Interactions between antiepileptic drugs and hormones

Seizure

Volumn 28, Issue , 2015, Pages 12-17

  Svalheim, Sigrid ^a   Sveberg, Line ^a   Mochol, Monika ^b   Taubøll, Erik ^a,c  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b Østfold County Hospital   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

Antiepileptic drugs; Epilepsy; Fertility; Hormones; Osteoporosis; Thyroid

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; ESTRADIOL; ETIRACETAM; HORMONE; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; TOPIRAMATE; VALPROIC ACID; SEX HORMONE;

CLINICAL TRIAL (TOPIC); ENDOCRINE FUNCTION; EPILEPSY; FERTILITY; HEALTH; HUMAN; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; REVIEW; SEXUALITY; THYROID FUNCTION; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; ENDOCRINE DISEASE; FEMALE; MALE; METABOLISM;

ANIMALS; ANTICONVULSANTS; ENDOCRINE SYSTEM DISEASES; EPILEPSY; FEMALE; FERTILITY; GONADAL STEROID HORMONES; HUMANS; MALE; OSTEOPOROSIS; SEX HORMONE-BINDING GLOBULIN;

EID: 84929287029     PISSN: 10591311     EISSN: 15322688     Source Type: Journal    
DOI: 10.1016/j.seizure.2015.02.022     Document Type: Review

References (80)

1. H.E. Edwards, W.M. Burnham, M.M. Ng, S. Asa, and N.J. MacLusky Limbic seizures alter reproductive function in the female rat Epilepsia 40 1999 1370 1377
2. H.E. Edwards, W.M. Burnham, and N.J. MacLusky Partial and generalized seizures affect reproductive physiology differentially in the male rat Epilepsia 40 1999 1490 1498
3. D.M. Feeney, F.P. Gullotta, and W. Gilmore Hyposexuality produced by temporal lobe epilepsy in the cat Epilepsia 39 1998 140 149
4. A.G. Herzog A relationship between particular reproductive endocrine disorders and the laterality of epileptiform discharges in women with epilepsy Neurology 43 1993 1907 1910
5. P. Banczerowski, Z. Csaba, V. Csernus, and I. Gerendai Lesion of the amygdala on the right and left side suppresses testosterone secretion but only left-sided intervention decreases serum luteinizing hormone level J Endocrinol Invest 26 2003 429 434
6. G.J. Macphee, J.G. Larkin, E. Butler, G.H. Beastall, and M.J. Brodie Circulating hormones and pituitary responsiveness in young epileptic men receiving long-term antiepileptic medication Epilepsia 29 1988 468 475
7. J.I. Isojärvi, A.J. Pakarinen, P.J. Ylipalosaari, and V.V. Myllylä Serum hormones in male epileptic patients receiving anticonvulsant medication Arch Neurol 47 1990 670 676
8. J.I. Isojärvi Serum steroid hormones and pituitary function in female epileptic patients during carbamazepine therapy Epilepsia 31 1990 438 445
9. G. Murialdo, C.A. Galimberti, M.V. Gianelli, A. Rollero, A. Polleri, and F. Copello Effects of valproate, phenobarbital, and carbamazepine on sex steroid setup in women with epilepsy Clin Neuropharmacol 21 1998 52 58
10. A.G. Herzog Reproductive endocrine considerations and hormonal therapy for men with epilepsy Epilepsia 32 Suppl. 6 1991 S34 S37
11. L.A. Levesque, A.G. Herzog, and M.M. Seibel The effect of phenytoin and carbamazepine on serum dehydroepiandrosterone sulfate in men and women who have partial seizures with temporal lobe involvement J Clin Endocrinol Metab 63 1986 243 245
12. A.G. Herzog, F.W. Drislane, D.L. Schomer, P.B. Pennell, E.B. Bromfield, and B.A. Dworetzky Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy Neurology 65 2005 1016 1020
13. S.S. Chen, M.R. Shen, T.J. Chen, and S.L. Lai Effects of antiepileptic drugs on sperm motility of normal controls and epileptic patients with long-term therapy Epilepsia 33 1992 149 153
14. L.S. Røste, E. Taubøll, T.B. Haugen, T. Bjørnenak, E.R. Saetre, and L. Gjerstad Alterations in semen parameters in men with epilepsy treated with valproate or carbamazepine monotherapy Eur J Neurol 10 2003 501 506
15. J.I. Isojärvi, E. Löfgren, K.S. Juntunen, A.J. Pakarinen, M. Päivänsalo, and I. Rautakorpi Effect of epilepsy and antiepileptic drugs on male reproductive health Neurology 62 2004 247 253
16. M. Artama, J.I. Isojärvi, and A. Auvinen Antiepileptic drug use and birth rate in patients with epilepsy - a population-based cohort study in Finland Hum Reprod 21 2006 2290 2295
17. E. Löfgren, J.S. Tapanainen, R. Koivunen, A. Pakarinen, and J.I.T. Isojärvi Effects of carbamazepine and oxcarbazepine on the reproductive endocrine function in women with epilepsy Epilepsia 47 2006 1441 1446
18. J. Rättyä, A.J. Pakarinen, M. Knip, M. Repo-Outakoski, V.V. Myllylä, and J.I. Isojärvi Early hormonal changes during valproate or carbamazepine treatment: a 3-month study Neurology 57 2001 440 444
19. A. Krogenæs, E. Taubøll, A. Stien, I.C. Oskam, J.L. Lyche, and E. Dahl Valproate affects reproductive endocrine function, testis diameter and some semen variables in non-epileptic adolescent goat bucks Theriogenology 70 2008 15 26
20. D. Escalier, and G. David Pathology of the cytoskeleton of the human sperm flagellum: axonemal and peri-axonemal anomalies Biol Cell 50 1984 37 52
21. Y. Toyama, H. Sumiya, H. Fuse, and J. Shimazaki A case of an infertile man with short-tailed spermatozoa Andrologia 28 1986 81 87
22. P. Jouannet, B. Ducot, D. Feneux, and A. Spira Male factors and the likelyhood of pregnancy in infertile couples, I. Study of sperm characteristics Int J Androl 11 1988 379 394
23. R. Morand, L. Todesco, M. Donzelli, D. Fischer-Barnicol, P.J. Mullen, and S. Krähenbühl Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans Ther Drug Monit 34 2012 406 414
24. L.S. Røste, E. Taubøll, L. Mørkrid, T. Bjørnenak, E.R. Sætre, and T. Mørland Chronic valproate treatment reduces free carnitine vs total carnitine ratio in men - of importance for semen quality? Epilepsia 45 Suppl. 7 2004 127 128
25. L.S. Røste, E. Taubøll, A. Berner, J.I. Isojärvi, and L. Gjerstad Valproate, but not lamotrigine, induces ovarian morphological changes in Wistar rats Exp Toxicol Pathol 52 2001 545 552
26. L.S. Røste, E. Taubøll, J.I. Isojarvi, A. Berner, K.A. Berg, and A.J. Pakarinen Gonadal morphology and sex hormones in male and female Wistar rats after long-term lamotrigine treatment Seizure 12 2003 621 627
27. S. Svalheim, E. Taubøll, T. Bjørnenak, L.S. Røste, T. Mørland, and E.R. Saetre Do women with epilepsy have increased frequency of menstrual disturbances? Seizure 12 2003 529 533
28. S. Svalheim, E. Taubøll, G. Luef, A. Lossius, M. Rauchenzauner, and F. Sandvand Differential effects of levetiracetam, carbamazepine, and lamotrigine on reproductive endocrine function in adults Epilepsy Behav 16 2009 281 287
29. C.L. Harden, B.G. Nikolov, P. Kandula, D.R. Labar, and S. Pannullo Effect of levetiracetam on testosterone levels in male patients Epilepsia 51 2010 2348 2351
30. X. Xiaotian, Z. Hengzhong, X. Yao, Z. Zhipan, X. Daoliang, and W. Yumei Effects of antiepileptic drugs on reproductive endocrine function, sexual function and sperm parameters in Chinese Han men with epilepsy J Clin Neurosci 20 2013 1492 1497
31. M. Holtkamp, F. Weissinger, and H. Meierkord Erectile dysfunction with topiramate Epilepsia 46 2005 166 167
32. R.S. Calabrò, P. Bramanti, D. Italiano, and E. Ferlazzo Topiramate-induced erectile dysfunction Epilepsy Behav 14 2009 560 561
33. C. Civardi, A. Collini, P. Gontero, and F. Monaco Vasogenic erectile dysfunction Topiramate-induced Clin Neurol Neurosurg 114 2012 70 71
34. C. Sun, C. Lay, S. Broner, S. Silberstein, S. Tepper, and L. Newman Reversible anorgasmia with topiramate therapy for headache: a report of 7 patients Headache 46 2006 1450 1453
35. J.A. Coebergh, and M.D. Waldinger Reversible anorgasmia with topiramate for migraine prophylaxis J Neuropsychiatry Clin Neurosci 24 2012 E30 E31
36. J.I.T. Isojärvi Disorders of reproduction in patients with epilepsy: antiepileptic drug related mechanisms Seizure 17 2008 111 119
37. J.I.T. Isojärvi, T.J. Laatikainen, A.J. Pakarinen, K.T.S. Juntunen, and V.V. Myllylä Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy N Engl J Med 329 1993 1383 1388
38. J.I.T. Isojärvi, E. Tauboll, and A. Herzog Effect of antiepileptic drugs on reproductive endocrine function in individuals with epilepsy CNS Drugs 19 2005 207 223
39. J.I.T. Isojärvi, E. Taubøll, A.J. Pakarinen, J. Van Parys, J. Rättyä, and H. Flinstad Harbo Altered ovarian function and cardiovascular risks in valproate treated women Am J Med 111 2001 290 296
40. L.K. Vainionpää, J. Rättyä, M. Knip, J.S. Tapanainen, A. Pakarinen, and P. Lanning Valproate-induced hyperandrogenism during pubertal maturation in girls with epilepsy Ann Neurol 44 1999 444 450
41. K. Mikkonen, L.K. Vainionpää, A.J. Pakarinen, M. Knip, I. Järvelä, and J.S. Tapanainen Long-term reproductive endocrine health in young women with epilepsy during puberty Neurology 62 2004 445 450
42. L.S. Røste, E. Taubøll, J.I. Isojärvi, A.J. Pakarinen, I.T. Huhtaniemi, and M. Knip Effects of chronic valproate treatment on reproductive endocrine hormones in female and male Wistar rats Reprod Toxicol 16 2002 767 773
43. F. Akdeniz, F. Taneli, A. Noyan, Z. Yüncü, and S. Vahip Valproate-associated reproductive and metabolic abnormalities: are epileptic women at greater risk than bipolar women? Prog Neuropsychopharmacol Biol Psychiatry 27 2003 115 121
44. C. O'Donovan, V. Kusumakar, G.R. Graves, and D.C. Bird Menstrual abnormalities and polycystic ovary syndrome in women taking valproate for bipolar mood disorder J Clin Psychiatry 63 2002 322 330
45. M.I. Lossius, E. Taubøll, P. Mowinckel, L. Mørkrid, and L. Gjerstad Reversible effects of antiepileptic drugs on reproductive endocrine function in men and women with epilepsy - a prospective randomized double-blind withdrawal study Epilepsia 48 2007 1875 1882
46. J.I. Isojärvi, J. Rättyä, V.V. Myllylä, M. Knip, R. Koivunen, and A.J. Pakarinen Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy Ann Neurol 43 1998 446 451
47. E. Tauboll, A.K. Wójtowicz, E. Ropstad, and E.L. Gregoraszczuk Valproate irreversibly alters steroid secretion patterns from porcine follicular cells in vitro Reprod Toxicol 16 2002 319 325
48. E. Taubøl, E.L. Gregoraszczuk, A. Kołodziej, M. Kajta, and E. Ropstad Valproate inhibits conversion of testosterone to estradiol and acts as an apoptotic agent in growing porcine ovarian follicular cells Epilepsia 44 2003 1014 1021
49. E. Taubøll, E.L. Gregoraszczuk, A. Tworzydło, A.K. Wójtowicz, and E. Ropstad Comparison of reproductive effects of levetiracetam and valproate studied in prepubertal porcine ovarian follicular cells Epilepsia 47 2006 1580 1583
50. E. Taubøll, E.L. Gregoraszczuk, A.K. Wojtowicz, and T. Milewicz Effects of levetiracetam and valproate on reproductive endocrine function studied in human ovarian follicular cells Epilepsia 50 2009 1868 1874
51. N. Hattori, H. Fujiwara, M. Maeda, S. Fujii, and M. Ueda Epoxide hydrolase affects estrogen production in the human ovary Endocrinology 141 2000 3353 3365
52. V.L. Nelson-DeGrave, J.K. Wickenheisser, J.E. Cockrell, J.R. Wood, R.S. Legro, and J.F. Strauss VPA increases androgen biosynthesis in human ovarial theca cells by affecting gene expression Endocrinology 145 2004 799 808
53. M.W. Gustavsen, K. von Krogh, E. Taubøll, K.E. Zimmer, E. Dahl, and I. Olsaker Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model Acta Neurol Scand Suppl189 2009 14 21
54. K. von Krogh, H. Harjen, C. Almås, K.E. Zimmer, E. Dahl, and I. Olsaker The effect of valproate and levetiracetam on steroidogenesis in forskolin stimulated H295R cells Epilepsia 51 2010 2280 2288
55. M.J. Morrell, K.L. Flynn, C.G. Seale, S. Done, A.J. Paulson, and E.R. Flaster Reproductive dysfunction in women with epilepsy: antiepileptic drug effects on sex-steroid hormones CNS Spectr 6 2001 783 786 771-2
56. A.G. Herzog Disorders of reproduction in patients with epilepsy: primary neurological mechanisms Seizure 17 2008 101 110
57. M.P. Webber, W.A. Hauser, R. Ottman, and J.F. Annegers Fertility in persons with epilepsy: 1935-1974 Epilepsia 27 1986 746 752
58. E. Olafsson, W.A. Hauser, and G. Gudmundsson Fertility in patients with epilepsy: a population-based study Neurology 51 1998 71 73
59. N. Schupf, and R. Ottman Reproduction among individuals with idiopathic/cryptogenic epilepsy: risk factors for reduced fertility in marriage Epilepsia 37 1996 833 840
60. L.V. Dansky, E. Andermann, and F. Andermann Marriage and fertility in epileptic patients Epilepsia 21 1980 261 271
61. C.L. Harden Sexual dysfunction in women with epilepsy Seizure 17 2008 131 135
62. E. Hellmis Sexual problems in males with epilepsy - an interdisciplinary challenge! Seizure 17 2008 136 140
63. R.H. Mattson, J.A. Cramer, J.F. Collins, D.B. Smith, A.V. Delgado-Escueta, and T.R. Browne Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures N Engl J Med 313 1985 145 151
64. G.E. Brannon, and P.D. Rolland Anorgasmia in a patient with bipolar disorder type 1 treated with gabapentin J Clin Psychopharmacol 20 2000 379 381
65. A.M. Husain, S.T. Carwile, P.P. Miller, and R.A. Radtke Improved sexual function in three men taking lamotrigine for F epilepsy South Med F J 93 2000 335 336
66. P. Vestergaard, L. Rejnmark, and L. Moeskilde Fracture risk associated with use of antiepileptic drugs Epilepsia 45 2004 1330 1337
67. A.M. Pack, and T.S. Walczak Bone health in women with epilepsy: clinical features and potential mechanisms Int Rev Neurobiol 83 2008 305 328
68. A.M. Pack, M.J. Morrell, R. Marcus, L. Holloway, E. Flaster, and S. Doñe Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy Ann Neurol 57 2005 252 257
69. S.J. Petty, T.J. O'Brien, and J.D. Wark Anti-epileptic medication and bone health Osteoporos Int 18 2007 129 142
70. K.O. Nakken, and E. Taubøll Bone loss associated with use of antiepileptic drugs Expert Opin Drug Saf 9 2010 561 571
71. K. Onodera, A. Takahashi, S. Sakurada, and Y. Okano Effects of phenytoin and/or vitamin K2 (menatetrenone) on bone mineral density in the tibiae of growing rats Life Sci 70 2002 1533 1542
72. K.E. Ensrud, T.S. Walczak, T. Blackwell, E.R. Ensrud, P.J. Bowman, and K.L. Stone Antiepileptic drug use increases rates of bone loss in older women: a prospective study Neurology 62 2004 2051 2057
73. T. Apeland, M. Mansoor, and R.E. Strandjord Antiepileptic drugs as independent predictors of plasma total homocysteine levels Epilepsy Res 47 2001 27 35
74. R.E. Strandjord, S. Aanderud, O.L. Myking, and S.I. Johannessen Influence of carbamazepine on serum thyroxine and triiodothyronine in patients with epilepsy Acta Neurol Scand 63 1981 111 121
75. J.I.T. Isojärvi, J. Turkka, A.J. Pakarinen, M. Kotila, J. Rättyä, and V. Myllylä Thyroid function in men taking carbamazepine, oxcarbazepine, or valproate for Epilepsy Epilepsia 42 2001 930 934
76. A. Verrotti, M. Laus, A. Scardapane, E. Franzoni, and F. Chiarelli Thyroid hormones in children with epilepsy during long-term administration of carbamazepine and valproate Eur J Endocrinol 160 2009 81 86
77. M. Tiihonen, K. Liewendahl, O. Waltimo, M. Ojala, and M. Välimäki Thyroid status of patients receiving long-term anticonvulsant therapy assessed by peripheral parameters: a placebo-controlled thyroxine therapy trial Epilepsia 36 1995 1118 1125
78. A. Garoufi, E. Koemtzidou, E. Katsarou, A. Dinopoulos, I. Kalimeraki, and A. Fotinou Lipid profile and thyroid hormone concentrations in children with epilepsy treated with oxcarbazepine monotherapy: a prospective long-term study Eur J Neurol 21 2014 118 123
79. M.I. Lossius, E. Taubøll, P. Mowinckel, and L. Gjerstad Reversible effects of antiepileptic drugs on thyroid hormones in men and women with epilepsy: a prospective randomized double-blind withdrawal study Epilepsy Behav 16 2009 64 68
80. E. Taubøll, J.I.T. Isojärvi, and L. Gjerstad Gender-specific side-effects of antiepileptic drugs P.A. Schwartzkroin, Encyclopedia of basic epilepsy research vol. 3 2009 Academic Press Elsevier, UK 1485 1490