A capacitance-to-frequency converter with on-chip passivated microelectrodes for bacteria detection in saline buffers up to 575 MHz

IEEE Transactions on Circuits and Systems II: Express Briefs

Volumn 62, Issue 2, 2015, Pages 159-163

  Couniot, Numa ^a   Bol, David ^a   Poncelet, Olivier ^a   Francis, Laurent A ^a   Flandre, Denis ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

broadband GHz readout; CMOS capacitive biosensor; impedance spectroscopy; interdigitated electrodes

Indexed keywords

BACTERIA; CMOS INTEGRATED CIRCUITS; OXIDE SEMICONDUCTORS;

BROADBAND GHZ READOUT; CAPACITIVE BIOSENSORS; ELECTRICAL CONDUCTIVITY; IMPEDANCE SPECTROSCOPY; INTER-DIGITATED ELECTRODES; INTERDIGITATED MICROELECTRODES; POINT OF CARE DIAGNOSTIC; STAPHYLOCOCCUS EPIDERMIDIS;

MICROELECTRODES;

EID: 84923100722     PISSN: 15497747     EISSN: 15583791     Source Type: Journal    
DOI: 10.1109/TCSII.2014.2369111     Document Type: Article

References (19)

1. M. Varshney and Y. Li, quot;Interdigitated array microelectrodes based impedance biosensors for detection of bacterial cells,quot; Biosensors Bioelectron., vol. 24, no. 10, pp. 2951-2960, Jun. 2009.
2. M. Varshney, quot;Interdigitated array microelectrode based impedance biosensor coupled with magnetic nanoparticle-antibody conjugates for detection of Escherichia coli O157:H7 in food samples,quot; Biosensors Bioelectron., vol. 22, no. 11, pp. 2408-2414, May 2007.
3. L. Yang, quot;Electrical impedance spectroscopy for detection of bacterial cells in suspensions using interdigitated microelectrodes,quot; Talanta, vol. 74, no. 5, pp. 1621-1629, Feb. 2008.
4. N. Couniot et al., quot;Lytic enzymes as selectivity means for labelfree, microfluidic and impedimetric detection of whole-cell bacteria using ALD-Al2O3 passivated microelectrodes,quot; Biosensors Bioelectron., DOI:10.1016/j.bios.2014.07.084, to be published.
5. E. Ghafar-Zadeh, M. Sawan, and D. Therriault, quot;A 0.18-μm CMOS capacitive sensor lab-on-chip,quot; Sensors Actuators A, Physical, vol. 141, no. 2, pp. 454-462, 2008.
6. C. Berggren and B. Bjarnason, quot;Capacitive biosensors,quot; Electroanalysis, vol. 13, no. 3, pp. 173-180, 2001.
7. S. Druart, D. Flandre, and L. A. Francis, quot;A self-oscillating system to measure the conductivity and the permittivity of liquids within a single triangular signal,quot; J. Sensors, vol. 2014, no. 1-3, pp. 1-11, 2014.
8. S. B. Prakash and P. Abshire, quot;A CMOS capacitance sensor that monitors cell viability,quot; in Proc. IEEE Sensors Conf., 2005, pp. 1177-1180.
9. T. Lederer, S. Clara, B. Jakoby, and W. Hilber, quot;Integration of impedance spectroscopy sensors in a digital microfluidic platform,quot; Microsyst. Technol., vol. 18, no. 7/8, pp. 1163-1180, Aug. 2012.
10. M. Bakhshiani, M. A. Suster, and P. Mohseni, quot;A broadband biosensor interface IC for miniaturized dielectric spectroscopy from MHz to GHz,quot; in Proc. IEEE CICC, 2013, pp. 1-4.
11. J.-C. Chien, M. Anwar, E.-C. Yeh, L. P. Lee, and A. M. Niknejad, quot;A 1-50 GHz dielectric spectroscopy biosensor with integrated receiver front-end in 65 nm CMOS,quot; in Proc. IEEE MTT-S IMS, 2013, pp. 1-4.
12. O. Elhadidy, M. Elkholy, A. A. Helmy, S. Palermo, and K. Entesari, quot;A CMOS fractional-PLL-based microwave chemical sensor with 1.5 accuracy,quot; IEEE Trans. Microw. Theory Techn., vol. 61, no. 9, pp. 3402-3416, Sep. 2013.
13. A. A. Helmy et al., quot;A self-sustained CMOS microwave chemical sensor using a frequency synthesizer,quot; IEEE J. Solid-State Circuits, vol. 47, no. 10, pp. 2467-2483, Oct. 2012.
14. N. Couniot, D. Bol, O. Poncelet, L. A. Francis, and D. Flandre, quot;A very high frequency capacitance-controlled oscillator for improved biosensing in high-salt solutions,quot; in Proc. Biosensors Conf., Melbourne, Vic., Australia, 2014.
15. A. Sanchis et al., quot;Dielectric characterization of bacterial cells using dielectrophoresis,quot; Bioelectromagnetics, vol. 28, no. 5, pp. 393-401, 2007.
16. A. I. Abdulagatov et al., quot;Al2O3 and TiO2 atomic layer deposition on copper for water corrosion resistance,quot; ACS Appl. Mater. Interfaces, vol. 3, no. 12, pp. 4593-4601, 2011.
17. N. Couniot, D. Flandre, L. A. Francis, and A. Afzalian, quot;Signal-to-noise ratio optimization for detecting bacteria with interdigitated microelectrodes,quot; Sensors Actuators B, Chem., vol. 189, pp. 43-51, Dec. 2013.
18. O. Laczka, E. Baldrich, F. X. Muñoz, and F. J. del Campo, quot;Detection of Escherichia coli and Salmonella typhimurium using interdigitated microelectrode capacitive immunosensors: The importance of transducer geometry,quot; Anal. Chem., vol. 80, no. 19, pp. 7239-7247, 2008.
19. N. Van Overstraeten-Schlögel, O. Lefèvre, N. Couniot, and D. Flandre, quot;Assessment of different functionalization methods for grafting a protein to an alumina-covered biosensor,quot; Biofabrication, vol. 6, no. 3, 2014, Art. ID. 035007.