Disruption of the F-actin cytoskeleton and monolayer barrier integrity induced by PAF and the protective effect of ITF on intestinal epithelium

Archives of Pharmacal Research

Volumn 34, Issue 2, 2011, Pages 245-251

  Xu, Ling Fen ^a   Xu, Cheng ^b   Mao, Zhi Qin ^a   Teng, Xu ^a   Ma, Li ^a   Sun, Mei ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Claudin 1; Cytoskeleton; F actin; Intestinal trefoil factor; Platelet activating factor; Transepithelial electrical resistance; ZO 1

Indexed keywords

CLAUDIN 1; F ACTIN; INTESTINAL TREFOIL FACTOR; LUCIFER YELLOW; PROTEIN ZO1; THROMBOCYTE ACTIVATING FACTOR;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL PROTECTION; CELL STRAIN CACO 2; CONTROLLED STUDY; CYTOSKELETON; ELECTRIC RESISTANCE; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; IN VITRO STUDY; INTESTINE EPITHELIUM; NONHUMAN; PERMEABILITY BARRIER;

ACTINS; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CYTOSKELETON; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENCE; HUMANS; INTESTINAL MUCOSA; MEMBRANE PROTEINS; PEPTIDES; PLATELET ACTIVATING FACTOR; TIGHT JUNCTIONS;

EID: 79953294006     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-0210-4     Document Type: Article

References (36)

1. Banan, A., Fields, J. Z., Farhadi, A., Talmage, D. A., Zhang, L., and Keshavarzian, A., The beta 1 isoform of protein kinase C mediates the protective effects of epidermal growth factor on the dynamic assembly of F-actin cytoskeleton and normalization of calcium homeostasis in human colonic cells. J. Pharmacol. Exp. Ther., 301, 852-866 (2002).
2. Banan, A., Zhang, L. J., Shaikh, M., Fields, J. Z., Farhadi, A., and Keshavarzian, A., Key role of PLC-gamma in EGF protection of epithelial barrier against iNOS upregulation and F-actin nitration and disassembly. Am. J. Physiol. Cell Physiol., 285, C977-C993 (2003).
3. Chen, L. P., Zhang, B. H., Li, Y., Mai, G. R., and Liu, Z. X., The Effect and Significance of Intestinal Trefoil Factor IL-8 and MDA for Neonatal Rat Model for Hypoxia-induced Intestinal Injury. Chin. J. Perinat. Med., 36, 306-309 (2003).
4. De Plaen, I. G., Tan, X. D., Chang, H., Qu, X. W., Liu, Q. P., and Hsueh, W., Intestinal NF-kappaB is activated, mainly as p50 homodimers, by platelet-activating factor. Biochim. Biophys. Acta, 1392, 185-192 (1998).
5. Dignass, A., Lynch-Devaney, K., Kindon, H., Thim, L., and Podolsky, D. K., Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway. J. Clin. Invest., 94, 376-383 (1994).
6. Eliakim, R., Karmeli, F., Razin, E., and Rachmilewitz, D., Role of platelet-activating factor in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine and prednisolone. Gastroenterology, 95, 1167-1172 (1988).
7. Emami, S., Le Floch, N., Bruyneel, E., Thim, L., May, F., Westley, B., Rio, M., Mareel, M., and Gespach, C., Induction of scattering and cellular invasion by trefoil peptides in src- and RhoA-transformed kidney and colonic epithelial cells. FASEB J., 15, 351-361 (2001).
8. Guerrant, R. L., Fang, G. D., Thielman, N. M., and Fonteles, M. C., Role of platelet activating factor in the intestinal epithelial secretory and Chinese hamster ovary cell cytoskeletal responses to cholera toxin. Proc. Natl. Acad. Sci. U. S. A., 91, 9655-9658 (1994).
9. Gustafson, C., Kald, B., Sjödahl, R., and Tagesson, C., Phospholipase C from Clostridium perfringens stimulates formation and release of platelet-activating factor (PAF-acether) in cultured intestinal epithelial cells (INT 407). Scand. J. Gastroenterol., 26, 1000-1006 (1991).
10. Hidalgo, I. J., Raub, T. J., and Borchardt, R. T., Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96, 736-749 (1989).
11. Hollander, D., Crohn's disease-permeability disorder of the tight junction? Gut, 29, 1621-1624 (1988).
12. Hollander, D., The intestinal permeability barrier: a hypothesis as to its regulation and involvement in Crohn's disease. Scand. J. Gastroenterol., 27, 721-726 (1992).
13. Hsueh, W, Caplan, M. S., Sun, X., Tan, X., MacKendrick, W., and Gonzalez-Crussi, F., Platelet-activating factor, tumor necrosis factor, hypoxia and necrotizing enterocolitis. Acta Paediatr. Suppl., 396, 11-17 (1994).
14. Huang, L., Tan, X., Crawford, S. E., and Hsueh, W., Platelet-activating factor and endotoxin induce tumour necrosis factor gene expression in rat intestine and liver. Immunology, 83, 65-69 (1994).
15. Imaizumi, T., Stafforini, D. M., Yamada, Y., Mcintyre, T. M., Prescott, S. M., and Zimmerman, G. A., Platelet-activating factor: a mediator for clinicians. J. Intern. Med., 238, 5-20 (1995).
16. Keshavarzian, A., Holmes, E. W., Patel, M., Iber, F., Fields, J. Z., and Pethkar, S., Leaky gut in alcoholic cirrhosis: a possible mechanism for alcohol-induced liver damage. Am. J. Gastroenterol., 94, 200-207 (1999).
17. Kindon, H., Pothoulakis, C., Thim, L., Lynch-Devaney, K., and Podolsky, D. K., Trefoil peptide protection of intestinal epithelial barrier function: cooperative interaction with mucin glycoprotein. Gastroenterology, 109, 516-523 (1995).
18. Kotelevets, L., Noë, V., Bruyneel, E., Myssiakine, E., Chastre, E., and Mareel, M., Inhibition by platelet-activating factor of src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells: phosphatidylinositol 3′-kinase is a critical mediator of tumor invasion. J. Biol. Chem., 273, 14138-14145 (1998).
19. Kubes, P., Arfors, K. E., and Granger, D. N., Platelet-activating factor-induced mucosal dysfunction: role of oxidants and granulocytes. Am. J. Physiol., 260, G965-G971 (1991).
20. Lago, J., Santaclara, F., Vieites, J. M., and Cabado, A. G., Collapse of mitochondrial membrane potential and caspases activation are early events in okadaic acid-treated Caco-2 cells. Toxicon, 46, 579-586 (2005).
21. Li, J., Xu, L. F., Sun, M., Li, Q., Gao, H., and Jiang, W. G., Protective effects of recombinant intestinal trefoil factor against intestinal injuries induced by endotoxin in young rats. Chin. J. Contemp. Pediatr., 8, 425-428 (2006a).
22. Li, J., Zhao, Y. J., Sun, M., Pan, L. L., and Gao, H., Effects of recombinant intestinal trefoil factor on endotoxin-induced expression of nitric oxide and malondialdehyde in intestinal tissues of infant rats. World Chin. J. Dig., 14, 63-67 (2006b).
23. Menconi, M. J., Salzman, A. L., Unno, N., Ezzell, R. M., Casey, D. M., Brown, D. A., Tsuji, Y., and Fink, M. P., Acidosis induces hyperpermeability in Caco-2BBe cultured intestinal epithelial monolayers. Am. J. Physiol., 272, G1007-G1021 (1997).
24. Merendino, N., Dwinell, M. B., Varki, N., Eckmann, L., and Kagnoff, M. F., Human intestinal epithelial cells express receptors for platelet-activating factor. Am. J. Physiol., 277, G810-G818 (1999).
25. Meyer zum Büschenfelde, D., Tauber, R., and Huber, O., TFF3-peptide increases transepithelial resistance in epithelial cells by modulating claudin-1 and -2 expression. Peptide, 27, 3383-3390 (2006).
26. Playford, R. J., Marchbank, T., Chinery, R., Evison, R., Pignatelli, M., Boulton, R. A., Thim, L., and Hanby, A. M., Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration. Gastroenterology, 108, 108-116 (1995).
27. Prescott, S. M., Zimmerman, G. A., and McIntyre, T. M., Platelet-activating factor. J. Biol. Chem., 265, 17381-17384 (1990).
28. Qu, X., Huang, L., Burthart, T., Crawford, S. E., Caplan, M. S., and Hsueh, W., Endotoxin induces PAF production in the rat ileum: quantitation of tissue PAF by an improved method. Prostaglandins, 51, 249-262 (1996).
29. Renes, I. B., Verburg, M., Van Nispen, D. J., Büller, H. A., Dekker, J., and Einerhand, A. W., Distinct epithelial responses in experimental colitis: implications for ion uptake and mucosal protection. Am. J. Physiol. Gastrointest. Liver Physiol., 283, G169-G179 (2002).
30. Suemori, S, Lynch-Devaney, K., and Podolsky, D. K., Identification and characterization of rat intestinal trefoil factor: Tissue and cell-specific. Proc. Natl. Acad. Sci. U. S. A., 88, 11017-11021 (1991).
31. Tan, X., Sun, X., Gonzalez-Crussi, F. X., Gonzalez-Crussi, F., and Hsueh, W., PAF and TNF increase the precursor of NF-kappa B p50 mRNA in mouse intestine: quantitative analysis by competitive PCR. Biochim. Biophys. Acta, 1215, 157-162 (1994).
32. Tan, X. D., Wang, H., Gonzalez-Crussi, F. X., Chang, H., Gonzalez-Crussi, F., and Hsueh, W., Platelet activating factor and endotoxin increase the enzyme activity and gene expression of type II phospholipase A2 in the rat intestine. Role of polymorphonuclear leukocytes. J. Immunol., 156, 2985-2990 (1996).
33. Thim, L., Trefoil peptides: A new family of gastrointestinal molecules. Digestion, 55, 353-360 (1994).
34. Thim, L., Trefoil peptides: from structure to function. Cell. Mol. Life Sci., 53, 888-903 (1997).
35. Unno, N., Menconi, M. J., Smith, M., and Fink, M. P., Hyperpermeability of intestinal epithelial monolayers induced by NO: effect of low extracellular pH. Am. J. Physiol., 272, G923-G934 (1997).
36. Wang, H., Tan, X., Chang, H., Gonzalez-Crussi, F., Remick, D. G., and Hsueh, W., Regulation of platelet-activating factor receptor gene expression in vivo by endotoxin, platelet-activating factor and endogenous tumour necrosis factor. Biochem. J., 322, 603-608 (1997).