Changes in echocardiographic parameters in iron deficiency patients with heart failure and chronic kidney disease treated with intravenous iron

Heart Lung and Circulation

Volumn 24, Issue 7, 2015, Pages 686-695

  Toblli, Jorge E ^a   Di Gennaro, Federico ^a   Rivas, Carlos ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Chronic kidney disease; Ferritin; Heart failure; Iron deficiency; Iron sucrose; TSAT

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; FERRITIN; HEMOGLOBIN; IRON SACCHARATE; PLACEBO; TRANSFERRIN; ANTIANEMIC AGENT; FERRIC ION; FERRIC OXIDE, SACCHARATED; IRON; SACCHARIC ACID;

ABDOMINAL PAIN; AGED; ARTICLE; BODY MASS; CARDIOVASCULAR PARAMETERS; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; ECHOCARDIOGRAPHY; FEMALE; FERRITIN BLOOD LEVEL; HEADACHE; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART RATE; HEART VENTRICLE SEPTUM; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON BALANCE; IRON DEFICIENCY ANEMIA; IRON STATUS; KIDNEY FUNCTION; LEFT VENTRICULAR DIASTOLIC DIAMETER; LEFT VENTRICULAR SYSTOLIC DIAMETER; MAJOR CLINICAL STUDY; MALE; NAUSEA; NEW YORK HEART ASSOCIATION CLASS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; SYSTOLIC BLOOD PRESSURE; TRANSFERRIN BLOOD LEVEL; ANEMIA, IRON-DEFICIENCY; BLOOD; CLINICAL TRIAL; COMPLICATION; DEFICIENCY; DRUG EFFECTS; MULTICENTER STUDY; PATHOPHYSIOLOGY; PILOT STUDY; RENAL INSUFFICIENCY, CHRONIC; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANEMIA, IRON-DEFICIENCY; DOUBLE-BLIND METHOD; FEMALE; FERRIC COMPOUNDS; GLUCARIC ACID; HEART FAILURE; HEMATINICS; HUMANS; IRON; MALE; PILOT PROJECTS; RENAL INSUFFICIENCY, CHRONIC; VENTRICULAR FUNCTION, LEFT;

EID: 84929188470     PISSN: 14439506     EISSN: 14442892     Source Type: Journal    
DOI: 10.1016/j.hlc.2014.12.161     Document Type: Article

References (31)

1. Rastogi A., Fonarow G.C. The cardiorenal connection in heart failure. Current Cardiology Reports. 2008, 10:190-197.
2. Attanasio P., Ronco C., Anker S.D., Cicoira M., von Haehling S. Role of iron deficiency and anemia in cardio-renal syndromes. Seminars in Nephrology. 2012, 32:57-62.
3. Macdougall I.C., Canaud B., de Francisco A.L., Filippatos G., Ponikowski P., Silverberg D., et al. Beyond the cardiorenal anaemia syndrome: recognizing the role of iron deficiency. European Journal of Heart Failure. 2012, 14:882-886.
4. Jankowska E.A., von Haehling S., Anker S.D., Macdougall I.C., Ponikowski P. Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives. European Heart Journal. 2013, 34:816-829.
5. Deicher R., Horl W.H. New insights into the regulation of iron homeostasis. European Journal of Clinical Investigation. 2006, 36:301-309.
6. van Veldhuisen D.J., Anker S.D., Ponikowski P., Macdougall I.C. Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches. Nature Reviews Cardiology. 2011, 8:485-493.
7. Groenveld H.F., Januzzi J.L., Damman K., van Wijngaarden J., Hillege H.L., van Veldhuisen D.J., et al. Anemia and mortality in heart failure patients a systematic review and meta-analysis. Journal of the American College of Cardiology. 2008, 52:818-827.
8. Bolger A.P., Bartlett F.R., Penston H.S., O'Leary J., Pollock N., Kaprielian R., et al. Intravenous iron alone for the treatment of anemia in patients with chronic heart failure. Journal of the American College of Cardiology. 2006, 48:1225-1227.
9. Okonko D.O., Grzeslo A., Witkowski T., Mandal A.K., Slater R.M., Roughton M., et al. Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial. Journal of the American College of Cardiology. 2008, 51:103-112.
10. Anker S.D., Comin Colet J., Filippatos G., Willenheimer R., Dickstein K., Drexler H., et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. The New England Journal of Medicine. 2009, 361:2436-2448.
11. Ponikowski P., Comin Colet J., Filippatos G., Willenheimer R., Dickstein K., Lüscher T., et al. The impact of intravenous ferric carboxymaltose on renal function: an analysis of the FAIR-HF study 2010, Amercan Heart Association, Chicago, Illinois, USA.
12. Comin-Colet J., Enjuanes C., Gonzalez G., Torrens A., Cladellas M., Merono O., et al. Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status. European Journal of Heart Failure. 2013, 15:1164-1172.
13. Florian A., Ludwig A., Rosch S., Yildiz H., Klumpp S., Sechtem U., et al. Positive effect of intravenous iron-oxide administration on left ventricular remodelling in patients with acute ST-elevation myocardial infarction - a cardiovascular magnetic resonance (CMR) study. International Journal of Cardiology. 2014, 173:184-189.
14. Toblli J.E., Lombrana A., Duarte P., Di Gennaro F. Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. Journal of the American College of Cardiology. 2007, 50:1657-1665.
15. Schiller N.B., Shah P.M., Crawford M., DeMaria A., Devereux R., Feigenbaum H., et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. Journal of the American Society of Echocardiography. 1989, 2:358-367.
16. Jankowska E.A., Rozentryt P., Witkowska A., Nowak J., Hartmann O., Ponikowska B., et al. Iron deficiency: an ominous sign in patients with systolic chronic heart failure. European Heart Journal. 2010, 31:1872-1880.
17. Okonko D.O., Mandal A.K., Missouris C.G., Poole-Wilson P.A. Disordered iron homeostasis in chronic heart failure: prevalence, predictors, and relation to anemia, exercise capacity, and survival. Journal of the American College of Cardiology. 2011, 58:1241-1251.
18. Nanas J.N., Matsouka C., Karageorgopoulos D., Leonti A., Tsolakis E., Drakos S.G., et al. Etiology of anemia in patients with advanced heart failure. Journal of the American College of Cardiology. 2006, 48:2485-2489.
19. Klip I.T., Comin-Colet J., Voors A.A., Ponikowski P., Enjuanes C., Banasiak W., et al. Iron deficiency in chronic heart failure: an international pooled analysis. American Heart Journal. 2013, 165:575-582. e3.
20. Maeder M.T., Khammy O., Dos Remedios C., Kaye D.M. Myocardial and systemic iron depletion in heart failure implications for anemia accompanying heart failure. Journal of the American College of Cardiology. 2011, 58:474-480.
21. Leszek P., Sochanowicz B., Szperl M., Kolsut P., Brzoska K., Piotrowski W., et al. Myocardial iron homeostasis in advanced chronic heart failure patients. International Journal of Cardiology. 2012, 159:47-52.
22. McMurray J.J., Adamopoulos S., Anker S.D., Auricchio A., Bohm M., Dickstein K., et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. European Journal of Heart Failure. 2012, 14:803-869.
23. Usmanov R.I., Zueva E.B., Silverberg D.S., Shaked M. Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency. Journal of Nephrology. 2008, 21:236-242.
24. Gaber R., Kotb N.A., Ghazy M., Nagy H.M., Salama M., Elhendy A. Tissue Doppler and strain rate imaging detect improvement of myocardial function in iron deficient patients with congestive heart failure after iron replacement therapy. Echocardiography. 2012, 29:13-18.
25. Dong F., Zhang X., Culver B., Chew H.G., Kelley R.O., Ren J. Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: involvement of nitric oxide synthase and protein tyrosine nitration. Clinical Science. 2005, 109:277-286.
26. Naito Y., Tsujino T., Matsumoto M., Sakoda T., Ohyanagi M., Masuyama T. Adaptive response of the heart to long-term anemia induced by iron deficiency. American Journal of Physiology (Heart and Circulatory Physiology). 2009, 296:H585-H593.
27. Toblli J.E., Cao G., Rivas C., Kulaksiz H. Heart and iron deficiency anaemia in rats with renal insufficiency: the role of hepcidin. Nephrology. 2008, 13:636-645.
28. Toblli J.E., Giani J.F., Muñoz M.C., Dominici F.P., Rivas C. Iron sucrose complex ameliorates oxidative stress and reduces TNFalpha and NFkB activation in heart of iron-deficient anemic rats. European Journal of Heart Failure. 2009, 8(Suppl 2):ii373.
29. Comin-Colet J., Lainscak M., Dickstein K., Filippatos G.S., Johnson P., Luscher T.F., et al. The effect of intravenous ferric carboxymaltose on health-related quality of life in patients with chronic heart failure and iron deficiency: a subanalysis of the FAIR-HF study. European Heart Journal. 2013, 34:30-38.
30. Swedberg K., Young J.B., Anand I.S., Cheng S., Desai A.S., Diaz R., et al. Treatment of anemia with darbepoetin alfa in systolic heart failure. The New England Journal of Medicine. 2013, 368:1210-1219.
31. Ponikowski P., van Veldhuisen D.J., Comin-Colet J., Ertl G., Komajda M., Mareev V., et al. Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. European Heart Journal 2014, pii: ehu385 [Epub ahead of print].