Sustained BMP-2 delivery and injectable bone regeneration using thermosensitive polymeric nanoparticle hydrogel bearing dual interactions with BMP-2

Journal of Controlled Release

Volumn 209, Issue , 2015, Pages 67-76

  Seo, Bo Bae ^a,b   Choi, Hyuck ^c   Koh, Jeong Tae ^c   Song, Soo Chang ^a,b  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Chonnam National University   (South Korea)

Author keywords

Bone morphogenetic protein 2 (BMP 2); Dual interactions; Injectable hydrogel; Polymeric nanoparticles; Sustained BMP 2 release

Indexed keywords

AMINO ACIDS; BONE; ETHYLENE; ETHYLENE GLYCOL; HYDROPHOBICITY; NANOPARTICLES; POLYMERS; PROTEINS;

BONE MORPHOGENETIC PROTEIN-2; BONE REGENERATION; HYDROPHOBIC INTERACTIONS; INJECTABLE HYDROGELS; IONIC INTERACTION; POLYMERIC NANOPARTICLES; SUSTAINED BMP-2 RELEASE; THERMO SENSITIVE;

HYDROGELS;

BONE MORPHOGENETIC PROTEIN 2; CARBOXYLIC ACID; MACROGOL; NANOPARTICLE; OSTEOCALCIN; DELAYED RELEASE FORMULATION; HYDROGEL; ORGANOPHOSPHORUS COMPOUND; POLY(ORGANOPHOSPHAZENE); POLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; BONE MASS; BONE REGENERATION; CELL VIABILITY; CELL VIABILITY ASSAY; CONTROLLED STUDY; CYTOTOXICITY TEST; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL PERMEATION CHROMATOGRAPHY; HEAT SENSITIVITY; HISTOLOGY; HYDROGEL; HYDROGEN BOND; HYDROPHOBICITY; IN VITRO STUDY; MALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSSIFICATION; PARTICLE SIZE; PH; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN SECRETION; PROTON NUCLEAR MAGNETIC RESONANCE; SURFACE CHARGE; SUSTAINED DRUG RELEASE; SYNTHESIS; TEMPERATURE; VISCOSITY; ZETA POTENTIAL; 3T3 CELL LINE; ADMINISTRATION AND DOSAGE; ANIMAL; C57BL MOUSE; CELL LINE; CELL SURVIVAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECTS; DRUG RELEASE; INJECTION; METABOLISM; PHARMACOLOGY;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE REGENERATION; CELL LINE; CELL SURVIVAL; DELAYED-ACTION PREPARATIONS; DRUG LIBERATION; HYDROGELS; INJECTIONS; MALE; MICE; MICE, INBRED C57BL; NANOPARTICLES; NIH 3T3 CELLS; ORGANOPHOSPHORUS COMPOUNDS; OSTEOCALCIN; POLYMERS;

EID: 84928963884     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.04.023     Document Type: Article

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