Mass spectrometry imaging and GC-MS profiling of the mammalian peripheral sensory-motor circuit

Journal of the American Society for Mass Spectrometry

Volumn 26, Issue 6, 2015, Pages 958-966

  Rubakhin, Stanislav S ^a   Ulanov, Alexander ^a   Sweedler, Jonathan V ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Dorsal root ganglia; Gas chromatography mass spectrometry; Mass spectrometry imaging; Peripheral sensory motor system; Spinal nerve

Indexed keywords

CHROMATOGRAPHY; DESORPTION; LASER DIAGNOSTICS; MAMMALS; MASS SPECTROMETRY; PARTIAL DISCHARGES; PRINCIPAL COMPONENT ANALYSIS; SENSORY ANALYSIS; SPECTROMETRY;

DORSAL ROOT GANGLIA; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MASS-SPECTROMETRY IMAGING; PERIPHERAL SENSORY; SPINAL NERVES;

GAS CHROMATOGRAPHY;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DORSAL ROOT; FEMALE; IMAGING; MALE; MAMMAL; MASS FRAGMENTOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; RAT; SENSORIMOTOR FUNCTION; SPINAL GANGLION; ANATOMY AND HISTOLOGY; ANIMAL; CHEMISTRY; LONG EVANS RAT; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; PROCEDURES;

MAMMALIA;

ANIMALS; FEMALE; GANGLIA, SPINAL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; PRINCIPAL COMPONENT ANALYSIS; RATS, LONG-EVANS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84929068960     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-015-1128-8     Document Type: Article

References (68)

1. McDonnell, L.A., Heeren, R.M.: Imaging mass spectrometry. Mass Spectrom. Rev. 26, 606-643 (2007)
2. Rubakhin, S.S., Sweedler, J.V.: A mass spectrometry primer for mass spectrometry imaging. Methods Mol. Biol. 656, 21-49 (2010)
3. Rubakhin, S.S., Hatcher, N.G., Monroe, E.B., Heien, M.L., Sweedler, J.V.: Mass spectrometric imaging of the nervous system. Curr. Pharm. Des. 13, 3325-3334 (2007)
4. Chaurand, P., Sanders, M.E., Jensen, R.A., Caprioli, R.M.: Proteomics in diagnostic pathology: profiling and imaging proteins directly in tissue sections. Am. J. Pathol. 165, 1057-1068 (2004)
5. Gessel, M.M., Norris, J.L., Caprioli, R.M.: MALDI imaging mass spectrometry: spatial molecular analysis to enable a new age of discovery. J. Proteome 107, 71-82 (2014)
6. Wu, C., Dill, A.L., Eberlin, L.S., Cooks, R.G., Ifa, D.R.: Mass spectrometry imaging under ambient conditions. Mass Spectrom. Rev. 32, 218-243 (2013)
7. Setou, M., Kurabe, N.: Mass microscopy: high-resolution imaging mass spectrometry. J. Electron Microsc. (Tokyo) 60, 47-56 (2011)
8. Cornett, D.S., Frappier, S.L., Caprioli, R.M.: MALDI-FTICR imaging mass spectrometry of drugs and metabolites in tissue. Anal. Chem. 80, 5648-5653 (2008)
9. Petyuk, V.A., Qian, W.J., Chin, M.H., Wang, H., Livesay, E.A., Monroe, M.E., Adkins, J.N., Jaitly, N., Anderson, D.J., Camp II, D.G., Smith, D.J., Smith, R.D.: Spatial mapping of protein abundances in the mouse brain by voxelation integrated with high-throughput liquid chromatography-mass spectrometry. Genome Res. 17, 328-336 (2007)
10. Stoeckli, M., Chaurand, P., Hallahan, D.E., Caprioli, R.M.: Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues. Nat. Med. 7, 493-496 (2001)
11. McLean, J.A., Fenn, L.S., Enders, J.R.: Structurally selective imaging mass spectrometry by imaging ion mobility-mass spectrometry. Methods Mol. Biol. 656, 363-383 (2010)
12. Woods, A.S., Jackson, S.N.: The application and potential of ion mobility mass spectrometry in imaging MS with a focus on lipids. Methods Mol. Biol. 656, 99-111 (2010)
13. Stauber, J., MacAleese, L., Franck, J., Claude, E., Snel, M., Kaletas, B.K., Wiel, I.M., Wisztorski, M., Fournier, I., Heeren, R.M.: On-tissue protein identification and imaging by MALDI-ion mobility mass spectrometry. J. Am. Soc. Mass Spectrom. 21, 338-347 (2010)
14. McLean, J.A., Ridenour, W.B., Caprioli, R.M.: Profiling and imaging of tissues by imaging ion mobility-mass spectrometry. J. Mass Spectrom. 42, 1099-1105 (2007)
15. Manicke, N.E., Dill, A.L., Ifa, D.R., Cooks, R.G.: High-resolution tissue imaging on an orbitrap mass spectrometer by desorption electrospray ionization mass spectrometry. J. Mass Spectrom. 45, 223-226 (2010)
16. Schober, Y., Guenther, S., Spengler, B., Rompp, A.: Single cell matrix-assisted laser desorption/ionization mass spectrometry imaging. Anal. Chem. 84, 6293-6297 (2012)
17. Chen, B., Lietz, C.B., Li, L.: In situ characterization of proteins using laserspray ionization on a high-performance MALDI-LTQ-Orbitrap mass spectrometer. J. Am. Soc. Mass Spectrom. 25, 2177-2180 (2014)
18. Tomlinson, L., Fuchser, J., Futterer, A., Baumert, M., Hassall, D.G., West, A., Marshall, P.S.: Using a single, high mass resolution mass spectrometry platform to investigate ion suppression effects observed during tissue imaging. Rapid Commun. Mass Spectrom. 28, 995-1003 (2014)
19. Todd, P.J., Schaaff, T.G., Chaurand, P., Caprioli, R.M.: Organic ion imaging of biological tissue with secondary ion mass spectrometry and matrix-assisted laser desorption/ionization. J. Mass Spectrom. 36, 355-369 (2001)
20. Vickerman, J.C.: Molecular imaging and depth profiling by mass spectrometry - SIMS, MALDI or DESI? Analyst 136, 2199-2217 (2011)
21. Touboul, D., Roy, S., Germain, D.P., Chaminade, P., Brunelle, A., Laprevote, O.: MALDI-TOF and cluster-TOF-SIMS imaging of Fabry disease biomarkers. Int. J. Mass Spectrom. 260, 158-165 (2007)
22. Monroe, E.B., Annangudi, S.P., Hatcher, N.G., Gutstein, H.B., Rubakhin, S.S., Sweedler, J.V.: SIMS and MALDI MS imaging of the spinal cord. Proteomics 8, 3746-3754 (2008)
23. National Institute of Standards and Technology. Available at: http://maldi.nist.gov. Accessed 26 Jan (2015)
24. Caprioli, R.M., Farmer, T.B., Gile, J.: Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS. Anal. Chem. 69, 4751-4760 (1997)
25. Zimmerman, T.A., Rubakhin, S.S., Sweedler, J.V.: Mass spectrometry imaging using the stretched sample approach. Methods Mol. Biol. 656, 465-479 (2010)
26. Rompp, A., Guenther, S., Schober, Y., Schulz, O., Takats, Z., Kummer, W., Spengler, B.: Histology by mass spectrometry: label-free tissue characterization obtained from high-accuracy bioanalytical imaging. Angew. Chem. 49, 3834-3838 (2010)
27. Becker, J.S., Kumtabtim, U., Wu, B., Steinacker, P., Otto, M., Matusch, A.: Mass spectrometry imaging (MSI) of metals in mouse spinal cord by laser ablation ICP-MS. Metallomics 4, 284-288 (2012)
28. Girod, M., Shi, Y., Cheng, J.X., Cooks, R.G.: Mapping lipid alterations in traumatically injured rat spinal cord by desorption electrospray ionization imaging mass spectrometry. Anal. Chem. 83, 207-215 (2011)
29. Hanrieder, J., Ekegren, T., Andersson, M., Bergquist, J.: MALDI imaging of post-mortem human spinal cord in amyotrophic lateral sclerosis. J. Neurochem. 124, 695-707 (2013)
30. Hanrieder, J., Ewing, A.G.: Spatial elucidation of spinal cord lipid- and metabolite- regulations in amyotrophic lateral sclerosis. Sci. Rep. 4, 5266 (2014)
31. Tucker, K.R., Serebryannyy, L.A., Zimmerman, T.A., Rubakhin, S.S., Sweedler, J.V.: The modified-bead stretched sample method: development and application to MALDI-MS imaging of protein localization in the spinal cord. Chem. Sci. 2, 785-795 (2011)
32. Ye, H., Hui, L.M., Kellersberger, K., Li, L.J.: Mapping of neuropeptides in the crustacean stomatogastric nervous system by imaging mass spectrometry. J. Am. Soc. Mass Spectrom. 24, 134-147 (2013)
33. Li, L., Moroz, T.P., Garden, R.W., Floyd, P.D., Weiss, K.R., Sweedler, J.V.: Mass spectrometric survey of interganglionically transported peptides in Aplysia. Peptides 19, 1425-1433 (1998)
34. Cheng, H., Sun, G., Yang, K., Gross, R.W., Han, X.L.: Selective desorption/ionization of sulfatides by MALDI-MS facilitated using 9-aminoacridine as matrix. J. Lipid Res. 51, 1599-1609 (2010)
35. Anderson, D.M.G., Mills, D., Spraggins, J., Lambert, W.S., Calkins, D.J., Schey, K.L.: High-resolution matrix- assisted laser desorption ionization-imaging mass spectrometry of lipids in rodent optic nerve tissue. Mol. Vis. 19, 581-592 (2013)
36. Patti, G.J., Yanes, O., Shriver, L.P., Courade, J.P., Tautenhahn, R., Manchester, M., Siuzdak, G.: Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin. Nat. Chem. Biol. 8, 232-234 (2012)
37. Katano, T., Mabuchi, T., Okuda-Ashitaka, E., Inagaki, N., Kinumi, T., Ito, S.: Proteomic identification of a novel isoform of collapsin response mediator protein-2 in spinal nerves peripheral to dorsal root ganglia. Proteomics 6, 6085-6094 (2006)
38. Muir, W.W., Woolf, C.J.: Mechanisms of pain and their therapeutic implications. J. Am. Vet. Med. Assoc. 219, 1346-1356 (2001)
39. Scholz, J., Woolf, C.J.: Can we conquer pain? Nat. Neurosci. 5, 1062-1067 (2002)
40. Woolf, C.J.: Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann. Intern. Med. 140, 441-451 (2004)
41. Devor, M.: Unexplained peculiarities of the dorsal root ganglion. Pain. Suppl 6, S27-S35 (1999)
42. Ding, H., Goldberg, M.M., Raymer, J.H., Holmes, J., Stanko, J., Chaney, S.G.: Determination of platinum in rat dorsal root ganglion using ICP-MS. Biol. Trace Elem. Res. 67, 1-11 (1999)
43. Cheng, H., Jiang, X., Han, X.: Alterations in lipid homeostasis of mouse dorsal root ganglia induced by apolipoprotein E deficiency: a shotgun lipidomics study. J. Neurochem. 101, 57-76 (2007)
44. Wong, A., Sagar, D.R., Ortori, C.A., Kendall, D.A., Chapman, V., Barrett, D.A.: Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis. J. Lipid Res. 55, 1902-1913 (2014)
45. Rimmerman, N., Hughes, H.V., Bradshaw, H.B., Pazos, M.X., Mackie, K., Prieto, A.L., Walker, J.M.: Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line. Br. J. Pharmacol. 153, 380-389 (2008)
46. Mar, F.M., Simoes, A.R., Leite, S., Morgado, M.M., Santos, T.E., Rodrigo, I.S., Teixeira, C.A., Misgeld, T., Sousa, M.M.: CNS axons globally increase axonal transport after peripheral conditioning. J. Neurosci. 34, 5965-5970 (2014)
47. Zhang, X.J., Leung, F.P., Hsiao, W.W.L., Tan, S., Li, S., Xu, H.X., Sung, J.J.Y., Bian, Z.X.: Proteome profiling of spinal cord and dorsal root ganglia in rats with trinitrobenzene sulfonic acid-induced colitis. World J. Gastroenterol. 18, 2914-2928 (2012)
48. Komori, N., Takemori, N., Kim, H.K., Singh, A., Hwang, S.H., Foreman, R.D., Chung, K., Chung, J.M., Matsumoto, H.: Proteomics study of neuropathic and nonneuropathic dorsal root ganglia: altered protein regulation following segmental spinal nerve ligation injury. Physiol. Genomics 29, 215-230 (2007)
49. Riedl, M.S., Braun, P.D., Kitto, K.F., Roiko, S.A., Anderson, L.B., Honda, C.N., Fairbanks, C.A., Vulchanova, L.: Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. J. Neurosci. 29, 13377-13388 (2009)
50. Benabdellah, F., Touboul, D., Brunelle, A., Laprevote, O.: In situ primary metabolites localization on a rat brain section by chemical mass spectrometry imaging. Anal. Chem. 81, 5557-5560 (2009)
51. Le Belle, J.E., Harris, N.G., Williams, S.R., Bhakoo, K.K.: A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy. NMR Biomed. 15, 37-44 (2002)
52. Roessner, U., Wagner, C., Kopka, J., Trethewey, R.N., Willmitzer, L.: Simultaneous analysis of metabolites in potato tuber by gas chromatography-mass spectrometry. Plant J. 23, 131-142 (2000)
53. National Institute of Standards and Technology. Available at: http://www.amdis.net/index.html. Accessed 31 Jan (2015)
54. Wiley Registry of Mass Spectral Data. Available at: http://www.sisweb.com/software/ms/wiley.htm. Accessed 31 Jan (2015)
55. Westerhuis, J., Hoefsloot, H.J., Smit, S., Vis, D., Smilde, A., van Velzen, E.J., van Duijnhoven, J.M., van Dorsten, F.: Assessment of PLSDA cross validation. Metabolomics 4, 81-89 (2008)
56. Trygg, J., Holmes, E., Lundstedt, T.: Chemometrics in metabonomics. J. Proteome Res. 6, 469-479 (2007)
57. Smit, S., van Breemen, M.J., Hoefsloot, H.C., Smilde, A.K., Aerts, J.M., de Koster, C.G.: Assessing the statistical validity of proteomics based biomarkers. Anal. Chim. Acta 592, 210-217 (2007)
58. Wiklund, S., Johansson, E., Sjostrom, L., Mellerowicz, E.J., Edlund, U., Shockcor, J.P., Gottfries, J., Moritz, T., Trygg, J.: Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal. Chem. 80, 115-122 (2008)
59. Bro, R., Smilde, A.K.: Centering and scaling in component analysis. J. Chemometr. 17, 16-33 (2003)
60. van den Berg, R.A., Hoefsloot, H.C., Westerhuis, J.A., Smilde, A.K., van der Werf, M.J.: Centering, scaling, and transformations: improving the biological information content of metabolomics data. BMC Genomics 7, 142 (2006)
61. Storey, J.D.: A direct approach to false discovery rates. J. R. Stat. Soc. Ser. (Stat. Methodol.) 64, 479-498 (2002)
62. Gode, D., Volmer, D.A.: Lipid imaging by mass spectrometry - a review. Analyst 138, 1289-1315 (2013)
63. Fraher, J.P.: Myelin-axon relationships in the rat phrenic nerve: longitudinal variation and lateral asymmetry. J. Comp. Neurol. 323, 551-557 (1992)
64. Lubinska, L., Waryszewska, J.: Fibre population of the phrenic nerve of rat: changes of myelinated fibre dimensions along the nerve and characteristics of axonal branchings. Acta Neurobiol. Exp. (Wars) 34, 525-541 (1974)
65. Rodrigues, A.R., Ferreira, R.S., Salgado, H.C., Fazan, V.P.: Morphometric analysis of the phrenic nerve in male and female Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Braz. J. Med. Biol. Res. 44, 583-591 (2011)
66. Jeronimo, A., Jeronimo, C.A., Rodrigues Filho, O.A., Sanada, L.S., Fazan, V.P.: A morphometric study on the longitudinal and lateral symmetry of the sural nerve in mature and aging female rats. Brain Res. 1222, 51-60 (2008)
67. Jeronimo, A., Jeronimo, C.A., Rodrigues Filho, O.A., Sanada, L.S., Fazan, V.P.: Microscopic anatomy of the sural nerve in the postnatal developing rat: a longitudinal and lateral symmetry study. J. Anat. 206, 93-99 (2005)
68. Campos, S.A., Sanada, L.S., Sato, K.L., Fazan, V.P.: Morphometry of saphenous nerve in young rats. J. Neurosci. Methods 168, 8-14 (2008)