HGF gene modification in mesenchymal stem cells reduces radiation-induced intestinal injury by modulating immunity

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Wang, Hua ^a   Sun, Rui Ting ^a,b   Li, Yang ^a   Yang, Yue Feng ^a   Xiao, Feng Jun ^a   Zhang, Yi Kun ^a   Wang, Shao Xia ^a   Sun, Hui Yan ^a   Zhang, Qun Wei ^a   Wu, Chu Tse ^a,c   Wang, Li Sheng ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^b BEIJING UNIVERSITY OF TECHNOLOGY   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; PROTEIN ZO1; SCATTER FACTOR; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL BASED GENE THERAPY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; DNA MODIFICATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOMODULATION; INFLAMMATION; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; MESENCHYMAL STEM CELL; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PEYER PATCH; PROTEIN EXPRESSION; RADIATION INDUCED INTESTINAL INJURY; RADIATION INJURY; TREATMENT OUTCOME; ANIMAL; BLOOD; C57BL MOUSE; CYTOLOGY; DISEASE MODEL; FEMALE; GENE THERAPY; GENETIC TRANSDUCTION; GENETICS; IMMUNITY; IMMUNOLOGY; IMMUNOPHENOTYPING; INJURIES; INTESTINE; LYMPH NODE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; RADIATION INJURIES;

MUS;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GENETIC THERAPY; HEPATOCYTE GROWTH FACTOR; HUMANS; IMMUNITY; IMMUNOPHENOTYPING; INFLAMMATION MEDIATORS; INTESTINES; LYMPH NODES; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE, INBRED C57BL; PEYER'S PATCHES; RADIATION INJURIES; TRANSDUCTION, GENETIC;

EID: 84929209006     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0124420     Document Type: Article

References (31)

1. Monti P, Wysocki J, van der Meeren A, Griffiths NM. The contribution of radiation-induced injury to the gastrointestinal tract in the development of multi-organ dysfunction syndrome or failure. BJR supplement / BIR. 2005; 27:89-94.
2. Kudo K, Liu Y, Takahashi K, Tarusawa K, Osanai M, Hu DL, et al. Transplantation of mesenchymal stem cells to prevent radiation-induced intestinal injury in mice. Journal of radiation research. 2010; 51 (1):73-9. PMID: 19851042
3. Rodrigo SF, van Ramshorst J, Hoogslag GE, Boden H, Velders MA, Cannegieter SC, et al. Intramyocardial injection of autologous bone marrow-derived ex vivo expanded mesenchymal stem cells in acute myocardial infarction patients is feasible and safe up to 5 years of follow-up. Journal of cardiovascular translational research. 2013; 6(5):816-25. doi: 10.1007/s12265-013-9507-7 PMID: 23982478
4. Galipeau J. The mesenchymal stromal cells dilemma-does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road? Cytotherapy. 2013; 15(1):2-8. doi: 10.1016/j.jcyt.2012.10.002 PMID: 23260081
5. Hernigou P, Pariat J, Queinnec S, Homma Y, Flouzat Lachaniette CH, Chevallier N, et al. Supercharging irradiated allografts with mesenchymal stem cells improves acetabular bone grafting in revision arthroplasty. International orthopaedics. 2014; 38(9):1913-21. doi: 10.1007/s00264-014-2285-2 PMID: 24509980
6. Reagan MR, Seib FP, McMillin DW, Sage EK, Mitsiades CS, Janes SM, et al. Stem Cell Implants for Cancer Therapy: TRAIL-Expressing Mesenchymal Stem Cells Target Cancer Cells In Situ. Journal of breast cancer. 2012; 15(3):273-82. doi: 10.4048/jbc.2012.15.3.273 PMID: 23091539
7. Semont A, Mouiseddine M, Francois A, Demarquay C, Mathieu N, Chapel A, et al. Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis. Cell death and differentiation. 2010; 17(6):952-61. doi: 10.1038/cdd.2009.187 PMID: 20019749
8. Garcia-Olmo D, Garcia-Arranz M, Herreros D, Pascual I, Peiro C, Rodriguez-Montes JA. A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Diseases of the colon and rectum. 2005; 48(7):1416-23. PMID: 15933795
9. Selleri S, Dieng MM, Nicoletti S, Louis I, Beausejour C, Le Deist F, et al. Cord-blood-derived mesenchymal stromal cells downmodulate CD4+ T-cell activation by inducing IL-10-producing Th1 cells. Stem cells and development. 2013; 22(7):1063-75. doi: 10.1089/scd.2012.0315 PMID: 23167734
10. Luz-Crawford P, Kurte M, Bravo-Alegria J, Contreras R, Nova-Lamperti E, Tejedor G, et al. Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells. Stem cell research & therapy. 2013; 4(3):65.
11. Matsumoto K, Nakamura T. Hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regeneration. Biochemical and biophysical research communications. 1997; 239(3):639-44. PMID: 9367820
12. Setoyama H, Ido A, Numata M, Moriuchi A, Yamaji N, Tamai T, et al. Repeated enemas with hepatocyte growth factor selectively stimulate epithelial cell proliferation of injured mucosa in rats with experimental colitis. Life sciences. 2011; 89(7-8):269-75.
13. Kanayama M, Takahara T, Yata Y, Xue F, Shinno E, Nonome K, et al. Hepatocyte growth factor promotes colonic epithelial regeneration via Akt signaling. American journal of physiology Gastrointestinal and liver physiology. 2007; 293(1):G230-9. PMID: 17412827
14. Ido A, Numata M, Kodama M, Tsubouchi H. Mucosal repair and growth factors: recombinant human hepatocyte growth factor as an innovative therapy for inflammatory bowel disease. Journal of gastroenterology. 2005; 40(10):925-31. PMID: 16261428
15. Lu LL, Liu YJ, Yang SG, Zhao QJ, Wang X, Gong W, et al. Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica. 2006; 91(8):1017-26. PMID: 16870554
16. Hu ZB, Wu CT, Wang H, Zhang QW, Wang L, Wang RL, et al. A simplified system for generating oncolytic adenovirus vector carrying one or two transgenes. Cancer gene therapy. 2008; 15(3):173-82. PMID: 18157145
17. Hamada K, Shitara Y, Sekine S, Horie T. Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats. Cancer chemotherapy and pharmacology. 2010; 66(6):1031-8. doi: 10.1007/s00280-010-1253-9 PMID: 20119715
18. Bian L, Guo ZK, Wang HX, Wang JS, Wang H, Li QF, et al. In vitro and in vivo immunosuppressive characteristics of hepatocyte growth factor-modified murine mesenchymal stem cells. In Vivo. 2009; 23 (1):21-7. PMID: 19368120
19. Onal C, Kayaselcuk F, Topkan E, Yavuz M, Bacanli D, Yavuz A. Protective effects of melatonin and octreotide against radiation-induced intestinal injury. Digestive diseases and sciences. 2011; 56 (2):359-67. doi: 10.1007/s10620-010-1322-2 PMID: 20652743
20. Zhang J, Gong JF, Zhang W, Zhu WM, Li JS. Effects of transplanted bone marrow mesenchymal stem cells on the irradiated intestine of mice. Journal of biomedical science. 2008; 15(5):585-94. doi: 10.1007/s11373-008-9256-9 PMID: 18763056
21. Yang C, Chen HX, Zhou Y, Liu MX, Wang Y, Wang JX, et al. Manganese superoxide dismutase gene therapy protects against irradiation- induced intestinal injury. Current gene therapy. 2013; 13(5):305-14. PMID: 24060314
22. Tanaka F, Tominaga K, Ochi M, Tanigawa T, Watanabe T, Fujiwara Y, et al. Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats. Life sciences. 2008; 83(23-24):771-9. doi: 10.1016/j.lfs.2008.09.018 PMID: 18930069
23. Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. Journal of cellular biochemistry. 2006; 98(5):1076-84. PMID: 16619257
24. Phinney DG, Prockop DJ. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views. Stem Cells. 2007; 25(11):2896-902. PMID: 17901396
25. Lange C, Brunswig-Spickenheier B, Cappallo-Obermann H, Eggert K, Gehling UM, Rudolph C, et al. Radiation rescue: mesenchymal stromal cells protect from lethal irradiation. PloS one. 2011; 6(1): e14486. doi: 10.1371/journal.pone.0014486 PMID: 21245929
26. Billiard F, Buard V, Benderitter M, Linard C. Abdominal gamma-radiation induces an accumulation of function-impaired regulatory T cells in the small intestine. International journal of radiation oncology, biology, physics. 2011; 80(3):869-76. doi: 10.1016/j.ijrobp.2010.12.041 PMID: 21345609
27. Turner JD, Jenkins GR, Hogg KG, Aynsley SA, Paveley RA, Cook PC, et al. CD4+CD25+ regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection. PLoS neglected tropical diseases. 2011; 5(8):e1269. doi: 10.1371/journal.pntd.0001269 PMID: 21858239
28. Linard C, Billiard F, Benderitter M. Intestinal irradiation and fibrosis in a Th1-deficient environment. International journal of radiation oncology, biology, physics. 2012; 84(1):266-73. doi: 10.1016/j.ijrobp.2011.11.027 PMID: 22336200
29. Madrigal M, Rao KS, Riordan NH. A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods. Journal of translational medicine. 2014; 12(1):260. PMID: 25304688
30. Wang H, Yang YF, Zhao L, Xiao FJ, Zhang QW, Wen ML, et al. Hepatocyte growth factor gene-modified mesenchymal stem cells reduce radiation-induced lung injury. Human gene therapy. 2013; 24 (3):343-53. doi: 10.1089/hum.2012.177 PMID: 23458413
31. Xu LF, Xu C, Mao ZQ, Teng X, Ma L, Sun M. Disruption of the F-actin cytoskeleton and monolayer barrier integrity induced by PAF and the protective effect of ITF on intestinal epithelium. Archives of pharmacal research. 2011; 34(2):245-51. doi: 10.1007/s12272-011-0210-4 PMID: 21380808