Proliferation to apoptosis ratio as a prognostic marker in adenocarcinoma of uterine cervix

Gynecologic Oncology

Volumn 92, Issue 3, 2004, Pages 866-872

  Leung, Tsin Wah ^a   Xue, Wei Cheng ^a   Cheung, Annie N Y ^a   Khoo, Ui Soon ^a   Ngan, Hextan Y S ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Adenocarcinoma; AIS; MI AI ratio

Indexed keywords

DNA NUCLEOTIDYLEXOTRANSFERASE; EOSIN; HEMATOXYLIN; KI 67 ANTIGEN;

ADULT; AGED; APOPTOSIS; ARTICLE; CARCINOMA IN SITU; CELL PROLIFERATION; CELL STRUCTURE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; MITOSIS INDEX; MULTIVARIATE ANALYSIS; NICK END LABELING; PRIORITY JOURNAL; PROGNOSIS; STAINING; STATISTICAL SIGNIFICANCE; UTERINE CERVIX CARCINOMA; UTERINE ENDOCERVIX;

EID: 1342300677     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ygyno.2003.11.051     Document Type: Article

References (33)

1. Evan G.I., Brown L., Whyte M., Harrington E. Apoptosis and the cell cycle. Curr. Opin. Cell Biol. 7:1995;825-834.
2. Sheets E.E., Yeh J. The role of apoptosis in gynecological malignancies. Ann. Med. 29:1997;121-126.
3. Kerr J.F.R., Winterford C.M., Harmon B.V. Apoptosis: its significance in cancer and cancer therapy. Cancer. 73:1994;2013-2023.
4. Staunton M.J., Gaffney E.F. Tumor type is a determinant of susceptibility to apoptosis. Am. J. Clin. Pathol. 103:1995;300-307.
5. Langlois N.E., Lamb J., Eremin O., Heys S.D. Apoptosis in colorectal carcinoma occurring in patients aged 45 years and under: relationship to prognosis, mitosis, and immunohistochemical demonstration of p53, c-myc and bcl-2 protein products. J. Pathol. 182:1997;392-397.
6. Yamasaki F., Tokunaga O., Sugimori H. Apoptotic index in ovarian carcinoma: correlation with clinicopathologic factors and prognosis. Gynecol. Oncol. 66:1997;439-448.
7. Biscotti C.V., Hart W.R. Apoptotic bodies: a consistent morphologic feature of endocervical adenocarcinoma in situ. Am. J. Surg. Pathol. 22:1998;434-439.
8. Tsang R.W., Wong C.S., Fyles A.W., Levin W., Manchul L.A., Milosevic M. et al. Tumor proliferation and apoptosis in human uterine cervix carcinoma II: correlations with clinical outcome. Radiother. Oncol. 50:1999;93-101.
9. Lipponen P.K., Aaltomaa S. Apoptosis in bladder cancer as related to standard prognostic factors and prognosis. J. Pathol. 173:1994;333-339.
10. Vesalainen S., Lipponen P., Talja M., Syrjanen K. Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis in prostatic adenocarcinoma. Eur. J. Cancer. 30A:1994;1797-1803.
11. Dubray B., Breton C., Delic J., Klijanienko J., Maciorowski Z., Vielh P.et al. In vitro radiation-induced apoptosis and early response to low-dose radiotherapy in non-Hodgkin's lymphomas. Radiother. Oncol. 46:1998;185-191.
12. Parazzini F., La Vecchia C. Epidemiology of adenocarcinoma of cervix. Gynecol. Oncol. 39:1990;40-46.
13. Hopkins M.P., Morley G.W. A comparison of adenocarcinoma and squamous cell carcinoma of the cervix. Obstet. Gynecol. 77:1991;912-917.
14. Korhonen M.O. Adenocarcinoma of the uterine cervix: prognosis and prognostic significance of histology. Cancer. 53:1984;1760-1763.
15. Wright T.C. Precancerous lesions of the cervix. Kurman R.J. Blaustein's Pathology of the Female Genital Tract. fourth ed. 1994;229-277 Springer-Verlag, New York.
16. Griffin N.R., Wells M. Premalignant and malignant glandular lesions of the cervix. Fox H. Haines and Taylor obstetrical and gynecological pathology. fourth ed. 1995;323-343 Churchill Livingstone, New York.
17. Heller D.S. Malignant diseases of the cervix. Heller D.S. The lower female genital tract - A clinicopathologic approach. first ed. 1998;223-270 Williams and Wilkins, Baltimore.
18. Creasman W.T. New gynecologic cancer staging. Gynecol. Oncol. 58:1995;157-158.
19. Hall P.A., Levison D.A. Review: assessment of cell proliferation in histological material. J. Clin. Pathol. 43:1990;184-192.
20. Quinn C.M., Wright N.A. Review: the usefulness of clinical measurement of cell proliferation in gynaecological cancer. Int. J. Gyn. Pathol. 11:1992;131-143.
21. Wong S.Y.Y., Ngan H.Y.S., Chan C.C.W., Cheung A.N.Y. Apoptosis in gestational trophoblastic disease-correlated with clinical outcome and bcl-2 expression but not bax expression. Mod. Pathol. 12:1999;1025-1033.
22. Soini Y., Paakko P., Lehto V.P. Histopathological evaluation of apoptosis in cancer. Am. J. Pathol. 153:1998;1041-1053.
23. Lehr H.A., Hansen D.A., Kussick S., Li M., Hwang H., Krummenauer F.et al. Assessment of proliferative activity in breast cancer: MIB-1 immunohistochemistry versus mitotic figure count. Hum. Pathol. 30:1999;1314-1320.
24. Kihara S., Nehlsen Cannarella N., Kirsch W.M., Chase D., Garvin A.J. A comparative study of apoptosis and cell proliferation in infantile and adult fibrosarcomas. Am. J. Clin. Pathol. 106:1996;493-497.
25. Levine E.L., Renehan A., Gossiel R., Davidson S.E., Roberts S.A., Chadwick C.et al. Apoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma. Radiother. Oncol. 37:1995;1-9.
26. Gasinska A., Urbanski K., Gruchala A., Biesaga B., Kojs Z. A ratio of apoptosis to mitosis, proliferation pattern and prediction of radiotherapy response in cervical carcinoma. Neoplasma. 49(6):2002;379-386.
27. Liu S.S., Tsang B.K., Cheung A.N., Xue W.C., Cheng D.K., Ng T.Y.et al. Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma. Eur. J. Cancer. 37(9):2001;1104-1110.
28. Kim J.Y., Cho H.Y., Lee K.C., Hwang Y.J., Lee M.H., Roberts S.A.et al. Tumor apoptosis in cervical cancer: its role as a prognostic factor in 42 radiotherapy patients. Int. J. Cancer. 96(5):2001;305-312.
29. Wheeler J.A., Stephens L.C., Tornos C., Eifel P.J., Ang K.K., Milas L.et al. ASTRO Research Fellowship: apoptosis as a predictor of tumor response to radiation in stage IB cervical carcinoma. American Society for Therapeutic Radiology and Oncology. Int. J. Radiat. Oncol. Biol. Phys. 32:1995;1487-1493.
30. Sheridan M.T., Cooper R.A., West C.M. A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy for cervical adenocarcinoma. Int. J. Radiat. Oncol. Biol. Phys. 44:1999;507-512.
31. Paxton J.R., Bolger B.S., Armour A., Symonds R.P., Mao J.H., Burnett R.A. Apoptosis in cervical squamous carcinoma: predictive value for survival following radiotherapy. J. Clin. Pathol. 53(3):2000;197-200.
32. Migheli A., Cavalla P., Marino S., Schiffer D. A study of apoptosis in normal and pathologic nervous tissue after in situ end-labeling of DNA strand breaks. J. Neuropathol. Exp. Neurol. 53:1994;606-616.
33. Mundle X.D., Gao X.Z., Khan S., Gregory S.A., Preisler H.D., Raza A. Two in situ labeling techniques reveal different patterns of DNA fragmentation during spontaneous apoptosis in vivo, and induced apoptosis in vitro. Anticancer Res. 15:1995;1895-1904.