Rutin attenuates gentamicin-induced renal damage by reducing oxidative stress, inflammation, apoptosis, and autophagy in rats

Renal Failure

Volumn 37, Issue 3, 2015, Pages 518-525

  Kandemir, Fatih Mehmet ^a   Ozkaraca, Mustafa ^a   Yildirim, Betul Apaydin ^a   Hanedan, Basak ^a   Kirbas, Akin ^a   Kilic, Kubra ^a   Aktas, Esra ^a   Benzer, Fulya ^b  

^a ATATÜRK UNIVERSITY   (Turkey)

^b TUNCELI UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Autophagy; Gentamicin; Nephrotoxicity; Oxidative stress; Rutin

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CASPASE 3; CATALASE; CREATININE; GENTAMICIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; RUTOSIDE; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE; UREA; NOS2 PROTEIN, HUMAN; PROTECTIVE AGENT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL INFILTRATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG INDUCED DISEASE; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY FUNCTION; KIDNEY INJURY; MALE; MONONUCLEAR CELL; NEPHRITIS; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RAT; UREA BLOOD LEVEL; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; INFLAMMATION; KIDNEY; KIDNEY DISEASES; KIDNEY FUNCTION TEST; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOPTOSIS; AUTOPHAGY; DISEASE MODELS, ANIMAL; GENTAMICINS; GLUTATHIONE PEROXIDASE; INFLAMMATION; KIDNEY; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; MALONDIALDEHYDE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RUTIN; SUPEROXIDE DISMUTASE;

EID: 84929073889     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/0886022X.2015.1006100     Document Type: Article

References (42)

1. Quiros Y, Vicente-Vicente L, Morales AI, Lopez-Novoa JM. An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin. Toxicol Sci. 2011;119:245-256.
2. Plumb DC. Plumb's Veterinary Drug Handbook. 5th ed. Stockholm, WI: Blackwell Publishing; 2005: 359-363.
3. Balakumar P, Rohilla A, Thangathirupathi A. Gentamicin-induced nephrotoxicity: Do we have a promising therapeutic approach to blunt it? Pharmacol Res. 2010;62:170-186.
4. Baliga R, Ueda N, Walker PD, Shah SV. Oxidant mechanisms in toxic acute renal failure. Drug Metab Rev. 1999;31:971-997.
5. Morales AI, Detaille D, Prieto M, et al. Metformin prevents experimental gentamicin-induced nephropathy by a mitochondriadependent pathway. Kidney Int. 2010;77:861-869.
6. Xie Z, Klionsky DJ. Autopgasome formation: Core machinery and adaptations. Nat Cell Biol. 2007;9:1102-1109.
7. Scarlatti F, Granata R, Meijer AJ, Codogno P. Does autophagy have a licence to kill mammalian cells? Cell Death Differ. 2009;16: 12-20.
8. Sharma S, Asgar A, Javed A, Jasjeet KS, Sanjula B. Rutin: Therapeutic potential and recent advances in drug delivery. Expert Opin Investig Drugs. 2013;22:1063-1079.
9. Koyner JL, Sher AR, Murray PT. Antioxidants. Do they have a place in the prevention or therapy of acute kidney injury? Nephron Exp Nephrol. 2008;109:e109-e117.
10. Manikandan R, Beulaja M, Thiagarajan R, Priyadarsini A, Saravanan R, Arumugam M. Ameliorative effects of curcumin against renal injuries mediated by inducible nitric oxide synthase and nuclear factor kappa B during gentamicin-induced toxicity in Wistar rats. Eur J Pharmacol. 2011;670:578-585.
11. Jain A, Nahata A, Singhai AK. Effect of Tephrosia purpurea (L.) Pers. Leaves on gentamicin induced nephrotoxicity in rats. Sci Pharm. 2013;81:1071-1087.
12. Kang C, Lee H, Hah DY, et al. Protective effects of Houttuynia cordata Thunb. On gentamicin-induced oxidative stress and nephrotoxicity in rats. Toxicol Res. 2013;29:61-67.
13. Ali BH, Al Za'abi M, Blunden G, Nemmar A. Experimental gentamicin nephrotoxicity and agents that modify it: A mini-review of recent research. Basic Clin Pharmacol Toxicol. 2011;109: 225-232.
14. Arjumand W, Seth A, Sultana S. Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFkB, TNF-a and caspase-3 expression in wistar rats. Food Chem Toxicol. 2011;49: 2013-2021.
15. Abdel-Raheem IT, Abdel-Ghany AA, Mohamed A. Protective effect of quercetin against gentamicin-induced nephrotoxicity. Biol Pharm Bull. 2009;32:61-67.
16. Placer ZA, Cushmanni LL, Johnson BC. Estimation of products of lipid peroxidation (as malondialdehyde) in biochemical systems. Anal Biochem. 1966;16:359-364.
17. Aebi H. Catalase. In: Bergmeyer HU, ed. Methods in Enzymatic Analysis. New York: Academic Press; 1983: 276-286.
18. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem. 1951; 193:265-275.
19. Sun Y, Larry WO, Ying L. A simple method for clinical assay of superoxide dismutase. Clin Chem. 1988;34:497-500.
20. Sedlak J, Lindsay RHC. Estimation of total protein bound and nonprotein sulfhydryl groups in tissue with Ellmann's reagent. Anal Biochem. 1968;25:192-205.
21. Lawrence RA, Burk RF. Glutathione peroxidase activity in selenium-deficient rat liver. Bioch Biophys Res Comm. 1976;71: 952-958.
22. Nagai J, Takano M. Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity. Drug Metab Pharmacokinet. 2004;19:159-170.
23. Lee KE, Kim EY, Kim CS, et al. Macrophage-stimulating protein attenuates gentamicin-induced inflammation and apoptosis in human renal proximal tubular epithelial cells. Biochem Biophys Res Commun. 2013;434:527-533.
24. Singh D, Kaur R, Chander V, Chopra K. Antioxidants in the prevention of renal disease. J Med Food. 2006;9:443-450.
25. Khan RA, Khan MR, Sahreen S. Protective effects of rutin against potassium bromate induced nephrotoxicity in rats. BMC Complement Altern Med. 2012;12:204.
26. Sadeghnia HR, Yousefsani BS, Rashidfar M, Boroushaki MT, Asadpour E, Ghorbani A. Protective effect of rutin on hexachlorobutadiene-induced nephrotoxicity. Ren Fail. 2013;35:1151-1155.
27. Korkmaz A, Kolankaya D. Inhibiting inducible nitric oxide synthase with rutin reduces renal ischemia/reperfusion injury. Can J Surg. 2013;56:6-14.
28. Al-Rejaie SS, Abuohashaish HM, Alkhamees OA, Aleisa AM, Alroujayee AS. Gender difference following high cholesterol diet induced renal injury and the protective role of rutin and ascorbic acid combination in Wistar albino rats. Lipids Health Dis. 2012;11: 1-10.
29. Hao H-H, Shao Z-M, Tang D-Q, et al. Preventive effects of rutin on the development of experimental diabetic nephropathy in rats. Life Sci. 2012;91:959-967.
30. Seçilmis MA, Karatąs Y, Yorulmaz O, et al. Protective effect of L-arginine intake on the impaired renal vascular responses in the gentamicin-treated rats. Nephron Physiol. 2005;100:13-20.
31. Kiang JG, Tsen KT. Biology of hypoxia. Chin J Physiol. 2006;49: 223-233.
32. Pedraza-Chaverri J, Barrera D, Maldonado PD, et al. S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo. BMC Clin Pharmacol. 2004;4:5.
33. Goligorsky MS, Gross SS. Nitric Oxide and the Kidney. New York: Chapman & Hall; 1997:22-38.
34. Ghaznavi R, Kadkhodaee M. Comparative effects of selective and non-selective nitric oxide synthase inhibition in gentamicin-induced rat nephrotoxicity. Arch Toxicol. 2007;81:453-457.
35. Servais H, Ortiz A, Devuyst O, Denamur S, Tulkens PM, Mingeot-Leclercq MP. Renal cell apoptosis induced by nephrotoxic drugs: Cellular and molecular mechanisms and potential approaches to modulation. Apoptosis. 2008;13:11-32.
36. Hsu Y-H, Chen T-H, Wu M-Y, et al. Protective effects of Zhibai Dihuang Wan on renal tubular cells affected with gentamicininduced apoptosis. J Ethnopharmacol. 2014;151:635-642.
37. Chen Y-C, Chen C-H, Hsu Y-H, et al. Leptin reduces gentamicininduced apoptosis in rat renal tubular cells via the PI3K-Akt signaling pathway. Eur J Pharmacol. 2011;658:213-218.
38. Juan S-H, Chen C-H, Hsu Y-H, et al. Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin. Nephrol Dial Transplant. 2007;22:732-739.
39. Kundu M, Thombson CB. Autophagy: Basic principles and relevance to disease. Annu Rev Pathol. 2008;3:427-455.
40. Levine B, Yuan J. Autophagy in cell death: an innocent convict? J Clin Invest. 2005;10:2679-2788.
41. Domitrovic R, Cvijanovic O, Pernjak-Pugel E, Skoda M, Mikelic L, Crncevic-Orlic Z. Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/ nitrosative stress, inflammation, autophagy and apoptosis. Food Chem Toxicol. 2013;62:397-406.
42. Xiang Y, Piao SG, Zou HB, et al. L-carnitine protects against cyclosporine-induced pancreatic and renal injury in rats. Transplant Proc. 2013;45:3127-3134.