Developmentally stable whole-brain volume reductions and developmentally sensitive caudate and putamen volume alterations in those with attention-deficit/hyperactivity disorder and their unaffected siblings

JAMA Psychiatry

Volumn 72, Issue 5, 2015, Pages 490-499

  Greven, Corina U ^a,b,c   Bralten, Janita ^a,d   Mennes, Maarten ^a   O'Dwyer, Laurence ^a   Van Hulzen, Kimm J E ^d   Rommelse, Nanda ^a,b   Schweren, Lizanne J S ^e   Hoekstra, Pieter J ^e   Hartman, Catharina A ^e   Heslenfeld, Dirk ^f   Oosterlaan, Jaap ^f   Faraone, Stephen V ^g   Franke, Barbara ^a,d   Zwiers, Marcel P ^a   Arias Vasquez, Alejandro ^a,d   Buitelaar, Jan K ^a,b  

^a RADBOUD UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f VU UNIVERSITY AMSTERDAM   (Netherlands)

^g SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; ATTENTION DEFICIT DISORDER; BRAIN DEVELOPMENT; BRAIN SIZE; BRAIN STEM; CAUDATE NUCLEUS; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; GLOBUS PALLIDUS; GRAY MATTER; HIPPOCAMPUS; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; PUTAMEN; SIBLING; THALAMUS; WHITE MATTER; ADOLESCENT; ADOLESCENT DEVELOPMENT; AGE; AMYGDALOID NUCLEUS; ANATOMY AND HISTOLOGY; BRAIN; CHILD DEVELOPMENT; NUCLEUS ACCUMBENS; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; PSYCHOLOGY; RISK FACTOR; YOUNG ADULT;

ADOLESCENT; ADOLESCENT DEVELOPMENT; ADULT; AGE FACTORS; AMYGDALA; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BRAIN; BRAIN STEM; CAUDATE NUCLEUS; CHILD; CHILD DEVELOPMENT; CROSS-SECTIONAL STUDIES; FEMALE; GLOBUS PALLIDUS; GRAY MATTER; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; NUCLEUS ACCUMBENS; ORGAN SIZE; PUTAMEN; RISK FACTORS; SIBLINGS; THALAMUS; WHITE MATTER; YOUNG ADULT;

EID: 84929340297     PISSN: 2168622X     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapsychiatry.2014.3162     Document Type: Article

References (56)

1. Polanczyk G, Rohde LA. Epidemiology of attention-deficit/hyperactivity disorder across the lifespan. Curr Opin Psychiatry. 2007;20(4):386-392.
2. Castellanos FX, Lee PP, Sharp W, et al. Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. JAMA. 2002;288(14):1740-1748.
3. Castellanos FX, Giedd JN, Marsh WL, et al. Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder. Arch Gen Psychiatry. 1996;53(7):607-616.
4. Durston S, Hulshoff Pol HE, Schnack HG, et al. Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblings. J Am Acad Child Adolesc Psychiatry. 2004;43(3):332-340.
5. Valera EM, Faraone SV, Murray KE, Seidman LJ. Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder. Biol Psychiatry. 2007;61(12):1361-1369.
6. Ellison-Wright I, Ellison-Wright Z, Bullmore E. Structural brain change in attention deficit hyperactivity disorder identified by meta-analysis. BMC Psychiatry. 2008;8(51):51.
7. Nakao T, Radua J, Rubia K, Mataix-Cols D. Gray matter volume abnormalities in ADHD: voxel-based meta-analysis exploring the effects of age and stimulant medication. Am J Psychiatry. 2011;168(11):1154-1163.
8. Frodl T, Skokauskas N. Meta-analysis of structural MRI studies in children and adults with attention deficit hyperactivity disorder indicates treatment effects. Acta Psychiatr Scand. 2012;125(2):114-126.
9. Halperin JM, Schulz KP. Revisiting the role of the prefrontal cortex in the pathophysiology of attention-deficit/hyperactivity disorder. Psychol Bull. 2006;132(4):560-581.
10. Biederman J, Mick E, Faraone SV. Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type. Am J Psychiatry. 2000;157(5):816-818.
11. Greven CU, Asherson P, Rijsdijk FV, Plomin R. A longitudinal twin study on the association between inattentive and hyperactive-impulsive ADHD symptoms. J Abnorm Child Psychol. 2011;39(5):623-632.
12. Larsson H, Lichtenstein P, Larsson JO. Genetic contributions to the development of ADHD subtypes from childhood to adolescence. J Am Acad Child Adolesc Psychiatry. 2006;45(8):973-981.
13. Greven CU, Rijsdijk FV, Plomin R. A twin study of ADHD symptoms in early adolescence: hyperactivity-impulsivity and inattentiveness show substantial genetic overlap but also genetic specificity. J Abnorm Child Psychol. 2011;39(2):265-275.
14. Onnink AM, Zwiers MP, Hoogman M, et al. Brain alterations in adult ADHD: effects of gender, treatment and comorbid depression. Eur Neuropsychopharmacol. 2014;24(3):397-409.
15. Levy F, Hay DA, Bennett KS. Genetics of attention deficit hyperactivity disorder: a current review and future prospects. Int J Disabil Dev Educ. 2006;53(1):5-20.
16. Faraone SV, Biederman J, Mick E, et al. Family study of girls with attention deficit hyperactivity disorder. Am J Psychiatry. 2000;157(7):1077-1083.
17. Sprich S, Biederman J, Crawford MH, Mundy E, Faraone SV. Adoptive and biological families of children and adolescents with ADHD. J Am Acad Child Adolesc Psychiatry. 2000;39(11):1432-1437.
18. Faraone SV, Mick E. Molecular genetics of attention deficit hyperactivity disorder. Psychiatr Clin North Am. 2010;33(1):159-180.
19. Peper JS, Brouwer RM, Boomsma DI, Kahn RS, Hulshoff Pol HE. Genetic influences on human brain structure: a review of brain imaging studies in twins. Hum Brain Mapp. 2007;28(6):464-473.
20. den Braber A, Bohlken MM, Brouwer RM, et al. Heritability of subcortical brain measures: a perspective for future genome-wide association studies. Neuroimage. 2013;83:98-102.
21. Pironti VA, Lai MC, Müller U, et al. Neuroanatomical abnormalities and cognitive impairments are shared by adults with attention-deficit/hyperactivity disorder and their unaffected first-degree relatives. Biol Psychiatry. 2014;76(8):639-647.
22. von Rhein D, Mennes M, van Ewijk H, et al. The NeuroIMAGE Study: a prospective phenotypic, cognitive, genetic and MRI study in children with attention-deficit/hyperactivity disorder: design and descriptives [published online July 11, 2014]. Eur Child Adolesc Psychiatry.
23. Müller UC, Asherson P, Banaschewski T, et al. The impact of study design and diagnostic approach in a large multi-centre ADHD study, part 1: ADHD symptom patterns. BMC Psychiatry. 2011;11(54):54.
24. Müller UC, Asherson P, Banaschewski T, et al. The impact of study design and diagnostic approach in a large multi-centre ADHD study, part 2: dimensional measures of psychopathology and intelligence. BMC Psychiatry. 2011;11(55):55.
25. Nijmeijer JS, Hoekstra PJ, Minderaa RB, et al. PDD symptoms in ADHD: an independent familial trait? J Abnorm Child Psychol. 2009;37(3):443-453.
26. Rommelse NN, Altink ME, Martin NC, et al. Neuropsychological measures probably facilitate heritability research of ADHD. Arch Clin Neuropsychol. 2008;23(5):579-591.
27. Conners CK, Sitarenios G, Parker JD, Epstein JN. The revised Conners' Parent Rating Scale (CPRS-R): factor structure, reliability, and criterion validity. J Abnorm Child Psychol. 1998;26(4):257-268.
28. Blumenthal JD, Zijdenbos A, Molloy E, Giedd JN. Motion artifact inmagnetic resonance imaging: implications for automated analysis. Neuroimage. 2002;16(1):89-92.
29. Patenaude B, Smith SM, Kennedy DN, Jenkinson M. A Bayesian model of shape and appearance for subcortical brain segmentation. Neuroimage. 2011;56(3):907-922.
30. Brain Development Cooperative Group. Total and regional brain volumes in a population-based normative sample from 4 to 18 years: the NIH MRI Study of Normal Brain Development. Cereb Cortex. 2012;22(1):1-12.
31. Reiss AL, Abrams MT, Singer HS, Ross JL, Denckla MB. Brain development, gender and IQ in children: a volumetric imaging study. Brain. 1996;119(pt 5):1763-1774.
32. Mechelli A, Price CJ, Friston KJ, Ashburner J. Voxel-based morphometry of the human brain: methods and applications. Curr Med Imaging Rev. 2005;1(2):105-113.
33. Bradley RA, Srivastava SS. Correlation in polynomial regression. Am Stat. 1979;33(1):11-14. doi:10.2307/2683059.
34. StataCorp. Stata Statistical Software: Release 10. College Station, TX: StataCorp; 2007.
35. Williams RL. A note on robust variance estimation for cluster-correlated data. Biometrics. 2000;56(2):645-646.
36. Li J, Ji L. Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity (Edinb). 2005;95(3):221-227.
37. Kwan KY, Sestan N, Anton ES. Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex. Development. 2012;139(9):1535-1546.
38. Kuan CY, Roth KA, Flavell RA, Rakic P. Mechanisms of programmed cell death in the developing brain. Trends Neurosci. 2000;23(7):291-297.
39. Poelmans G, Pauls DL, Buitelaar JK, Franke B. Integrated genome-wide association study findings: identification of a neurodevelopmental network for attention deficit hyperactivity disorder. Am J Psychiatry. 2011;168(4):365-377.
40. Franke B, Neale BM, Faraone SV. Genome-wide association studies in ADHD. Hum Genet. 2009;126(1):13-50.
41. Hoogman M, Rijpkema M, Janss L, et al. Current self-reported symptoms of attention deficit/hyperactivity disorder are associated with total brain volume in healthy adults. PLoS One. 2012;7(2):e31273.
42. Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci. 1986;9:357-381.
43. Ring HA, Serra-Mestres J. Neuropsychiatry of the basal ganglia. J Neurol Neurosurg Psychiatry. 2002;72(1):12-21.
44. Goddings AL, Mills KL, Clasen LS, Giedd JN, Viner RM, Blakemore SJ. The influence of puberty on subcortical brain development. Neuroimage. 2014;88:242-251.
45. Qiu A, Crocetti D, Adler M, et al. Basal ganglia volume and shape in children with attention deficit hyperactivity disorder. Am J Psychiatry. 2009;166(1):74-82.
46. Sobel LJ, Bansal R, Maia TV, et al. Basal ganglia surface morphology and the effects of stimulant medications in youth with attention deficit hyperactivity disorder. Am J Psychiatry. 2010;167(8):977-986.
47. Almeida Montes LG, Ricardo-Garcell J, Barajas De La Torre LB, et al. Clinical correlations of grey matter reductions in the caudate nucleus of adults with attention deficit hyperactivity disorder. J Psychiatry Neurosci. 2010;35(4):238-246.
48. Seidman LJ, Biederman J, Liang L, et al. Gray matter alterations in adults with attention-deficit/hyperactivity disorder identified by voxel based morphometry. Biol Psychiatry. 2011;69(9):857-866.
49. Ahrendts J, Rüsch N, Wilke M, et al. Visual cortex abnormalities in adults with ADHD: a structural MRI study. World J Biol Psychiatry. 2011;12(4):260-270.
50. Depue BE, Burgess GC, Bidwell LC, Willcutt EG, Banich MT. Behavioral performance predicts grey matter reductions in the right inferior frontal gyrus in young adults with combined type ADHD. Psychiatry Res. 2010;182(3):231-237.
51. Seidman LJ, Valera EM, Makris N, et al. Dorsolateral prefrontal and anterior cingulate cortex volumetric abnormalities in adults with attention-deficit/hyperactivity disorder identified by magnetic resonance imaging. Biol Psychiatry. 2006;60(10):1071-1080.
52. Shaw P, De Rossi P, Watson B, et al. Mapping the development of the basal ganglia in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2014;53(7):780-789.e11.
53. Faraone SV, Perlis RH, Doyle AE, et al. Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;57(11):1313-1323.
54. Dennis M, Francis DJ, Cirino PT, Schachar R, Barnes MA, Fletcher JM. Why IQ is not a covariate in cognitive studies of neurodevelopmental disorders. J Int Neuropsychol Soc. 2009;15(3):331-343.
55. Rommelse NN, Altink ME, Oosterlaan J, Buschgens CJ, Buitelaar J, Sergeant JA. Support for an independent familial segregation of executive and intelligence endophenotypes in ADHD families. Psychol Med. 2008;38(11):1595-1606.
56. Spencer TJ, Brown A, Seidman LJ, et al. Effect of psychostimulants on brain structure and function in ADHD: a qualitative literature review of magnetic resonance imaging-based neuroimaging studies. J Clin Psychiatry. 2013;74(9):902-917.