16-channel CMOS impedance spectroscopy DNA analyzer with dual-slope multiplying ADCs

IEEE Transactions on Biomedical Circuits and Systems

Volumn 6, Issue 5, 2012, Pages 468-478

  Jafari, Hamed ^a   Soleymani, Leyla ^b   Genov, Roman ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Biosensor; DNA; electrochemical sensor; frequency response analysis; impedance spectroscopy; multiplying ADC

Indexed keywords

DNA DETECTION; FREQUENCY RESPONSE ANALYSIS; IMPEDANCE SPECTROSCOPY; IN-CHANNELS; INPUT CURRENT; MINIMAL AREA; MIXED SIGNAL; MULTIPLE INPUTS; MULTIPLYING ADC; PROSTATE CANCERS; STANDARD CMOS TECHNOLOGY;

BIOSENSORS; CMOS INTEGRATED CIRCUITS; ELECTROCHEMICAL SENSORS; SPECTROSCOPY;

DNA;

DNA;

ALGORITHM; ARTICLE; BIOMEDICAL ENGINEERING; CHEMISTRY; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; EQUIPMENT; EQUIPMENT DESIGN; GENETIC PROCEDURES; HUMAN; MALE; PROSTATE TUMOR; SEMICONDUCTOR; SIGNAL PROCESSING; STATISTICS;

ALGORITHMS; BIOMEDICAL ENGINEERING; BIOSENSING TECHNIQUES; DIELECTRIC SPECTROSCOPY; DNA; DNA, NEOPLASM; EQUIPMENT DESIGN; HUMANS; MALE; PROSTATIC NEOPLASMS; SEMICONDUCTORS; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 84870543301     PISSN: 19324545     EISSN: None     Source Type: Journal    
DOI: 10.1109/TBCAS.2012.2226334     Document Type: Article

References (29)

1. F. Heer, M. Keller, G. Yu, J. Janata, M. Josowicz, and A. Hierlemann, "CMOS electro-chemical DNA-detection array with on-chip ADC, " in Proc. IEEE Int. Solid-State Circuits Conf., 2008, pp. 168-169.
2. M. Schienle, C. Paulus, A. Frey, F. Hofmann, B. Holzapfl, P. S. Bauer, and R. Thewes, "A fully electronic DNA sensor with 128 positions and in-pixel A/D conversion, " IEEE J. Solid-State Circuits, vol. 39, no. 12, pp. 2438-2445, 2004.
3. D. M. Garner, H. Bai, P. Georgiou, T. G. Constandinou, S. Reed, L. M. Shepherd, W. Wong, K. T. Lim, and C. Toumazou, "A multichannel DNA SoC for rapid point-of-care gene detection, " in Proc. IEEE Int. Solid-State Circuits Conf., 2010, pp. 492-493.
4. A. Hassibi and T. H. Lee, "A programmable 0. 18 m CMOS electrochemical sensor microarray for bimolecular detection, " IEEE Sensors J., vol. 6, pp. 1380-1388, 2006. (Pubitemid 44955713)
5. A. Hassibi, H. Vikalo, J. L. Riechmann, and B. Hassibi, "Real-time DNA microarray analysis, " Nucl. Acids Res., pp. 1-12, Aug. 2009.
6. B. Jang, P. Cao, A. Chevalier, A. Ellington, and A. Hassibi, "A CMOS fluorescence-based biosensor microarray, " in Proc. IEEE Int. Solid-State Circuits Conf., Feb. 2009, pp. 436-437.
7. H. Wang, Y. Chen, A. Hassibi, A. Scherer, and A. Hajimiri, "A frequency-shift CMOS magnetic biosensor array with single-bead sensitivity and no external magnet, " in Proc. IEEE Int. Solid-State Circuits Conf., Feb. 2009, pp. 438-439.
8. P. M. Levine, P. Gong, R. Levicky, and K. L. Shepard, "Active CMOS sensor array for electrochemical biomolecular detection, " IEEE J. Solid-State Circuits, vol. 43, no. 8, pp. 1859-1871, 2008.
9. J. Wang, "Electrochemical nucleic acid biosensors, " Analytica Chimica Acta, vol. 469, pp. 63-71, 2002. (Pubitemid 35304575)
10. T. G. Drummond, M. G. Hill, and J. K. Barton, "Electrochemical DNA sensors, " Nature Biotechnol., vol. 21, no. 10, pp. 1192-1199, Oct. 2003. (Pubitemid 37186176)
11. D. A. D. Giusto, W. A. Wlassoff, S. Giesebrecht, J. J. Gooding, and G. C. King, "Enzymatic synthesis of redox-labeled RNA and dual-potential detection at DNA-modified electrodes, " Angewandte Chemie Int. Ed., vol. 43, pp. 2809-2812, 2004. (Pubitemid 39257670)
12. M. Schena, D. Shalon, R. W. Davis, and P. O. Brown, "Quantitative monitoring of gene expression patterns with a complementary DNA microarray, " Science, vol. 270, no. 5235, pp. 467-470, Oct. 1995.
13. C. Yang, Y. Huang, B. L. Hassler, R. M. Worden, and A. J. Mason, "Amperometric electrochemical microsystem for a miniaturized protein biosensor array, " IEEE Trans. Biomed. Circuits Syst., vol. 3, no. 3, pp. 160-168, 2009.
14. R. Genov, M. Stanacevic, M. Naware, G. Cauwenberghs, and N. Thakor, "16-channel integrated potentiostat for distributed neurochemical sensing, " IEEE Trans. Circuits Syst. I, Reg. Papers, vol. 53, no. 11, pp. 2371-2376, Nov. 2006. (Pubitemid 44824315)
15. M. Roham, M. P. Garris, and P. Mohseni, "A wireless IC for time-share chemical and electrical neural recording, " IEEE J. Solid-State Circuits, vol. 44, no. 12, pp. 3645-3658, 2009.
16. M. Stanacevic, K. Murari, A. Rege, G. Cauwenberghs, and N. Thakor, "VLSI potentiostat array with oversampling gain modulation for widerange neurotransmitter sensing, " IEEE Trans. Biomed. Circuits Syst., vol. 1, no. 1, pp. 63-72, Feb. 2007. (Pubitemid 46695337)
17. M. Nazari and R. Genov, "A fully differential CMOS potentiostat, " in Proc. IEEE Int. Symp. Circuits and Systems, May 2009, vol. 2, pp. 2177-2180.
18. M. Nazari, H. M. Jafari, and R. Genov, "192-channel CMOS neurochemical microarray, " in proc. IEEE Custom Integrated Circuits Conf., Sep. 2010, pp. 121-125.
19. J. Kafka, O. Pnke, B. Abendroth, and F. Lisdat, "A label-free DNA sensor based on impedance spectroscopy, " Electrochimica Acta, vol. 53, no. 25, pp. 7467-7474, Oct. 2008.
20. Y. T. Long, C. Z. Li, H. B. Kraatz, and J. S. Lee, "AC impedance spectroscopy of native DNA and M-DNA, " Biophys. J., vol. 84, no. 5, pp. 3218-3225, May 2003. (Pubitemid 36531769)
21. C. Yang, S. R. Jadhav, R. M. Worden, and A. J. Mason, "Compact lowpower impedance-to-digital converter for sensor array microsystems, " IEEE J. Solid-State Circuits, vol. 44, no. 10, pp. 2844-2855, 2009.
22. M. Min and T. Parve, "Improvement of lock-in bio-impedance analyzer for implantable medical devices, " IEEE Trans. Instrum. Meas., vol. 56, pp. 968-974, 2007. (Pubitemid 46794897)
23. A. Manickam, A. Chevalier, M. McDermortt, A. D. Ellington, and A. Hassibi, "A CMOS electrochemical impedance spectroscopy biosensor array for label-free biomolecular detection, " in Proc. IEEE Int. Solid-State Circuits Conf., 2010, pp. 130-131.
24. E. Barsoukov and J. R. Macdonald, Impedance Spectroscopy: Theory, Experiment, and Applications, 2nd ed. Hoboken, NJ: Wiley, 2005.
25. M. Alubaidy, L. Soleymani, K. Venkatakrishnan, and B. Tan, "Femtosecond laser nanostructuring for femtosensitive DNA detection, " Biosens. Bioelectron., vol. 33, no. 1, pp. 83-87, Mar. 2012.
26. L. Aorga, A. Rebollo, J. Herrn, S. Arana, E. Bandrs, and J. Garca-Foncillas, "Development of a DNA microelectrochemical biosensor for CEACAM5 detection, " IEEE Sensors J., vol. 10, no. 8, pp. 1368-1374, Aug. 2010.
27. Y. S. Choi, K. S. Lee, and D. H. Park, "A genomic detection using an indicator-free DNA on a DNA chip microarray, " Appl. Phys., vol. 6, pp. 772-776, 2006.
28. H. M. Jafari and R. Genov, "CMOS impedance spectrum analyzer with dual-slope multiplying ADC, " in Proc. IEEE Biomedical Circuits and Systems Conf., San Diego, CA, Nov. 2011.
29. L. Li, X. Liu, W. A. Qureshi, and A. J. Mason, "CMOS amperometric instrumentation and packaging for biosensor array applications, " IEEE Trans. Biomed. Circuits Syst., vol. 5, no. 5, pp. 439-448, 2011.