Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

Molecular and Cellular Biology

Volumn 23, Issue 1, 2003, Pages 186-194

  Hsieh, James J D ^a   Ernst, Patricia ^a   Erdjument Bromage, Hediye ^b   Tempst, Paul ^b   Korsmeyer, Stanley J ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; MIXED LINEAGE LEUKEMIA PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHROMOSOME 11Q; CHROMOSOME TRANSLOCATION; COMPLEX FORMATION; DROSOPHILA; GENE EXPRESSION; HOX GENE; HUMAN; HUMAN CELL; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SEQUENCE HOMOLOGY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CELL NUCLEUS STRUCTURES; CELLS, CULTURED; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; HUMANS; MUTATION; MYELOID-LYMPHOID LEUKEMIA PROTEIN; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENES; RECOMBINANT PROTEINS; TRANSCRIPTION FACTORS;

DROSOPHILA TRITHORAX;

EID: 0037215399     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.1.186-194.2003     Document Type: Article

References (36)

1. Armstrong, S. A., J. E. Staunton, L. B. Silverman, R. Pieters, M. L. den Boer, M. D. Minden, S. E. Sallan, E. S. Lander, T. R. Golub, and S. J. Korsmeyer. 2002. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat. Genet. 30:41-47.
2. Ayton, P. M., and M. L. Cleary. 2001. Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene 20:5695-5707.
3. Breen, T. R., and P. J. Harte. 1993. Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each. Development 117:119-134.
4. Butler, L. H., R. Slany, X. Cui, M. L. Cleary, and D. Y. Mason. 1997. The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures. Blood 89:3361-3370.
5. Caslini, C., A. Shilatifard, L. Yang, and J. L. Hess. 2000. The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation. Proc. Natl. Acad. Sci. USA 97:2797-2802.
6. Cheng, E. H., M. C. Wei, S. Weiler, R. A. Flavell, T. W. Mak, T. Lindsten, and S. J. Korsmeyer. 2001. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol. Cell 8:705-711.
7. Corral, J., I. Lavenir, H. Impey, A. J. Warren, A. Forster, T. A. Larson, S. Bell, A. N. McKenzie, G. King, and T. H. Rabbitts. 1996. An MII-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes. Cell 85:853-861.
8. Cross, S. H., R. R. Meehan, X. Nan, and A. Bird. 1997. A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins. Nat. Genet. 16:256-259.
9. Cui, X., I. De Vivo, R. Slany, A. Miyamoto, R. Firestein, and M. L. Cleary. 1998. Association of SET domain and myotubularin-related proteins modulates growth control. Nat. Genet. 18:331-337.
10. Dobson, C. L., A. J. Warren, R. Pannell, A. Forster, and T. H. Rabbitts. 2000. Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene. EMBO J. 19:843-851.
11. Domer, P. H., S. S. Fakharzadeh, C. S. Chen, J. Jockel, L. Johansen, G. A. Silverman, J. H. Kersey, and S. J. Korsmeyer. 1993. Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. Proc. Natl. Acad. Sci. USA 90:7884-7888.
12. Downing, J. R., and A. T. Look. 1996. MLL fusion genes in the 11q23 acute leukemias. Cancer Treat. Res. 84:73-92.
13. Ernst, P., J. Wang, M. Huang, R. H. Goodman, and S. J. Korsmeyer. 2001. MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Mol. Cell. Biol. 21:2249-2258.
14. Fair, K., M. Anderson, E. Bulanova, H. Mi, M. Tropschug, and M. O. Diaz. 2001. Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells, Mol. Cell. Biol. 21:3589-3597.
15. Gu, Y., T. Nakamura, H. Alder, R. Prasad, O. Canaani, G. Cimino, C. M. Croce, and E. Canaani. 1992. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71:701-708.
16. Hanson, R. D., J. L. Hess, B. D. Yu, P. Ernst, M. van Lohuizen, A. Berns, N. M. van der Lugt, C. S. Shashikant, F. H. Ruddle, M. Seto, and S. J. Korsmeyer. 1999. Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proc. Natl. Acad. Sci. USA 96:14372-14377.
17. Katsani, K. R., J. J. Arredondo, A. J. Kal, and C. P. Verrijzer. 2001. A homeotic mutation in the trithorax SET domain impedes histone binding. Genes Dev. 15:2197-2202.
18. Krumlauf, R. 1994. Hox genes in vertebrate development. Cell 78:191-201.
19. Kuzin, B., S. Tillib, Y. Sedkov, L. Mizrokhi, and A. Mazo. 1994. The Drosophila trithorax gene encodes a chromosomal protein and directly regulates the region-specific homeotic gene fork head. Genes Dev. 8:2478-2490.
20. Mazo, A. M., D. H. Huang, B. A. Mozer, and I. B. Dawid. 1990. The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains. Proc. Natl. Acad. Sci. USA 87:2112-2116.
21. Pirrotta, V. 1998. Polycombing the genome: PcG, trxG, and chromatin silencing. Cell 93:333-336.
22. Prasad, R., T. Yano, C. Sorio, T. Nakamura, R. Rallapalli, Y. Gu, D. Leshkowitz, C. M. Croce, and E. Canaani. 1995. Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia. Proc. Natl. Acad. Sci. USA 92:12160-12164.
23. Prasad, R., A. B. Zhadanov, Y. Sedkov, F. Bullrich, T. Druck, R. Rallapalli, T. Yano, H. Alder, C. M. Croce, K. Huebner, A. Mazo, and E. Canaani. 1997. Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax. Oncogene 15:549-560.
24. Rogaia, D., F. Grignani, R. Carbone, D. Riganelli, F. LoCoco, T. Nakamura, C. M. Croce, P. P. Di Fiore, and P. G. Pelieci. 1997. The localization of the HRX/ALL1 protein to specific nuclear subdomains is altered by fusion with its eps15 translocation partner. Cancer Res. 57:799-802.
25. Rozovskaia, T., O. Rozenblatt-Rosen, Y. Sedkov, D. Burakov, T. Yano, T. Nakamura, S. Petruck, L. Ben-Simchon, C. M. Croce, A. Mazo, and E. Canaani. 2000. Self-association of the SET domains of human ALL-1 and of Drosophila TRITHORAX and ASH1 proteins. Oncogene 19:351-357.
26. Schumacher, A., and T. Magnuson. 1997. Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends Genet. 13:167-170.
27. Sedkov, Y., J. J. Benes, J. R. Berger, K. M. Riker, S. Tillib, R. S. Jones, and A. Mazo. 1999. Molecular genetic analysis of the Drosophila trithorax-related gene which encodes a novel SET domain protein. Mech. Dev. 82:171-179.
28. Sedkov, Y., S. Tillib, L. Mizrokhi, and A. Mazo. 1994. The bithorax complex is regulated by trithorax earlier during Drosophila embryogenesis than is the Antennapedia complex, correlating with a bithorax-like expression pattern of distinct early trithorax transcripts. Development 120:1907-1917.
29. Tan, Y. C., and V. T. Chow. 2001. Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects. Cancer Detect. Prev. 25:454-469.
30. Thirman, M. J., H. J. Gill, R. C. Burnett, D. Mbangkollo, N. R. McCabe, H. Kobayashi, S. Ziemin-van der Poel, Y. Kaneko, R. Morgan, A. A. Sandberg, et al. 1993. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. N. Engl. J. Med. 329:909-914.
31. Tkachuk, D. C., S. Kohler, and M. L. Cleary. 1992. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 71:691-700.
32. Yano, T., T. Nakamura, J. Blechman, C. Sorio, C. V. Dang, B. Geiger, and E. Canaani. 1997. Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein. Proc. Natl. Acad. Sci. USA 94:7286-7291.
33. Yeoh, E. J., M. E. Ross, S. A. Shurtleff, W. K. Williams, D. Patel, R. Mahfouz, F. G. Behm, S. C. Raimondi, M. V. Relling, A. Patel, C. Cheng, D. Campana, D. Wilkins, X. Zhou, J. Li, H. Liu, C. H. Pui, W. E. Evans, C. Naeve, L. Wong, and J. R. Downing. 2002. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 1:133-143.
34. Yu, B. D., R. D. Hanson, J. L. Hess, S. E. Horning, and S. J. Korsmeyer. 1998. MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis. Proc. Natl. Acad. Sci. USA 95:10632-10636.
35. Yu, B. D., J. L. Hess, S. E. Horning, G. A. Brown, and S. J. Korsmeyer. 1995. Altered Hox expression and segmental identity in Mll-mutant mice. Nature 378:505-508.
36. Zeleznik-Le, N. J., A. M. Harden, and J. D. Rowley. 1994. 11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene. Proc. Natl. Acad. Sci. USA 91:10610-10614.