Monitoring PAI-1 and VEGF levels in 6 human squamous cell carcinoma xenografts during fractionated irradiation

International Journal of Radiation Oncology Biology Physics

Volumn 84, Issue 3, 2012, Pages

  Bayer, Christine ^a   Kielow, Achim ^a   Schilling, Daniela ^a,b   Maftei, Constantin Alin ^a   Zips, Daniel ^b   Yaromina, Ala ^b   Baumann, Michael ^b   Molls, Michael ^a   Multhoff, Gabriele ^a,b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CO-LOCALIZATION STUDIES; COLOCALIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION LEVELS; EXTRACELLULAR MATRICES; FRACTIONATED IRRADIATION; HEAD AND NECK; HOECHST; IN-VIVO; LYSATES; MICROVESSELS; NEOANGIOGENESIS; PLASMINOGEN ACTIVATOR INHIBITOR; RADIATION RESISTANCE; RADIATION SENSITIVITY; SQUAMOUS CELL CARCINOMA; STROMA CELLS; TUMOR CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR;

CELL CULTURE; CELLS; ENZYME INHIBITION; IRRADIATION;

TUMORS;

CD31 ANTIGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RADIOTHERAPY; CANCER RESISTANCE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ENDOTHELIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FIBROBLAST; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXEMIA; IMMUNOFLUORESCENCE; IN VIVO STUDY; MICROVASCULATURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE FRACTIONATION; RADIOSENSITIVITY; SQUAMOUS CELL CARCINOMA; STROMA CELL; TISSUE PERFUSION; TUMOR CELL; TUMOR LOCALIZATION; TUMOR XENOGRAFT;

ANIMALS; BIOLOGICAL MARKERS; CARCINOMA, SQUAMOUS CELL; CELL HYPOXIA; CELL LINE, TUMOR; DOSE FRACTIONATION; HEAD AND NECK NEOPLASMS; HUMANS; MICE; NEOPLASM PROTEINS; PLASMINOGEN ACTIVATOR INHIBITOR 1; RADIATION TOLERANCE; TRANSPLANTATION, HETEROLOGOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84866731669     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2012.04.033     Document Type: Article

References (24)

1. U. Duvvuri, and J.N. Myers Cancer of the head and neck is the sixth most common cancer worldwide Curr Probl Surg 46 2009 114 117
2. K. Bajou, V. Masson, and R.D. Gerard The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies J Cell Biol 152 2001 777 784
3. P. Carmeliet VEGF as a key mediator of angiogenesis in cancer Oncology 69 Suppl 3 2005 4 10
4. G.W. Prager, J.M. Breuss, and S. Steurer Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells Blood 103 2004 955 962
5. M.J. Duffy, and J. Crown A personalized approach to cancer treatment: how biomarkers can help Clin Chem 54 2008 1770 1779
6. C. Bayer, D. Schilling, and J. Hoetzel PAI-1 levels predict response to fractionated irradiation in 10 human squamous cell carcinoma lines of the head and neck Radiother Oncol 86 2008 361 368
7. P. Manders, F.C. Sweep, and V.C. Tjan-Heijnen Vascular endothelial growth factor independently predicts the efficacy of postoperative radiotherapy in node-negative breast cancer patients Clin Cancer Res 9 2003 6363 6370
8. R.R. Parikh, Q. Yang, and B.G. Haffty Prognostic significance of vascular endothelial growth factor protein levels in T1-2 N0 laryngeal cancer treated with primary radiation therapy Cancer 109 2007 566 573
9. B.D. Smith, G.L. Smith, and D. Carter Prognostic significance of vascular endothelial growth factor protein levels in oral and oropharyngeal squamous cell carcinoma J Clin Oncol 18 2000 2046 2052
10. D.M. Aebersold, K.T. Beer, and J. Laissue Intratumoral microvessel density predicts local treatment failure of radically irradiated squamous cell cancer of the oropharynx Int J Radiat Oncol Biol Phys 48 2000 17 25
11. P. Manders, L.V. Beex, and V.C. Tjan-Heijnen Vascular endothelial growth factor levels do not predict efficacy of systemic adjuvant treatment as assessed in 1127 breast cancer patients Int J Oncol 25 2004 511 517
12. A. Yaromina, H. Thames, and X. Zhou Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation Radiother Oncol 96 2010 116 122
13. A. Yaromina, T. Kroeber, and A. Meinzer Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts Int J Radiat Oncol Biol Phys 80 2011 1205 1213
14. N. Grebenschikov, A. Geurts-Moespot, and W.H. De A sensitive and robust assay for urokinase and tissue-type plasminogen activators (uPA and tPA) and their inhibitor type I (PAI-1) in breast tumor cytosols Int J Biol Markers 12 1997 6 14
15. T. Artman, D. Schilling, and J. Gnann Irradiation-induced regulation of plasminogen activator inhibitor type-1 and vascular endothelial growth factor in six human squamous cell carcinoma lines of the head and neck Int J Radiat Oncol Biol Phys 76 2010 574 582
16. P. Vaupel Pathophysiology of solid tumors M. Molls, P. Vaupel, C. Nieder, The impact of tumor biology on cancer treatment and multidisciplinary strategies 2009 Springer Berlin-Heidelberg 51 92
17. P. Vaupel Physiological mechansisms of treatment resistance M. Molls, P. Vaupel, C. Nieder, The impact of tumor biology on cancer treatment and multidisciplinary strategies 2009 Springer Berlin-Heidelberg 273 290
18. D. Schilling, C. Bayer, and A. Geurts-Moespot Induction of plasminogen activator inhibitor type-1 (PAI-1) by hypoxia and irradiation in human head and neck carcinoma cell lines BMC Cancer 7 2007 143
19. D.H. Gorski, M.A. Beckett, and N.T. Jaskowiak Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation Cancer Res 59 1999 3374 3378
20. C.G. Lee, M. Heijn, and T.E. di Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions Cancer Res 60 2000 5565 5570
21. C.G. Willett, S.V. Kozin, and D.G. Duda Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice Semin Oncol 33 2006 S35 S40
22. M. Nakawatari, M. Iwakawa, and T. Ohno Change in fibroblast growth factor 2 expression as an early phase radiotherapy-responsive marker in sequential biopsy samples from patients with cervical cancer during fractionated radiotherapy Cancer 116 2010 5082 5092
23. J.A. Raleigh, D.P. Calkins-Adams, and L.H. Rinker Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker Cancer Res 58 1998 3765 3768
24. S. Kono, J.S. Rao, and J.M. Bruner Immunohistochemical localization of plasminogen activator inhibitor type 1 in human brain tumors J Neuropathol Exp Neurol 53 1994 256 262