A 16 × 16 CMOS Capacitive Biosensor Array Towards Detection of Single Bacterial Cell

IEEE Transactions on Biomedical Circuits and Systems

Volumn 10, Issue 2, 2016, Pages 364-374

  Couniot, Numa ^a   Francis, Laurent A ^a   Flandre, Denis ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Bacteria detection; correlated double sampling (CDS); impedance sensor; multi electrode array (MEA); real time

Indexed keywords

BACTERIA; BIOSENSORS; CMOS INTEGRATED CIRCUITS; MICROELECTRODES; PIXELS;

CAPACITIVE BIOSENSORS; COMPREHENSIVE ANALYSIS; DIELECTRIC MEASUREMENTS; ELECTRICAL CONDUCTIVITY; LAB-ON-CHIP SYSTEMS; LOW-POWER CONSUMPTION; REAL-TIME DETECTION; STAPHYLOCOCCUS EPIDERMIDIS;

SIGNAL TO NOISE RATIO;

DEVICES; ELECTRIC CAPACITANCE; EQUIPMENT DESIGN; GENETIC PROCEDURES; ISOLATION AND PURIFICATION; LAB ON A CHIP; MICROELECTRODE; POINT OF CARE SYSTEM; SIGNAL NOISE RATIO; STAPHYLOCOCCUS EPIDERMIDIS;

BIOSENSING TECHNIQUES; ELECTRIC CAPACITANCE; EQUIPMENT DESIGN; LAB-ON-A-CHIP DEVICES; MICROELECTRODES; POINT-OF-CARE SYSTEMS; SIGNAL-TO-NOISE RATIO; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 84929192874     PISSN: 19324545     EISSN: None     Source Type: Journal    
DOI: 10.1109/TBCAS.2015.2416372     Document Type: Article

References (29)

1. J. M. Rothberg, W. Hinz, T. M. Rearick, J. Schultz, W. Mileski, M. Davey, J. H. Leamon, K. Johnson, M. J. Milgrew, M. Edwards, J. Hoon, J. F. Simons, D. Marran, J. W. Myers, J. F. Davidson, A. Branting, J. R. Nobile, B. P. Puc, D. Light, T. A. Clark, M. Huber, J. T. Branciforte, I. B. Stoner, S. E. Cawley, M. Lyons, Y. Fu, N. Homer, M. Sedova, X. Miao, B. Reed, J. Sabina, E. Feierstein, M. Schorn, M. Alanjary, E. Dimalanta, D. Dressman, R. Kasinskas, T. Sokolsky, J. A. Fidanza, E. Namsaraev, K. J. McKernan, A. Williams, G. T. Roth, and J. Bustillo, "An integrated semiconductor device enabling non-optical genome sequencing," Nature, vol. 475, no. 7356, pp. 348-352, 2011.
2. A. Hierlemann, U. Frey, S. Hafizovic, and F. Heer, "Growing cells atop microelectronic chips: interfacing electrogenic cells in vitro with CMOS-based microelectrode arrays," Proc. IEEE, vol. 99, no. 2, pp. 252-284, 2011.
3. A. H. D. Graham, J. Robbins, C. R. Bowen, and J. Taylor, "Commercialisation of CMOS integrated circuit technology in multi-electrode arrays for neuroscience and cell-based biosensors," Sensors, vol. 11, no. 5, pp. 4943-4971, 2011.
4. American Academy of Microbiology, Bringing the Lab to the Patient, 2012, pp. 1-24.
5. N. Couniot, A. Afzalian, and D. Flandre, "Scaling laws and performance improvements of integrated biosensor microarrays with multi-pixel per spot," Sensors Actuators B, Chem., vol. 166-167, pp. 184-192, 2012.
6. R. Hamada, H. Takayama, Y. Shonishi, L. Mao, M. Nakano, and J. Suehiro, "A rapid bacteria detection technique utilizing impedance measurement combined with positive and negative dielectrophoresis," Sensors Actuators B, Chem., vol. 181, pp. 439-445, 2013.
7. M. Varshney, "Interdigitated array microelectrode based impedance biosensor coupled with magnetic nanoparticle-antibody conjugates for detection of escherichia coli O157:H7 in food samples," Biosensors Bioelectron., vol. 22, pp. 2408-2414, 2007.
8. M. Varshney and Y. Li, "Interdigitated array microelectrodes based impedance biosensors for detection of bacterial cells," Biosensors Bioelectron., vol. 24, no. 10, pp. 2951-2960, 2009.
9. L. Moreno-Hagelsieb, B. Foultier, G. Laurent, R. Pampin, J. Remacle, J. P. Raskin, and D. Flandre, "Electrical detection of DNA hybridization: Three extraction techniques based on interdigitated AL/Al2O3 capacitors," Biosensors Bioelectron., vol. 22, no. 9-10, pp. 2199-2207, 2007.
10. N. Couniot, T. Vanzieleghem, J. Rasson, N. V. Overstraeten-Schlögel, O. Poncelet, J. Mahillon, L. Francis, and D. Flandre, "Lytic enzymes as selectivity means for label-free, microfluidic and impedimetric detection of whole-cell bacteria using ALD-AL2O3 passivated microelectrodes," Biosensors Bioelectron., vol. 67, pp. 154-161, 2015.
11. N. Couniot, D. Bol, O. Poncelet, L. A. Francis, and D. Flandre, "A capacitance-to-Frequency converter with on-chip passivated microelectrodes for bacteria detection in saline buffers up to 575 MHz," IEEE Trans. Circuits Syst. II, Exp. Briefs, vol. 62, no. 2, pp. 159-163, 2015.
12. A. Romani, N. Manaresi, L. Marzocchi, G. Medoro, A. Leonardi, L. Altomare, M. Tartagni, and R. Guerrieri, "Capacitive sensor array for localization of bioparticles in CMOS lab-on-a-chip," in Proc. IEEE Int. Solid-State Circuits Conf., Dig. Tech. Papers, 2004, pp. 224-225.
13. C. Stagni, C. Guiducci, L. Benini, B. Ricco, S. Carrara, B. Samori, C. Paulus, M. Schienle, M. Augustyniak, and R. Thewes, "CMOS DNA sensor array with integrated A/D conversion based on label-free capacitance measurement," IEEE J. Solid-State Circuits, vol. 41, no. 12, pp. 2956-2964, 2006.
14. K.-H. Lee, J.-O. Lee, M.-J. Sohn, B. Lee, S.-H. Choi, S. K. Kim, J.-B. Yoon, and G.-H. Cho, "One-chip electronic detection of DNA hybridization using precision impedance-based CMOS array sensor," Biosensors Bioelectron., vol. 26, no. 4, pp. 1373-1379, 2010.
15. A. Manickam, A. Chevalier, M. McDermott, A. D. Ellington, and A. Hassibi, "A CMOS electrochemical impedance spectroscopy (EIS) biosensor array," IEEE Trans. Biomed. Circuits Syst., vol. 4, no. 6, pp. 379-390, 2010.
16. H. Mazhab-Jafari, L. Soleymani, and R. Genov, "16-channel CMOS impedance spectroscopy DNA analyzer with dual-slope multiplying ADCs," IEEE Trans. Biomed. Circuits Syst., vol. 6, no. 5, pp. 468-478, 2012.
17. M. S. C. Lu, Y.-C. Chen, and P.-C. Huang, "5 × 5 CMOS capacitive sensor array for detection of the neurotransmitter dopamine," Biosensors Bioelectron., vol. 26, no. 3, pp. 1093-1097, 2010.
18. A.-Y. Chang and M. S. C. Lu, "A CMOS magnetic microbead-based capacitive biosensor array with on-chip electromagnetic manipulation," Biosensors Bioelectron., vol. 45, no. C, pp. 6-12, 2013.
19. S. B. Prakash and P. Abshire, "A fully differential rail-to-rail CMOS capacitance sensor with floating-gate trimming for mismatch compensation," IEEE Trans. Circuits Syst. I. Reg. Papers, vol. 56, no. 5, pp. 975-986, 2009.
20. E. Ghafar-Zadeh, M. Sawan, V. P. Chodavarapu, and T. Hosseini-Nia, "Bacteria growth monitoring through a differential CMOS capacitive sensor," IEEE Trans. Biomed. Circuits Syst., vol. 4, no. 4, pp. 232-238, 2010.
21. C. Berggren, B. Bjarnason, and G. Johansson, "Capacitive biosensors," Electroanalysis, vol. 13, no. 3, pp. 173-180, 2001.
22. S. B. Prakash and P. Abshire, "Tracking cancer cell proliferation on a CMOS capacitance sensor chip," Biosensors Bioelectron., vol. 23, no. 10, pp. 1449-1457, 2008.
23. A. E. Gamal and H. Eltoukhy, "CMOS image sensors," IEEE Circuits Devices Mag., vol. 21, no. 3, pp. 6-20, 2005.
24. N. Couniot, A. Afzalian, N. Van overstraeten, L. A. Francis, and D. Flandre, "Capacitive biosensing of bacterial cells: analytical model and numerical simulations," Sensors Actuators B, Chem., vol. 211, pp. 428-438, 2015.
25. N. Couniot, D. Flandre, L. A. Francis, and A. Afzalian, "Signal-tonoise ratio optimization for detecting bacteria with interdigitated microelectrodes," Sensors Actuators B, Chem., vol. 189, pp. 43-51, 2013.
26. A. I. Abdulagatov, Y. Yan, J. R. Cooper, Y. Zhang, Z. M. Gibbs, A. S. Cavanagh, R. G. Yang, Y. C. Lee, and S. M. George, "Al2O3 and TiO2 atomic layer deposition on copper for water corrosion resistance," ACS Appl. Mater. Interfaces, vol. 3, no. 12, pp. 4593-4601, 2011.
27. F. Silveira, D. Flandre, and P. Jespers, "A gm/ID based methodology for the design of CMOS analog circuits and its application to the synthesis of a silicon-on-insulator micropower OTA," IEEE J. Solid-State Circuits, vol. 31, no. 9, pp. 1314-1319, 1996.
28. M. A. Miled, G. Massicotte, and M. Sawan, "Dielectrophoresis-based integrated lab-on-chip for nano and micro-particles manipulation and capacitive detection," IEEE Trans. Biomed. Circuits Syst., vol. 6, no. 2, pp. 120-132, 2012.
29. N. V. Overstraeten-Schlögel, O. Lefèvre, N. Couniot, and D. Flandre, "Assessment of different functionalization methods for grafting a protein to an alumina-covered biosensor," Biofabrication, vol. 6, no. 3, p. 035007, 2014.