Reduction in maternal circulating ouabain impairs offspring growth and kidney development

Journal of the American Society of Nephrology

Volumn 26, Issue 5, 2015, Pages 1103-1114

  Dvela Levitt, Moran ^a,b   Cohen Ben Ami, Hagit ^a,b   Rosen, Haim ^a,b   Ornoy, Asher ^a,b   Hochner Celnikier, Drorith ^a   Granat, Menachem ^a   Lichtstein, David ^a,b  

^a HEBREW UNIVERSITY   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CASPASE 3; CYCLIN D1; CYCLINE; GROWTH FACTOR; KI 67 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OUABAIN; PROTEIN BAX; PROTEIN KINASE B; PROTEIN P 90RSK; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIOMEGALY; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HORMONE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY DEVELOPMENT; LIVER DEVELOPMENT; MOUSE; NEPHRON; NEWBORN; NONHUMAN; PLACENTA; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; RAT; RISK ASSESSMENT; SIGNAL TRANSDUCTION; SMALL FOR DATE INFANT; TUNEL ASSAY; ANIMAL; BLOOD; BODY WEIGHT; CELL SURVIVAL; EMBRYOLOGY; GROWTH, DEVELOPMENT AND AGING; INSTITUTE FOR CANCER RESEARCH MOUSE; KIDNEY; METABOLISM; ORGAN SIZE; PREGNANCY;

ANIMALS; BODY WEIGHT; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; HUMANS; INFANT, NEWBORN; INFANT, SMALL FOR GESTATIONAL AGE; KIDNEY; MICE, INBRED ICR; ORGAN SIZE; OUABAIN; PREGNANCY;

EID: 84929379191     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2014020130     Document Type: Article

References (37)

1. Bagrov AY, Shapiro JI, Fedorova OV: Endogenous cardiotonic steroids: Physiology, pharmacology, and novel therapeutic targets. Pharmacol Rev 61: 9-38, 2009
2. Blaustein MP, Zhang J, Chen L, Song H, Raina H, Kinsey SP, Izuka M, Iwamoto T, Kotlikoff MI, Lingrel JB, Philipson KD, Wier WG, Hamlyn JM: The pump, the exchanger, and endogenous ouabain: Signaling mechanisms that link salt retention to hypertension. Hypertension 53: 291-298, 2009
3. Blanco G, Mercer RW: Isozymes of the Na-K-ATPase: Heterogeneity in structure, diversity in function. Am J Physiol 275: F633-F650, 1998
4. Kaplan JH: Biochemistry of Na,K-aATPase. Annu Rev Biochem 71: 511-535, 2002
5. Lichtstein D, Steinitz M, Gati I, Samuelov S, Deutsch J, Orly J: Biosynthesis of digitalis-like compounds in rat adrenal cells: Hydroxycholesterol as possible precursor. Life Sci 62: 2109-2126, 1998
6. Shah JR, Laredo J, Hamilton BP, Hamlyn JM: Different signaling pathways mediate stimulated secretions of endogenous ouabain and aldosterone from bovine adrenocortical cells. Hypertension 31: 463-468, 1998
7. Silva E, Soares-da-Silva P: New insights into the regulation of Na+, K+-ATPase by ouabain. Int Rev Cell Mol Biol 294: 99-132, 2012
8. Liu J, Xie ZJ: The sodium pump and cardiotonic steroids-induced signal transduction protein kinases and calcium-signaling microdomain in regulation of transporter trafficking. Biochim Biophys Acta 1802: 1237-1245, 2010
9. Xie Z, Askari A: Na(+)/K(+)-ATPase as a signal transducer. Eur J Biochem 269: 2434-2439, 2002
10. Schoner W, Scheiner-Bobis G: Endogenous and exogenous cardiac glycosides: Their roles in hypertension, salt metabolism, and cell growth. Am J Physiol Cell Physiol 293: C509-C536, 2007
11. Nguyen AN, Wallace DP, Blanco G: Ouabain binds with high affinity to the Na,K-ATPase in human polycystic kidney cells and induces extracellular signal-regulated kinase activation and cell proliferation. J Am Soc Nephrol 18: 46-57, 2007
12. Kulikov A, Eva A, Kirch U, Boldyrev A, Scheiner-Bobis G: Ouabain activates signaling pathways associated with cell death in human neuroblastoma. Biochim Biophys Acta 1768: 1691-1702, 2007
13. Dvela M, Rosen H, Ben-Ami HC, Lichtstein D: Endogenous ouabain regulates cell viability. Am J Physiol Cell Physiol 302: C442-C452, 2012
14. Li J, Khodus GR, Kruusmägi M, Kamali-Zare P, Liu XL, Eklöf AC, Zelenin S, Brismar H, Aperia A: Ouabain protects against adverse developmental programming of the kidney. Nat Commun 1: 42, 2010
15. Jacobs BE, Liu Y, Pulina MV, Golovina VA, Hamlyn JM: Normal pregnancy: Mechanisms underlying the paradox of a ouabain-resistant state with elevated endogenous ouabain, suppressed arterial sodium calcium exchange, and low blood pressure. Am J Physiol Heart Circ Physiol 302: H1317-H1329, 2012
16. Féliers D, Frank MA, Riley DJ: Activation of cyclin D1-Cdk4 and Cdk4-directed phosphorylation of RB protein in diabetic mesangial hypertrophy. Diabetes 51: 3290-3299, 2002
17. Shankland SJ, Wolf G: Cell cycle regulatory proteins in renal disease: Role in hypertrophy, proliferation, and apoptosis. Am J Physiol Renal Physiol 278: F515-F529, 2000
18. Huang H, Wang H, Lu Y: [Antisense to cyclin D1 inhibits the proliferation of glomerular mesangial cells]. Zhonghua Yi Xue Za Zhi (Taipei) 78: 293-295, 1998
19. Lucas TF, Amaral LS, Porto CS, Quintas LE: Na+/K+-ATPase α1 isoform mediates ouabain-induced expression of cyclin D1 and proliferation of rat sertoli cells. Reproduction 144: 737-745, 2012
20. Romeo Y, Zhang X, Roux PP: Regulation and function of the RSK family of protein kinases. Biochem J 441: 553-569, 2012
21. Vakkuri O, Arnason SS, Pouta A, Vuolteenaho O, Leppäluoto J: Radioimmunoassay of plasma ouabain in healthy and pregnant individuals. J Endocrinol 165: 669-677, 2000
22. Kanaka-Gantenbein C, Mastorakos G, Chrousos GP: Endocrine-related causes and consequences of intrauterine growth retardation. Ann N Y Acad Sci 997: 150-157, 2003
23. Langley-Evans SC, Welham SJ, Jackson AA: Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat. Life Sci 64: 965-974, 1999
24. Brennan KA, Olson DM, Symonds ME: Maternal nutrient restriction alters renal development and blood pressure regulation of the offspring. Proc Nutr Soc 65: 116-124, 2006
25. Woods LL, Weeks DA, Rasch R: Programming of adult blood pressure by maternal protein restriction: Role of nephrogenesis. Kidney Int 65: 1339-1348, 2004
26. Pham TD, MacLennan NK, Chiu CT, Laksana GS, Hsu JL, Lane RH: Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney. Am J Physiol Regul Integr Comp Physiol 285: R962-R970, 2003
27. Rumballe BA, Georgas KM, Combes AN, Ju AL, Gilbert T, Little MH: Nephron formation adopts a novel spatial topology at cessation of nephrogenesis. Dev Biol 360: 110-122, 2011
28. Hughson M, Farris AB 3rd, Douglas-Denton R, Hoy WE, Bertram JF: Glomerular number and size in autopsy kidneys: The relationship to birth weight. Kidney Int 63: 2113-2122, 2003
29. Ma J, Esplin MS, Adair CD, Mason LA, Graves SW: Increasing evidence for and regulation of a human placental endogenous digitalis-like factor. Reprod Sci 19: 437-448, 2012
30. Oshiro N, Dostanic-Larson I, Neumann JC, Lingrel JB: The ouabain-binding site of the α2 isoform of Na,K-ATPase plays a role in blood pressure regulation during pregnancy. Am J Hypertens 23: 1279-1285, 2010
31. Kaiser N, Sasson S, Feener EP, Boukobza-Vardi N, Higashi S, Moller DE, Davidheiser S, Przybylski RJ, King GL: Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells. Diabetes 42: 80-89, 1993
32. Epstein H, Rabinovich L, Banai S, Elazar V, Gao J, Chorny M, Danenebrg HD, Golomb G: Predicting in vivo efficacy of potential restenosis therapies by cell culture studies: Species-dependent susceptibility of vascular smooth muscle cells. Open Cardiovasc Med J 2: 60-69, 2008
33. Hansen MB, Nielsen SE, Berg K: Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 119: 203-210, 1989
34. Akimova OA, Mongin AA, Hamet P, Orlov SN: The rapid decline of MTT reduction is not a marker of death signaling in ouabain-treated cells. Cell Mol Biol (Noisy-le-grand) 52: 71-77, 2006
35. Muscogiuri G, Chavez AO, Gastaldelli A, Perego L, Tripathy D, Saad MJ, Velloso L, Folli F: The crosstalk between insulin and renin-angiotensin-aldosterone signaling systems and its effect on glucose metabolism and diabetes prevention. Curr Vasc Pharmacol 6: 301-312, 2008
36. Lichtstein D, Steinitz M, Gati I, Samuelov S, Deutsch J, Orly J: Bufodienolides as endogenous Na+, K+-ATPase inhibitors: Biosynthesis in bovine and rat adrenals. Clin Exp Hypertens 20: 573-579, 1998
37. Masugi F, Ogihara T, Hasegawa T, Tomii A, Nagano M, Higashimori K, Kumahara K, Terano Y: Circulating factor with ouabain-like immunoreactivity in patients with primary aldosteronism. Biochem Biophys Res Commun 135: 41-45, 1986