Deletion of protein tyrosine phosphatase 1B (PTP1B) enhances endothelial cyclooxygenase 2 expression and protects mice from type 1 diabetes-induced endothelial dysfunction

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Herre, David J ^a   Norman, J Blake ^a   Anderson, Ruchi ^a   Tremblay, Michel L ^b   Huby, Anne Cecile ^a   De Chantemèle, Eric J Belin ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CYCLOOXYGENASE 2; GLUCOSE; INDOMETACIN; INSULIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PROSTACYCLIN; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE 1B; STREPTOZOCIN; TRIACYLGLYCEROL; TYROSINE KINASE RECEPTOR; CYCLOOXYGENASE 2 INHIBITOR; GLUCOSE BLOOD LEVEL; PTPN1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL REACTIVITY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN DEPENDENT DIABETES MELLITUS INDUCED ENDOTHELIAL DYSFUNCTION; INSULIN RELEASE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION; WILD TYPE; ANALYSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; AORTA; BAGG ALBINO MOUSE; BLOOD; CELL CULTURE; CHEMICALLY INDUCED; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHENOTYPE; RNA INTERFERENCE;

MUS;

ANIMALS; AORTA; BLOOD GLUCOSE; CELLS, CULTURED; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIAL CELLS; EPOPROSTENOL; HUMANS; INDOMETHACIN; INSULIN; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PHENOTYPE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RNA INTERFERENCE; STREPTOZOCIN;

EID: 84929353124     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0126866     Document Type: Article

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