Is infant immunization by breastfeeding possible?

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 370, Issue 1671, 2015, Pages

  Verhasselt, Valerie ^a  

^a UNIVERSITÉ CÔTE D'AZUR   (France)

Author keywords

Breastfeeding; Neonate immunity; Tolerance; Vaccine

Indexed keywords

BREASTFEEDING; DISEASE CONTROL; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNIZATION; INFANT FEEDING; INFECTIOUS DISEASE; MILK; NEONATE; VACCINATION;

BREAST FEEDING; HUMAN; HYPERSENSITIVITY; IMMUNIZATION; INFANT; PASSIVE IMMUNIZATION; PROCEDURES;

BREAST FEEDING; HUMANS; HYPERSENSITIVITY; IMMUNITY, MATERNALLY-ACQUIRED; IMMUNIZATION; INFANT;

EID: 84929241158     PISSN: 09628436     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rstb.2014.0139     Document Type: Review

References (54)

1. Lawrence RM, Pane CA. 2007 Human breast milk: current concepts of immunology and infectious diseases. Curr. Probl. Pediatric Adolesc. Health Care 37, 7–36. (doi:10.1016/j.cppeds.2006.10.002)
2. Labbok MH, Clark D, Goldman AS. 2004 Breastfeeding: maintaining an irreplaceable immunological resource. Nat. Rev. Immunol. 4, 565–572. (doi:10.1038/nri1393)
3. Wahn U, von Mutius E. 2001 Childhood risk factors for atopy and the importance of early intervention. J. Allergy Clin. Immunol. 107, 567–574. (doi:10.1067/mai.2001.112943)
4. Karlsson MR, Rugtveit J, Brandtzaeg P. 2004 Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow’s milk allergy. J. Exp. Med. 199, 1679–1688. (doi:10.1084/jem.20032121)
5. Tulic MK, Hodder M, Forsberg A, McCarthy S, Richman T, D’Vaz N, van den Biggelaar AH, Thornton CA, Prescott SL. 2011 Differences in innate immune function between allergic and nonallergic children: new insights into immune ontogeny. J. Allergy Clin. Immunol. 127, 470–478, e471. (doi:10.1016/j.jaci.2010.09.020)
6. Macchiaverni P et al. 2014 Respiratory allergen from house dust mite is present in human milk and primes for allergic sensitization in a mouse model of asthma. Allergy 69, 395–398. (doi:10.1111/all.12332)
7. Mosconi E et al. 2010 Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development. Mucosal Immunol. 3, 461–474. (doi:10.1038/mi.2010.23)
8. Verhasselt V. 2010 Neonatal tolerance under breastfeeding influence. Curr. Opinion Immunol. 22, 623–630. (doi:10.1016/j.coi.2010.08.008)
9. Verhasselt V. 2010 Oral tolerance in neonates: from basics to potential prevention of allergic disease. Mucosal Immunol. 3, 326–333. (doi:10.1038/mi.2010.25)
10. Verhasselt V, Milcent V, Cazareth J, Kanda A, Fleury S, Dombrowicz D, Glaichenhaus N, Julia V. 2008 Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma. Nat. Med. 14, 170–175. (doi:10.1038/nm1718)
11. van Rood JJ, Claas F. 2000 Both self and noninherited maternal HLA antigens influence the immune response. Immunol. Today 21, 269–273. (doi:10.1016/S0167-5699(00)01628-5)
12. Tiittanen M, Paronen J, Savilahti E, Virtanen SM, Ilonen J, Knip M, Akerblom HK, Vaarala O, Finnish TSG. 2006 Dietary insulin as an immunogen and tolerogen. Pediatric Allergy Immunol. 17, 538–543. (doi:10.1111/j.1399-3038.2006.00447.x)
13. Shehadeh N, Shamir R, Berant M, Etzioni A. 2001 Insulin in human milk and the prevention of type 1 diabetes. Pediatr. Diabetes 2, 175–177. (doi:10.1034/j.1399-5448.2001.20406.x)
14. Malcova H, Sumnik Z, Drevinek P, Venhacova J, Lebl J, Cinek O. 2006 Absence of breast-feeding is associated with the risk of type 1 diabetes: a casecontrol study in a population with rapidly increasing incidence. Eur. J. Pediatr. 165, 114–119. (doi:10.1007/s00431-005-0008-9)
15. Holmberg H, Wahlberg J, Vaarala O, Ludvigsson J. 2007 Short duration of breast-feeding as a riskfactor for beta-cell autoantibodies in 5-year-old children from the general population. Br. J. Nutr. 97, 111–116. (doi:10.1017/S0007114507210189)
16. Hummel M, Fuchtenbusch M, Schenker M, Ziegler AG. 2000 No major association of breast-feeding, vaccinations, and childhood viral diseases with early islet autoimmunity in the German BABYDIAB Study. Diabetes Care 23, 969–974. (doi:10.2337/diacare.23.7.969)
17. Couper JJ et al. 1999 Lack of association between duration of breast-feeding or introduction of cow’s milk and development of islet autoimmunity. Diabetes 48, 2145–2149. (doi:10.2337/diabetes.48.11.2145)
18. Virtanen SM, Laara E, Hypponen E, Reijonen H, Rasanen L, Aro A, Knip M, Ilonen J, Akerblom HK. 2000 Cow’s milk consumption, HLA-DQB1 genotype, and type 1 diabetes: a nested casecontrol study of siblings of children with diabetes. Childhood diabetes in Finland study group. Diabetes 49, 912–917. (doi:10.2337/diabetes.49.6.912)
19. Knip M, Veijola R, Virtanen SM, Hyoty H, Vaarala O, Akerblom HK. 2005 Environmental triggers and determinants of type 1 diabetes. Diabetes 54(Suppl. 2), S125–S136. (doi:10.2337/diabetes.54.suppl_2.S125)
20. Harrison LC, Honeyman MC. 1999 Cow’s milk and type 1 diabetes: the real debate is about mucosal immune function. Diabetes 48, 1501–1507. (doi:10.2337/diabetes.48.8.1501)
21. Macchiaverni P, Tulicz MK, Verhasselt V. 2012 Antigens in breast milk: possible impact on immune system education. In Handbook of dietary and nutritonal aspects of human breast milk (eds RWR Zibadi, S Preedy), pp. 447–459. The Netherlands: Wageningen Academics.
22. Palmer DJ, Makrides M. 2006 Diet of lactating women and allergic reactions in their infants. Curr. Opin. Clin. Nutr. Metab. Care 9, 284–288. (doi:10.1097/01.mco.0000222113.46042.50)
23. Sorva R, Makinen-Kiljunen S, Juntunen-Backman K. 1994 Beta-lactoglobulin secretion in human milk varies widely after cow’s milk ingestion in mothers of infants with cow’s milk allergy. J. Allergy Clin. Immunol. 93, 787–792. (doi:10.1016/0091-6749(94)90259-3)
24. Greer FR, Sicherer SH, Burks AW, N. American Academy of Pediatrics Committee on Nutrition, Section on Allergy and Immunology. 2008 Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics 121, 183–191. (doi:10.1542/peds.2007-3022)
25. Sicherer SH. 2002 The impact of maternal diets during breastfeeding on the prevention of food allergy. Curr. Opin. Allergy Clin. Immunol. 2, 207–210. (doi:10.1097/00130832-200206000-00009)
26. Palmer DJ, Makrides M. 2006 Diet of lactating women and allergic reactions in their infants. Curr. Opin. Clin. Nutr. Metab. Care 9, 284–288. (doi:10.1097/01.mco.0000222113.46042.50)
27. Komatsu T, Okao M, Miyamoto H, Chen T, Shinka S. 1988 Effects of early antigen exposure through lactation on later specific antibody responses in mice. J. Immunol. 141, 2895–2906.
28. Korotkova M, Telemo E, Yamashiro Y, Hanson LA, Strandvik B. 2004 The ratio of n-6 to n-3 fatty acids in maternal diet influences the induction of neonatal immunological tolerance to ovalbumin. Clin. Exp. Immunol. 137, 237–244. (doi:10.1111/j.1365-2249.2004.02527.x)
29. Strobel S, Ferguson A. 1984 Immune responses to fed protein antigens in mice. 3. Systemic tolerance or priming is related to age at which antigen is first encountered. Pediatr. Res. 18, 588–594. (doi:10.1203/00006450-198407000-00004)
30. Yamamoto T, Tsubota Y, Kodama T, Kageyama- Yahara N, Kadowaki M. 2012 Oral tolerance induced by transfer of food antigens via breast milk of allergic mothers prevents offspring from developing allergic symptoms in a mouse food allergy model. Clin. Dev. Immunol. 2012, 721085. (doi:10.1155/2012/721085)
31. Lopez-Exposito I, Song Y, Jarvinen KM, Srivastava K, Li XM. 2009 Maternal peanut exposure during pregnancy and lactation reduces peanut allergy risk in offspring. J. Allergy Clin. Immunol. 124, 1039–1046. (doi:10.1016/j.jaci.2009.08.024)
32. Pabst O, Mowat AM. 2012 Oral tolerance to food protein. Mucosal Immunol. 5, 232–239. (doi:10.1038/mi.2012.4)
33. Turfkruyer M, Rekima A, Macchiaverni P, Le Bourhis L, Muncan V, van den Brink GR, Tulic MK, Verhasselt V. Submitted. Oral tolerance is inefficient in neonatal mice due to a physiological vitamin A deficiency.
34. Roopenian DC, Akilesh S. 2007 FcRn: the neonatal Fc receptor comes of age. Nat. Rev. Immunol. 7, 715–725. (doi:10.1038/nri2155)
35. Qiao SW, Kobayashi K, Johansen FE, Sollid LM, Andersen JT, Milford E, Roopenian DC, Lencer WI, Blumberg RS. 2008 Dependence of antibodymediated presentation of antigen on FcRn. Proc. Natl Acad. Sci. USA 105, 9337–9342. (doi:10.1073/pnas.0801717105)
36. Dogaru CM, Nyffenegger D, Pescatore AM, Spycher BD, Kuehni CE. 2014 Breastfeeding and childhood asthma: systematic review and meta-analysis. Am. J. Epidemiol. 179, 1153–1167. (doi:10.1093/aje/kwu072)
37. Gdalevich M, Mimouni D, Mimouni M. 2001 Breastfeeding and the risk of bronchial asthma in childhood: a systematic review with meta-analysis of prospective studies. J. Pediatr. 139, 261–266. (doi:10.1067/mpd.2001.117006)
38. Ip S, Chung M, Raman G, Chew P, Magula N, DeVine D, Trikalinos T, Lau J. 2007 Breastfeeding and maternal and infant health outcomes in developed countries. Evid. Report/Technol. Assess. 153, 1–186.
39. Willoughby JB, Willoughby WF. 1977 In vivo responses to inhaled proteins. I. Quantitative analysis of antigen uptake, fate, and immunogenicity in a rabbit model system. J. Immunol. 119, 2137–2146.
40. Holt PG, Batty JE, Turner KJ. 1981 Inhibition of specific IgE responses in mice by pre-exposure to inhaled antigen. Immunology 42, 409–417.
41. Gregory LG, Lloyd CM. 2011 Orchestrating house dust mite-associated allergy in the lung. Trends Immunol. 32, 402–411. (doi:10.1016/j.it.2011.06.006)
42. Lawrence RM, Lawrence RA. 2004 Breast milk and infection. Clin. Perinatol. 31, 501–528. (doi:10.1016/j.clp.2004.03.019)
43. Lindsey B, Kampmann B, Jones C. 2013 Maternal immunization as a strategy to decrease susceptibility to infection in newborn infants. Curr. Opin. Infect. Dis. 26, 248–253. (doi:10.1097/QCO.0b013e3283607a58)
44. Siegrist CA. 2003 Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants. Vaccine 21, 3406–3412. (doi:10.1016/S0264-410X(03)00342-6)
45. Yoshida M, Claypool SM, Wagner JS, Mizoguchi E, Mizoguchi A, Roopenian DC, Lencer WI, Blumberg RS. 2004 Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity 20, 769–783. (doi:10.1016/j.immuni.2004.05.007)
46. Yoshida M et al. 2006 Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J. Clin. Invest. 116, 2142–2151. (doi:10.1172/JCI27821)
47. Harris NL et al. 2006 Mechanisms of neonatal mucosal antibody protection. J. Immunol. 177, 6256–6262. (doi:10.4049/jimmunol.177.9.6256)
48. Anthony RM, Wermeling F, Ravetch JV. 2012 Novel roles for the IgG Fc glycan. Ann. NY Acad. Sci. 1253, 170–180. (doi:10.1111/j.1749-6632.2011.06305.x)
49. Massoud AH, Yona M, Xue D, Chouiali F, Alturaihi H, Ablona A, Mourad W, Piccirillo CA, Mazer BD. 2014 Dendritic cell immunoreceptor: a novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells. J. Allergy Clin. Immunol. 133, 853–863.e855. (doi:10.1016/j.jaci.2013.09.029)
50. van de Geijn FE, Wuhrer M, Selman MH, Willemsen SP, de Man YA, Deelder AM, Hazes JM, Dolhain RJ. 2009 Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study. Arthritis Res. Therapy 11, R193. (doi:10.1186/ar2892)
51. Ramakrishna C, Cantin EM. 2014 Fc-sialylated IgGs in intravenous immunoglobulins are not responsible for induction of regulatory T cells. J. Allergy Clin. Immunol. 134, 1469. (doi:10.1016/j.jaci.2014.08.049)
52. Caulfield MJ, Shaffer D. 1987 Immunoregulation by antigen/antibody complexes. I. Specific immunosuppression induced in vivo with immune complexes formed in antibody excess. J. Immunol. 138, 3680–3683.
53. Guilliams M, Bruhns P, Saeys Y, Hammad H, Lambrecht BN. 2014 The function of Fcgamma receptors in dendritic cells and macrophages. Nat. Rev. Immunol. 14, 94–108. (doi:10.1038/nri3582)
54. Nimmerjahn F, Ravetch JV. 2008 Fcgamma receptors as regulators of immune responses. Nat. Rev. Immunol. 8, 34–47. (doi:10.1038/nri2206)