The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission

EMBO Reports

Volumn 16, Issue 5, 2015, Pages 590-598

  Safory, Hazem ^a   Neame, Samah ^a   Shulman, Yoav ^a   Zubedat, Salman ^a   Radzishevsky, Inna ^a   Rosenberg, Dina ^a   Sason, Hagit ^a   Engelender, Simone ^a   Avital, Avi ^a,b   Hülsmann, Swen ^c   Schiller, Jackie ^a   Wolosker, Herman ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b HAEMEK MEDICAL CENTER   (Israel)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

D serine; glycine receptor; GlyT2; hyperekplexia; non ketotic hyperglycinemia

Indexed keywords

AMINO ACID TRANSPORTER; ASC 1 TRANSPORTER; GLYCINE; UNCLASSIFIED DRUG; GLYCINE RECEPTOR; SERINE; SLC7A10 PROTEIN, MOUSE;

AMINO ACID BRAIN LEVEL; AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; CONTROLLED STUDY; EX VIVO STUDY; HYPEREKPLEXIA; IN VIVO STUDY; METABOLOMICS; MOUSE; NEUROTRANSMISSION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; ANIMAL; BRAIN; CYTOLOGY; GENETICS; GENOTYPE; HYPOGLOSSAL NERVE; KNOCKOUT MOUSE; METABOLISM; METABOLOME; MUTATION; NERVE CELL; PROCEDURES; SYNAPTIC TRANSMISSION; TRANSPORT AT THE CELLULAR LEVEL;

MUS;

AMINO ACID TRANSPORT SYSTEM Y+; ANIMALS; BIOLOGICAL TRANSPORT; BRAIN; GENOTYPE; GLYCINE; HYPOGLOSSAL NERVE; METABOLOME; METABOLOMICS; MICE; MICE, KNOCKOUT; MUTATION; NEURONS; PHENOTYPE; RECEPTORS, GLYCINE; SERINE; SYNAPTIC TRANSMISSION;

EID: 84928926220     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201439561     Document Type: Article

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