Valproate affects reproductive endocrine function, testis diameter and some semen variables in non-epileptic adolescent goat bucks

Theriogenology

Volumn 70, Issue 1, 2008, Pages 15-26

  Krogenaes A K ^a   Tauboll E ^b   Stien, A ^c   Oskam, I C ^b   Lyche, J L ^a   Dahl, E ^a   Thomassen, R F ^a   Sweeney, T ^d   Ropstad, E ^a  

^a NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c NORWEGIAN INSTITUTE FOR NATURE RESEARCH   (Norway)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Flow cytometry; Goat bucks; Semen; Testosterone; Valproate

Indexed keywords

ANTICONVULSIVE AGENT; HORMONE; VALPROIC ACID;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; BODY WEIGHT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; ENDOCRINE SYSTEM; EPILEPSY; FLOW CYTOMETRY; GOAT; GOAT DISEASE; MALE; PHYSIOLOGY; SEMINIFEROUS TUBULE EPITHELIUM; SPERM; TESTIS;

ANIMALS; ANTICONVULSANTS; BODY WEIGHT; ENDOCRINE SYSTEM; EPILEPSY; FLOW CYTOMETRY; GOAT DISEASES; GOATS; HORMONES; MALE; SEMEN; SEMINIFEROUS EPITHELIUM; TESTIS; VALPROIC ACID;

CAPRA HIRCUS;

EID: 44549085864     PISSN: 0093691X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.theriogenology.2008.01.029     Document Type: Article

References (65)

1. Alstrom C.H. A study of epilepsy in its clinical, social and genetic aspects. Acta Psychiatr Neurol Suppl 63 (1950) 1-284
2. Dansky L.V., Andermann E., and Andermann F. Marriage and fertility in epileptic patients. Epilepsia 21 (1980) 261-271
3. Webber M.P., Hauser W.A., Ottman R., and Annegers J.F. Fertility in persons with epilepsy: 1935-1974. Epilepsia 27 (1986) 746-752
4. Herzog A.G., Seibel M.M., Schomer D.L., Vaitukaitis J.L., and Geschwind N. Reproductive endocrine disorders in men with partial seizures of temporal lobe origin. Arch Neurol 43 (1986) 347-350
5. Herzog A.G., Seibel M.M., Schomer D.L., Vaitukaitis J.L., and Geschwind N. Reproductive endocrine disorders in women with partial seizures of temporal lobe origin. Arch Neurol 43 (1986) 341-346
6. Herzog A.G., Drislane F.W., Schomer D.L., Pennell P.B., Bromfield E.B., Dworetzky B.A., et al. Differential effects of antileptic drugs on sexual function and hormones in men with epilepsy. Neurology 65 (2005) 1016-1020
7. Morrell M.J., Sperling M.R., Stecker M., and Dichter M.A. Sexual dysfunction in partial epilepsy: a deficit in physiological sexual arousal. Neurology 44 (1994) 243-247
8. Lösher W. Basic pharmacology of valproate: A review after 35 years of clinical use for the treatment of epilepsy. CNS Drugs 16 (2002) 669-694
9. Isojärvi J.I., Taubøll E., and Herzog A.G. Effect of antiepileptic drugs on reproductive endocrine function in individuals with epilepsy. CNS Drugs 19 (2005) 207-223
10. Henry T.R. The history of valproate in clinical neuroscience. Psychopharmacol Bull 2 (2003) 5-16
11. Kostrouchova M., Kostrouch Z., and Kostrouchova M. Valproic acid, a molecular lead to multiple regulatory pathways. Folia Biol 53 (2007) 37-49
12. Davis R., Peters D.H., and McTavish D. Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy. Drugs 47 (1994) 332-372
13. Nasrallah H.A., Ketter T.A., and Kalali A.H. Carbamazepine and valproate for the treatment of bipolar disorder: a review of the literature. J Affect Disord 95 (2006) 69-78
14. Krymchantowski A.V., Bigal M.E., and Moreira P.F. New and emerging prophylactic agents for migraine. CNS Drugs 16 (2002) 611-634
15. Røste L.S., Taubøll E., Mørkrid L., Bjørnenak T., Sætre E.R., Mørland T., et al. Antiepileptic drugs alter reproductive endocrine hormones in men with epilepsy. Eur J Neurol 12 (2005) 118-124
16. Isojärvi J.I., Lofgren E., Juntunen K.S., Pakarinen A.J., Paivansalo M., Rautakorpi I., et al. Effect of epilepsy and antiepileptic drugs on male reproductive health. Neurology 27 (2004) 247-253
17. Taubøll E., Gregoraszczuk E.L., Kolodziej A., Kajta M., and Ropstad E. Valproate inhibits the conversion of testosterone to estradiol and acts as an apoptotic agent in growing porcine ovarian follicular cells. Epilepsia 44 (2003) 1014-1021
18. Taubøll E., Wojtowicz A.K., Ropstad E., and Gregoraszczuk E.L. Valproate irreversibly alters steroid secretion patterns from porcine follicular cells in vitro. Reprod Toxicol 16 (2002) 319-325
19. Hattori N., Fujiwara H., Maeda M., Fujii S., and Ueda M. Epoxide hydrolase affects estrogen production in the human ovary. Endocrinology 141 (2000) 3353-3365
20. Mikkonen K., Tapanainen P., Pakarinen A.J., Päivänsalo M., Isojärvi J.I., and Vainionpää L.K. Serum androgen levels and testicular structure during pubertal maturation in male subjects with epilepsy. Epilepsia 45 (2004) 769-776
21. Cohn D.F., Homonnai Jr. Z.T., and Paz G.F. The effect of anticonvulsant drugs on the development of male rats and their fertility. J Neurol Neurosurg Psychiatry 45 (1982) 844-846
22. Walker R.M., Smith G.S., Barsoum N.J., and Macallum G.E. Preclinical toxicology of the anticonvulsant calcium valproate. Toxicology 63 (1990) 137-155
23. Snyder P.J., and Badura L.L. Chronic administration of sodium valproic acid slows pubertal maturation in inbred DBA/2J mice: skeletal, histological, and endocrinological evidence. Epilepsy Res 20 (1995) 203-211
24. Røste L.S., Taubøll E., Berner A., Berg K.A., Aleksandersen M., and Gjerstad L. Morphological changes in the testis after long-term valproate treatment in male Wistar rats. Seizure 10 (2001) 559-565
25. Røste L.S., Taubøll E., Isojärvi J.I., Pakarinen A.J., Huhtaniemi I.T., Knip M., et al. Effects of chronic valproate treatment on reproductive endocrine hormones in female and male Wistar rats. Reprod Toxicol 16 (2002) 767-773
26. Rättyä J., Turkka J., Pakarinen A.J., Knip M., Kotila M.A., Lukkarinen O., et al. Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy. Neurology 56 (2001) 31-36
27. Rättyä J., Pakarinen A.J., Knip M., Repo-Outakoski M., Myllyla V.V., and Isojarvi J.I. Early hormonal changes during valproate or carbamazepine treatment: a 3-month study. Neurology 57 (2001) 440-444
28. Røste L.S., Taubøll E., Haugen T.B., Bjørnenak T., Sætre E.R., and Gjerstad L. Alterations in semen parameters in men with epilepsy treated with valproate or carbamazepine monotherapy. Eur J Neurol 10 (2003) 501-506
29. Mattson R.H., and Cramer J.A. Valproic acid. In: Browne T.R., and Feldman R.G. (Eds). Epilepsy: diagnosis and management (1983), Little, Brown, Boston 225-233
30. Everitt B.J., and Keverne E.B. Reproduction. In: Lightman S.L., and Everitt B.J. (Eds). Neuroendocrinology (1986), Blackwell Scientific, Boston 472-537
31. Klonisch T., Fowler P.A., and Hombach-Klonisch S. Molecular and genetic regulation of testis descent and external genitalia development. Dev Biol 270 (2004) 1-18
32. Paulenz H., Soderquist L., Adnoy T., Nordstoga A., Gulbrandsen B., and Berg K.A. Fertility results after different thawing procedures for ram semen frozen in minitubes and mini straws. Theriogenology 61 (2004) 1719-1727
33. Andersen K. Insemination with frozen semen in goats. Nord Vet Med 21 (1969) 625-628
34. Suter L., Koch E., Bechter R., and Bobadilla M. Three-parameter flow cytometric analysis of rat spermatogenesis. Cytometry 27 (1997) 161-168
35. Crowe M.A., Padmanabhan V., Hynes N., Sunderland S.J., Enright W.J., Beitins I.Z., et al. Validation of a sensitive radioimmunoassay to measure serum follicle-stimulating hormone in cattle: correlation with biological activity. Anim Reprod Sci 48 (1997) 123-136
36. Beckers J.F., Wouters-Ballmann P., Ectors F., and Derivaux J. Induction de l'oestrus chez les génisses en anoestrus fonctionnel. Ann Med Vet 122 (1978) 597-605
37. Roosen-Runge E.C., and Giesel Jr. L.O. Quantitative studies on spermatogenesis in the albino rat. Am J Anat 87 (1950) 1-30
38. Ortavant R., Courot M., and Hochereau M.T. Spermatogenesis and morphology of the spermatozoon. In: Cole H.H., and Cupps P.T. (Eds). Reproduction in domestic animals. 2nd ed. (1969), Academic Press, London 251-276
39. Evenson D., and Jost L. Sperm chromatin structure assay is useful for fertility assessment. Methods Cell Sci 22 (2000) 169-189
40. Littell R.C., Milliken G.A., Stroup W.W., and Wolfinger R.D. SAS system for mixed models (1996), SAS Institute Inc., Cary, NC
41. SAS Institute Inc. JMP. Cary, NC, USA; 2003, p. 5.
42. Quigg M., Kiely J.M., Shneker B., Veldhuis J.D., and Bertram III E.H. Interictal and postictal alterations of pulsatile secretions of luteinizing hormone in temporal lobe epilepsy in men. Ann Neurol 51 (2002) 559-566
43. Herzog A.G., Coleman A.E., Jacobs A.R., Klein P., Friedman M.N., Drislane F.W., et al. Relationship of sexual dysfunction to epilepsy laterality and reproductive hormone levels in women. Epilepsy Behav 4 (2003) 407-413
44. Bauer J., Blumenthal S., Reuber M., and Stoffel-Wagner B. Epilepsy syndrome, focus location, and treatment choice affect testicular function in men with epilepsy. Neurology 62 (2004) 243-246
45. Edwards H.E., MacLusky N.J., and Burnham W.M. The effect of seizures and kindling on reproductive hormones in the rat. Neurosci Biobehav Rev 24 (2000) 753-762
46. Wulff K., Flachs H., Wurtz-Jørgensen A., and Gram L. Clinical and pharmacological aspects of valproate sodium. Epilepsia 18 (1977) 149-157
47. Gram L., Wulff K., Rasmussen K.E., Flachs H., Wurtz-Jørgensen A., Sommerbeck K.W., et al. Valproate sodium: a controlled clinical trial including monitoring of drug levels. Epilepsia 18 (1977) 141-148
48. Nishimura T., Sakai M., and Yonezawa H. Effects of valproic acid on fertility and reproductive organs in male rats. J Toxicol Sci 25 (2000) 85-93
49. Jallon P., and Picard F. Bodyweight gain and anticonvulsants: a comparative review. Drug Saf 24 (2001) 969-978
50. Luef G.J., Lechleitner M., Bauer G., Trinka E., and Hengster P. Valproic acid modulates islet cell insulin secretion: a possible mechanism of weight gain in epilepsy patients. Epilepsy Res 55 (2003) 53-58
51. Pylvanen V., Pakarinen A., Knip M., and Isojärvi J. Insulin-related metabolic changes during treatment with valproate in patients with epilepsy. Epilepsy Behav 8 (2006) 643-648
52. Snyder P.J., and Badura L.L. A potential mechanism of slowed pubertal maturation after chronic administration of sodium valproic acid. Neurology 50 (1998) 922-925
53. Sanford L.M., Moore C., Voglmayr J.K., and Fahmy M.H. Sexual maturational changes circulatory inhibin concentration in relation to FSH concentration and testicular size in Suffolk and DLS rams. Theriogenology 54 (2000) 719-730
54. Cook J.S., Bale J.F., and Hoffman R.P. Pubertal arrest associated with valproic acid therapy. Pediatr Neurol 8 (1992) 229-231
55. Balaguer Martinez J.V., Lopez Garcia M.J., Andrés Celma M., Contell Villagrasa A., and Castello Pomares M.L. Efectos del ácido valproico sobre el desarrollo sexual. Ann Pediatr 58 (2003) 443-448
56. Rättyä J., Vainionpää L., Knip M., Lanning P., and Isojarvi J.I. The effects of valproate, carbamazepine, and oxcarbazepine on growth and sexual maturation in girls with epilepsy. Pediatrics 103 (1999) 588-593
57. Mikkonen K., Knip M., Pakarinen A.J., Lanning P., Isojärvi J.I.T., and Vainionpaa L.K. Growth and lipid metabolism in girls and young women with epilepsy during pubertal maturation. Epilepsia 46 (2005) 1114-1120
58. Hayashi T., Yoshida S., Yoshinaga A., Ohno R., Ishii N., and Yamada T. Improvement of oligoasthenozoospermia in epileptic patients on switching anti-epilepsy medication from sodium valproate to phenytoin. Scand J Urol Nephrol 39 (2005) 431-432
59. Yerby M.S., and McCoy G.B. Male infertility: possible association with valproate exposure. Epilepsia 40 (1999) 520-521
60. Evenson D.P., Jost L.K., Marshall D., Zinaman M.J., Clegg E., Purvis K., et al. Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic. Hum Reprod 14 (1999) 1039-1049
61. Januskauskas A., Johannisson A., and Rodriguez-Martinez H. Subtle membrane changes in cryopreserved bull semen in relation with sperm viability, chromatin structure, and field fertility. Theriogenology 60 (2003) 743-758
62. ®) parameters are related to fertilization, blastocyst development, and ongoing pregnancy in in vitro fertilization and intracytoplasmic sperm injection cycles. Fertil Steril 81 (2004) 1289-1295
63. Waterhouse K.E., Haugan T., Kommisrud E., Tverdal A., Flatberg G., Farstad W., et al. Sperm DNA damage is related to field fertility of semen from young Norwegian Red bulls. Reprod Fertil Dev 18 (2006) 781-788
64. Ahmadi A. NG SC. Fertilizing ability of DNA-damaged spermatozoa. J Exp Zool 284 (1999) 696-704
65. Seli E., Gardner D.K., Schoolcraft W.B., Moffatt O., and Sakkas D. Extent of nuclear DNA damage in ejaculated spermatozoa impacts on blastocyst development after in vitro fertilization. Fertil Steril 82 (2004) 378-383