Toll-like receptor-4-mediated autophagy contributes to microglial activation and inflammatory injury in mouse models of intracerebral haemorrhage

Neuropathology and Applied Neurobiology

Volumn 41, Issue 4, 2015, Pages e95-e106

  Yang, Zhao ^a   Liu, B ^a   Zhong, L ^a   Shen, Hanchao ^b   Lin, Chuangan ^b   Lin, Li ^b   Zhang, Nan ^c   Yuan, Bangqing ^b  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b Third Department Internal Medicine   (China)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Autophagy; ICH; Microglia; TLR4

Indexed keywords

3 METHYLADENINE; TOLL LIKE RECEPTOR 4; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BRAIN DAMAGE; BRAIN HEMORRHAGE; BRAIN WATER; CELL ACTIVATION; CELL MIGRATION; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTRON MICROSCOPY; EMBRYO; ERYTHROCYTE; FLOW CYTOMETRY; HEMOLYSIS; HISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; MICROGLIA; MOUSE; MTT ASSAY; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL MOTION; CELL SURVIVAL; COMPLICATION; DISEASE MODEL; ENCEPHALITIS; METABOLISM; NERVE CELL;

ANIMALS; AUTOPHAGY; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL HEMORRHAGE; DISEASE MODELS, ANIMAL; ENCEPHALITIS; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; NEURONS; TOLL-LIKE RECEPTOR 4;

EID: 84929237100     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/nan.12177     Document Type: Article

References (35)

1. Florczak-Rzepka M, Grond-Ginsbach C, Montaner J, Steiner T. Matrix metalloproteinases in human spontaneous intracerebral hemorrhage: an update. Cerebrovasc Dis 2012; 34: 249-262
2. Lee HK, Ghani AR, Awang MS, Sayuthi S, Idris B, Abdullah JM. Role of high augmentation index in spontaneous intracerebral haemorrhage. Asian J Surg 2010; 33: 42-50
3. Anderson CS. Medical management of acute intracerebral hemorrhage. Curr Opin Crit Care 2009; 15: 93-98
4. Tanaka Y, Marumo T, Shibuta H, Omura T, Yoshida S. Serum S100B, brain edema, and hematoma formation in a rat model of collagenase-induced hemorrhagic stroke. Brain Res Bull 2009; 78: 158-163
5. Zhou QB, Jin YL, Jia Q, Zhang Y, Li LY, Liu P, Liu YT. Baicalin attenuates brain edema in a rat model of intracerebral hemorrhage. Inflammation 2014; 37: 107-115
6. Wang J. Preclinical and clinical research on inflammation after intracerebral hemorrhage. Prog Neurobiol 2010; 92: 463-477
7. Ermolaeva MA, Michallet MC, Papadopoulou N, Utermohlen O, Kranidioti K, Kollias G, Tschopp J, Pasparakis M. Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol 2008; 9: 1037-1046
8. Pimentel-Coelho PM, Michaud JP, Rivest S. Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury. J Neurosci 2013; 33: 11556-11572
9. Lan L, Tao J, Chen A, Xie G, Huang J, Lin J, Peng J, Chen L. Electroacupuncture exerts anti-inflammatory effects in cerebral ischemia-reperfusion injured rats via suppression of the TLR4/NF-kappaB pathway. Int J Mol Med 2013; 31: 75-80
10. Zhang YK, Liu JT, Peng ZW, Fan H, Yao AH, Cheng P, Liu L, Ju G, Kuang F. Different TLR4 expression and microglia/macrophage activation induced by hemorrhage in the rat spinal cord after compressive injury. J Neuroinflammation 2013; 10: 112
11. Sansing LH, Harris TH, Welsh FA, Kasner SE, Hunter CA, Kariko K. Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage. Ann Neurol 2011; 70: 646-656
12. Lin S, Yin Q, Zhong Q, Lv FL, Zhou Y, Li JQ, Wang JZ, Su BY, Yang QW. Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage. J Neuroinflammation 2012; 9: 46
13. Wirawan E, Vanden Berghe T, Lippens S, Agostinis P, Vandenabeele P. Autophagy: for better or for worse. Cell Res 2012; 22: 43-61
14. Bennett HL, Fleming JT, O'Prey J, Ryan KM, Leung HY. Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells. Cell Death Dis 2010; 1: e72
15. Wellnitz K, Taegtmeyer H. Mechanical unloading of the failing heart exposes the dynamic nature of autophagy. Autophagy 2010; 6: 155-156
16. Xu Y, Jagannath C, Liu XD, Sharafkhaneh A, Kolodziejska KE, Eissa NT. Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 2007; 27: 135-144
17. Seay MD, Dinesh-Kumar SP. Autophagy takes its TOLL on innate immunity. Cell Host Microbe 2007; 2: 69-70
18. Xu Y, Liu XD, Gong X, Eissa NT. Signaling pathway of autophagy associated with innate immunity. Autophagy 2008; 4: 110-112
19. Chen J, Qin J, Su Q, Liu Z, Yang J. Treadmill rehabilitation treatment enhanced BDNF-TrkB but not NGF-TrkA signaling in a mouse intracerebral hemorrhage model. Neurosci Lett 2012; 529: 28-32
20. Haussen DC, Henninger N, Kumar S, Selim M. Statin use and microbleeds in patients with spontaneous intracerebral hemorrhage. Stroke 2012; 43: 2677-2681
21. Cordonnier C, Klijn CJ, van Beijnum J, Al-Shahi Salman R. Radiological investigation of spontaneous intracerebral hemorrhage: systematic review and trinational survey. Stroke 2010; 41: 685-690
22. Lee ST, Chu K, Jung KH, Kang KM, Kim JH, Bahn JJ, Jeon D, Kim M, Lee SK, Roh JK. Cholinergic anti-inflammatory pathway in intracerebral hemorrhage. Brain Res 2010; 1309: 164-171
23. Munakata M, Shirakawa H, Nagayasu K, Miyanohara J, Miyake T, Nakagawa T, Katsuki H, Kaneko S. Transient receptor potential canonical 3 inhibitor Pyr3 improves outcomes and attenuates astrogliosis after intracerebral hemorrhage in mice. Stroke 2013; 44: 1981-1987
24. Tang XN, Zheng Z, Giffard RG, Yenari MA. Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke. Ann Neurol 2011; 70: 606-615
25. Jo EK. Mycobacterial interaction with innate receptors: TLRs, C-type lectins, and NLRs. Curr Opin Infect Dis 2008; 21: 279-286
26. Dietrich N, Rohde M, Geffers R, Kroger A, Hauser H, Weiss S, Gekara NO. Mast cells elicit proinflammatory but not type I interferon responses upon activation of TLRs by bacteria. Proc Natl Acad Sci U S A 2010; 107: 8748-8753
27. Matsushita H, Hijioka M, Hisatsune A, Isohama Y, Shudo K, Katsuki H. A retinoic acid receptor agonist Am80 rescues neurons, attenuates inflammatory reactions, and improves behavioral recovery after intracerebral hemorrhage in mice. J Cereb Blood Flow Metab 2011; 31: 222-234
28. Ducruet AF, Zacharia BE, Hickman ZL, Grobelny BT, Yeh ML, Sosunov SA, Connolly ES Jr. The complement cascade as a therapeutic target in intracerebral hemorrhage. Exp Neurol 2009; 219: 398-403
29. Lu H, Li G, Liu L, Feng L, Wang X, Jin H. Regulation and function of mitophagy in development and cancer. Autophagy 2013; 9: 1720-1736
30. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132: 27-42
31. Deretic V, Saitoh T, Akira S. Autophagy in infection, inflammation and immunity. Nat Rev 2013; 13: 722-737
32. Campbell GR, Spector SA. Toll-like receptor 8 ligands activate a vitamin D mediated autophagic response that inhibits human immunodeficiency virus type 1. PLoS Pathog 2012; 8: e1003017
33. Fujita K, Srinivasula SM. TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS). Autophagy 2011; 7: 552-554
34. Fujita K, Maeda D, Xiao Q, Srinivasula SM. Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation. Proc Natl Acad Sci U S A 2011; 108: 1427-1432
35. Yang HZ, Wang JP, Mi S, Liu HZ, Cui B, Yan HM, Yan J, Li Z, Liu H, Hua F, Lu W, Hu ZW . TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury. Am J Pathol 2012; 180: 275-292