In vivo bacterial imaging without engineering; a novel probe-based strategy facilitated by endogenous nitroreductase enzymes

Current Gene Therapy

Volumn 15, Issue 3, 2015, Pages 277-288

  Stanton, Michael ^a   Cronin, Michelle ^a   Lehouritis, Panos ^a   Tangney, Mark ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Cancer; CytoCy5S; Fluorescence; NTR; Optical imaging

Indexed keywords

FLUORESCENT DYE; NITROREDUCTASE; PRODRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIFIDOBACTERIUM; CELL VIABILITY ASSAY; DNA MODIFICATION; ENZYME ACTIVITY; ESCHERICHIA COLI; FEMALE; FLUORESCENCE IMAGING; GENE EXPRESSION; GENE THERAPY; GENETIC ENGINEERING; GENETIC LOAD; LISTERIA; LUMINESCENCE; MOUSE; NONHUMAN; PEPTOCLOSTRIDIUM DIFFICILE; SALMONELLA; SALMONELLOSIS; WESTERN BLOTTING; ANIMAL; BACTERIUM; BAGG ALBINO MOUSE; GENE VECTOR; GENETICS; METABOLISM; NEOPLASMS; PROCEDURES;

BACTERIA (MICROORGANISMS); BIFIDOBACTERIUM; CLOSTRIDIUM DIFFICILE; LISTERIA; MAMMALIA; NEGIBACTERIA; SALMONELLA;

ANIMALS; BACTERIA; FEMALE; FLUORESCENT DYES; GENETIC THERAPY; GENETIC VECTORS; MICE; MICE, INBRED BALB C; NEOPLASMS; NITROREDUCTASES; PRODRUGS;

EID: 84928953151     PISSN: 15665232     EISSN: 18755631     Source Type: Journal    
DOI: 10.2174/1566523215666150126122712     Document Type: Article

References (42)

1. Cronin M, Stanton R, Francis K, Tangney M. Bacterial vectors for imaging and cancer gene therapy: a review. Cancer Gene Ther 2012;19(11):731-40.
2. Matthews PM, Coatney R, Alsaid H, et al. Technologies: preclinical imaging for drug development. Drug Discovery Today: Technologies 2013;10(3):e343-e50.
3. ECDC/EMEA. ECDC/EMEA Joint Technical Report: The bacterial challenge: time to react 2009.
4. Rice BW, Cable MD, Nelson MB. In vivo imaging of light-emitting probes. J Biomed Optics 2001;6(4):432-40.
5. Byrne WL, Delille A, Kuo C, et al. Use of optical imaging to progress novel therapeutics to the clinic. J Control Release 2013; 172(2):523-34.
6. Tangney M, Francis KP. In vivo optical imaging in gene & cell therapy. Curr Gene Ther 2012;12(1):2-11.
7. Niska JA, Meganck JA, Pribaz JR, et al. Monitoring Bacterial Burden, Inflammation and Bone Damage Longitudinally Using Optical and μCT Imaging in an Orthopaedic Implant Infection in Mice. PLoS ONE 2012;7(10):e47397.
8. Riedel CU, Monk IR, Casey PG, et al. Improved luciferase tagging system for Listeria monocytogenes allows real-time monitoring in vivo and in vitro. Appl Environ Microbiol 2007;73(9):3091-4.
9. Guglielmetti S, Ciranna A, Mora D, Parini C, Karp M. Construction, characterization and exemplificative application of bioluminescent Bifidobacterium longum biovar longum. Int J Food Microbiol 2008;124(3):285-90.
10. Foucault ML, Thomas L, Goussard S, Branchini BR, Grillot-Courvalin C. In vivo bioluminescence imaging for the study of intestinal colonization by Escherichia coli in mice. Appl Environ Microbiol 2010;76(1):264-74.
11. Hoffman RM, Zhao M. Whole-body imaging of bacterial infection and antibiotic response. Nature Protocols 2006;1(6):2988-94.
12. Clinicopathological statistics on registered prostate cancer patients in Japan: 2000 report from the Japanese Urological Association. Int J Urol 2005;12(1):46-61.
13. White AG, Gray BD, Pak KY, Smith BD. Deep-red fluorescent imaging probe for bacteria. Bioorg Med Chem Lett 2012;22(8):2833-36.
14. Leevy WM, Gammon ST, Jiang H, et al. Optical Imaging of Bacterial Infection in Living Mice Using a Fluorescent Near-Infrared Molecular Probe. J Am Chem Soc 2006;128(51):16476-7.
15. Leevy WM, Gammon ST, Johnson JR, et al. Noninvasive Optical Imaging of Staphylococcus aureus Bacterial Infection in Living Mice Using a Bis-Dipicolylamine-Zinc(II) Affinity Group Conjugated to a Near-Infrared Fluorophore. Bioconjugate Chem 2008;19(3):686-92.
16. Ning X, Lee S, Wang Z, et al. Maltodextrin-based imaging probes detect bacteria in vivo with high sensitivity and specificity. Nat Materials 2011;10(8):602-7.
17. Orenga S, James AL, Manafi M, Perry JD, Pincus DH. Enzymatic substrates in microbiology. J Microbiol Methods 2009;79(2):139-55.
18. Kong Y, Yao H, Ren H, et al. Imaging tuberculosis with endogenous β-lactamase reporter enzyme fluorescence in live mice. Proc Natl Acad Sci USA 2010;107(27):12239-44.
19. Rice LB, editor. Mechanisms of resistance and clinical relevance of resistance to β-lactams, glycopeptides, and fluoroquinolones. Mayo Clinic Proceedings; 2012: Elsevier.
20. Roldan MD, Perez-Reinado E, Castillo F, Moreno-Vivian C. Reduction of polynitroaromatic compounds: the bacterial nitroreductases. FEMS Microbiol Rev 2008;32(3):474-500.
21. Patel P, Young JG, Mautner V, et al. A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1954 [correction of CB1984]. Mol Ther 2009;17(7):1292-9.
22. James AL, Perry JD, Jay C, et al. Fluorogenic substrates for the detection of microbial nitroreductases. Lett Appl Microbiol 2001;33(6):403-8.
23. Cellier M, Fabrega OJ, Fazackerley E, et al. 2-Arylbenzothiazole, benzoxazole and benzimidazole derivatives as fluorogenic substrates for the detection of nitroreductase and aminopeptidase activity in clinically important bacteria. Bioorg Med Chem 2011;19(9):2903-10.
24. Bhaumik S, Sekar T, Depuy J, Klimash J, Paulmurugan R. Noninvasive optical imaging of nitroreductase gene-directed enzyme prodrug therapy system in living animals. Gene Ther 2011;19(3):295-302.
25. McCormack E, Silden E, West RM, et al. Nitroreductase, a nearinfrared reporter platform for in vivo time-domain optical imaging of metastatic cancer. Cancer Res 2013;73(4):1276-86.
26. González-Pérez MM, Van Dillewijn P, Wittich R-M, Ramos JL. Escherichia coli has multiple enzymes that attack TNT and release nitrogen for growth. Environ Microbiol 2007;9(6):1535-40.
27. Mathur H, O'Connor PM, Hill C, Cotter PD, Ross RP. Analysis of Anti-Clostridium difficile Activity of Thuricin CD, Vancomycin, Metronidazole, Ramoplanin, and Actagardine, both Singly and in Paired Combinations. Antimicrob Agents Chemother 2013;57(6):2882-86.
28. Cronin M, Akin AR, Collins SA, et al. High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting. PLoS One 2012;7(1):e30940.
29. Baban CK, Cronin M, Akin AR, et al. Bioluminescent bacterial imaging in vivo. J Vis Exp 2012;(69):e4318.
30. Prosser G, Copp J, Syddall S, et al. Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954. Biochem Pharmacol 2010;79(5):678-87.
31. Valle A, Le Borgne S, Bolívar J, Cabrera G, Cantero D. Study of the role played by NfsA, NfsB nitroreductase and NemA flavin reductase from Escherichia coli in the conversion of ethyl 2-(2′-nitrophenoxy) acetate to 4-hydroxy-(2H)-1, 4-benzoxazin-3 (4H)-one (D-DIBOA), a benzohydroxamic acid with interesting biological properties. App Microbiol Biotechnol 2012;94(1):163-71.
32. Leevy WM, Lambert TN, Johnson JR, Morris J, Smith BD. Quantum dot probes for bacteria distinguish Escherichia coli mutants and permit in vivo imaging. Chem Commun 2008(20):2331-3.
33. Yu YA, Zhang Q, Szalay AA. Establishment and characterization of conditions required for tumor colonization by intravenously delivered bacteria. Biotechnol Bioeng 2008;100(3):567-78.
34. Cummins J, Tangney M. Bacteria and tumours: causative agents or opportunistic inhabitants? Infect Agent Cancer 2013;8(1):1-8.
35. Tangney M. Gene therapy for cancer: dairy bacteria as delivery vectors. Discov Med 2010;10(52):195.
36. Hoffman RM. Tumor-seeking Salmonella amino acid auxotrophs. Curr Opin Biotechnol 2011;22(6):917-23.
37. Morrissey D, O'Sullivan GC, Tangney M. Tumour targeting with systemically administered bacteria. Curr Gene Ther 2010;10(1):3-14.
38. Cronin M, Morrissey D, Rajendran S, et al. Orally administered bifidobacteria as vehicles for delivery of agents to systemic tumors. Mol Ther 2010;18(7):1397-407.
39. Baban CK, Cronin M, O'Hanlon D, O'Sullivan GC, Tangney M. Bacteria as vectors for gene therapy of cancer. Bioeng Bugs 2010;1(6):385-94.
40. Lehouritis P, Springer C, Tangney M. Bacterial-directed enzyme prodrug therapy. J Control Release 2013;170(1):120-31.
41. Tangney M. Editorial: in vivo imaging & gene therapy. Curr Gene Ther 2012;12(1):1.
42. Collins SA, Hiraoka K, Inagaki A, Kasahara N, Tangney M. PET Imaging for Gene & Cell Therapy. Curr Gene Ther 2012;12(1):20-32.