplastic lymphoma kinase fusion-positive non-small cell lung carcinoma: Implications for optimal clinical testing
-
Wallander ML, Geiersbach KB, Tripp SR, Layfield LJ. Comparison of reverse transcription-polymerase chain reaction, immunohistochemistry, and fluorescence in situ hybridization methodologies for detection of echinoderm microtubule-associated proteinlike 4-anaplastic lymphoma kinase fusion-positive non-small cell lung carcinoma: implications for optimal clinical testing. Arch Pathol Lab Med. 2012;136(7):796–803.
-
(2012)
Arch Pathol Lab Med
, vol.136
, Issue.7
, pp. 796-803
-
-
Wallander, M.L.1
Geiersbach, K.B.2
Tripp, S.R.3
Layfield, L.J.4
-
29
-
-
84880776583
-
ALK-rearranged lung cancer in Chinese: A comprehensive assessment of clinicopathology, IHC, FISH and RT-PCR
-
Li Y, Pan Y, Wang R, et al. ALK-rearranged lung cancer in Chinese: a comprehensive assessment of clinicopathology, IHC, FISH and RT-PCR. PLoS One. 2013;8(7):e69016.
-
(2013)
Plos One
, vol.8
, Issue.7
, pp. e69016
-
-
Li, Y.1
Pan, Y.2
Wang, R.3
-
30
-
-
84881339295
-
Comparison of IHC, FISH and RT-PCR methods for detection of ALK rearrangements in 312 non-small cell lung cancer patients in Taiwan
-
Wu YC, Chang IC, Wang CL, et al. Comparison of IHC, FISH and RT-PCR methods for detection of ALK rearrangements in 312 non-small cell lung cancer patients in Taiwan. PLoS One. 2013;8(8):e70839.
-
(2013)
Plos One
, vol.8
, Issue.8
, pp. e70839
-
-
Wu, Y.C.1
Chang, I.C.2
Wang, C.L.3
-
31
-
-
84878576680
-
Evaluation of ALK rearrangement in Chinese non-small cell lung cancer using FISH, immunohistochemistry, and real-time quantitative RT-PCR on paraffin-embedded tissues
-
Zhang YG, Jin ML, Li L, et al. Evaluation of ALK rearrangement in Chinese non-small cell lung cancer using FISH, immunohistochemistry, and real-time quantitative RT-PCR on paraffin-embedded tissues. PLoS One. 2013;8(5):e64821.
-
(2013)
Plos One
, vol.8
, Issue.5
, pp. e64821
-
-
Zhang, Y.G.1
Jin, M.L.2
Li, L.3
-
32
-
-
84866934606
-
Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: Updated results from a phase 1 study
-
Camidge DR, Bang YJ, Kwak EL, et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol. 2012;13(10):1011–1019.
-
(2012)
Lancet Oncol
, vol.13
, Issue.10
, pp. 1011-1019
-
-
Camidge, D.R.1
Bang, Y.J.2
Kwak, E.L.3
-
33
-
-
84929394209
-
Overall survival in patients with advanced non-small cell lung cancer harboring concomitant EGFR mutations and ALK rearrangements: A cohort study
-
abstre19010
-
Shaw AT, Yeap BY, Solomon BJ, et al. Overall survival in patients with advanced non-small cell lung cancer harboring concomitant EGFR mutations and ALK rearrangements: A cohort study. J Clin Oncol. 2014;32(suppl):abstre19010.
-
(2014)
J Clin Oncol
, vol.32
-
-
Shaw, A.T.1
Yeap, B.Y.2
Solomon, B.J.3
-
35
-
-
0042854722
-
A crucial role for the anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster
-
Loren CE, Englund C, Grabbe C, Hallberg B, Hunter T, Palmer RH. A crucial role for the anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster. EMBO Rep. 2003;4(8):781–786.
-
(2003)
EMBO Rep
, vol.4
, Issue.8
, pp. 781-786
-
-
Loren, C.E.1
Englund, C.2
Grabbe, C.3
Hallberg, B.4
Hunter, T.5
Palmer, R.H.6
-
36
-
-
33847389237
-
Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila
-
Bazigou E, Apitz H, Johansson J, et al. Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila. Cell. 2007;128(5):961–975.
-
(2007)
Cell
, vol.128
, Issue.5
, pp. 961-975
-
-
Bazigou, E.1
Apitz, H.2
Johansson, J.3
-
38
-
-
80054728915
-
Phase 2 data for crizotinib (PF-02341066) in ALK-positive advanced non-small cell lung cancer (NSCLC): Profile 1005
-
Frampton JE. Phase 2 data for crizotinib (PF-02341066) in ALK-positive advanced non-small cell lung cancer (NSCLC): profile 1005. J Thorac Oncol. 2011;6(suppl 2):S411.
-
(2011)
J Thorac Oncol
, vol.6
, pp. S411
-
-
Frampton, J.E.1
-
39
-
-
84908205686
-
Crizotinib therapy for patients with advanced ROS1-rearranged non-small cell lung cancer (NSCLC)
-
Ou S-HI, Kim D-W, Camidge DR, et al. Crizotinib therapy for patients with advanced ROS1-rearranged non-small cell lung cancer (NSCLC). J Thorac Oncol. 2013;8(suppl 2):S295.
-
(2013)
J Thorac Oncol
, vol.8
, pp. S295
-
-
Ou, S.-H.1
Kim, D.-W.2
Camidge, D.R.3
-
40
-
-
84929399959
-
Efficacy and safety of crizotinib in patients with advanced c-MET-amplified non-small cell lung cancer (NSCLC)
-
abstr8001
-
Cao Y, Xiao G, Qiu X, Ye S, Lin T. Efficacy and safety of crizotinib in patients with advanced c-MET-amplified non-small cell lung cancer (NSCLC). J Clin Oncol. 2014;32(suppl):abstr8001.
-
(2014)
J Clin Oncol
, vol.32
-
-
Cao, Y.1
Xiao, G.2
Qiu, X.3
Ye, S.4
Lin, T.5
-
41
-
-
84869404688
-
Clinical presentation of hepatotoxicity-associated crizotinib in ALK-positive (ALK+) advanced non-small cell lung cancer (NSCLC)
-
abstr7598
-
Schnell P, Safferman AZ, Bartlett CH, Tang Y, Wilner KD. Clinical presentation of hepatotoxicity-associated crizotinib in ALK-positive (ALK+) advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2012;30(suppl):abstr7598.
-
(2012)
J Clin Oncol
, vol.30
-
-
Schnell, P.1
Safferman, A.Z.2
Bartlett, C.H.3
Tang, Y.4
Wilner, K.D.5
-
42
-
-
84929414056
-
Exploratory subgroup analysis of crizotinib efficacy and safety in Asian and non-Asian patients with advanced ALK-positive non-small cell lung cancer (NSCLC) enrolled in a global phase II study
-
Hida T, Shi Y, Ahn M-J, et al. Exploratory subgroup analysis of crizotinib efficacy and safety in Asian and non-Asian patients with advanced ALK-positive non-small cell lung cancer (NSCLC) enrolled in a global phase II study. J Thorac Oncol. 2012;7(suppl):5.
-
(2012)
J Thorac Oncol
, vol.7
, pp. 5
-
-
Hida, T.1
Shi, Y.2
Ahn, M.-J.3
-
43
-
-
84930687446
-
Characterization of heart rate (HR) changes during crizotinib treatment: A retrospective analysis of 1,053 ALK+ NSCLC patients
-
abstre13065
-
Ou S-HI, Tang Y, Polli A, Wilner KD, Schnell P. Characterization of heart rate (HR) changes during crizotinib treatment: a retrospective analysis of 1,053 ALK+ NSCLC patients. J Clin Oncol. 2014;32(suppl):abstre13065.
-
(2014)
J Clin Oncol
, vol.32
-
-
Ou, S.-H.1
Tang, Y.2
Polli, A.3
Wilner, K.D.4
Schnell, P.5
-
44
-
-
84856990335
-
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
-
Doebele RC, Pilling AB, Aisner DL, et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res. 2012;18(5):1472–1482.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.5
, pp. 1472-1482
-
-
Doebele, R.C.1
Pilling, A.B.2
Aisner, D.L.3
-
45
-
-
84856999699
-
Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers
-
120ra117
-
Katayama R, Shaw AT, Khan TM, et al. Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers. Sci Transl Med. 2012;4(120):120ra117.
-
(2012)
Sci Transl Med
, vol.4
, Issue.120
-
-
Katayama, R.1
Shaw, A.T.2
Khan, T.M.3
-
46
-
-
84896957081
-
Ceritinib in ALK-rearranged non-small-cell lung cancer
-
Shaw AT, Kim DW, Mehra R, et al. Ceritinib in ALK-rearranged non-small-cell lung cancer. N Engl J Med. 2014;370(13):1189–1197.
-
(2014)
N Engl J Med
, vol.370
, Issue.13
, pp. 1189-1197
-
-
Shaw, A.T.1
Kim, D.W.2
Mehra, R.3
-
47
-
-
84923775088
-
Antitumor activity of alectinib (CH5424802/RO5424802) for ALK-rearranged NSCLC with or without prior crizotinib treatment in bioequivalence study
-
abstr8103
-
Nakagawa K, Hida T, Seto T, et al. Antitumor activity of alectinib (CH5424802/RO5424802) for ALK-rearranged NSCLC with or without prior crizotinib treatment in bioequivalence study. J Clin Oncol. 2014;32(suppl):abstr8103.
-
(2014)
J Clin Oncol
, vol.32
-
-
Nakagawa, K.1
Hida, T.2
Seto, T.3
-
48
-
-
84911917752
-
Updated efficacy and safety of the ALK inhibitor AP26113 in patients (Pts) with advanced malignancies, including ALK+ non-small cell lung cancer (NSCLC)
-
abstr8047
-
Gettinger SN, Bazhenova L, Salgia R, et al. Updated efficacy and safety of the ALK inhibitor AP26113 in patients (pts) with advanced malignancies, including ALK+ non-small cell lung cancer (NSCLC). J Clin Oncol. 2014;32(suppl):abstr8047.
-
(2014)
J Clin Oncol
, vol.32
-
-
Gettinger, S.N.1
Bazhenova, L.2
Salgia, R.3
-
49
-
-
84929412492
-
Clinical benefit of continuing crizotinib beyond initial disease progression in patients with advanced ALK-positive non-small cell lung cancer
-
Ou SH, Jänne PA, Bartlett CH, et al. Clinical benefit of continuing crizotinib beyond initial disease progression in patients with advanced ALK-positive non-small cell lung cancer. J Thorac Oncol. 2013;8(suppl 2):S294.
-
(2013)
J Thorac Oncol
, vol.8
, pp. S294
-
-
Ou, S.H.1
Jänne, P.A.2
Bartlett, C.H.3
-
50
-
-
0028198206
-
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin’s lymphoma
-
Morris SW, Kirstein MN, Valentine MB, et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin’s lymphoma. Science. 1994;263(5151):1281–1284.
-
(1994)
Science
, vol.263
, Issue.5151
, pp. 1281-1284
-
-
Morris, S.W.1
Kirstein, M.N.2
Valentine, M.B.3
-
51
-
-
0033564831
-
Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors
-
Griffin CA, Hawkins AL, Dvorak C, Henkle C, Ellingham T, Perlman EJ. Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. Cancer Res. 1999;59(12):2776–2780.
-
(1999)
Cancer Res
, vol.59
, Issue.12
, pp. 2776-2780
-
-
Griffin, C.A.1
Hawkins, A.L.2
Dvorak, C.3
Henkle, C.4
Ellingham, T.5
Perlman, E.J.6
-
52
-
-
0141705307
-
ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma
-
De Paepe P, Baens M, van Krieken H, et al. ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma. Blood. 2003;102(7):2638–2641.
-
(2003)
Blood
, vol.102
, Issue.7
, pp. 2638-2641
-
-
De Paepe, P.1
Baens, M.2
Van Krieken, H.3
-
53
-
-
33845419068
-
Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer
-
Jazii FR, Najafi Z, Malekzadeh R, et al. Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer. World J Gastroenterol. 2006;12(44):7104–7112.
-
(2006)
World J Gastroenterol
, vol.12
, Issue.44
, pp. 7104-7112
-
-
Jazii, F.R.1
Najafi, Z.2
Malekzadeh, R.3
-
54
-
-
79952192916
-
Renal cell carcinoma with novel VCL-ALK fusion: New representative of ALK-associated tumor spectrum
-
Debelenko LV, Raimondi SC, Daw N, et al. Renal cell carcinoma with novel VCL-ALK fusion: new representative of ALK-associated tumor spectrum. Mod Pathol. 2011;24(3):430–442.
-
(2011)
Mod Pathol
, vol.24
, Issue.3
, pp. 430-442
-
-
Debelenko, L.V.1
Raimondi, S.C.2
Daw, N.3
-
55
-
-
70349510460
-
Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers
-
Lin E, Li L, Guan Y, et al. Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers. Mol Cancer Res. 2009;7(9):1466–1476.
-
(2009)
Mol Cancer Res
, vol.7
, Issue.9
, pp. 1466-1476
-
-
Lin, E.1
Li, L.2
Guan, Y.3
-
56
-
-
84866322989
-
ALKoma: A cancer subtype with a shared target
-
Mano H. ALKoma: A cancer subtype with a shared target. Cancer Discov. 2012;2(6):495–502.
-
(2012)
Cancer Discov
, vol.2
, Issue.6
, pp. 495-502
-
-
Mano, H.1
-
57
-
-
78049428879
-
Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor
-
Butrynski JE, D’Adamo DR, Hornick JL, et al. Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor. N Engl J Med. 2010;363(18):1727–1733.
-
(2010)
N Engl J Med
, vol.363
, Issue.18
, pp. 1727-1733
-
-
Butrynski, J.E.1
D’Adamo, D.R.2
Hornick, J.L.3
-
59
-
-
36849065315
-
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
-
Rikova K, Guo A, Zeng Q, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007;131(6):1190–1203.
-
(2007)
Cell
, vol.131
, Issue.6
, pp. 1190-1203
-
-
Rikova, K.1
Guo, A.2
Zeng, Q.3
-
60
-
-
84865089246
-
Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: Identification of a FIG-ROS1 fusion
-
Rimkunas VM, Crosby KE, Li D, et al. Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: Identification of a FIG-ROS1 fusion. Clin Cancer Res. 2012;18(16):4449–4457.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.16
, pp. 4449-4457
-
-
Rimkunas, V.M.1
Crosby, K.E.2
Li, D.3
-
61
-
-
84899471648
-
ALK, ROS1 and RET fusions in 1139 lung adenocarcinomas: A comprehensive study of common and fusion pattern-specific clinicopathologic, histologic and cytologic features
-
Pan Y, Zhang Y, Li Y, et al. ALK, ROS1 and RET fusions in 1139 lung adenocarcinomas: A comprehensive study of common and fusion pattern-specific clinicopathologic, histologic and cytologic features. Lung Cancer. 2014;84(2):121–126.
-
(2014)
Lung Cancer
, vol.84
, Issue.2
, pp. 121-126
-
-
Pan, Y.1
Zhang, Y.2
Li, Y.3
-
62
-
-
84929420099
-
ROS1 rearrangements and copy number alterations in NSCLC patients: High frequency of ROS1 deletions
-
iv566
-
Clavé S, Gimeno J, De Muga S, et al. ROS1 rearrangements and copy number alterations in NSCLC patients: High frequency of ROS1 deletions. Ann Oncol. 2014;25(suppl 4):iv566.
-
(2014)
Ann Oncol
, vol.25
-
-
Clavé, S.1
Gimeno, J.2
De Muga, S.3
-
63
-
-
84886545743
-
Clinicopathologic analysis of ROS1-rearranged non-small-cell lung cancer and proposal of a diagnostic algorithm
-
Go H, Kim DW, Kim D, et al. Clinicopathologic analysis of ROS1-rearranged non-small-cell lung cancer and proposal of a diagnostic algorithm. J Thorac Oncol. 2013;8(11):1445–1450.
-
(2013)
J Thorac Oncol
, vol.8
, Issue.11
, pp. 1445-1450
-
-
Go, H.1
Kim, D.W.2
Kim, D.3
-
64
-
-
84908019201
-
Detection of ROS1 translocations in triple-negative lung adenocarcinomas
-
abstr8099
-
Mescam-Mancini L, Lantuéjoul S, Moro-Sibilot D, et al. Detection of ROS1 translocations in triple-negative lung adenocarcinomas. J Clin Oncol. 2013;31(suppl):abstr8099.
-
(2013)
J Clin Oncol
, vol.31
-
-
Mescam-Mancini, L.1
Lantuéjoul, S.2
Moro-Sibilot, D.3
-
65
-
-
84911372597
-
Crizotinib in ROS1-rearranged non-small-cell lung cancer
-
Shaw AT, Ou SH, Bang YJ, et al. Crizotinib in ROS1-rearranged non-small-cell lung cancer. N Engl J Med. 2014;371(21):1963–1971.
-
(2014)
N Engl J Med
, vol.371
, Issue.21
, pp. 1963-1971
-
-
Shaw, A.T.1
Ou, S.H.2
Bang, Y.J.3
-
66
-
-
84975496208
-
Targeting de novo cMET overexpression in advanced non-small cell lung cancer
-
iv68
-
Li A, Yang J, Zhang X, Zhou Q, Wu Y. Targeting de novo cMET overexpression in advanced non-small cell lung cancer. Ann Oncol. 2014;25(suppl 4):iv68.
-
(2014)
Ann Oncol
, vol.25
-
-
Li, A.1
Yang, J.2
Zhang, X.3
Zhou, Q.4
Wu, Y.5
-
67
-
-
84929407119
-
Targeting the MET pathway for potential treatment of NSCLC
-
Li A, Gao HF, Wu YL. Targeting the MET pathway for potential treatment of NSCLC. Expert Opin Ther Targets. 2014;23:1–12.
-
(2014)
Expert Opin Ther Targets
, vol.23
, pp. 1-12
-
-
Li, A.1
Gao, H.F.2
Wu, Y.L.3
-
68
-
-
84929395082
-
De novo MET overexpression coexisting with oncogenic drivers in advanced non-small cell lung cancer
-
iv462
-
Lou NN, Yang J, Zhang X, Chen H, Wu Y. De novo MET overexpression coexisting with oncogenic drivers in advanced non-small cell lung cancer. Ann Oncol. 2014;25(suppl 4):iv462.
-
(2014)
Ann Oncol
, vol.25
-
-
Lou, N.N.1
Yang, J.2
Zhang, X.3
Chen, H.4
Wu, Y.5
-
69
-
-
84895814426
-
Lung cancers with concomitant EGFR mutations and ALK rearrangements: Diverse responses to EGFR-TKI and crizotinib in relation to diverse receptors phosphorylation
-
Yang JJ, Zhang XC, Su J, et al. Lung cancers with concomitant EGFR mutations and ALK rearrangements: Diverse responses to EGFR-TKI and crizotinib in relation to diverse receptors phosphorylation. Clin Cancer Res. 2014;20(5):1383–1392.
-
(2014)
Clin Cancer Res
, vol.20
, Issue.5
, pp. 1383-1392
-
-
Yang, J.J.1
Zhang, X.C.2
Su, J.3
-
70
-
-
84891738696
-
Dual ALK and EGFR inhibition targets a mechanism of acquired resistance to the tyrosine kinase inhibitor crizotinib in ALK rearranged lung cancer
-
Yamaguchi N, Lucena-Araujo AR, Nakayama S, et al. Dual ALK and EGFR inhibition targets a mechanism of acquired resistance to the tyrosine kinase inhibitor crizotinib in ALK rearranged lung cancer. Lung Cancer. 2014;83(1):37–43.
-
(2014)
Lung Cancer
, vol.83
, Issue.1
, pp. 37-43
-
-
Yamaguchi, N.1
Lucena-Araujo, A.R.2
Nakayama, S.3
-
71
-
-
84871087595
-
Clinical modes of EGFR tyrosine kinase inhibitor failure and subsequent management in advanced non-small cell lung cancer
-
Yang JJ, Chen HJ, Yan HH, et al. Clinical modes of EGFR tyrosine kinase inhibitor failure and subsequent management in advanced non-small cell lung cancer. Lung Cancer. 2013;79(1):33–39.
-
(2013)
Lung Cancer
, vol.79
, Issue.1
, pp. 33-39
-
-
Yang, J.J.1
Chen, H.J.2
Yan, H.H.3
-
72
-
-
84929420100
-
MET overexpression as a promising therapeutic target in non-small cell lung cancer with acquired resistance to EGFR TKIs
-
abstract 19047
-
Landi L, Minuti G, D’Incecco A, Cappuzzo F. MET overexpression as a promising therapeutic target in non-small cell lung cancer with acquired resistance to EGFR TKIs. J Clin Oncol. 2014;32(suppl):abstract 19047.
-
(2014)
J Clin Oncol
, vol.32
-
-
Landi, L.1
Minuti, G.2
D’Incecco, A.3
Cappuzzo, F.4
-
73
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007;316(5827):1039–1043.
-
(2007)
Science
, vol.316
, Issue.5827
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
-
74
-
-
84878355043
-
Phase I trial of irreversible pan-ERBB inhibitor dacomitinib (DAC) in combination with ALK/MET inhibitor crizotinib (CRIZ) in previously treated advanced non-small cell lung cancer (NSCLC)
-
ix423
-
Janne PA, Shaw AT, Giaccone G, et al. Phase I trial of irreversible pan-ERBB inhibitor dacomitinib (DAC) in combination with ALK/MET inhibitor crizotinib (CRIZ) in previously treated advanced non-small cell lung cancer (NSCLC). Ann Oncol. 2012;23(suppl 9):ix423.
-
(2012)
Ann Oncol
, vol.23
-
-
Janne, P.A.1
Shaw, A.T.2
Giaccone, G.3
-
75
-
-
84929420101
-
Targeting c-MET overexpression for acquired resistance to EGFR TKIs
-
iv450
-
Gou L, Wu Y, Yang J, Zhang X. Targeting c-MET overexpression for acquired resistance to EGFR TKIs. Ann Oncol. 2014;25(suppl 4):iv450.
-
(2014)
Ann Oncol
, vol.25
-
-
Gou, L.1
Wu, Y.2
Yang, J.3
Zhang, X.4
|