Rational design of adjuvant for skin delivery: Conjugation of synthetic β-glucan dectin-1 agonist to protein antigen

Molecular Pharmaceutics

Volumn 12, Issue 5, 2015, Pages 1662-1672

  Donadei, Agnese ^a   Gallorini, Simona ^a   Berti, Francesco ^a   O'Hagan, Derek T ^b   Adamo, Roberto ^a   Baudner, Barbara C ^a  

^a NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

^b Vaccine Chemistry and Formulation Novartis Vaccines and Diagnostics   (United States)

Author keywords

adjuvant conjugation; dectin 1 targeting; glycoconjugates; skin delivery; glucans

Indexed keywords

ANTIGEN; BETA GLUCAN; BETA GLUCAN HEXASACCHARIDE; CARRIER PROTEIN; CURDLAN; DECTIN 1; DIPHTHERIA TOXOID CRM197; GLUCAN; GLYCOCONJUGATE; IMMUNOGLOBULIN G; UNCLASSIFIED DRUG; IMMUNOLOGICAL ADJUVANT; LECTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DRUG CONJUGATION; FEMALE; GLYCOSYLATION; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SKIN CELL; AGONISTS; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS; BETA-GLUCANS; CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; LECTINS, C-TYPE; MICE; MICE, INBRED BALB C;

EID: 84929206862     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00072     Document Type: Article

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