Proliferation index: A continuous model to predict prognosis in patients with tumours of the Ewing's sarcoma family

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Brownhill, Samantha ^a   Cohen, Dena ^a   Burchill, Sue ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 10; CASPASE 8; CASPASE 9; KI 67 ANTIGEN;

APOPTOTIC INDEX; ARTICLE; CANCER FAMILY; CANCER LOCALIZATION; CANCER MORTALITY; CANCER PROGNOSIS; CANCER SIZE; CELL PROLIFERATION; CONTROLLED STUDY; EWING SARCOMA; HIGH RISK POPULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; METASTASIS; NICK END LABELING; ONCOLOGICAL PARAMETERS; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PELVIS TUMOR; PROLIFERATION INDEX; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RECURRENCE FREE SURVIVAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL TIME; APOPTOSIS; BIOLOGICAL MODEL; BONE; BONE NEOPLASMS; MULTIVARIATE ANALYSIS; NEOPLASM RECURRENCE, LOCAL; PATHOLOGY; PROGNOSIS; SARCOMA, EWING; STATISTICAL MODEL; SURVIVAL;

APOPTOSIS; BONE AND BONES; BONE NEOPLASMS; CASPASE 10; CASPASE 8; CASPASE 9; CELL PROLIFERATION; HUMANS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; MULTIVARIATE ANALYSIS; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; SARCOMA, EWING; SURVIVAL ANALYSIS;

EID: 84929291687     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0104106     Document Type: Article

References (56)

1. Burchill SA (2003) Ewing's sarcoma: diagnostic, prognostic, and therapeutic implications of molecular abnormalities. Journal of clinical pathology 56: 96-102.
2. Terrier P, Llombart-Bosch A, Contesso G (1996) Small round blue cell tumors in bone: prognostic factors correlated to Ewing's sarcoma and neuroectodermal tumors. Semin Diagn Pathol 13: 250-257. (Pubitemid 26282691)
3. Ahrens S, Hoffmann C, Jabar S, Braun-Munzinger G, Paulussen M, et al. (1999) Evaluation of prognostic factors in a tumor volume-adapted treatment strategy for localized Ewing sarcoma of bone: the CESS 86 experience. Cooperative Ewing Sarcoma Study. Med Pediatr Oncol 32: 186-195. (Pubitemid 29095978)
4. Craft AW, Cotterill SJ, Bullimore JA, Pearson D (1997) Long-term results from the first UKCCSG Ewing's Tumour Study (ET-1). United Kingdom Children's Cancer Study Group (UKCCSG) and the Medical Research Council Bone Sarcoma Working Party. Eur J Cancer 33: 1061-1069.
5. Nesbit ME, Jr., Gehan EA, Burgert EO, Jr., Vietti TJ, Cangir A, et al. (1990) Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: a long-term follow-up of the First Intergroup study. J Clin Oncol 8: 1664-1674. (Pubitemid 20334321)
6. Sinicrope FA, Hart J, Hsu HA, Lemoine M, Michelassi F, et al. (1999) Apoptotic and mitotic indices predict survival rates in lymph node-negative colon carcinomas. Clin Cancer Res 5: 1793-1804. (Pubitemid 29334461)
7. Rioux-Leclercq N, Turlin B, Bansard J, Patard J, Manunta A, et al. (2000) Value of immunohistochemical Ki-67 and p53 determinations as predictive factors of outcome in renal cell carcinoma. Urology 55: 501-505. (Pubitemid 30157952)
8. Gasinska A, Urbanski K, Gruchala A, Biesaga B, Kojs Z (2002) A ratio of apoptosis to mitosis, proliferation pattern and prediction of radiotherapy response in cervical carcinoma. Neoplasma 49: 379-386. (Pubitemid 36139238)
9. Mejia C, Navarro S, Pellin A, Ruiz A, Castel V, et al. (2003) Prognostic significance of cell proliferation in human neuroblastoma: comparison with other prognostic factors. Oncol Rep 10: 243-247.
10. Lopez-Beltran A, Luque RJ, Alvarez-Kindelan J, Quintero A, Merlo F, et al. (2004) Prognostic factors in stage T1 grade 3 bladder cancer survival: the role of G1-S modulators (p53, p21Waf1, p27kip1, Cyclin D1, and Cyclin D3) and proliferation index (ki67-MIB1). Eur Urol 45: 606-612. (Pubitemid 38481688)
11. Ali HR, Dawson SJ, Blows FM, Provenzano E, Leung S, et al. (2012) A Ki67/BCL2 index based on immunohistochemistry is highly prognostic in ER-positive breast cancer. The Journal of pathology 226: 97-107.
12. Ibrahim T, Farolfi A, Scarpi E, Mercatali L, Medri L, et al. (2012) Hormonal Receptor, Human Epidermal Growth Factor Receptor-2, and Ki67 Discordance between Primary Breast Cancer and Paired Metastases: Clinical Impact. Oncology 84: 150-157.
13. van Diest PJ, van der Wall E, Baak JP (2004) Prognostic value of proliferation in invasive breast cancer: a review. J Clin Pathol 57: 675-681.
14. Amir G, Issakov J, Meller I, Sucher E, Peyser A, et al. (2002) Expression of p53 gene product and cell proliferation marker Ki-67 in Ewing's sarcoma: correlation with clinical outcome. Hum Pathol 33: 170-174. (Pubitemid 34298731)
15. Lopez-Guerrero JA, Machado I, Scotlandi K, Noguera R, Pellin A, et al. (2011) Clinicopathological significance of cell cycle regulation markers in a large series of genetically confirmed Ewing's sarcoma family of tumors. International journal of cancer Journal international du cancer 128: 1139-1150.
16. Sollazzo MR, Benassi MS, Magagnoli G, Gamberi G, Molendini L, et al. (1999) Increased c-myc oncogene expression in Ewing's sarcoma: correlation with Ki67 proliferation index. Tumori 85: 167-173. (Pubitemid 29350103)
17. Wu X, Cai ZD, Lou LM, Zhu YB (2012) Expressions of p53, c-MYC, BCL-2 and apoptotic index in human osteosarcoma and their correlations with prognosis of patients. Cancer epidemiology 36: 212-216.
18. Jia Y, Dong B, Tang L, Liu Y, Du H, et al. (2012) Apoptosis index correlates with chemotherapy efficacy and predicts the survival of patients with gastric cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 33: 1151-1158.
19. Yamasaki F, Tokunaga O, Sugimori H (1997) Apoptotic index in ovarian carcinoma: correlation with clinicopathologic factors and prognosis. Gynecol Oncol 66: 439-448. (Pubitemid 27388137)
20. Tannapfel A, Hahn HA, Katalinic A, Fietkau RJ, Kuhn R, et al. (1997) Incidence of apoptosis, cell proliferation and P53 expression in renal cell carcinomas. Anticancer Res 17: 1155-1162. (Pubitemid 27182915)
21. Stammler G, Sauerbrey A, Zintl F, Volm M (1997) Apoptotic index, Fas and bcl-2 in initial and relapsed childhood acute lymphoblastic leukaemia. Apoptosis 2: 377-383. (Pubitemid 127504721)
22. Bendardaf R, Ristamaki R, Kujari H, Laine J, Lamlum H, et al. (2003) Apoptotic index and bcl-2 expression as prognostic factors in colorectal carcinoma. Oncology 64: 435-442. (Pubitemid 36682959)
23. Leung TW, Xue WC, Cheung AN, Khoo US, Ngan HY (2004) Proliferation to apoptosis ratio as a prognostic marker in adenocarcinoma of uterine cervix. Gynecol Oncol 92: 866-872. (Pubitemid 38251390)
24. Pingoud-Meier C, Lang D, Janss AJ, Rorke LB, Phillips PC, et al. (2003) Loss of caspase-8 protein expression correlates with unfavorable survival outcome in childhood medulloblastoma. Clin Cancer Res 9: 6401-6409. (Pubitemid 38031826)
25. Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, et al. (2000) Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med 6: 529-535. (Pubitemid 30305902)
26. Yang Q, Kiernan CM, Tian Y, Salwen HR, Chlenski A, et al. (2007) Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome. Clin Cancer Res 13: 3191-3197. (Pubitemid 46944901)
27. Fulda S, Poremba C, Berwanger B, Hacker S, Eilers M, et al. (2006) Loss of caspase-8 expression does not correlate with MYCN amplification, aggressive disease, or prognosis in neuroblastoma. Cancer Res 66: 10016-10023. (Pubitemid 44672054)
28. Kaseta MK, Gomatos IP, Khaldi L, Tzagarakis GP, Alevizos L, et al. (2007) Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma. Hybridoma (Larchmt) 26: 355-362.
29. Andressakis D, Lazaris AC, Tsiambas E, Kavantzas N, Rapidis A, et al. (2008) Evaluation of caspase-3 and caspase-8 deregulation in tongue squamous cell carcinoma, based on immunohistochemistry and computerised image analysis. J Laryngol Otol 122: 1213-1218.
30. Takita J, Yang HW, Bessho F, Hanada R, Yamamoto K, et al. (2000) Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma. Med Pediatr Oncol 35: 541-543.
31. Harada K, Toyooka S, Shivapurkar N, Maitra A, Reddy JL, et al. (2002) Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. Cancer Res 62: 5897-5901. (Pubitemid 35204751)
32. de Hooge AS, Berghuis D, Santos SJ, Mooiman E, Romeo S, et al. (2007) Expression of cellular FLICE inhibitory protein, caspase-8, and protease inhibitor-9 in Ewing sarcoma and implications for susceptibility to cytotoxic pathways. Clin Cancer Res 13: 206-214. (Pubitemid 46121870)
33. Lissat A, Vraetz T, Tsokos M, Klein R, Braun M, et al. (2007) Interferon-gamma sensitizes resistant Ewing's sarcoma cells to tumor necrosis factor apoptosis-inducing ligand-induced apoptosis by up-regulation of caspase-8 without altering chemosensitivity. Am J Pathol 170: 1917-1930. (Pubitemid 47339266)
34. Santon A, Garcia-Cosio M, Cristobal E, Pascual A, Muriel A, et al. (2011) Expression of heat shock proteins in classical Hodgkin lymphoma: correlation with apoptotic pathways and prognostic significance. Histopathology 58: 1072-1080.
35. Strater J, Herter I, Merkel G, Hinz U, Weitz J, et al. (2010) Expression and prognostic significance of APAF-1, caspase-8 and caspase-9 in stage II/III colon carcinoma: caspase-8 and caspase-9 is associated with poor prognosis. Int J Cancer 127: 873-880.
36. Liu LX, Liu ZH, Jiang HC, Qu X, Zhang WH, et al. (2002) Profiling of differentially expressed genes in human gastric carcinoma by cDNA expression array. World J Gastroenterol 8: 580-585. (Pubitemid 34918645)
37. Xu B, Zhou ZG, Li Y, Wang L, Yang L, et al. (2008) Clinicopathological significance of caspase-8 and caspase-10 expression in rectal cancer. Oncology 74: 229-236.
38. Shen XG, Wang C, Li Y, Zhou B, Xu B, et al. (2011) Downregulation of caspase-10 predicting poor survival after resection of stage II colorectal cancer. International journal of colorectal disease 26: 1519-1524.
39. Dalal S, Berry AM, Cullinane CJ, Mangham DC, Grimer R, et al. (2005) Vascular endothelial growth factor: a therapeutic target for tumors of the Ewing's sarcoma family. Clinical cancer research : an official journal of the American Association for Cancer Research 11: 2364-2378.
40. Rosito P, Mancini AF, Rondelli R, Abate ME, Pession A, et al. (1999) Italian Cooperative Study for the treatment of children and young adults with localized Ewing sarcoma of bone: a preliminary report of 6 years of experience. Cancer 86: 421-428. (Pubitemid 29347404)
41. Bacci G, Ferrari S, Bertoni F, Rimondini S, Longhi A, et al. (2000) Prognostic factors in nonmetastatic Ewing's sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli. J Clin Oncol 18: 4-11. (Pubitemid 30036330)
42. Royston P, Sauerbrei W (2004) A new approach to modelling interactions between treatment and continuous covariates in clinical trials by using fractional polynomials. Statistics in medicine 23: 2509-2525. (Pubitemid 39149264)
43. Tang LH, Gonen M, Hedvat C, Modlin IM, Klimstra DS (2012) Objective quantification of the Ki67 proliferative index in neuroendocrine tumors of the gastroenteropancreatic system: a comparison of digital image analysis with manual methods. The American journal of surgical pathology 36: 1761-1770.
44. Davis DW, Buchholz TA, Hess KR, Sahin AA, Valero V, et al. (2003) Automated quantification of apoptosis after neoadjuvant chemotherapy for breast cancer: early assessment predicts clinical response. Clin Cancer Res 9: 955-960. (Pubitemid 36323697)
45. Stearns V, Singh B, Tsangaris T, Crawford JG, Novielli A, et al. (2003) A prospective randomized pilot study to evaluate predictors of response in serial core biopsies to single agent neoadjuvant doxorubicin or paclitaxel for patients with locally advanced breast cancer. Clin Cancer Res 9: 124-133. (Pubitemid 36109724)
46. Duan WR, Garner DS, Williams SD, Funckes-Shippy CL, Spath IS, et al. (2003) Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with the TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts. J Pathol 199: 221-228. (Pubitemid 36176028)
47. Gown AM, Willingham MC (2002) Improved detection of apoptotic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved caspase 3. J Histochem Cytochem 50: 449-454. (Pubitemid 34250583)
48. Oudejans JJ, Harijadi A, Cillessen SA, Busson P, Tan IB, et al. (2005) Absence of caspase 3 activation in neoplastic cells of nasopharyngeal carcinoma biopsies predicts rapid fatal outcome. Mod Pathol 18: 877-885. (Pubitemid 41059946)
49. Kobayashi T, Masumoto J, Tada T, Nomiyama T, Hongo K, et al. (2007) Prognostic significance of the immunohistochemical staining of cleaved caspase-3, an activated form of caspase-3, in gliomas. Clin Cancer Res 13: 3868-3874. (Pubitemid 47037593)
50. McStay GP, Salvesen GS, Green DR (2008) Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways. Cell Death Differ 15: 322-331.
51. Ashkenazi A (2008) Directing cancer cells to self-destruct with pro-apoptotic receptor agonists. Nat Rev Drug Discov 7: 1001-1012.
52. Debatin KM, Krammer PH (2004) Death receptors in chemotherapy and cancer. Oncogene 23: 2950-2966.
53. Van Valen F, Fulda S, Truckenbrod B, Eckervogt V, Sonnemann J, et al. (2000) Apoptotic responsiveness of the Ewing's sarcoma family of tumours to tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). International journal of cancer Journal international du cancer 88: 252-259.
54. van Valen F, Harrer H, Hotfilder M, Dirksen U, Pap T, et al. (2012) A Novel Role of IGF1 in Apo2L/TRAIL-Mediated Apoptosis of Ewing Tumor Cells. Sarcoma 2012: 782970.
55. White DE, Burchill SA (2010) Fenretinide-dependent upregulation of death receptors through ASK1 and p38alpha enhances death receptor ligand-induced cell death in Ewing's sarcoma family of tumours. Br J Cancer.
56. Martinez R, Setien F, Voelter C, Casado S, Quesada MP, et al. (2007) CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme. Carcinogenesis 28:1264-1268. (Pubitemid 47062686)