Interleukin-18 is associated with protection against rhinovirus-induced colds and asthma exacerbations

Clinical Infectious Diseases

Volumn 60, Issue 10, 2015, Pages 1528-1531

  Jackson, David J ^a,b,c   Glanville, Nicholas ^a,b   Trujillo Torralbo, Maria Belen ^a,b,c   Shamji, Betty W H ^d   Del Rosario, Jerico ^a,b,c   Mallia, Patrick ^a,b,c   Edwards, Matthew J ^d   Walton, Ross P ^a,b   Edwards, Michael R ^a,b   Johnston, Sebastian L ^a,b,c  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

asthma; inflammasome; interleukin 18; rhinovirus infection

Indexed keywords

CORTICOSTEROID; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 1BETA; VIRUS ANTIBODY;

ARTICLE; ASTHMA; CLINICAL ARTICLE; COMMON COLD; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE EXACERBATION; HUMAN; HUMAN EXPERIMENT; HUMAN RHINOVIRUS A16; NEBULIZER; NORMAL HUMAN; PRIORITY JOURNAL; RHINOVIRUS; RHINOVIRUS INFECTION; ADULT; CHEMISTRY; FEMALE; IMMUNOLOGY; MALE; MIDDLE AGED; PATHOLOGY; RESPIRATORY MUCOSA; VIROLOGY;

ADULT; ASTHMA; COMMON COLD; FEMALE; HUMANS; INTERLEUKIN-18; MALE; MIDDLE AGED; RESPIRATORY MUCOSA; RHINOVIRUS;

EID: 84929206846     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/civ062     Document Type: Article

References (17)

1. Kanneganti T-D. Central roles of NLRs and inflammasomes in viral infection. Nat Rev Immunol 2010; 10:688-98.
2. Liu B, Mori I, Hossain MJ, Dong L, Takeda K, Kimura Y. Interleukin-18 improves the early defence system against influenza virus infection by augmenting natural killer cell-mediated cytotoxicity. J Gen Virol 2004; 85(pt 2):423-8.
3. Miao EA, Leaf IA, Treuting PM, et al. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol 2010; 11:1136-42.
4. Triantafilou K, Kar S, van Kuppeveld FJM, Triantafilou M. Rhinovirusinduced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells. Am J Respir Cell Mol Biol 2013; 49:923-34.
5. Thomas PG, Dash P, Aldridge JR, et al. NLRP3 (NALP3/CIAS1/Cryopyrin) mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 2009; 30:566-75.
6. Ceballos-Olvera I, Sahoo M, Miller MA, del Barrio L, Re F. Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1? is deleterious. PLoS Pathog 2011; 7:e1002452.
7. Allen IC, Scull MA, Moore CB, et al. The NLRP3 inflammasome mediates in vivo innate immunity to influenza Avirus through recognition of viral RNA. Immunity 2009; 30:556-65.
8. Sugawara I, Yamada H, Mizuno S, Takeda K, Akira S. Mycobacterial infection in MyD88-deficient mice. Microbiol Immunol 2003; 47:841-7.
9. Brieland JK, Jackson C, Hurst S, et al. Immunomodulatory role of endogenous interleukin-18 in gamma interferon-mediated resolution of replicative Legionella pneumophila lung infection. Infect Immun 2000; 68:6567-73.
10. Piper SC, Ferguson J, Kay L, et al. The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells. PLoS One 2013; 8:e63365.
11. Shi L, Manthei DM, Guadarrama AG, Lenertz LY, Denlinger LC. Rhinovirus-induced IL-1? release from bronchial epithelial cells is independent of functional P2X7. Am J Respir Cell Mol Biol 2012; 47:363-71.
12. Moffatt MF, Gut IG, Demenais F, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010; 363: 1211-21.
13. Jackson DJ, Makrinioti H, Rana BMJ, et al. IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo. Am J Respir Crit Care Med 2014; 190:1373-82.
14. Beale J, Jayaraman A, Jackson DJ, et al. Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation. Sci Transl Med 2014; 6:256ra134.
15. Zaki H, Boyd KL, Kastan MB, Lamkanfi M, Kanneganti T-D. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 2010; 32:379-91.
16. Imaoka H, Gauvreau GM, Watson RM, et al. Interleukin-18 and interleukin-18 receptor-? expression in allergic asthma. Eur Respir J 2011; 38:981-3.
17. Tanaka-Kataoka M, Kunikata T, Takayama S, et al. In vivo antiviral effect of interleukin 18 in a mouse model of vaccinia virus infection. Cytokine 1999; 11:593-9.