Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway

Nature Cell Biology

Volumn 17, Issue 5, 2015, Pages 678-688

  Wei, Spencer C ^a,b,e   Fattet, Laurent ^a   Tsai, Jeff H ^a   Guo, Yurong ^c   Pai, Vincent H ^a,b   Majeski, Hannah E ^a,b   Chen, Albert C ^d   Sah, Robert L ^d   Taylor, Susan S ^a,b,c   Engler, Adam J ^d   Yang, Jing ^a,b  

^a San Diego   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; PROTEIN G3BP2; TUMOR PROTEIN; TWIST1 PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; G3BP2 PROTEIN, HUMAN; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR TWIST; TWIST1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CASE REPORT; CELLULAR PARAMETERS; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MATRIX STIFFNESS; MECHANOTRANSDUCTION; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEQUENCE ALIGNMENT; TUMOR INVASION; TUMOR MICROENVIRONMENT; TUMOR PROMOTION; ACTIVE TRANSPORT; ANIMAL; BREAST TUMOR; CANCER STAGING; CELL MEMBRANE; DISEASE FREE SURVIVAL; ELASTICITY; GENETIC DATABASE; GENETIC TRANSFECTION; GENETICS; INTRADUCTAL CARCINOMA; KAPLAN MEIER METHOD; METABOLISM; MORTALITY; PATHOLOGY; RETROSPECTIVE STUDY; RNA INTERFERENCE; SCID MOUSE; SECONDARY; TIME; TUMOR CELL LINE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BREAST NEOPLASMS; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CARRIER PROTEINS; CELL LINE, TUMOR; CELL-MATRIX JUNCTIONS; COLLAGEN; DATABASES, GENETIC; DISEASE-FREE SURVIVAL; ELASTICITY; EPITHELIAL-MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MECHANOTRANSDUCTION, CELLULAR; MICE, SCID; NEOPLASM INVASIVENESS; NEOPLASM STAGING; NUCLEAR PROTEINS; RETROSPECTIVE STUDIES; RNA INTERFERENCE; TIME FACTORS; TRANSFECTION; TUMOR MICROENVIRONMENT; TWIST TRANSCRIPTION FACTOR;

EID: 84928938456     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3157     Document Type: Article

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