Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis

Cell Death and Differentiation

Volumn 17, Issue 6, 2010, Pages 952-961

  Semont A ^a   Mouiseddine, M ^a   Francois A ^a   Demarquay, C ^a   Mathieu, N ^a   Chapel, A ^a   Sache A ^a   Thierry, D ^a   Laloi, P ^a   Gourmelon, P ^a  

^a DRPH/SRBE/LRTE   (France)

Author keywords

Apoptosis; Irradiation; MSC; Proliferation; Recovery; Small intestinal epithelium

Indexed keywords

KI 67 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CELL REGENERATION; CELL RENEWAL; CONTROLLED STUDY; DIGESTIVE SYSTEM INJURY; EPITHELIUM CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTESTINE EPITHELIUM; INTESTINE FUNCTION; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NICK END LABELING; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; RADIATION INJURY; SCID MOUSE; SMALL INTESTINE;

ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT; BONE MARROW CELLS; CELL PROLIFERATION; ELECTROLYTES; EPITHELIAL CELLS; GASTROINTESTINAL DISEASES; HOMEOSTASIS; HUMANS; INTESTINAL MUCOSA; INTESTINE, SMALL; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED NOD; MICE, SCID; MULTIPOTENT STEM CELLS; RADIATION INJURIES, EXPERIMENTAL; SODIUM-POTASSIUM-EXCHANGING ATPASE;

MUS;

EID: 77952243854     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2009.187     Document Type: Article

References (40)

1. Denham JW, Hauer-Jensen M. The radiotherapeutic injury-a complex 'wound'. Radiother Oncol 2002; 63: 129-145.
2. Erbil Y, Oztezcan S, Giris M, Barbaros U, Olgac V, Bilge H et al. The effect of glutamine on radiation-induced organ damage. Life Sci 2005; 78: 376-382.
3. Potten CS. Radiation, the ideal cytotoxic agent for studying the cell biology of tissues such as the small intestine. Radiat Res 2004; 161: 123-136.
4. Francois A, Milliat F, Vozenin-bretons M. Bowel injury associated with pelvic radiotherapy. Radiat Phys Chem 2005; 72: 399-407.
5. Ash D. Lessons from epinal. Clin Oncol (R Coll Radiol) 2007; 19: 614-615.
6. Fouillard L, Bensidhoum M, Bories D, Bonte H, Lopez M, Moseley AM et al. Engraftment of allogeneic mesenchymal stem cells in the bone marrow of a patient with severe idiopathic aplastic anemia improves stroma. Leukemia 2003; 17: 474-476.
7. Horwitz EM, Gordon PL, Koo WK, Marx JC, Neel MD, McNall RY et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci USA 2002; 99: 8932-8937.
8. Le Blanc K, Rasmusson I, Sundberg B, Gotherstrom C, Hassan M, Uzunel M et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004; 363: 1439-1441.
9. Ringden O, Uzunel M, Sundberg B, Lonnies L, Nava S, Gustafsson J et al. Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon. Leukemia 2007; 21: 2271-2276.
10. Garcia-Olmo D, Garcia-Arranz M, Herreros D, Pascual I, Peiro C, Rodriguez-Montes JA. A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum 2005; 48: 1416-1423.
11. Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007; 449: 1003-1007.
12. Wood JD. Neuro-immunophysiology of colon function. Pharmacology 1993; 47: 7-13.
13. Schultz SG, Hudson RL. Biology of sodium-absorbing epithelial cells: dawning of a new era. In: Schultz SG, Field M, Frizzell RA, Rauner BB (eds). Handbook of Physiology: The Gastrointestinal System, vol.4, Intestinal Absorption and Secretion. American Physiological Society: Bethesda, MA, USA, 1991, pp 45-81.
14. Pan HC, Cheng FC, Chen CJ, Lai SZ, Lee CW, Yang DY et al. Post-injury regeneration in rat sciatic nerve facilitated by neurotrophic factors secreted by amniotic fluid mesenchymal stem cells. J Clin Neurosci 2007; 14: 1089-1098.
15. Lim JH, Byeon YE, Ryu HH, Jeong YH, Lee YW, Kim WH et al. Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs. J Vet Sci 2007; 8: 275-282.
16. Beeres SL, Atsma DE, van der Laarse A, Pijnappels DA, van Tuyn J, Fibbe WE et al. Human adult bone marrow mesenchymal stem cells repair experimental conduction block in rat cardiomyocyte cultures. J Am Coll Cardiol 2005; 46: 1943-1952.
17. Marshman E, Booth C, Potten CS. The intestinal epithelial stem cell. Bioessays 2002; 24: 91-98.
18. Matsumoto T, Okamoto R, Yajima T, Mori T, Okamoto S, Ikeda Y et al. Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine. Gastroenterology 2005; 128: 1851-1867.
19. Togel F, Hu Z, Weiss K, Isaac J, Lange C, Westenfelder C. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol 2005; 289: F31-F42. (Pubitemid 40863570)
20. Chen J, Li Y, Katakowski M, Chen X, Wang L, Lu D et al. Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat. J Neurosci Res 2003; 73: 778-786.
21. Imberti B, Morigi M, Tomasoni S, Rota C, Corna D, Longaretti L et al. Insulin-like growth factor-1 sustains stem cell mediated renal repair. J Am Soc Nephrol 2007; 18: 2921-2928.
22. Moon MH, Kim SY, Kim YJ, Kim SJ, Lee JB, Bae YC et al. Human adipose tissue-derived mesenchymal stem cells improve postnatal neovascularization in a mouse model of hindlimb ischemia. Cell Physiol Biochem 2006; 17: 279-290.
23. Liu K, Chi L, Guo L, Liu X, Luo C, Zhang S et al. The interactions between brain microvascular endothelial cells and mesenchymal stem cells under hypoxic conditions. Microvasc Res 2008; 75: 59-67.
24. Sadat S, Gehmert S, Song YH, Yen Y, Bai X, Gaiser S et al. The cardioprotective effect of mesenchymal stem cells is mediated by IGF-I and VEGF. Biochem Biophys Res Commun 2007; 363: 674-679.
25. Parekkadan B, van Poll D, Megeed Z, Kobayashi N, Tilles AW, Berthiaume F et al. Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells. Biochem Biophys Res Commun 2007; 363: 247-252.
26. Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009; 459: 262-265.
27. Moore KA, Lemischka IR. Stem cells and their niches. Science 2006; 311: 1880-1885.
28. Brittan M, Chance V, Elia G, Poulsom R, Alison MR, MacDonald TT et al. A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts. Gastroenterology 2005; 128: 1984-1995.
29. Crisostomo PR, Wang Y, Markel TA, Wang M, Lahm T, Meldrum DR. Human mesenchymal stem cells stimulated by Tnf, Lps, or hypoxia produce growth factors by an Nfkb but Not Jnk dependent mechanism. Am J Physiol Cell Physiol 2008; 294: C675-C682.
30. Kim DH, Yoo KH, Choi KS, Choi J, Choi SY, Yang SE et al. Gene expression profile of cytokine and growth factor during differentiation of bone marrow-derived mesenchymal stem cell. Cytokine 2005; 31: 119-126.
31. Schinkothe T, Bloch W, Schmidt A. In vitro secreting profile of human mesenchymal stem cells. Stem Cells Dev 2008; 17: 199-206.
32. Boerma M, Wang J, Burnett AF, Santin AD, Roman JJ, Hauer-Jensen M. Local administration of interleukin-11 ameliorates intestinal radiation injury in rats. Cancer Res 2007; 67: 9501-9506.
33. Houchen CW, George RJ, Sturmoski MA, Cohn SM. FGF-2 enhances intestinal stem cell survival and its expression is induced after radiation injury. Am J Physiol 1999; 276: G249-G258.
34. Kanayama M, Takahara T, Yata Y, Xue F, Shinno E, Nonome K et al. Hepatocyte growth factor promotes colonic epithelial regeneration via Akt signaling. Am J Physiol Gastrointest Liver Physiol 2007; 293: G230-G239.
35. Mylonas PG, Matsouka PT, Papandoniou EV, Vagianos C, Kalfarentzos F, Alexandrides TK. Growth hormone and insulin-like growth factor I protect intestinal cells from radiation induced apoptosis. Mol Cell Endocrinol 2000; 160: 115-122.
36. Nasef A, Mathieu N, Chapel A, Frick J, Francois S, Mazurier C et al. Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G. Transplantation 2007; 84: 231-237.
37. Mouiseddine M, Francois S, Semont A, Sache A, Allenet B, Mathieu N et al. Human mesenchymal stem cells home specifically to radiation-injured tissues in a non-obese diabetes/severe combined immunodeficiency mouse model. Br J Radiol 2007; 80: S49-S55.
38. Murer H, Ammann E, Biber J, Hopfer U. The surface membrane of the small intestinal epithelium. I. Localization of adenylate cyclase. Biochim Biophys Acta 1979; 433: 509-519.
39. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
40. Kaneko Y, Sakakibara S, Imai T, Suzuki A, Nakamura Y, Sawamoto K et al. Musashi1: an evolutionally conserved marker for CNS progenitor cells including neural stem cells. Dev Neurosci 2000; 22: 139-153.